#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P25586	uniprotkb:Q03280	intact:EBI-21773|uniprotkb:D6VQV7|ensemblfungi:YCL059C	intact:EBI-36817|uniprotkb:Q7LIK7|uniprotkb:D6VT81|ensemblfungi:YDR457W	psi-mi:krr1_yeast(display_long)|uniprotkb:KRR1(gene name)|psi-mi:KRR1(display_short)|uniprotkb:KRR-R motif-containing protein 1(gene name synonym)|uniprotkb:Ribosomal RNA assembly protein KRR1(gene name synonym)|uniprotkb:YCL59C(orf name)|uniprotkb:YCL059C(locus name)	psi-mi:tom1_yeast(display_long)|uniprotkb:TOM1(gene name)|psi-mi:TOM1(display_short)|uniprotkb:SSR2(gene name synonym)|uniprotkb:YDR457W(locus name)|uniprotkb:Temperature-dependent organization in mitotic nucleus protein 1(gene name synonym)|uniprotkb:Suppressor of snRNA protein 2(gene name synonym)|uniprotkb:D8035.1(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase TOM1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sasaki et al. (2000)	pubmed:11027267	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1565372	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009872.1|sgd:S000000564|mint:P25586|dip:DIP-1408N|ensemblfungi:YCL059C_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030686"(90S preribosome)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0032040"(small-subunit processome)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR004087(K Homology)|interpro:IPR024166|interpro:IPR036612|interpro:IPR041174|rcsb pdb:4QMF|rcsb pdb:5WLC|rcsb pdb:5WYJ|rcsb pdb:5WYK|rcsb pdb:6KE6|rcsb pdb:6LQP|rcsb pdb:6LQQ|rcsb pdb:6LQU|rcsb pdb:6ZQA|rcsb pdb:6ZQB|rcsb pdb:6ZQC|rcsb pdb:7AJT|reactome:R-SCE-6791226|ensemblfungi:YCL059C(gene)	sgd:S000002865|refseq:NP_010745.3|mint:Q03280|dip:DIP-5927N|ensemblfungi:YDR457W(gene)|ensemblfungi:YDR457W_mRNA(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000448"("cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006997"(nucleus organization)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051028"(mRNA transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000569(HECT)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|reactome:R-SCE-6798695|reactome:R-SCE-983168	-	crc64:7A7F964E2C7FD056	crc64:8F71F3493D70A6C9	figure legend:No figure	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/12/06	2014/10/16	rogid:wveCX/DmVjCNLOIejb/nWbrbX3o559292	rogid:3PNs+b34pHEg6EywF7pK15QF9zA559292	intact-crc:27336C92C4A31D9E|rigid:jwtLCSDVLFKMi6L5JG2CEkdjJrI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P42846	uniprotkb:P25586	intact:EBI-28360|uniprotkb:D6W0N7|ensemblfungi:YNL308C	intact:EBI-21773|uniprotkb:D6VQV7|ensemblfungi:YCL059C	psi-mi:kri1_yeast(display_long)|uniprotkb:YNL308C(locus name)|uniprotkb:N0388(orf name)|uniprotkb:KRR1-interacting protein 1(gene name synonym)|uniprotkb:KRI1(gene name)|psi-mi:KRI1(display_short)	psi-mi:krr1_yeast(display_long)|uniprotkb:KRR1(gene name)|psi-mi:KRR1(display_short)|uniprotkb:KRR-R motif-containing protein 1(gene name synonym)|uniprotkb:Ribosomal RNA assembly protein KRR1(gene name synonym)|uniprotkb:YCL59C(orf name)|uniprotkb:YCL059C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sasaki et al. (2000)	pubmed:11027267	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1565377	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014091.1|sgd:S000005252|dip:DIP-4073N|mint:P42846|ensemblfungi:YNL308C(gene)|ensemblfungi:YNL308C_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005730"(nucleolus)|go:"GO:0030686"(90S preribosome)|interpro:IPR018034|interpro:IPR024626	refseq:NP_009872.1|sgd:S000000564|mint:P25586|dip:DIP-1408N|ensemblfungi:YCL059C_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030686"(90S preribosome)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0032040"(small-subunit processome)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR004087(K Homology)|interpro:IPR024166|interpro:IPR036612|interpro:IPR041174|rcsb pdb:4QMF|rcsb pdb:5WLC|rcsb pdb:5WYJ|rcsb pdb:5WYK|rcsb pdb:6KE6|rcsb pdb:6LQP|rcsb pdb:6LQQ|rcsb pdb:6LQU|rcsb pdb:6ZQA|rcsb pdb:6ZQB|rcsb pdb:6ZQC|rcsb pdb:7AJT|reactome:R-SCE-6791226|ensemblfungi:YCL059C(gene)	-	crc64:3B637571EDB05EA6	crc64:7A7F964E2C7FD056	figure legend:Fig. 7A & 7B|comment:Interactions were performed at 26 and 37 degrees Celsius. A further decrease of the interaction was observed at 37 degrees Celsius in the case of the two mutants.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/12/06	2014/10/16	rogid:NhrYBQD07sx7vTVgiDFulg1FrAI559292	rogid:wveCX/DmVjCNLOIejb/nWbrbX3o559292	intact-crc:193DDB68FD6EFA72|rigid:1c0+9/V3ELObNRz0k+idPMqvXR4	false	myc tag:?-?	mutation decreasing interaction:45-45,95-95,207-207|mutation decreasing interaction:20-20,66-66,162-162,261-261|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P15646	uniprotkb:P25586	intact:EBI-6838|uniprotkb:P89890|uniprotkb:D6VRX5|ensemblfungi:YDL014W	intact:EBI-21773|uniprotkb:D6VQV7|ensemblfungi:YCL059C	psi-mi:fbrl_yeast(display_long)|uniprotkb:NOP1(gene name)|psi-mi:NOP1(display_short)|uniprotkb:LOT3(gene name synonym)|uniprotkb:YDL014W(locus name)|uniprotkb:D2870(orf name)|uniprotkb:U3 small nucleolar RNA-associated protein NOP1(gene name synonym)|uniprotkb:Histone-glutamine methyltransferase(gene name synonym)	psi-mi:krr1_yeast(display_long)|uniprotkb:KRR1(gene name)|psi-mi:KRR1(display_short)|uniprotkb:KRR-R motif-containing protein 1(gene name synonym)|uniprotkb:Ribosomal RNA assembly protein KRR1(gene name synonym)|uniprotkb:YCL59C(orf name)|uniprotkb:YCL059C(locus name)	psi-mi:"MI:0663"(confocal microscopy)	Sasaki et al. (2000)	pubmed:11027267	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1641490	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010270.1|sgd:S000002172|mint:P15646|dip:DIP-698N|ensemblfungi:YDL014W(gene)|ensemblfungi:YDL014W_mRNA(transcript)|go:"GO:0000451"(rRNA 2'-O-methylation)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006364"(rRNA processing)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008649"(rRNA methyltransferase activity)|go:"GO:0030686"(90S preribosome)|go:"GO:0031167"(rRNA methylation)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0043144"("sno(s)RNA processing")|go:"GO:1990258"(histone glutamine methylation)|go:"GO:1990259"(histone-glutamine methyltransferase activity)|interpro:IPR000692(Fibrillarin)|interpro:IPR020813|interpro:IPR029063|rcsb pdb:5WLC|rcsb pdb:5WYJ|rcsb pdb:5WYK|rcsb pdb:6KE6|rcsb pdb:6LQP|rcsb pdb:6LQQ|rcsb pdb:6LQR|rcsb pdb:6LQS|rcsb pdb:6LQT|rcsb pdb:6LQU|rcsb pdb:6LQV|rcsb pdb:6ND4|rcsb pdb:6ZDT|rcsb pdb:6ZQA|rcsb pdb:6ZQB|rcsb pdb:6ZQC|rcsb pdb:6ZQD|rcsb pdb:6ZQE|rcsb pdb:7AJT|rcsb pdb:7AJU|reactome:R-SCE-6791226	refseq:NP_009872.1|sgd:S000000564|mint:P25586|dip:DIP-1408N|ensemblfungi:YCL059C_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030686"(90S preribosome)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0032040"(small-subunit processome)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR004087(K Homology)|interpro:IPR024166|interpro:IPR036612|interpro:IPR041174|rcsb pdb:4QMF|rcsb pdb:5WLC|rcsb pdb:5WYJ|rcsb pdb:5WYK|rcsb pdb:6KE6|rcsb pdb:6LQP|rcsb pdb:6LQQ|rcsb pdb:6LQU|rcsb pdb:6ZQA|rcsb pdb:6ZQB|rcsb pdb:6ZQC|rcsb pdb:7AJT|reactome:R-SCE-6791226|ensemblfungi:YCL059C(gene)	go:"GO:0005730"(nucleolus)	crc64:56A8B958A7B6066E	crc64:7A7F964E2C7FD056	figure legend:Fig. 3|comment:Both Krr1 and Nop1 localize in the nucleolus.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/12/06	2014/10/16	rogid:zc81RbHf8PxId/8oPXPD3/MpmBU559292	rogid:wveCX/DmVjCNLOIejb/nWbrbX3o559292	intact-crc:9577723A08803054|rigid:yS7YzszcPWoITNmlYEpOhYvtmUM	false	green fluorescent protein tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P15646	uniprotkb:P42846	intact:EBI-6838|uniprotkb:P89890|uniprotkb:D6VRX5|ensemblfungi:YDL014W	intact:EBI-28360|uniprotkb:D6W0N7|ensemblfungi:YNL308C	psi-mi:fbrl_yeast(display_long)|uniprotkb:NOP1(gene name)|psi-mi:NOP1(display_short)|uniprotkb:LOT3(gene name synonym)|uniprotkb:YDL014W(locus name)|uniprotkb:D2870(orf name)|uniprotkb:U3 small nucleolar RNA-associated protein NOP1(gene name synonym)|uniprotkb:Histone-glutamine methyltransferase(gene name synonym)	psi-mi:kri1_yeast(display_long)|uniprotkb:YNL308C(locus name)|uniprotkb:N0388(orf name)|uniprotkb:KRR1-interacting protein 1(gene name synonym)|uniprotkb:KRI1(gene name)|psi-mi:KRI1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Sasaki et al. (2000)	pubmed:11027267	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1641499	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010270.1|sgd:S000002172|mint:P15646|dip:DIP-698N|ensemblfungi:YDL014W(gene)|ensemblfungi:YDL014W_mRNA(transcript)|go:"GO:0000451"(rRNA 2'-O-methylation)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006364"(rRNA processing)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008649"(rRNA methyltransferase activity)|go:"GO:0030686"(90S preribosome)|go:"GO:0031167"(rRNA methylation)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0043144"("sno(s)RNA processing")|go:"GO:1990258"(histone glutamine methylation)|go:"GO:1990259"(histone-glutamine methyltransferase activity)|interpro:IPR000692(Fibrillarin)|interpro:IPR020813|interpro:IPR029063|rcsb pdb:5WLC|rcsb pdb:5WYJ|rcsb pdb:5WYK|rcsb pdb:6KE6|rcsb pdb:6LQP|rcsb pdb:6LQQ|rcsb pdb:6LQR|rcsb pdb:6LQS|rcsb pdb:6LQT|rcsb pdb:6LQU|rcsb pdb:6LQV|rcsb pdb:6ND4|rcsb pdb:6ZDT|rcsb pdb:6ZQA|rcsb pdb:6ZQB|rcsb pdb:6ZQC|rcsb pdb:6ZQD|rcsb pdb:6ZQE|rcsb pdb:7AJT|rcsb pdb:7AJU|reactome:R-SCE-6791226	refseq:NP_014091.1|sgd:S000005252|dip:DIP-4073N|mint:P42846|ensemblfungi:YNL308C(gene)|ensemblfungi:YNL308C_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005730"(nucleolus)|go:"GO:0030686"(90S preribosome)|interpro:IPR018034|interpro:IPR024626	go:"GO:0005730"(nucleolus)	crc64:56A8B958A7B6066E	crc64:3B637571EDB05EA6	figure legend:Fig. 3|comment:Both Krr1 and Nop1 localize in the nucleolus.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/12/06	2014/10/16	rogid:zc81RbHf8PxId/8oPXPD3/MpmBU559292	rogid:NhrYBQD07sx7vTVgiDFulg1FrAI559292	intact-crc:77E9DB4DD0E67889|rigid:mx2DomoVw7JjQ8tBhE5sGlCsdoI	false	green fluorescent protein tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)