#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P42124	uniprotkb:Q24338	intact:EBI-112315|uniprotkb:Q9VTA3|uniprotkb:B7Z0G2|ensemblmetazoa:FBpp0076008|ensemblmetazoa:FBpp0271846	intact:EBI-88911|ensemblmetazoa:FBpp0079907	psi-mi:ez_drome(display_long)|uniprotkb:KMT6(gene name synonym)|uniprotkb:"E(z)"(gene name)|psi-mi:"E(z)"(display_short)|uniprotkb:CG6502(orf name)|uniprotkb:Protein enhancer of zeste(gene name synonym)|uniprotkb:Lysine N-methyltransferase 6(gene name synonym)	psi-mi:esc_drome(display_long)|uniprotkb:esc(gene name)|psi-mi:esc(display_short)|uniprotkb:CG14941(orf name)|uniprotkb:Protein extra sex combs(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Ng et al. (2000)	pubmed:10757791|imex:IM-19921	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1203900|imex:IM-19921-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524021.2|refseq:NP_001137932.1|flybase:FBgn0000629|dip:DIP-20386N|ensemblmetazoa:FBgn0000629(gene)|ensemblmetazoa:FBtr0076279(transcript)|ensemblmetazoa:FBtr0273338(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0007411"(axon guidance)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016571"(histone methylation)|go:"GO:0022008"(neurogenesis)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:P42124|reactome:R-DME-2559580|reactome:R-DME-8943724	ensemblmetazoa:FBgn0000588(gene)|ensemblmetazoa:FBtr0080325(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006342"|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042802"(identical protein binding)|go:"GO:0048096"|go:"GO:0070734"(histone H3-K27 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q24338|go:"GO:0016458"(obsolete gene silencing)|refseq:NP_477431.1|flybase:FBgn0000588|dip:DIP-20069N	go:"GO:0035098"("ESC/E(Z) complex")	-	-	figure legend:2|complex-properties:"HA-ESC and E(Z) cofractionate in complexes of about 600 kDa"|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-embryo)|taxid:7227(drosophilla melanogaster embryo)	-	2007/02/20	2014/10/16	rogid:SgDch3Z90h2XcA4b2MqjzZN+gSI7227	rogid:owOOCkwb0LdPVnElMax3J1OIkEE7227	intact-crc:8DDEC765ACD65049|rigid:97CWoQ2IMfsQ4bSxZAjIKwtv42U	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24338	uniprotkb:P42124	intact:EBI-88911|ensemblmetazoa:FBpp0079907	intact:EBI-112315|uniprotkb:Q9VTA3|uniprotkb:B7Z0G2|ensemblmetazoa:FBpp0076008|ensemblmetazoa:FBpp0271846	psi-mi:esc_drome(display_long)|uniprotkb:esc(gene name)|psi-mi:esc(display_short)|uniprotkb:CG14941(orf name)|uniprotkb:Protein extra sex combs(gene name synonym)	psi-mi:ez_drome(display_long)|uniprotkb:KMT6(gene name synonym)|uniprotkb:"E(z)"(gene name)|psi-mi:"E(z)"(display_short)|uniprotkb:CG6502(orf name)|uniprotkb:Protein enhancer of zeste(gene name synonym)|uniprotkb:Lysine N-methyltransferase 6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ng et al. (2000)	pubmed:10757791|imex:IM-19921	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1203922|imex:IM-19921-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0000588(gene)|ensemblmetazoa:FBtr0080325(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006342"|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042802"(identical protein binding)|go:"GO:0048096"|go:"GO:0070734"(histone H3-K27 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q24338|go:"GO:0016458"(obsolete gene silencing)|refseq:NP_477431.1|flybase:FBgn0000588|dip:DIP-20069N	refseq:NP_524021.2|refseq:NP_001137932.1|flybase:FBgn0000629|dip:DIP-20386N|ensemblmetazoa:FBgn0000629(gene)|ensemblmetazoa:FBtr0076279(transcript)|ensemblmetazoa:FBtr0273338(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0007411"(axon guidance)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016571"(histone methylation)|go:"GO:0022008"(neurogenesis)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:P42124|reactome:R-DME-2559580|reactome:R-DME-8943724	go:"GO:0035098"("ESC/E(Z) complex")	-	-	figure legend:3|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-embryo)|taxid:7227(drosophilla melanogaster embryo)	-	2007/02/20	2014/10/16	rogid:owOOCkwb0LdPVnElMax3J1OIkEE7227	rogid:SgDch3Z90h2XcA4b2MqjzZN+gSI7227	intact-crc:0A62EC12B04FA224|rigid:97CWoQ2IMfsQ4bSxZAjIKwtv42U	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)