#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04437	uniprotkb:P11978	intact:EBI-8224|uniprotkb:Q0P737|uniprotkb:Q0P738|uniprotkb:Q0P741|uniprotkb:Q0P749|uniprotkb:D6VZS9|ensemblfungi:YMR106C	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	psi-mi:ku80_yeast(display_long)|uniprotkb:YKU80(gene name)|psi-mi:YKU80(display_short)|uniprotkb:HDF2(gene name synonym)|uniprotkb:YMR106C(locus name)|uniprotkb:YM9718.05C(orf name)|uniprotkb:Yeast Ku80(gene name synonym)|uniprotkb:High affinity DNA-binding factor subunit 2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II subunit Ku80(gene name synonym)	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Roy et al. (2004)	pubmed:14551211	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1393481	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013824.1|sgd:S000004712|mint:Q04437|dip:DIP-2757N|ensemblfungi:YMR106C(gene)|ensemblfungi:YMR106C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006348"|go:"GO:0007535"(donor selection)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|rcsb pdb:5Y58|rcsb pdb:5Y59|reactome:R-SCE-6798695	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	-	crc64:58126164EE375643	crc64:9C698765964F094E	figure legend:4, 5a and 5c|comment:Deletion of KU70 did not change the interaction.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/11	2014/10/16	rogid:/N3a9q2fCKmobRCO3NKX0AACMTY559292	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	intact-crc:0BD9B811A798CF4E|rigid:qudu0iWHzIb/ssDixO48t6S7kZg	false	mutation decreasing interaction:441-441|sufficient binding region:426-450|mutation decreasing interaction:437-438	sufficient binding region:1-175	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11978	uniprotkb:Q04437	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	intact:EBI-8224|uniprotkb:Q0P737|uniprotkb:Q0P738|uniprotkb:Q0P741|uniprotkb:Q0P749|uniprotkb:D6VZS9|ensemblfungi:YMR106C	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:ku80_yeast(display_long)|uniprotkb:YKU80(gene name)|psi-mi:YKU80(display_short)|uniprotkb:HDF2(gene name synonym)|uniprotkb:YMR106C(locus name)|uniprotkb:YM9718.05C(orf name)|uniprotkb:Yeast Ku80(gene name synonym)|uniprotkb:High affinity DNA-binding factor subunit 2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II subunit Ku80(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Roy et al. (2004)	pubmed:14551211	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1393499	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	refseq:NP_013824.1|sgd:S000004712|mint:Q04437|dip:DIP-2757N|ensemblfungi:YMR106C(gene)|ensemblfungi:YMR106C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006348"|go:"GO:0007535"(donor selection)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|rcsb pdb:5Y58|rcsb pdb:5Y59|reactome:R-SCE-6798695	-	crc64:9C698765964F094E	crc64:58126164EE375643	figure legend:5b	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/11	2014/10/16	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	rogid:/N3a9q2fCKmobRCO3NKX0AACMTY559292	intact-crc:48D806750FBE0DEB|rigid:qudu0iWHzIb/ssDixO48t6S7kZg	false	binding-associated region:1-200|ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)