#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P40957	uniprotkb:P41695	intact:EBI-10354|ensemblfungi:YGL086W|uniprotkb:D6VU58	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	psi-mi:mad1_yeast(display_long)|uniprotkb:MAD1(gene name)|psi-mi:MAD1(display_short)|uniprotkb:Mitotic arrest deficient protein 1(gene name synonym)|uniprotkb:YGL086W(locus name)	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brady et al. (2000)	pubmed:10837255	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1394421	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003054|ensemblfungi:YGL086W(gene)|ensemblfungi:YGL086W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1901925"(negative regulation of protein import into nucleus during spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|refseq:NP_011429.3|dip:DIP-293N|mint:P40957	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	go:"GO:0007067"	-	crc64:6D76FC980775D3F9	figure legend:1a|comment:BUB1 was detected from 40 min to 60 min of the unperturbed cell cycle, and at significantly higher levels in the nocodazole-treated cells from 40 min onwards.|comment:Apparently a MAD1-BUB1-BUB3 complex was formed 40 minutes after release from an alpa-factor arrest and was then maintained.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/12	2014/10/16	rogid:KN5bSe+qhWpvc7W6Sh2IolgtLXE559292	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	intact-crc:0EC7DBCE697A06A1|rigid:nGO6/aO/GlNXI4xW9iKKzZv9sA8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P40957	uniprotkb:P41695	intact:EBI-10354|ensemblfungi:YGL086W|uniprotkb:D6VU58	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	psi-mi:mad1_yeast(display_long)|uniprotkb:MAD1(gene name)|psi-mi:MAD1(display_short)|uniprotkb:Mitotic arrest deficient protein 1(gene name synonym)|uniprotkb:YGL086W(locus name)	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brady et al. (2000)	pubmed:10837255	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1394470	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003054|ensemblfungi:YGL086W(gene)|ensemblfungi:YGL086W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1901925"(negative regulation of protein import into nucleus during spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|refseq:NP_011429.3|dip:DIP-293N|mint:P40957	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	go:"GO:0007067"	-	crc64:6D76FC980775D3F9	figure legend:3a|comment:Interaction requires MAD2 and BUB3.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/12	2014/10/16	rogid:KN5bSe+qhWpvc7W6Sh2IolgtLXE559292	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	intact-crc:62B595C4DF4757BB|rigid:nGO6/aO/GlNXI4xW9iKKzZv9sA8	false	mutation disrupting interaction:653-653,655-655	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P26449	uniprotkb:P41695	intact:EBI-3830|uniprotkb:D6W292|ensemblfungi:YOR026W	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	psi-mi:bub3_yeast(display_long)|uniprotkb:OR26.16(orf name)|uniprotkb:YOR026W(locus name)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brady et al. (2000)	pubmed:10837255	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1394476	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014669.1|sgd:S000005552|reactome:R-SCE-141430|dip:DIP-1219N|ensemblfungi:YOR026W(gene)|ensemblfungi:YOR026W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:1U4C|rcsb pdb:1YFQ|rcsb pdb:2I3S|rcsb pdb:2I3T|rcsb pdb:4BL0	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	go:"GO:0007067"	crc64:0BDFB8697935BCEB	crc64:6D76FC980775D3F9	figure legend:3a|comment:Interaction does not require MAD1, MAD2, MAD3, and BUB2.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/12	2014/10/16	rogid:y8P+TfgWS+dySWQDW7eo6YOGjwU559292	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	intact-crc:2BDF419530FD5229|rigid:uPMpRTuexHAEMob+3KmUDHDObUs	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P26449	uniprotkb:P40957	intact:EBI-3830|uniprotkb:D6W292|ensemblfungi:YOR026W	intact:EBI-10354|ensemblfungi:YGL086W|uniprotkb:D6VU58	psi-mi:bub3_yeast(display_long)|uniprotkb:OR26.16(orf name)|uniprotkb:YOR026W(locus name)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:mad1_yeast(display_long)|uniprotkb:MAD1(gene name)|psi-mi:MAD1(display_short)|uniprotkb:Mitotic arrest deficient protein 1(gene name synonym)|uniprotkb:YGL086W(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brady et al. (2000)	pubmed:10837255	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1394433	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014669.1|sgd:S000005552|reactome:R-SCE-141430|dip:DIP-1219N|ensemblfungi:YOR026W(gene)|ensemblfungi:YOR026W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:1U4C|rcsb pdb:1YFQ|rcsb pdb:2I3S|rcsb pdb:2I3T|rcsb pdb:4BL0	sgd:S000003054|ensemblfungi:YGL086W(gene)|ensemblfungi:YGL086W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1901925"(negative regulation of protein import into nucleus during spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|refseq:NP_011429.3|dip:DIP-293N|mint:P40957	go:"GO:0007067"	crc64:0BDFB8697935BCEB	-	figure legend:1a|comment:BUB3 was detected from 40 min to 60 min of the unperturbed cell cycle, and at significantly higher levels in the nocodazole-treated cells from 40 min onwards.|comment:Apparently a MAD1-BUB1-BUB3 complex was formed 40 minutes after release from an alpa-factor arrest and was then maintained.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/12	2014/10/16	rogid:y8P+TfgWS+dySWQDW7eo6YOGjwU559292	rogid:KN5bSe+qhWpvc7W6Sh2IolgtLXE559292	intact-crc:5E419B7DB43FF485|rigid:xsLDkTmUBg8aJDXgU6y4LFrFnXc	false	myc tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P26449	uniprotkb:P41695	intact:EBI-3830|uniprotkb:D6W292|ensemblfungi:YOR026W	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	psi-mi:bub3_yeast(display_long)|uniprotkb:OR26.16(orf name)|uniprotkb:YOR026W(locus name)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Brady et al. (2000)	pubmed:10837255	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1394448	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014669.1|sgd:S000005552|reactome:R-SCE-141430|dip:DIP-1219N|ensemblfungi:YOR026W(gene)|ensemblfungi:YOR026W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:1U4C|rcsb pdb:1YFQ|rcsb pdb:2I3S|rcsb pdb:2I3T|rcsb pdb:4BL0	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	go:"GO:0000089"(mitotic metaphase)|go:"GO:0051318"(G1 phase)	crc64:0BDFB8697935BCEB	crc64:6D76FC980775D3F9	comment:BUB1 was detected in G1, mitosis and metaphase precipitates.|figure legend:1b	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/12	2014/10/16	rogid:y8P+TfgWS+dySWQDW7eo6YOGjwU559292	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	intact-crc:88DE328EEFAEFEB0|rigid:uPMpRTuexHAEMob+3KmUDHDObUs	false	myc tag:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P26449	uniprotkb:P40957	intact:EBI-3830|uniprotkb:D6W292|ensemblfungi:YOR026W	intact:EBI-10354|ensemblfungi:YGL086W|uniprotkb:D6VU58	psi-mi:bub3_yeast(display_long)|uniprotkb:OR26.16(orf name)|uniprotkb:YOR026W(locus name)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:mad1_yeast(display_long)|uniprotkb:MAD1(gene name)|psi-mi:MAD1(display_short)|uniprotkb:Mitotic arrest deficient protein 1(gene name synonym)|uniprotkb:YGL086W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Brady et al. (2000)	pubmed:10837255	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1394462	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014669.1|sgd:S000005552|reactome:R-SCE-141430|dip:DIP-1219N|ensemblfungi:YOR026W(gene)|ensemblfungi:YOR026W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:1U4C|rcsb pdb:1YFQ|rcsb pdb:2I3S|rcsb pdb:2I3T|rcsb pdb:4BL0	sgd:S000003054|ensemblfungi:YGL086W(gene)|ensemblfungi:YGL086W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1901925"(negative regulation of protein import into nucleus during spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|refseq:NP_011429.3|dip:DIP-293N|mint:P40957	go:"GO:0007067"	crc64:0BDFB8697935BCEB	-	comment:"MAD1 was detected in mitosis precipitates (with activated spindle checkpoint)."|figure legend:1b	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/12	2014/10/16	rogid:y8P+TfgWS+dySWQDW7eo6YOGjwU559292	rogid:KN5bSe+qhWpvc7W6Sh2IolgtLXE559292	intact-crc:4DA8531F59FF8C12|rigid:xsLDkTmUBg8aJDXgU6y4LFrFnXc	false	myc tag:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P41695	uniprotkb:P40957	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	intact:EBI-10354|ensemblfungi:YGL086W|uniprotkb:D6VU58	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:mad1_yeast(display_long)|uniprotkb:MAD1(gene name)|psi-mi:MAD1(display_short)|uniprotkb:Mitotic arrest deficient protein 1(gene name synonym)|uniprotkb:YGL086W(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brady et al. (2000)	pubmed:10837255	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1394489	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	sgd:S000003054|ensemblfungi:YGL086W(gene)|ensemblfungi:YGL086W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1901925"(negative regulation of protein import into nucleus during spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|refseq:NP_011429.3|dip:DIP-293N|mint:P40957	-	crc64:6D76FC980775D3F9	-	comment:Interaction is dependent on MPS1.|figure legend:3b	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/12	2014/10/16	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rogid:KN5bSe+qhWpvc7W6Sh2IolgtLXE559292	intact-crc:1216E2FFEF5B7DBE|rigid:nGO6/aO/GlNXI4xW9iKKzZv9sA8	false	mutation decreasing interaction:733-733	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P40957	uniprotkb:P41695	intact:EBI-10354|ensemblfungi:YGL086W|uniprotkb:D6VU58	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	psi-mi:mad1_yeast(display_long)|uniprotkb:MAD1(gene name)|psi-mi:MAD1(display_short)|uniprotkb:Mitotic arrest deficient protein 1(gene name synonym)|uniprotkb:YGL086W(locus name)	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brady et al. (2000)	pubmed:10837255	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1394510	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003054|ensemblfungi:YGL086W(gene)|ensemblfungi:YGL086W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1901925"(negative regulation of protein import into nucleus during spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|refseq:NP_011429.3|dip:DIP-293N|mint:P40957	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	go:"GO:0007067"	-	crc64:6D76FC980775D3F9	comment:Detected in medium with nocodozole.|comment:A MAD1 653-RLK-AAA mutant did not interact with BUB1 and BUB3 but did not change the interaction with MAD2.|figure legend:4c	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/12	2014/10/16	rogid:KN5bSe+qhWpvc7W6Sh2IolgtLXE559292	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	intact-crc:CFD92C0A239B56BD|rigid:ES7olMWV9WPhC46jAPWYpi8yipI	false	binding-associated region:653-655	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40957	uniprotkb:P26449	intact:EBI-10354|ensemblfungi:YGL086W|uniprotkb:D6VU58	intact:EBI-3830|uniprotkb:D6W292|ensemblfungi:YOR026W	psi-mi:mad1_yeast(display_long)|uniprotkb:MAD1(gene name)|psi-mi:MAD1(display_short)|uniprotkb:Mitotic arrest deficient protein 1(gene name synonym)|uniprotkb:YGL086W(locus name)	psi-mi:bub3_yeast(display_long)|uniprotkb:OR26.16(orf name)|uniprotkb:YOR026W(locus name)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brady et al. (2000)	pubmed:10837255	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1394510	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003054|ensemblfungi:YGL086W(gene)|ensemblfungi:YGL086W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1901925"(negative regulation of protein import into nucleus during spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|refseq:NP_011429.3|dip:DIP-293N|mint:P40957	refseq:NP_014669.1|sgd:S000005552|reactome:R-SCE-141430|dip:DIP-1219N|ensemblfungi:YOR026W(gene)|ensemblfungi:YOR026W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:1U4C|rcsb pdb:1YFQ|rcsb pdb:2I3S|rcsb pdb:2I3T|rcsb pdb:4BL0	go:"GO:0007067"	-	crc64:0BDFB8697935BCEB	comment:Detected in medium with nocodozole.|comment:A MAD1 653-RLK-AAA mutant did not interact with BUB1 and BUB3 but did not change the interaction with MAD2.|figure legend:4c	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/12	2014/10/16	rogid:KN5bSe+qhWpvc7W6Sh2IolgtLXE559292	rogid:y8P+TfgWS+dySWQDW7eo6YOGjwU559292	intact-crc:CFD92C0A239B56BD|rigid:ES7olMWV9WPhC46jAPWYpi8yipI	false	binding-associated region:653-655	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40957	uniprotkb:P40958	intact:EBI-10354|ensemblfungi:YGL086W|uniprotkb:D6VU58	intact:EBI-10362|ensemblfungi:YJL030W|uniprotkb:D6VWF2	psi-mi:mad1_yeast(display_long)|uniprotkb:MAD1(gene name)|psi-mi:MAD1(display_short)|uniprotkb:Mitotic arrest deficient protein 1(gene name synonym)|uniprotkb:YGL086W(locus name)	psi-mi:mad2_yeast(display_long)|uniprotkb:MAD2(gene name)|psi-mi:MAD2(display_short)|uniprotkb:J1256(orf name)|uniprotkb:YJL030W(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brady et al. (2000)	pubmed:10837255	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1394510	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003054|ensemblfungi:YGL086W(gene)|ensemblfungi:YGL086W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1901925"(negative regulation of protein import into nucleus during spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|refseq:NP_011429.3|dip:DIP-293N|mint:P40957	sgd:S000003567|ensemblfungi:YJL030W(gene)|ensemblfungi:YJL030W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051312"(chromosome decondensation)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR027097|interpro:IPR036570|reactome:R-SCE-141405|reactome:R-SCE-141430|refseq:NP_012504.3|dip:DIP-815N|mint:P40958	go:"GO:0007067"	-	-	comment:Detected in medium with nocodozole.|comment:A MAD1 653-RLK-AAA mutant did not interact with BUB1 and BUB3 but did not change the interaction with MAD2.|figure legend:4c	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/12	2014/10/16	rogid:KN5bSe+qhWpvc7W6Sh2IolgtLXE559292	rogid:0pxFckODTcklkGn+JcczltjSHRU559292	intact-crc:CFD92C0A239B56BD|rigid:ES7olMWV9WPhC46jAPWYpi8yipI	false	binding-associated region:653-655	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)