#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02795	uniprotkb:P58062	intact:EBI-996616|uniprotkb:Q2HXR9|uniprotkb:Q53XT9|uniprotkb:Q14823|ensembl:ENSP00000245185	intact:EBI-1182445|uniprotkb:Q32LY0|ensembl:ENSP00000274565	psi-mi:mt2_human(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Metallothionein-2A(gene name synonym)|uniprotkb:MT2A(gene name)|psi-mi:MT2A(display_short)|uniprotkb:CES1(gene name synonym)|uniprotkb:MT2(gene name synonym)	psi-mi:isk7_human(display_long)|uniprotkb:Esophagus cancer-related gene 2 protein(gene name synonym)|uniprotkb:SPINK7(gene name)|psi-mi:SPINK7(display_short)|uniprotkb:ECG2(gene name synonym)|uniprotkb:UNQ745/PRO1474(orf name)	psi-mi:"MI:0018"(two hybrid)	Cui et al. (2003)	pubmed:12646258|imex:IM-19228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1182455|imex:IM-19228-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005944.1|ensembl:ENSG00000125148(gene)|ensembl:ENST00000245185(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P02795|rcsb pdb:1MHU|rcsb pdb:2MHU|go:"GO:0006882"(cellular zinc ion homeostasis)|reactome:R-HSA-877300|reactome:R-HSA-5661231|dip:DIP-35232N	refseq:NP_115955.1|ensembl:ENSG00000145879(gene)|ensembl:ENST00000274565(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:2LEO	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/01/08	2014/10/16	rogid:3adUmT5As6Rn1isYoH+jMsFKEgU9606	rogid:FhMQIDfR5y7lZeoYHWRpIMx8rRk9606	intact-crc:504A49DB5AA73CEB|rigid:+isPSX9987OvNK088LCNkIhbEYc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P58062	uniprotkb:Q8IZW4	intact:EBI-1182445|uniprotkb:Q32LY0|ensembl:ENSP00000274565	intact:EBI-1182458	psi-mi:isk7_human(display_long)|uniprotkb:Esophagus cancer-related gene 2 protein(gene name synonym)|uniprotkb:SPINK7(gene name)|psi-mi:SPINK7(display_short)|uniprotkb:ECG2(gene name synonym)|uniprotkb:UNQ745/PRO1474(orf name)	psi-mi:q8izw4_human(display_long)	psi-mi:"MI:0018"(two hybrid)	Cui et al. (2003)	pubmed:12646258|imex:IM-19228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1182463|imex:IM-19228-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115955.1|ensembl:ENSG00000145879(gene)|ensembl:ENST00000274565(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:2LEO	-	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/01/08	2014/10/16	rogid:FhMQIDfR5y7lZeoYHWRpIMx8rRk9606	rogid:j3j/wG+CVO0vMq2sTiuDzjpi4WU9606	intact-crc:4BE5677B972209ED|rigid:rwL3j5NI42dsJYvixblNfOrQYps	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P80294	uniprotkb:P58062	intact:EBI-296567|uniprotkb:B2RUY6|ensembl:ENSP00000330587	intact:EBI-1182445|uniprotkb:Q32LY0|ensembl:ENSP00000274565	psi-mi:mt1h_human(display_long)|uniprotkb:MT1H(gene name)|psi-mi:MT1H(display_short)|uniprotkb:Metallothionein-IH(gene name synonym)|uniprotkb:Metallothionein-0(gene name synonym)	psi-mi:isk7_human(display_long)|uniprotkb:Esophagus cancer-related gene 2 protein(gene name synonym)|uniprotkb:SPINK7(gene name)|psi-mi:SPINK7(display_short)|uniprotkb:ECG2(gene name synonym)|uniprotkb:UNQ745/PRO1474(orf name)	psi-mi:"MI:0018"(two hybrid)	Cui et al. (2003)	pubmed:12646258|imex:IM-19228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1182469|imex:IM-19228-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005942.1|ensembl:ENSG00000205358(gene)|ensembl:ENST00000332374(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|reactome:R-HSA-5661231	refseq:NP_115955.1|ensembl:ENSG00000145879(gene)|ensembl:ENST00000274565(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:2LEO	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/01/08	2014/10/16	rogid:8s9tQaRMzAWAkNfAXrwLjR795NQ9606	rogid:FhMQIDfR5y7lZeoYHWRpIMx8rRk9606	intact-crc:7B5815525A53690F|rigid:CkA2RCaGcU8GJr+0xSz3q8IZRu4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P58062	uniprotkb:P13640	intact:EBI-1182445|uniprotkb:Q32LY0|ensembl:ENSP00000274565	intact:EBI-1182473|uniprotkb:P80296|ensembl:ENSP00000369139	psi-mi:isk7_human(display_long)|uniprotkb:Esophagus cancer-related gene 2 protein(gene name synonym)|uniprotkb:SPINK7(gene name)|psi-mi:SPINK7(display_short)|uniprotkb:ECG2(gene name synonym)|uniprotkb:UNQ745/PRO1474(orf name)	psi-mi:mt1g_human(display_long)|uniprotkb:Metallothionein-IG(gene name synonym)|uniprotkb:Metallothionein-1K(gene name synonym)|uniprotkb:MT1G(gene name)|psi-mi:MT1G(display_short)|uniprotkb:MT1K(gene name synonym)|uniprotkb:MT1M(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Cui et al. (2003)	pubmed:12646258|imex:IM-19228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1182492|imex:IM-19228-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115955.1|ensembl:ENSG00000145879(gene)|ensembl:ENST00000274565(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:2LEO	refseq:NP_005941.1|refseq:NP_001288196.1|ensembl:ENSG00000125144(gene)|ensembl:ENST00000379811(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042117"(monocyte activation)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|reactome:R-HSA-5661231	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/01/08	2014/10/16	rogid:FhMQIDfR5y7lZeoYHWRpIMx8rRk9606	rogid:QCDdUFHdgIRCZ9UuMZ6r+EPwkeU9606	intact-crc:B4B4CE054B22ABB8|rigid:Xm3koQlcM9k1Cq9nrE5ttO5H4jE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P16452	uniprotkb:P58062	intact:EBI-1182496|uniprotkb:Q4VB97|uniprotkb:Q4KKX0|ensembl:ENSP00000396616	intact:EBI-1182445|uniprotkb:Q32LY0|ensembl:ENSP00000274565	psi-mi:epb42_human(display_long)|uniprotkb:EPB42(gene name)|psi-mi:EPB42(display_short)|uniprotkb:E42P(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.2(gene name synonym)	psi-mi:isk7_human(display_long)|uniprotkb:Esophagus cancer-related gene 2 protein(gene name synonym)|uniprotkb:SPINK7(gene name)|psi-mi:SPINK7(display_short)|uniprotkb:ECG2(gene name synonym)|uniprotkb:UNQ745/PRO1474(orf name)	psi-mi:"MI:0018"(two hybrid)	Cui et al. (2003)	pubmed:12646258|imex:IM-19228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1182523|imex:IM-19228-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000110.2|refseq:NP_001107606.1|refseq:XP_011519653.1|refseq:XP_011519651.1|refseq:XP_011519652.1|ensembl:ENSG00000166947(gene)|ensembl:ENST00000441366(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0048536"(spleen development)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765	refseq:NP_115955.1|ensembl:ENSG00000145879(gene)|ensembl:ENST00000274565(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:2LEO	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/01/08	2014/10/16	rogid:3HojdnCHcXhXVejly3k9UPytmh89606	rogid:FhMQIDfR5y7lZeoYHWRpIMx8rRk9606	intact-crc:1EA4B8A2F59C3705|rigid:wlhGPy0+qul8hUgaDgtbIgWSXtA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P58062	uniprotkb:O15235	intact:EBI-1182445|uniprotkb:Q32LY0|ensembl:ENSP00000274565	intact:EBI-712205|ensembl:ENSP00000308845|ensembl:ENSP00000384579|ensembl:ENSP00000384952|ensembl:ENSP00000488926|ensembl:ENSP00000489374|ensembl:ENSP00000489467|uniprotkb:Q53X98	psi-mi:isk7_human(display_long)|uniprotkb:Esophagus cancer-related gene 2 protein(gene name synonym)|uniprotkb:SPINK7(gene name)|psi-mi:SPINK7(display_short)|uniprotkb:ECG2(gene name synonym)|uniprotkb:UNQ745/PRO1474(orf name)	psi-mi:rt12_human(display_long)|uniprotkb:MT-RPS12(gene name synonym)|uniprotkb:MRPS12(gene name)|psi-mi:MRPS12(display_short)|uniprotkb:RPMS12(gene name synonym)|uniprotkb:RPSM12(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein uS12m(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Cui et al. (2003)	pubmed:12646258|imex:IM-19228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1182556|imex:IM-19228-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115955.1|ensembl:ENSG00000145879(gene)|ensembl:ENST00000274565(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:2LEO	go:"GO:0006412"(translation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR005679(Ribosomal protein S12, bacterial-type)|interpro:IPR006032(Ribosomal protein S12/S23)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|go:"GO:0005840"(ribosome)|ensembl:ENSG00000128626(gene)|ensembl:ENSG00000283018(gene)|ensembl:ENST00000308018(transcript)|ensembl:ENST00000402029(transcript)|ensembl:ENST00000407800(transcript)|ensembl:ENST00000634246(transcript)|ensembl:ENST00000634400(transcript)|ensembl:ENST00000634704(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|refseq:NP_066930.1|refseq:NP_203526.1|refseq:NP_203527.1	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/01/08	2014/10/16	rogid:FhMQIDfR5y7lZeoYHWRpIMx8rRk9606	rogid:FDGNbJ2YFbUR4eQ3AyFtC8trETo9606	intact-crc:F700B31B12AF9C95|rigid:FkORJw6vtUDB53AGgL4XgXiHDEc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3YEC7	uniprotkb:P58062	intact:EBI-742029|uniprotkb:A8QVZ7|uniprotkb:Q4F968|uniprotkb:Q5T5R7|uniprotkb:Q8IWK1|uniprotkb:Q8TCL4|uniprotkb:Q8WU94|uniprotkb:Q96SR8|uniprotkb:Q9BU21|uniprotkb:Q9H935|uniprotkb:A8QVZ8|uniprotkb:C6K8I4|uniprotkb:C6K8I5|ensembl:ENSP00000311134	intact:EBI-1182445|uniprotkb:Q32LY0|ensembl:ENSP00000274565	psi-mi:rabl6_human(display_long)|uniprotkb:RABL6(gene name)|psi-mi:RABL6(display_short)|uniprotkb:C9orf86(gene name synonym)|uniprotkb:GTP-binding protein Parf(gene name synonym)|uniprotkb:PARF(gene name synonym)|uniprotkb:Partner of ARF(gene name synonym)|uniprotkb:Rab-like protein 1(gene name synonym)	psi-mi:isk7_human(display_long)|uniprotkb:Esophagus cancer-related gene 2 protein(gene name synonym)|uniprotkb:SPINK7(gene name)|psi-mi:SPINK7(display_short)|uniprotkb:ECG2(gene name synonym)|uniprotkb:UNQ745/PRO1474(orf name)	psi-mi:"MI:0018"(two hybrid)	Cui et al. (2003)	pubmed:12646258|imex:IM-19228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1182565|imex:IM-19228-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001167459.1|refseq:NP_078994.3|refseq:NP_001167460.1|ensembl:ENSG00000196642(gene)|ensembl:ENST00000311502(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|interpro:IPR027417|interpro:IPR040385|go:"GO:0005634"(nucleus)	refseq:NP_115955.1|ensembl:ENSG00000145879(gene)|ensembl:ENST00000274565(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:2LEO	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/01/08	2014/10/16	rogid:AZhkTh4+32Qxv5/Dy4ebg+mv3Ls9606	rogid:FhMQIDfR5y7lZeoYHWRpIMx8rRk9606	intact-crc:C24163DA2559ECFB|rigid:4Cimr4VmE3SdhtJyPn2BfAwsCBQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P02795	uniprotkb:P58062	intact:EBI-996616|uniprotkb:Q2HXR9|uniprotkb:Q53XT9|uniprotkb:Q14823|ensembl:ENSP00000245185	intact:EBI-1182445|uniprotkb:Q32LY0|ensembl:ENSP00000274565	psi-mi:mt2_human(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Metallothionein-2A(gene name synonym)|uniprotkb:MT2A(gene name)|psi-mi:MT2A(display_short)|uniprotkb:CES1(gene name synonym)|uniprotkb:MT2(gene name synonym)	psi-mi:isk7_human(display_long)|uniprotkb:Esophagus cancer-related gene 2 protein(gene name synonym)|uniprotkb:SPINK7(gene name)|psi-mi:SPINK7(display_short)|uniprotkb:ECG2(gene name synonym)|uniprotkb:UNQ745/PRO1474(orf name)	psi-mi:"MI:0096"(pull down)	Cui et al. (2003)	pubmed:12646258|imex:IM-19228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1182578|imex:IM-19228-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005944.1|ensembl:ENSG00000125148(gene)|ensembl:ENST00000245185(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P02795|rcsb pdb:1MHU|rcsb pdb:2MHU|go:"GO:0006882"(cellular zinc ion homeostasis)|reactome:R-HSA-877300|reactome:R-HSA-5661231|dip:DIP-35232N	refseq:NP_115955.1|ensembl:ENSG00000145879(gene)|ensembl:ENST00000274565(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:2LEO	-	-	-	figure legend:1 C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/01/08	2014/10/16	rogid:3adUmT5As6Rn1isYoH+jMsFKEgU9606	rogid:FhMQIDfR5y7lZeoYHWRpIMx8rRk9606	intact-crc:836804DA30F46192|rigid:+isPSX9987OvNK088LCNkIhbEYc	false	ha tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P02795	uniprotkb:P58062	intact:EBI-996616|uniprotkb:Q2HXR9|uniprotkb:Q53XT9|uniprotkb:Q14823|ensembl:ENSP00000245185	intact:EBI-1182445|uniprotkb:Q32LY0|ensembl:ENSP00000274565	psi-mi:mt2_human(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Metallothionein-2A(gene name synonym)|uniprotkb:MT2A(gene name)|psi-mi:MT2A(display_short)|uniprotkb:CES1(gene name synonym)|uniprotkb:MT2(gene name synonym)	psi-mi:isk7_human(display_long)|uniprotkb:Esophagus cancer-related gene 2 protein(gene name synonym)|uniprotkb:SPINK7(gene name)|psi-mi:SPINK7(display_short)|uniprotkb:ECG2(gene name synonym)|uniprotkb:UNQ745/PRO1474(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2003)	pubmed:12646258|imex:IM-19228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1182621|imex:IM-19228-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005944.1|ensembl:ENSG00000125148(gene)|ensembl:ENST00000245185(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P02795|rcsb pdb:1MHU|rcsb pdb:2MHU|go:"GO:0006882"(cellular zinc ion homeostasis)|reactome:R-HSA-877300|reactome:R-HSA-5661231|dip:DIP-35232N	refseq:NP_115955.1|ensembl:ENSG00000145879(gene)|ensembl:ENST00000274565(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:2LEO	-	-	-	figure legend:2 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/01/08	2014/10/16	rogid:3adUmT5As6Rn1isYoH+jMsFKEgU9606	rogid:FhMQIDfR5y7lZeoYHWRpIMx8rRk9606	intact-crc:210798986D11A1AC|rigid:+isPSX9987OvNK088LCNkIhbEYc	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P02795	uniprotkb:P58062	intact:EBI-996616|uniprotkb:Q2HXR9|uniprotkb:Q53XT9|uniprotkb:Q14823|ensembl:ENSP00000245185	intact:EBI-1182445|uniprotkb:Q32LY0|ensembl:ENSP00000274565	psi-mi:mt2_human(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Metallothionein-2A(gene name synonym)|uniprotkb:MT2A(gene name)|psi-mi:MT2A(display_short)|uniprotkb:CES1(gene name synonym)|uniprotkb:MT2(gene name synonym)	psi-mi:isk7_human(display_long)|uniprotkb:Esophagus cancer-related gene 2 protein(gene name synonym)|uniprotkb:SPINK7(gene name)|psi-mi:SPINK7(display_short)|uniprotkb:ECG2(gene name synonym)|uniprotkb:UNQ745/PRO1474(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2003)	pubmed:12646258|imex:IM-19228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1182638|imex:IM-19228-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005944.1|ensembl:ENSG00000125148(gene)|ensembl:ENST00000245185(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P02795|rcsb pdb:1MHU|rcsb pdb:2MHU|go:"GO:0006882"(cellular zinc ion homeostasis)|reactome:R-HSA-877300|reactome:R-HSA-5661231|dip:DIP-35232N	refseq:NP_115955.1|ensembl:ENSG00000145879(gene)|ensembl:ENST00000274565(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:2LEO	-	-	-	figure legend:2 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/01/08	2014/10/16	rogid:3adUmT5As6Rn1isYoH+jMsFKEgU9606	rogid:FhMQIDfR5y7lZeoYHWRpIMx8rRk9606	intact-crc:B84780FE32A790AE|rigid:+isPSX9987OvNK088LCNkIhbEYc	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P02795	uniprotkb:P58062	intact:EBI-996616|uniprotkb:Q2HXR9|uniprotkb:Q53XT9|uniprotkb:Q14823|ensembl:ENSP00000245185	intact:EBI-1182445|uniprotkb:Q32LY0|ensembl:ENSP00000274565	psi-mi:mt2_human(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Metallothionein-2A(gene name synonym)|uniprotkb:MT2A(gene name)|psi-mi:MT2A(display_short)|uniprotkb:CES1(gene name synonym)|uniprotkb:MT2(gene name synonym)	psi-mi:isk7_human(display_long)|uniprotkb:Esophagus cancer-related gene 2 protein(gene name synonym)|uniprotkb:SPINK7(gene name)|psi-mi:SPINK7(display_short)|uniprotkb:ECG2(gene name synonym)|uniprotkb:UNQ745/PRO1474(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Cui et al. (2003)	pubmed:12646258|imex:IM-19228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1182786|imex:IM-19228-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005944.1|ensembl:ENSG00000125148(gene)|ensembl:ENST00000245185(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P02795|rcsb pdb:1MHU|rcsb pdb:2MHU|go:"GO:0006882"(cellular zinc ion homeostasis)|reactome:R-HSA-877300|reactome:R-HSA-5661231|dip:DIP-35232N	refseq:NP_115955.1|ensembl:ENSG00000145879(gene)|ensembl:ENST00000274565(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:2LEO	-	-	-	figure legend:3 C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ec109)|taxid:9606(Homo sapiens esophageal cancer cell line)	-	2007/01/08	2014/10/16	rogid:3adUmT5As6Rn1isYoH+jMsFKEgU9606	rogid:FhMQIDfR5y7lZeoYHWRpIMx8rRk9606	intact-crc:26E6E65C2BCCC907|rigid:+isPSX9987OvNK088LCNkIhbEYc	false	ha tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)