#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P49735 uniprotkb:Q9VIE6 intact:EBI-138228|uniprotkb:Q9VHU2|ensemblmetazoa:FBpp0081317 intact:EBI-91264|ensemblmetazoa:FBpp0081004|uniprotkb:Q95RC7 psi-mi:mcm2_drome(display_long)|uniprotkb:Mcm2(gene name)|psi-mi:Mcm2(display_short)|uniprotkb:CG7538(orf name)|uniprotkb:Minichromosome maintenance 2 protein(gene name synonym) psi-mi:mcm10_drome(display_long)|uniprotkb:Mcm10(gene name)|psi-mi:Mcm10(display_short)|uniprotkb:Scim19(gene name synonym)|uniprotkb:Sensitized chromosome inheritance modifier 19(gene name synonym)|uniprotkb:CG9241(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Christensen et al. (2003) pubmed:12808023 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1372621 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0014861(gene)|ensemblmetazoa:FBtr0081827(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0030261"(chromosome condensation)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|rcsb pdb:6RAW|rcsb pdb:6RAX|rcsb pdb:6RAY|rcsb pdb:6RAZ|reactome:R-DME-176187|reactome:R-DME-68867|reactome:R-DME-68949|reactome:R-DME-68962|reactome:R-DME-69052|refseq:NP_477121.1|flybase:FBgn0014861|dip:DIP-22529N ensemblmetazoa:FBgn0032929(gene)|ensemblmetazoa:FBtr0081475(transcript)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0030261"(chromosome condensation)|refseq:NP_610097.2|flybase:FBgn0032929|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0045678"(positive regulation of R7 cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:1901693"(negative regulation of compound eye retinal cell apoptotic process)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR015411(Mcm10 replication factor)|interpro:IPR040184|reactome:R-DME-176187|reactome:R-DME-68962|dip:DIP-20713N - - - figure legend:2A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:7227(drome-kc)|taxid:7227(Drosophila melanogaster embryo KC cells) - 2007/07/20 2014/10/16 rogid:Jnb71nPH/PDF5xcA8kTakW8zhDE7227 rogid:UR3VkJyT0QWaOIqUBzPgI6e1JDA7227 intact-crc:8436E2F94443E2B4|rigid:GZDeyaWAw1l4WT+lfcHCsEsxlLM false - glutathione s tranferase tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q7JVY2 uniprotkb:Q9VIE6 intact:EBI-164632|intact:EBI-1372627|ensemblmetazoa:FBpp0086519|ensemblmetazoa:FBpp0309018 intact:EBI-91264|ensemblmetazoa:FBpp0081004|uniprotkb:Q95RC7 psi-mi:q7jvy2_drome(display_long)|uniprotkb:dup(gene name)|psi-mi:dup(display_short)|uniprotkb:19k(gene name synonym)|uniprotkb:CDT1(gene name synonym)|uniprotkb:Cdt1(gene name synonym)|uniprotkb:DUP(gene name synonym)|uniprotkb:Dmel\CG8171(gene name synonym)|uniprotkb:Dup(gene name synonym)|uniprotkb:anon-WO0257455.31(gene name synonym)|uniprotkb:cdt1(gene name synonym)|uniprotkb:"fs(2)51Fa"(gene name synonym)|uniprotkb:"fs(2)PA77"(gene name synonym)|uniprotkb:"fs(2)ltoPA77"(gene name synonym)|uniprotkb:"l(2)51Ec"(gene name synonym)|uniprotkb:"l(2)k03308"(gene name synonym)|uniprotkb:CG8171(orf name)|uniprotkb:Dmel_CG8171(orf name) psi-mi:mcm10_drome(display_long)|uniprotkb:Mcm10(gene name)|psi-mi:Mcm10(display_short)|uniprotkb:Scim19(gene name synonym)|uniprotkb:Sensitized chromosome inheritance modifier 19(gene name synonym)|uniprotkb:CG9241(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Christensen et al. (2003) pubmed:12808023 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1372633 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0000996|refseq:NP_524878.1|refseq:NP_001286451.1|ensemblmetazoa:FBgn0000996(gene)|ensemblmetazoa:FBtr0087387(transcript)|ensemblmetazoa:FBtr0339999(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0007304"(chorion-containing eggshell formation)|go:"GO:0007307"(eggshell chorion gene amplification)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0042065"(glial cell growth)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|interpro:IPR014939(DNA replication factor CDT1-like)|interpro:IPR032054|interpro:IPR036390|interpro:IPR038090|reactome:R-DME-68827|reactome:R-DME-68949|reactome:R-DME-68962|reactome:R-DME-68867|dip:DIP-20004N ensemblmetazoa:FBgn0032929(gene)|ensemblmetazoa:FBtr0081475(transcript)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0030261"(chromosome condensation)|refseq:NP_610097.2|flybase:FBgn0032929|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0045678"(positive regulation of R7 cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:1901693"(negative regulation of compound eye retinal cell apoptotic process)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR015411(Mcm10 replication factor)|interpro:IPR040184|reactome:R-DME-176187|reactome:R-DME-68962|dip:DIP-20713N - - - figure legend:2A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:7227(drome-kc)|taxid:7227(Drosophila melanogaster embryo KC cells) - 2007/07/20 2014/10/16 rogid:2hvlsuUPmZyjL1SkMbYmMMcNajI7227 rogid:UR3VkJyT0QWaOIqUBzPgI6e1JDA7227 intact-crc:40457FC1354DDA1F|rigid:7i72qX61oT1DOtcjwc78OgK1yFc false - glutathione s tranferase tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9VIE6 uniprotkb:O96989 intact:EBI-91264|ensemblmetazoa:FBpp0081004|uniprotkb:Q95RC7 intact:EBI-156880|ensemblmetazoa:FBpp0070175 psi-mi:mcm10_drome(display_long)|uniprotkb:Mcm10(gene name)|psi-mi:Mcm10(display_short)|uniprotkb:Scim19(gene name synonym)|uniprotkb:Sensitized chromosome inheritance modifier 19(gene name synonym)|uniprotkb:CG9241(orf name) psi-mi:o96989_drome(display_long)|uniprotkb:Cdc45(gene name)|psi-mi:Cdc45(display_short)|uniprotkb:CDC45(gene name synonym)|uniprotkb:CDC45L(gene name synonym)|uniprotkb:D(gene name synonym)|uniprotkb:DmCdc45(gene name synonym)|uniprotkb:Dmel\CG3658(gene name synonym)|uniprotkb:"EG:BACR7A4.11"(gene name synonym)|uniprotkb:anon-1Ec(gene name synonym)|uniprotkb:cdc45(gene name synonym)|uniprotkb:dCDC45(gene name synonym)|uniprotkb:dCDC45L(gene name synonym)|uniprotkb:CG3658(orf name)|uniprotkb:Dmel_CG3658(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Christensen et al. (2003) pubmed:12808023 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1372639 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0032929(gene)|ensemblmetazoa:FBtr0081475(transcript)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0030261"(chromosome condensation)|refseq:NP_610097.2|flybase:FBgn0032929|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0045678"(positive regulation of R7 cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:1901693"(negative regulation of compound eye retinal cell apoptotic process)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR015411(Mcm10 replication factor)|interpro:IPR040184|reactome:R-DME-176187|reactome:R-DME-68962|dip:DIP-20713N refseq:NP_569880.1|flybase:FBgn0026143|dip:DIP-20144N|ensemblmetazoa:FBgn0026143(gene)|ensemblmetazoa:FBtr0070182(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006277"(DNA amplification)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0051301"(cell division)|go:"GO:0071162"(CMG complex)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:6RAW|rcsb pdb:6RAX|rcsb pdb:6RAZ|reactome:R-DME-176187|reactome:R-DME-68962|rcsb pdb:6RAY - - - figure legend:2A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:7227(drome-kc)|taxid:7227(Drosophila melanogaster embryo KC cells) - 2007/07/20 2014/10/16 rogid:UR3VkJyT0QWaOIqUBzPgI6e1JDA7227 rogid:/ivfSBShEpXOtbuOiXeQKg+9EC07227 intact-crc:185283E936A303B5|rigid:HBO33yqwBQxJWVczGQ46Z3fBDX0 false glutathione s tranferase tag:c-c - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q24168 uniprotkb:Q9VIE6 intact:EBI-179453|intact:EBI-1631787|uniprotkb:Q9VFP4|ensemblmetazoa:FBpp0082329 intact:EBI-91264|ensemblmetazoa:FBpp0081004|uniprotkb:Q95RC7 psi-mi:orc2_drome(display_long)|uniprotkb:Orc2(gene name)|psi-mi:Orc2(display_short)|uniprotkb:CG3041(orf name) psi-mi:mcm10_drome(display_long)|uniprotkb:Mcm10(gene name)|psi-mi:Mcm10(display_short)|uniprotkb:Scim19(gene name synonym)|uniprotkb:Sensitized chromosome inheritance modifier 19(gene name synonym)|uniprotkb:CG9241(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Christensen et al. (2003) pubmed:12808023 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1372645 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_731873.1|flybase:FBgn0015270|dip:DIP-23209N|ensemblmetazoa:FBgn0015270(gene)|ensemblmetazoa:FBtr0082866(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005723"(alpha-heterochromatin)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007307"(eggshell chorion gene amplification)|go:"GO:0030261"(chromosome condensation)|interpro:IPR007220(Origin recognition complex subunit 2)|rcsb pdb:4XGC|rcsb pdb:7JGR|rcsb pdb:7JGS|rcsb pdb:7JK2|rcsb pdb:7JK3|rcsb pdb:7JK4|rcsb pdb:7JK5|rcsb pdb:7JK6|reactome:R-DME-176187|reactome:R-DME-68616|reactome:R-DME-68689|reactome:R-DME-68827|reactome:R-DME-68867|reactome:R-DME-68949|reactome:R-DME-68962 ensemblmetazoa:FBgn0032929(gene)|ensemblmetazoa:FBtr0081475(transcript)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0030261"(chromosome condensation)|refseq:NP_610097.2|flybase:FBgn0032929|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0045678"(positive regulation of R7 cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:1901693"(negative regulation of compound eye retinal cell apoptotic process)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR015411(Mcm10 replication factor)|interpro:IPR040184|reactome:R-DME-176187|reactome:R-DME-68962|dip:DIP-20713N - - - figure legend:2A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:7227(drome-kc)|taxid:7227(Drosophila melanogaster embryo KC cells) - 2007/07/20 2014/10/16 rogid:SaBA2xfoQcWtCiLhN6rD5O5yMhg7227 rogid:UR3VkJyT0QWaOIqUBzPgI6e1JDA7227 intact-crc:58CBA930F4BDB2D3|rigid:WzVoNISf3L08pUnNcvsLQoUDo98 false - glutathione s tranferase tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9VIE6 uniprotkb:P05205 intact:EBI-91264|ensemblmetazoa:FBpp0081004|uniprotkb:Q95RC7 intact:EBI-155532|uniprotkb:Q9VLR6|uniprotkb:A4V0F1|uniprotkb:B6UVR4|uniprotkb:B6UVS1|uniprotkb:B6UVS2|uniprotkb:B6UVS3|uniprotkb:B6UVT2|uniprotkb:B6UVT6|uniprotkb:B6UVT7|ensemblmetazoa:FBpp0079251|ensemblmetazoa:FBpp0079252 psi-mi:mcm10_drome(display_long)|uniprotkb:Mcm10(gene name)|psi-mi:Mcm10(display_short)|uniprotkb:Scim19(gene name synonym)|uniprotkb:Sensitized chromosome inheritance modifier 19(gene name synonym)|uniprotkb:CG9241(orf name) psi-mi:hp1_drome(display_long)|uniprotkb:"Su(var)205"(gene name)|psi-mi:"Su(var)205"(display_short)|uniprotkb:HP1(gene name synonym)|uniprotkb:CG8409(orf name)|uniprotkb:Non-histone chromosomal protein C1A9 antigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Christensen et al. (2003) pubmed:12808023 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1372651 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0032929(gene)|ensemblmetazoa:FBtr0081475(transcript)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0030261"(chromosome condensation)|refseq:NP_610097.2|flybase:FBgn0032929|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0045678"(positive regulation of R7 cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:1901693"(negative regulation of compound eye retinal cell apoptotic process)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR015411(Mcm10 replication factor)|interpro:IPR040184|reactome:R-DME-176187|reactome:R-DME-68962|dip:DIP-20713N refseq:NP_476755.1|refseq:NP_723361.1|flybase:FBgn0003607|dip:DIP-21869N|ensemblmetazoa:FBgn0003607(gene)|ensemblmetazoa:FBtr0079635(transcript)|ensemblmetazoa:FBtr0079636(transcript)|go:"GO:0000182"(rDNA binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005701"(polytene chromosome chromocenter)|go:"GO:0005703"(polytene chromosome puff)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006342"|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010369"(chromocenter)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031060"(regulation of histone methylation)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0033697"(obsolete positive regulation of extent of heterochromatin assembly)|go:"GO:0034773"(histone H4-K20 trimethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051276"(chromosome organization)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1900111"(positive regulation of histone H3-K9 dimethylation)|go:"GO:1905632"(protein localization to euchromatin)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1905646"(positive regulation of FACT complex assembly)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|mint:P05205|rcsb pdb:1KNA|rcsb pdb:1KNE|rcsb pdb:1Q3L|rcsb pdb:3P7J|rcsb pdb:6ASZ|rcsb pdb:6AT0|rcsb pdb:6MHA - - - figure legend:2A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:7227(drome-kc)|taxid:7227(Drosophila melanogaster embryo KC cells) - 2007/07/20 2014/10/16 rogid:UR3VkJyT0QWaOIqUBzPgI6e1JDA7227 rogid:gWEeBI57HBgTrPkRsAgoftkxb+M7227 intact-crc:115D2A3EF19C956F|rigid:0RyujqDeA3ODsYHEYyxbYy9r7vk false glutathione s tranferase tag:c-c - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9VIE6 uniprotkb:Q9VIE6 intact:EBI-91264|ensemblmetazoa:FBpp0081004|uniprotkb:Q95RC7 intact:EBI-91264|ensemblmetazoa:FBpp0081004|uniprotkb:Q95RC7 psi-mi:mcm10_drome(display_long)|uniprotkb:Mcm10(gene name)|psi-mi:Mcm10(display_short)|uniprotkb:Scim19(gene name synonym)|uniprotkb:Sensitized chromosome inheritance modifier 19(gene name synonym)|uniprotkb:CG9241(orf name) psi-mi:mcm10_drome(display_long)|uniprotkb:Mcm10(gene name)|psi-mi:Mcm10(display_short)|uniprotkb:Scim19(gene name synonym)|uniprotkb:Sensitized chromosome inheritance modifier 19(gene name synonym)|uniprotkb:CG9241(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Christensen et al. (2003) pubmed:12808023 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1372657 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0032929(gene)|ensemblmetazoa:FBtr0081475(transcript)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0030261"(chromosome condensation)|refseq:NP_610097.2|flybase:FBgn0032929|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0045678"(positive regulation of R7 cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:1901693"(negative regulation of compound eye retinal cell apoptotic process)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR015411(Mcm10 replication factor)|interpro:IPR040184|reactome:R-DME-176187|reactome:R-DME-68962|dip:DIP-20713N ensemblmetazoa:FBgn0032929(gene)|ensemblmetazoa:FBtr0081475(transcript)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0030261"(chromosome condensation)|refseq:NP_610097.2|flybase:FBgn0032929|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0045678"(positive regulation of R7 cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:1901693"(negative regulation of compound eye retinal cell apoptotic process)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR015411(Mcm10 replication factor)|interpro:IPR040184|reactome:R-DME-176187|reactome:R-DME-68962|dip:DIP-20713N - - - figure legend:2A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:7227(drome-kc)|taxid:7227(Drosophila melanogaster embryo KC cells) - 2007/07/20 2014/10/16 rogid:UR3VkJyT0QWaOIqUBzPgI6e1JDA7227 rogid:UR3VkJyT0QWaOIqUBzPgI6e1JDA7227 intact-crc:235C46D4011E280B|rigid:OKQMOyRQ7NEFzgtgOZwxVIoo6Mk false glutathione s tranferase tag:c-c - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O96989 uniprotkb:Q9VIE6 intact:EBI-156880|ensemblmetazoa:FBpp0070175 intact:EBI-91264|ensemblmetazoa:FBpp0081004|uniprotkb:Q95RC7 psi-mi:o96989_drome(display_long)|uniprotkb:Cdc45(gene name)|psi-mi:Cdc45(display_short)|uniprotkb:CDC45(gene name synonym)|uniprotkb:CDC45L(gene name synonym)|uniprotkb:D(gene name synonym)|uniprotkb:DmCdc45(gene name synonym)|uniprotkb:Dmel\CG3658(gene name synonym)|uniprotkb:"EG:BACR7A4.11"(gene name synonym)|uniprotkb:anon-1Ec(gene name synonym)|uniprotkb:cdc45(gene name synonym)|uniprotkb:dCDC45(gene name synonym)|uniprotkb:dCDC45L(gene name synonym)|uniprotkb:CG3658(orf name)|uniprotkb:Dmel_CG3658(orf name) psi-mi:mcm10_drome(display_long)|uniprotkb:Mcm10(gene name)|psi-mi:Mcm10(display_short)|uniprotkb:Scim19(gene name synonym)|uniprotkb:Sensitized chromosome inheritance modifier 19(gene name synonym)|uniprotkb:CG9241(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Christensen et al. (2003) pubmed:12808023 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1372669 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_569880.1|flybase:FBgn0026143|dip:DIP-20144N|ensemblmetazoa:FBgn0026143(gene)|ensemblmetazoa:FBtr0070182(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006277"(DNA amplification)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0051301"(cell division)|go:"GO:0071162"(CMG complex)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:6RAW|rcsb pdb:6RAX|rcsb pdb:6RAZ|reactome:R-DME-176187|reactome:R-DME-68962|rcsb pdb:6RAY ensemblmetazoa:FBgn0032929(gene)|ensemblmetazoa:FBtr0081475(transcript)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0030261"(chromosome condensation)|refseq:NP_610097.2|flybase:FBgn0032929|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0045678"(positive regulation of R7 cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:1901693"(negative regulation of compound eye retinal cell apoptotic process)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR015411(Mcm10 replication factor)|interpro:IPR040184|reactome:R-DME-176187|reactome:R-DME-68962|dip:DIP-20713N - - - figure legend:2B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:7227(drome-kc)|taxid:7227(Drosophila melanogaster embryo KC cells) - 2007/07/20 2014/10/16 rogid:/ivfSBShEpXOtbuOiXeQKg+9EC07227 rogid:UR3VkJyT0QWaOIqUBzPgI6e1JDA7227 intact-crc:273967F4A25D6414|rigid:HBO33yqwBQxJWVczGQ46Z3fBDX0 false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7JVY2 uniprotkb:Q9VIE6 intact:EBI-164632|intact:EBI-1372627|ensemblmetazoa:FBpp0086519|ensemblmetazoa:FBpp0309018 intact:EBI-91264|ensemblmetazoa:FBpp0081004|uniprotkb:Q95RC7 psi-mi:q7jvy2_drome(display_long)|uniprotkb:dup(gene name)|psi-mi:dup(display_short)|uniprotkb:19k(gene name synonym)|uniprotkb:CDT1(gene name synonym)|uniprotkb:Cdt1(gene name synonym)|uniprotkb:DUP(gene name synonym)|uniprotkb:Dmel\CG8171(gene name synonym)|uniprotkb:Dup(gene name synonym)|uniprotkb:anon-WO0257455.31(gene name synonym)|uniprotkb:cdt1(gene name synonym)|uniprotkb:"fs(2)51Fa"(gene name synonym)|uniprotkb:"fs(2)PA77"(gene name synonym)|uniprotkb:"fs(2)ltoPA77"(gene name synonym)|uniprotkb:"l(2)51Ec"(gene name synonym)|uniprotkb:"l(2)k03308"(gene name synonym)|uniprotkb:CG8171(orf name)|uniprotkb:Dmel_CG8171(orf name) psi-mi:mcm10_drome(display_long)|uniprotkb:Mcm10(gene name)|psi-mi:Mcm10(display_short)|uniprotkb:Scim19(gene name synonym)|uniprotkb:Sensitized chromosome inheritance modifier 19(gene name synonym)|uniprotkb:CG9241(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Christensen et al. (2003) pubmed:12808023 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1372675 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0000996|refseq:NP_524878.1|refseq:NP_001286451.1|ensemblmetazoa:FBgn0000996(gene)|ensemblmetazoa:FBtr0087387(transcript)|ensemblmetazoa:FBtr0339999(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0007304"(chorion-containing eggshell formation)|go:"GO:0007307"(eggshell chorion gene amplification)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0042065"(glial cell growth)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|interpro:IPR014939(DNA replication factor CDT1-like)|interpro:IPR032054|interpro:IPR036390|interpro:IPR038090|reactome:R-DME-68827|reactome:R-DME-68949|reactome:R-DME-68962|reactome:R-DME-68867|dip:DIP-20004N ensemblmetazoa:FBgn0032929(gene)|ensemblmetazoa:FBtr0081475(transcript)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0030261"(chromosome condensation)|refseq:NP_610097.2|flybase:FBgn0032929|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0045678"(positive regulation of R7 cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:1901693"(negative regulation of compound eye retinal cell apoptotic process)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR015411(Mcm10 replication factor)|interpro:IPR040184|reactome:R-DME-176187|reactome:R-DME-68962|dip:DIP-20713N - - - figure legend:2B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:7227(drome-kc)|taxid:7227(Drosophila melanogaster embryo KC cells) - 2007/07/20 2014/10/16 rogid:2hvlsuUPmZyjL1SkMbYmMMcNajI7227 rogid:UR3VkJyT0QWaOIqUBzPgI6e1JDA7227 intact-crc:FE05CBE1188D8023|rigid:7i72qX61oT1DOtcjwc78OgK1yFc false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9VIE6 uniprotkb:P49735 intact:EBI-91264|ensemblmetazoa:FBpp0081004|uniprotkb:Q95RC7 intact:EBI-138228|uniprotkb:Q9VHU2|ensemblmetazoa:FBpp0081317 psi-mi:mcm10_drome(display_long)|uniprotkb:Mcm10(gene name)|psi-mi:Mcm10(display_short)|uniprotkb:Scim19(gene name synonym)|uniprotkb:Sensitized chromosome inheritance modifier 19(gene name synonym)|uniprotkb:CG9241(orf name) psi-mi:mcm2_drome(display_long)|uniprotkb:Mcm2(gene name)|psi-mi:Mcm2(display_short)|uniprotkb:CG7538(orf name)|uniprotkb:Minichromosome maintenance 2 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Christensen et al. (2003) pubmed:12808023 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1372681 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0032929(gene)|ensemblmetazoa:FBtr0081475(transcript)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0030261"(chromosome condensation)|refseq:NP_610097.2|flybase:FBgn0032929|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0045678"(positive regulation of R7 cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:1901693"(negative regulation of compound eye retinal cell apoptotic process)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR015411(Mcm10 replication factor)|interpro:IPR040184|reactome:R-DME-176187|reactome:R-DME-68962|dip:DIP-20713N ensemblmetazoa:FBgn0014861(gene)|ensemblmetazoa:FBtr0081827(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0030261"(chromosome condensation)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|rcsb pdb:6RAW|rcsb pdb:6RAX|rcsb pdb:6RAY|rcsb pdb:6RAZ|reactome:R-DME-176187|reactome:R-DME-68867|reactome:R-DME-68949|reactome:R-DME-68962|reactome:R-DME-69052|refseq:NP_477121.1|flybase:FBgn0014861|dip:DIP-22529N - - - figure legend:2B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:7227(drome-kc)|taxid:7227(Drosophila melanogaster embryo KC cells) - 2007/07/20 2014/10/16 rogid:UR3VkJyT0QWaOIqUBzPgI6e1JDA7227 rogid:Jnb71nPH/PDF5xcA8kTakW8zhDE7227 intact-crc:2CBBD9FCA4D63A70|rigid:GZDeyaWAw1l4WT+lfcHCsEsxlLM false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q24168 uniprotkb:Q9VIE6 intact:EBI-179453|intact:EBI-1631787|uniprotkb:Q9VFP4|ensemblmetazoa:FBpp0082329 intact:EBI-91264|ensemblmetazoa:FBpp0081004|uniprotkb:Q95RC7 psi-mi:orc2_drome(display_long)|uniprotkb:Orc2(gene name)|psi-mi:Orc2(display_short)|uniprotkb:CG3041(orf name) psi-mi:mcm10_drome(display_long)|uniprotkb:Mcm10(gene name)|psi-mi:Mcm10(display_short)|uniprotkb:Scim19(gene name synonym)|uniprotkb:Sensitized chromosome inheritance modifier 19(gene name synonym)|uniprotkb:CG9241(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Christensen et al. (2003) pubmed:12808023 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1372685 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_731873.1|flybase:FBgn0015270|dip:DIP-23209N|ensemblmetazoa:FBgn0015270(gene)|ensemblmetazoa:FBtr0082866(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005723"(alpha-heterochromatin)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007307"(eggshell chorion gene amplification)|go:"GO:0030261"(chromosome condensation)|interpro:IPR007220(Origin recognition complex subunit 2)|rcsb pdb:4XGC|rcsb pdb:7JGR|rcsb pdb:7JGS|rcsb pdb:7JK2|rcsb pdb:7JK3|rcsb pdb:7JK4|rcsb pdb:7JK5|rcsb pdb:7JK6|reactome:R-DME-176187|reactome:R-DME-68616|reactome:R-DME-68689|reactome:R-DME-68827|reactome:R-DME-68867|reactome:R-DME-68949|reactome:R-DME-68962 ensemblmetazoa:FBgn0032929(gene)|ensemblmetazoa:FBtr0081475(transcript)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0030261"(chromosome condensation)|refseq:NP_610097.2|flybase:FBgn0032929|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0045678"(positive regulation of R7 cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:1901693"(negative regulation of compound eye retinal cell apoptotic process)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR015411(Mcm10 replication factor)|interpro:IPR040184|reactome:R-DME-176187|reactome:R-DME-68962|dip:DIP-20713N - - - figure legend:2B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:7227(drome-kc)|taxid:7227(Drosophila melanogaster embryo KC cells) - 2007/07/20 2014/10/16 rogid:SaBA2xfoQcWtCiLhN6rD5O5yMhg7227 rogid:UR3VkJyT0QWaOIqUBzPgI6e1JDA7227 intact-crc:5E8FD6C4FB443FC3|rigid:WzVoNISf3L08pUnNcvsLQoUDo98 false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9VIE6 uniprotkb:P05205 intact:EBI-91264|ensemblmetazoa:FBpp0081004|uniprotkb:Q95RC7 intact:EBI-155532|uniprotkb:Q9VLR6|uniprotkb:A4V0F1|uniprotkb:B6UVR4|uniprotkb:B6UVS1|uniprotkb:B6UVS2|uniprotkb:B6UVS3|uniprotkb:B6UVT2|uniprotkb:B6UVT6|uniprotkb:B6UVT7|ensemblmetazoa:FBpp0079251|ensemblmetazoa:FBpp0079252 psi-mi:mcm10_drome(display_long)|uniprotkb:Mcm10(gene name)|psi-mi:Mcm10(display_short)|uniprotkb:Scim19(gene name synonym)|uniprotkb:Sensitized chromosome inheritance modifier 19(gene name synonym)|uniprotkb:CG9241(orf name) psi-mi:hp1_drome(display_long)|uniprotkb:"Su(var)205"(gene name)|psi-mi:"Su(var)205"(display_short)|uniprotkb:HP1(gene name synonym)|uniprotkb:CG8409(orf name)|uniprotkb:Non-histone chromosomal protein C1A9 antigen(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Christensen et al. (2003) pubmed:12808023 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1372689 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0032929(gene)|ensemblmetazoa:FBtr0081475(transcript)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0030261"(chromosome condensation)|refseq:NP_610097.2|flybase:FBgn0032929|go:"GO:0031298"(replication fork protection complex)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0045678"(positive regulation of R7 cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:1901693"(negative regulation of compound eye retinal cell apoptotic process)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR015411(Mcm10 replication factor)|interpro:IPR040184|reactome:R-DME-176187|reactome:R-DME-68962|dip:DIP-20713N refseq:NP_476755.1|refseq:NP_723361.1|flybase:FBgn0003607|dip:DIP-21869N|ensemblmetazoa:FBgn0003607(gene)|ensemblmetazoa:FBtr0079635(transcript)|ensemblmetazoa:FBtr0079636(transcript)|go:"GO:0000182"(rDNA binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005701"(polytene chromosome chromocenter)|go:"GO:0005703"(polytene chromosome puff)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006342"|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010369"(chromocenter)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031060"(regulation of histone methylation)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0033697"(obsolete positive regulation of extent of heterochromatin assembly)|go:"GO:0034773"(histone H4-K20 trimethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051276"(chromosome organization)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1900111"(positive regulation of histone H3-K9 dimethylation)|go:"GO:1905632"(protein localization to euchromatin)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1905646"(positive regulation of FACT complex assembly)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|mint:P05205|rcsb pdb:1KNA|rcsb pdb:1KNE|rcsb pdb:1Q3L|rcsb pdb:3P7J|rcsb pdb:6ASZ|rcsb pdb:6AT0|rcsb pdb:6MHA - - - figure legend:2B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation taxid:7227(drome-kc)|taxid:7227(Drosophila melanogaster embryo KC cells) - 2007/07/20 2014/10/16 rogid:UR3VkJyT0QWaOIqUBzPgI6e1JDA7227 rogid:gWEeBI57HBgTrPkRsAgoftkxb+M7227 intact-crc:CDE023974C6536B8|rigid:0RyujqDeA3ODsYHEYyxbYy9r7vk false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)