#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8IVI9	uniprotkb:P29474	intact:EBI-1391643|uniprotkb:Q27HG3|uniprotkb:Q53S62|uniprotkb:Q96CJ9|uniprotkb:A8K2I9|uniprotkb:B3KSF5|uniprotkb:E7EPT9|ensembl:ENSP00000318921	intact:EBI-1391623|uniprotkb:A0S0A7|uniprotkb:E9PFR2|uniprotkb:Q13662|uniprotkb:Q14251|uniprotkb:Q14434|uniprotkb:Q6GSL5|uniprotkb:A8KA63|uniprotkb:B2RCQ1|uniprotkb:Q548C1|uniprotkb:Q9UDC6|uniprotkb:A0S0A8|ensembl:ENSP00000297494	psi-mi:nostn_human(display_long)|uniprotkb:eNOS-trafficking inducer(gene name synonym)|uniprotkb:Nitric oxide synthase trafficker(gene name synonym)|uniprotkb:Nitric oxide synthase traffic inducer(gene name synonym)|uniprotkb:BM247 homolog(gene name synonym)|uniprotkb:NOSTRIN(gene name)|psi-mi:NOSTRIN(display_short)	psi-mi:nos3_human(display_long)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)	psi-mi:"MI:0018"(two hybrid)	Zimmermann et al. (2002)	pubmed:12446846|imex:IM-26485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1391639|imex:IM-26485-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034813.2|refseq:NP_001165102.1|refseq:NP_001165103.1|refseq:NP_443178.2|ensembl:ENSG00000163072(gene)|ensembl:ENST00000317647(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267|interpro:IPR028535|interpro:IPR031160|interpro:IPR035656|interpro:IPR036028|interpro:IPR036274|mint:Q8IVI9|rcsb pdb:2YUN|reactome:R-HSA-203641	refseq:NP_000594.2|refseq:NP_001153581.1|refseq:NP_001153582.1|refseq:NP_001153583.1|refseq:XP_016867721.1|dip:DIP-38479N|ensembl:ENSG00000164867(gene)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0097746"(blood vessel diameter maintenance)|ensembl:ENST00000297494(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007263"(nitric oxide mediated signal transduction)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|mint:P29474|rcsb pdb:1M9J|rcsb pdb:1M9K|rcsb pdb:1M9M|rcsb pdb:1M9Q|rcsb pdb:1M9R|rcsb pdb:1NIW|rcsb pdb:2LL7|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2MG5|rcsb pdb:2N8J|rcsb pdb:3EAH|rcsb pdb:3NOS|rcsb pdb:4D1O|rcsb pdb:4D1P|rcsb pdb:5UO8|rcsb pdb:5UO9|rcsb pdb:5UOA|rcsb pdb:5UOB|rcsb pdb:5UOC|rcsb pdb:5VVB|rcsb pdb:5VVC|rcsb pdb:5VVD|rcsb pdb:5XOF|rcsb pdb:6AV6|rcsb pdb:6AV7|rcsb pdb:6CIE|rcsb pdb:6CIF|rcsb pdb:6NH1|rcsb pdb:6NH2|rcsb pdb:6NH3|rcsb pdb:6NH4|rcsb pdb:6NH5|rcsb pdb:6NH6|rcsb pdb:6NH7|rcsb pdb:6NH8|rcsb pdb:6NHF|rcsb pdb:6POU|rcsb pdb:6POV|rcsb pdb:6POW|rcsb pdb:6POX|rcsb pdb:6POY|rcsb pdb:6POZ|rcsb pdb:6PP0|rcsb pdb:6PP1|rcsb pdb:6PP2|rcsb pdb:6PP3|rcsb pdb:6PP4|reactome:R-HSA-1222556|reactome:R-HSA-1474151|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-203754|reactome:R-HSA-392154|reactome:R-HSA-5218920|reactome:R-HSA-9009391	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/05	2018/04/06	rogid:995orjHO0YRgvNcLMP1kX2qC25s9606	rogid:FIvVY2y5ltfs8KVWaMEHCEt2pMk9606	intact-crc:3B23725373244581|rigid:+rZKVR9ltxTy5J+4XnHED+KP9uU	false	-	binding-associated region:1-486	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P29474	uniprotkb:Q8IVI9	intact:EBI-1391623|uniprotkb:A0S0A7|uniprotkb:E9PFR2|uniprotkb:Q13662|uniprotkb:Q14251|uniprotkb:Q14434|uniprotkb:Q6GSL5|uniprotkb:A8KA63|uniprotkb:B2RCQ1|uniprotkb:Q548C1|uniprotkb:Q9UDC6|uniprotkb:A0S0A8|ensembl:ENSP00000297494	intact:EBI-1391643|uniprotkb:Q27HG3|uniprotkb:Q53S62|uniprotkb:Q96CJ9|uniprotkb:A8K2I9|uniprotkb:B3KSF5|uniprotkb:E7EPT9|ensembl:ENSP00000318921	psi-mi:nos3_human(display_long)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)	psi-mi:nostn_human(display_long)|uniprotkb:eNOS-trafficking inducer(gene name synonym)|uniprotkb:Nitric oxide synthase trafficker(gene name synonym)|uniprotkb:Nitric oxide synthase traffic inducer(gene name synonym)|uniprotkb:BM247 homolog(gene name synonym)|uniprotkb:NOSTRIN(gene name)|psi-mi:NOSTRIN(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zimmermann et al. (2002)	pubmed:12446846|imex:IM-26485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1391675|imex:IM-26485-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000594.2|refseq:NP_001153581.1|refseq:NP_001153582.1|refseq:NP_001153583.1|refseq:XP_016867721.1|dip:DIP-38479N|ensembl:ENSG00000164867(gene)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0097746"(blood vessel diameter maintenance)|ensembl:ENST00000297494(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007263"(nitric oxide mediated signal transduction)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|mint:P29474|rcsb pdb:1M9J|rcsb pdb:1M9K|rcsb pdb:1M9M|rcsb pdb:1M9Q|rcsb pdb:1M9R|rcsb pdb:1NIW|rcsb pdb:2LL7|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2MG5|rcsb pdb:2N8J|rcsb pdb:3EAH|rcsb pdb:3NOS|rcsb pdb:4D1O|rcsb pdb:4D1P|rcsb pdb:5UO8|rcsb pdb:5UO9|rcsb pdb:5UOA|rcsb pdb:5UOB|rcsb pdb:5UOC|rcsb pdb:5VVB|rcsb pdb:5VVC|rcsb pdb:5VVD|rcsb pdb:5XOF|rcsb pdb:6AV6|rcsb pdb:6AV7|rcsb pdb:6CIE|rcsb pdb:6CIF|rcsb pdb:6NH1|rcsb pdb:6NH2|rcsb pdb:6NH3|rcsb pdb:6NH4|rcsb pdb:6NH5|rcsb pdb:6NH6|rcsb pdb:6NH7|rcsb pdb:6NH8|rcsb pdb:6NHF|rcsb pdb:6POU|rcsb pdb:6POV|rcsb pdb:6POW|rcsb pdb:6POX|rcsb pdb:6POY|rcsb pdb:6POZ|rcsb pdb:6PP0|rcsb pdb:6PP1|rcsb pdb:6PP2|rcsb pdb:6PP3|rcsb pdb:6PP4|reactome:R-HSA-1222556|reactome:R-HSA-1474151|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-203754|reactome:R-HSA-392154|reactome:R-HSA-5218920|reactome:R-HSA-9009391	refseq:NP_001034813.2|refseq:NP_001165102.1|refseq:NP_001165103.1|refseq:NP_443178.2|ensembl:ENSG00000163072(gene)|ensembl:ENST00000317647(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267|interpro:IPR028535|interpro:IPR031160|interpro:IPR035656|interpro:IPR036028|interpro:IPR036274|mint:Q8IVI9|rcsb pdb:2YUN|reactome:R-HSA-203641	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2007/09/05	2018/04/06	rogid:FIvVY2y5ltfs8KVWaMEHCEt2pMk9606	rogid:995orjHO0YRgvNcLMP1kX2qC25s9606	intact-crc:540E503754A3DD45|rigid:+rZKVR9ltxTy5J+4XnHED+KP9uU	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P29474	uniprotkb:Q8IVI9	intact:EBI-1391623|uniprotkb:A0S0A7|uniprotkb:E9PFR2|uniprotkb:Q13662|uniprotkb:Q14251|uniprotkb:Q14434|uniprotkb:Q6GSL5|uniprotkb:A8KA63|uniprotkb:B2RCQ1|uniprotkb:Q548C1|uniprotkb:Q9UDC6|uniprotkb:A0S0A8|ensembl:ENSP00000297494	intact:EBI-1391643|uniprotkb:Q27HG3|uniprotkb:Q53S62|uniprotkb:Q96CJ9|uniprotkb:A8K2I9|uniprotkb:B3KSF5|uniprotkb:E7EPT9|ensembl:ENSP00000318921	psi-mi:nos3_human(display_long)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)	psi-mi:nostn_human(display_long)|uniprotkb:eNOS-trafficking inducer(gene name synonym)|uniprotkb:Nitric oxide synthase trafficker(gene name synonym)|uniprotkb:Nitric oxide synthase traffic inducer(gene name synonym)|uniprotkb:BM247 homolog(gene name synonym)|uniprotkb:NOSTRIN(gene name)|psi-mi:NOSTRIN(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zimmermann et al. (2002)	pubmed:12446846|imex:IM-26485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1391679|imex:IM-26485-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000594.2|refseq:NP_001153581.1|refseq:NP_001153582.1|refseq:NP_001153583.1|refseq:XP_016867721.1|dip:DIP-38479N|ensembl:ENSG00000164867(gene)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0097746"(blood vessel diameter maintenance)|ensembl:ENST00000297494(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007263"(nitric oxide mediated signal transduction)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|mint:P29474|rcsb pdb:1M9J|rcsb pdb:1M9K|rcsb pdb:1M9M|rcsb pdb:1M9Q|rcsb pdb:1M9R|rcsb pdb:1NIW|rcsb pdb:2LL7|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2MG5|rcsb pdb:2N8J|rcsb pdb:3EAH|rcsb pdb:3NOS|rcsb pdb:4D1O|rcsb pdb:4D1P|rcsb pdb:5UO8|rcsb pdb:5UO9|rcsb pdb:5UOA|rcsb pdb:5UOB|rcsb pdb:5UOC|rcsb pdb:5VVB|rcsb pdb:5VVC|rcsb pdb:5VVD|rcsb pdb:5XOF|rcsb pdb:6AV6|rcsb pdb:6AV7|rcsb pdb:6CIE|rcsb pdb:6CIF|rcsb pdb:6NH1|rcsb pdb:6NH2|rcsb pdb:6NH3|rcsb pdb:6NH4|rcsb pdb:6NH5|rcsb pdb:6NH6|rcsb pdb:6NH7|rcsb pdb:6NH8|rcsb pdb:6NHF|rcsb pdb:6POU|rcsb pdb:6POV|rcsb pdb:6POW|rcsb pdb:6POX|rcsb pdb:6POY|rcsb pdb:6POZ|rcsb pdb:6PP0|rcsb pdb:6PP1|rcsb pdb:6PP2|rcsb pdb:6PP3|rcsb pdb:6PP4|reactome:R-HSA-1222556|reactome:R-HSA-1474151|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-203754|reactome:R-HSA-392154|reactome:R-HSA-5218920|reactome:R-HSA-9009391	refseq:NP_001034813.2|refseq:NP_001165102.1|refseq:NP_001165103.1|refseq:NP_443178.2|ensembl:ENSG00000163072(gene)|ensembl:ENST00000317647(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267|interpro:IPR028535|interpro:IPR031160|interpro:IPR035656|interpro:IPR036028|interpro:IPR036274|mint:Q8IVI9|rcsb pdb:2YUN|reactome:R-HSA-203641	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2007/09/05	2018/04/06	rogid:FIvVY2y5ltfs8KVWaMEHCEt2pMk9606	rogid:995orjHO0YRgvNcLMP1kX2qC25s9606	intact-crc:A1F72CF0A3651914|rigid:+rZKVR9ltxTy5J+4XnHED+KP9uU	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P29474	uniprotkb:Q8IVI9	intact:EBI-1391623|uniprotkb:A0S0A7|uniprotkb:E9PFR2|uniprotkb:Q13662|uniprotkb:Q14251|uniprotkb:Q14434|uniprotkb:Q6GSL5|uniprotkb:A8KA63|uniprotkb:B2RCQ1|uniprotkb:Q548C1|uniprotkb:Q9UDC6|uniprotkb:A0S0A8|ensembl:ENSP00000297494	intact:EBI-1391643|uniprotkb:Q27HG3|uniprotkb:Q53S62|uniprotkb:Q96CJ9|uniprotkb:A8K2I9|uniprotkb:B3KSF5|uniprotkb:E7EPT9|ensembl:ENSP00000318921	psi-mi:nos3_human(display_long)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)	psi-mi:nostn_human(display_long)|uniprotkb:eNOS-trafficking inducer(gene name synonym)|uniprotkb:Nitric oxide synthase trafficker(gene name synonym)|uniprotkb:Nitric oxide synthase traffic inducer(gene name synonym)|uniprotkb:BM247 homolog(gene name synonym)|uniprotkb:NOSTRIN(gene name)|psi-mi:NOSTRIN(display_short)	psi-mi:"MI:0018"(two hybrid)	Zimmermann et al. (2002)	pubmed:12446846|imex:IM-26485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1391690|imex:IM-26485-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000594.2|refseq:NP_001153581.1|refseq:NP_001153582.1|refseq:NP_001153583.1|refseq:XP_016867721.1|dip:DIP-38479N|ensembl:ENSG00000164867(gene)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0097746"(blood vessel diameter maintenance)|ensembl:ENST00000297494(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007263"(nitric oxide mediated signal transduction)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|mint:P29474|rcsb pdb:1M9J|rcsb pdb:1M9K|rcsb pdb:1M9M|rcsb pdb:1M9Q|rcsb pdb:1M9R|rcsb pdb:1NIW|rcsb pdb:2LL7|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2MG5|rcsb pdb:2N8J|rcsb pdb:3EAH|rcsb pdb:3NOS|rcsb pdb:4D1O|rcsb pdb:4D1P|rcsb pdb:5UO8|rcsb pdb:5UO9|rcsb pdb:5UOA|rcsb pdb:5UOB|rcsb pdb:5UOC|rcsb pdb:5VVB|rcsb pdb:5VVC|rcsb pdb:5VVD|rcsb pdb:5XOF|rcsb pdb:6AV6|rcsb pdb:6AV7|rcsb pdb:6CIE|rcsb pdb:6CIF|rcsb pdb:6NH1|rcsb pdb:6NH2|rcsb pdb:6NH3|rcsb pdb:6NH4|rcsb pdb:6NH5|rcsb pdb:6NH6|rcsb pdb:6NH7|rcsb pdb:6NH8|rcsb pdb:6NHF|rcsb pdb:6POU|rcsb pdb:6POV|rcsb pdb:6POW|rcsb pdb:6POX|rcsb pdb:6POY|rcsb pdb:6POZ|rcsb pdb:6PP0|rcsb pdb:6PP1|rcsb pdb:6PP2|rcsb pdb:6PP3|rcsb pdb:6PP4|reactome:R-HSA-1222556|reactome:R-HSA-1474151|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-203754|reactome:R-HSA-392154|reactome:R-HSA-5218920|reactome:R-HSA-9009391	refseq:NP_001034813.2|refseq:NP_001165102.1|refseq:NP_001165103.1|refseq:NP_443178.2|ensembl:ENSG00000163072(gene)|ensembl:ENST00000317647(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267|interpro:IPR028535|interpro:IPR031160|interpro:IPR035656|interpro:IPR036028|interpro:IPR036274|mint:Q8IVI9|rcsb pdb:2YUN|reactome:R-HSA-203641	-	-	-	figure legend:4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/05	2018/04/06	rogid:FIvVY2y5ltfs8KVWaMEHCEt2pMk9606	rogid:995orjHO0YRgvNcLMP1kX2qC25s9606	intact-crc:D567E525B5B7D243|rigid:+rZKVR9ltxTy5J+4XnHED+KP9uU	false	binding-associated region:98-366	binding-associated region:242-506	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29474	uniprotkb:Q8IVI9	intact:EBI-1391623|uniprotkb:A0S0A7|uniprotkb:E9PFR2|uniprotkb:Q13662|uniprotkb:Q14251|uniprotkb:Q14434|uniprotkb:Q6GSL5|uniprotkb:A8KA63|uniprotkb:B2RCQ1|uniprotkb:Q548C1|uniprotkb:Q9UDC6|uniprotkb:A0S0A8|ensembl:ENSP00000297494	intact:EBI-1391643|uniprotkb:Q27HG3|uniprotkb:Q53S62|uniprotkb:Q96CJ9|uniprotkb:A8K2I9|uniprotkb:B3KSF5|uniprotkb:E7EPT9|ensembl:ENSP00000318921	psi-mi:nos3_human(display_long)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)	psi-mi:nostn_human(display_long)|uniprotkb:eNOS-trafficking inducer(gene name synonym)|uniprotkb:Nitric oxide synthase trafficker(gene name synonym)|uniprotkb:Nitric oxide synthase traffic inducer(gene name synonym)|uniprotkb:BM247 homolog(gene name synonym)|uniprotkb:NOSTRIN(gene name)|psi-mi:NOSTRIN(display_short)	psi-mi:"MI:0018"(two hybrid)	Zimmermann et al. (2002)	pubmed:12446846|imex:IM-26485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1391698|imex:IM-26485-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000594.2|refseq:NP_001153581.1|refseq:NP_001153582.1|refseq:NP_001153583.1|refseq:XP_016867721.1|dip:DIP-38479N|ensembl:ENSG00000164867(gene)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0097746"(blood vessel diameter maintenance)|ensembl:ENST00000297494(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007263"(nitric oxide mediated signal transduction)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|mint:P29474|rcsb pdb:1M9J|rcsb pdb:1M9K|rcsb pdb:1M9M|rcsb pdb:1M9Q|rcsb pdb:1M9R|rcsb pdb:1NIW|rcsb pdb:2LL7|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2MG5|rcsb pdb:2N8J|rcsb pdb:3EAH|rcsb pdb:3NOS|rcsb pdb:4D1O|rcsb pdb:4D1P|rcsb pdb:5UO8|rcsb pdb:5UO9|rcsb pdb:5UOA|rcsb pdb:5UOB|rcsb pdb:5UOC|rcsb pdb:5VVB|rcsb pdb:5VVC|rcsb pdb:5VVD|rcsb pdb:5XOF|rcsb pdb:6AV6|rcsb pdb:6AV7|rcsb pdb:6CIE|rcsb pdb:6CIF|rcsb pdb:6NH1|rcsb pdb:6NH2|rcsb pdb:6NH3|rcsb pdb:6NH4|rcsb pdb:6NH5|rcsb pdb:6NH6|rcsb pdb:6NH7|rcsb pdb:6NH8|rcsb pdb:6NHF|rcsb pdb:6POU|rcsb pdb:6POV|rcsb pdb:6POW|rcsb pdb:6POX|rcsb pdb:6POY|rcsb pdb:6POZ|rcsb pdb:6PP0|rcsb pdb:6PP1|rcsb pdb:6PP2|rcsb pdb:6PP3|rcsb pdb:6PP4|reactome:R-HSA-1222556|reactome:R-HSA-1474151|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-203754|reactome:R-HSA-392154|reactome:R-HSA-5218920|reactome:R-HSA-9009391	refseq:NP_001034813.2|refseq:NP_001165102.1|refseq:NP_001165103.1|refseq:NP_443178.2|ensembl:ENSG00000163072(gene)|ensembl:ENST00000317647(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267|interpro:IPR028535|interpro:IPR031160|interpro:IPR035656|interpro:IPR036028|interpro:IPR036274|mint:Q8IVI9|rcsb pdb:2YUN|reactome:R-HSA-203641	-	-	-	figure legend:4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/05	2018/04/06	rogid:FIvVY2y5ltfs8KVWaMEHCEt2pMk9606	rogid:995orjHO0YRgvNcLMP1kX2qC25s9606	intact-crc:C17C4FC651B30757|rigid:+rZKVR9ltxTy5J+4XnHED+KP9uU	false	binding-associated region:98-366	binding-associated region:433-506	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IVI9	uniprotkb:P29474	intact:EBI-1391643|uniprotkb:Q27HG3|uniprotkb:Q53S62|uniprotkb:Q96CJ9|uniprotkb:A8K2I9|uniprotkb:B3KSF5|uniprotkb:E7EPT9|ensembl:ENSP00000318921	intact:EBI-1391623|uniprotkb:A0S0A7|uniprotkb:E9PFR2|uniprotkb:Q13662|uniprotkb:Q14251|uniprotkb:Q14434|uniprotkb:Q6GSL5|uniprotkb:A8KA63|uniprotkb:B2RCQ1|uniprotkb:Q548C1|uniprotkb:Q9UDC6|uniprotkb:A0S0A8|ensembl:ENSP00000297494	psi-mi:nostn_human(display_long)|uniprotkb:eNOS-trafficking inducer(gene name synonym)|uniprotkb:Nitric oxide synthase trafficker(gene name synonym)|uniprotkb:Nitric oxide synthase traffic inducer(gene name synonym)|uniprotkb:BM247 homolog(gene name synonym)|uniprotkb:NOSTRIN(gene name)|psi-mi:NOSTRIN(display_short)	psi-mi:nos3_human(display_long)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)	psi-mi:"MI:0096"(pull down)	Zimmermann et al. (2002)	pubmed:12446846|imex:IM-26485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1391713|imex:IM-26485-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034813.2|refseq:NP_001165102.1|refseq:NP_001165103.1|refseq:NP_443178.2|ensembl:ENSG00000163072(gene)|ensembl:ENST00000317647(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267|interpro:IPR028535|interpro:IPR031160|interpro:IPR035656|interpro:IPR036028|interpro:IPR036274|mint:Q8IVI9|rcsb pdb:2YUN|reactome:R-HSA-203641	refseq:NP_000594.2|refseq:NP_001153581.1|refseq:NP_001153582.1|refseq:NP_001153583.1|refseq:XP_016867721.1|dip:DIP-38479N|ensembl:ENSG00000164867(gene)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0097746"(blood vessel diameter maintenance)|ensembl:ENST00000297494(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007263"(nitric oxide mediated signal transduction)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|mint:P29474|rcsb pdb:1M9J|rcsb pdb:1M9K|rcsb pdb:1M9M|rcsb pdb:1M9Q|rcsb pdb:1M9R|rcsb pdb:1NIW|rcsb pdb:2LL7|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2MG5|rcsb pdb:2N8J|rcsb pdb:3EAH|rcsb pdb:3NOS|rcsb pdb:4D1O|rcsb pdb:4D1P|rcsb pdb:5UO8|rcsb pdb:5UO9|rcsb pdb:5UOA|rcsb pdb:5UOB|rcsb pdb:5UOC|rcsb pdb:5VVB|rcsb pdb:5VVC|rcsb pdb:5VVD|rcsb pdb:5XOF|rcsb pdb:6AV6|rcsb pdb:6AV7|rcsb pdb:6CIE|rcsb pdb:6CIF|rcsb pdb:6NH1|rcsb pdb:6NH2|rcsb pdb:6NH3|rcsb pdb:6NH4|rcsb pdb:6NH5|rcsb pdb:6NH6|rcsb pdb:6NH7|rcsb pdb:6NH8|rcsb pdb:6NHF|rcsb pdb:6POU|rcsb pdb:6POV|rcsb pdb:6POW|rcsb pdb:6POX|rcsb pdb:6POY|rcsb pdb:6POZ|rcsb pdb:6PP0|rcsb pdb:6PP1|rcsb pdb:6PP2|rcsb pdb:6PP3|rcsb pdb:6PP4|reactome:R-HSA-1222556|reactome:R-HSA-1474151|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-203754|reactome:R-HSA-392154|reactome:R-HSA-5218920|reactome:R-HSA-9009391	-	-	-	figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/05	2018/04/06	rogid:995orjHO0YRgvNcLMP1kX2qC25s9606	rogid:FIvVY2y5ltfs8KVWaMEHCEt2pMk9606	intact-crc:FB19FEED82B8156A|rigid:+rZKVR9ltxTy5J+4XnHED+KP9uU	false	glutathione s tranferase tag:?-?|binding-associated region:441-506	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29474	uniprotkb:Q8IVI9	intact:EBI-1391623|uniprotkb:A0S0A7|uniprotkb:E9PFR2|uniprotkb:Q13662|uniprotkb:Q14251|uniprotkb:Q14434|uniprotkb:Q6GSL5|uniprotkb:A8KA63|uniprotkb:B2RCQ1|uniprotkb:Q548C1|uniprotkb:Q9UDC6|uniprotkb:A0S0A8|ensembl:ENSP00000297494	intact:EBI-1391643|uniprotkb:Q27HG3|uniprotkb:Q53S62|uniprotkb:Q96CJ9|uniprotkb:A8K2I9|uniprotkb:B3KSF5|uniprotkb:E7EPT9|ensembl:ENSP00000318921	psi-mi:nos3_human(display_long)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)	psi-mi:nostn_human(display_long)|uniprotkb:eNOS-trafficking inducer(gene name synonym)|uniprotkb:Nitric oxide synthase trafficker(gene name synonym)|uniprotkb:Nitric oxide synthase traffic inducer(gene name synonym)|uniprotkb:BM247 homolog(gene name synonym)|uniprotkb:NOSTRIN(gene name)|psi-mi:NOSTRIN(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Zimmermann et al. (2002)	pubmed:12446846|imex:IM-26485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1391730|imex:IM-26485-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000594.2|refseq:NP_001153581.1|refseq:NP_001153582.1|refseq:NP_001153583.1|refseq:XP_016867721.1|dip:DIP-38479N|ensembl:ENSG00000164867(gene)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0097746"(blood vessel diameter maintenance)|ensembl:ENST00000297494(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007263"(nitric oxide mediated signal transduction)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|mint:P29474|rcsb pdb:1M9J|rcsb pdb:1M9K|rcsb pdb:1M9M|rcsb pdb:1M9Q|rcsb pdb:1M9R|rcsb pdb:1NIW|rcsb pdb:2LL7|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2MG5|rcsb pdb:2N8J|rcsb pdb:3EAH|rcsb pdb:3NOS|rcsb pdb:4D1O|rcsb pdb:4D1P|rcsb pdb:5UO8|rcsb pdb:5UO9|rcsb pdb:5UOA|rcsb pdb:5UOB|rcsb pdb:5UOC|rcsb pdb:5VVB|rcsb pdb:5VVC|rcsb pdb:5VVD|rcsb pdb:5XOF|rcsb pdb:6AV6|rcsb pdb:6AV7|rcsb pdb:6CIE|rcsb pdb:6CIF|rcsb pdb:6NH1|rcsb pdb:6NH2|rcsb pdb:6NH3|rcsb pdb:6NH4|rcsb pdb:6NH5|rcsb pdb:6NH6|rcsb pdb:6NH7|rcsb pdb:6NH8|rcsb pdb:6NHF|rcsb pdb:6POU|rcsb pdb:6POV|rcsb pdb:6POW|rcsb pdb:6POX|rcsb pdb:6POY|rcsb pdb:6POZ|rcsb pdb:6PP0|rcsb pdb:6PP1|rcsb pdb:6PP2|rcsb pdb:6PP3|rcsb pdb:6PP4|reactome:R-HSA-1222556|reactome:R-HSA-1474151|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-203754|reactome:R-HSA-392154|reactome:R-HSA-5218920|reactome:R-HSA-9009391	refseq:NP_001034813.2|refseq:NP_001165102.1|refseq:NP_001165103.1|refseq:NP_443178.2|ensembl:ENSG00000163072(gene)|ensembl:ENST00000317647(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267|interpro:IPR028535|interpro:IPR031160|interpro:IPR035656|interpro:IPR036028|interpro:IPR036274|mint:Q8IVI9|rcsb pdb:2YUN|reactome:R-HSA-203641	go:"GO:0005886"(plasma membrane)	-	-	figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2007/09/05	2018/04/06	rogid:FIvVY2y5ltfs8KVWaMEHCEt2pMk9606	rogid:995orjHO0YRgvNcLMP1kX2qC25s9606	intact-crc:FB4B6269C2F2F3E7|rigid:+rZKVR9ltxTy5J+4XnHED+KP9uU	false	-	-	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)