#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7K480	uniprotkb:P09081	intact:EBI-180984|intact:EBI-1201723|intact:EBI-499029|uniprotkb:Q86LF5|uniprotkb:Q9NJV6|ensemblmetazoa:FBpp0085336|ensemblmetazoa:FBpp0085337|ensemblmetazoa:FBpp0307591|ensemblmetazoa:FBpp0312329	intact:EBI-196628|intact:EBI-1628133|uniprotkb:Q5BI92|uniprotkb:Q86BA9|uniprotkb:Q86BP2|uniprotkb:Q8INR7|uniprotkb:Q8ST46|uniprotkb:Q8STB1|uniprotkb:Q8T9S9|uniprotkb:Q8T9T0|uniprotkb:Q8T9T1|uniprotkb:Q95TN3|uniprotkb:Q9UAM0|uniprotkb:Q9VI47|ensemblmetazoa:FBpp0081168	psi-mi:mepce_drome(display_long)|uniprotkb:bin3(gene name)|psi-mi:bin3(display_short)|uniprotkb:Bicoid-interacting protein 3(gene name synonym)|uniprotkb:CG8276(orf name)	psi-mi:bcd_drome(display_long)|uniprotkb:bcd(gene name)|psi-mi:bcd(display_short)|uniprotkb:CG1034(orf name)|uniprotkb:PRD-4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhu et al. (2000)	pubmed:10717484|imex:IM-19912	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-871574|imex:IM-19912-4	author score:++; 22.5 beta gal units	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523626.2|refseq:NP_724468.1|flybase:FBgn0263144|refseq:NP_001303336.1|refseq:NP_001260724.1|ensemblmetazoa:FBgn0263144(gene)|ensemblmetazoa:FBtr0085992(transcript)|ensemblmetazoa:FBtr0085993(transcript)|ensemblmetazoa:FBtr0336519(transcript)|ensemblmetazoa:FBtr0346718(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0017069"(snRNA binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032259"(methylation)|go:"GO:0032502"(developmental process)|go:"GO:0040031"(snRNA modification)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR010675(Bicoid-interacting 3)|interpro:IPR024160|interpro:IPR025714|interpro:IPR029063|interpro:IPR039772	refseq:NP_476825.1|refseq:NP_731111.1|refseq:NP_731113.2|refseq:NP_788587.1|refseq:NP_788588.1|flybase:FBgn0000166|ensemblmetazoa:FBgn0000166(gene)|ensemblmetazoa:FBtr0081668(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007355"(anterior region determination)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008358"(maternal determination of anterior/posterior axis, embryo)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048477"(oogenesis)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|rcsb pdb:1ZQ3	-	-	-	figure legend:1B, table 1|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/02/13	2014/10/16	rogid:GAGF7zQJlQjvzZLj2MCRCKPJ64I7227	rogid:Nt5CxfBC6SP6auZB0DEeSOXQHko7227	intact-crc:E8DA72BAA5F46D38|rigid:v5Hz8Ab0rKgaoJwmpj36nu5R+l0	false	-	sufficient binding region:1-343(IPR001356)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P09081	uniprotkb:Q7K480	intact:EBI-196628|intact:EBI-1628133|uniprotkb:Q5BI92|uniprotkb:Q86BA9|uniprotkb:Q86BP2|uniprotkb:Q8INR7|uniprotkb:Q8ST46|uniprotkb:Q8STB1|uniprotkb:Q8T9S9|uniprotkb:Q8T9T0|uniprotkb:Q8T9T1|uniprotkb:Q95TN3|uniprotkb:Q9UAM0|uniprotkb:Q9VI47|ensemblmetazoa:FBpp0081168	intact:EBI-180984|intact:EBI-1201723|intact:EBI-499029|uniprotkb:Q86LF5|uniprotkb:Q9NJV6|ensemblmetazoa:FBpp0085336|ensemblmetazoa:FBpp0085337|ensemblmetazoa:FBpp0307591|ensemblmetazoa:FBpp0312329	psi-mi:bcd_drome(display_long)|uniprotkb:bcd(gene name)|psi-mi:bcd(display_short)|uniprotkb:CG1034(orf name)|uniprotkb:PRD-4(gene name synonym)	psi-mi:mepce_drome(display_long)|uniprotkb:bin3(gene name)|psi-mi:bin3(display_short)|uniprotkb:Bicoid-interacting protein 3(gene name synonym)|uniprotkb:CG8276(orf name)	psi-mi:"MI:0018"(two hybrid)	Zhu et al. (2000)	pubmed:10717484|imex:IM-19912	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1201662|imex:IM-19912-2	author score:+; 150 beta gal units	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476825.1|refseq:NP_731111.1|refseq:NP_731113.2|refseq:NP_788587.1|refseq:NP_788588.1|flybase:FBgn0000166|ensemblmetazoa:FBgn0000166(gene)|ensemblmetazoa:FBtr0081668(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007355"(anterior region determination)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008358"(maternal determination of anterior/posterior axis, embryo)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048477"(oogenesis)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|rcsb pdb:1ZQ3	refseq:NP_523626.2|refseq:NP_724468.1|flybase:FBgn0263144|refseq:NP_001303336.1|refseq:NP_001260724.1|ensemblmetazoa:FBgn0263144(gene)|ensemblmetazoa:FBtr0085992(transcript)|ensemblmetazoa:FBtr0085993(transcript)|ensemblmetazoa:FBtr0336519(transcript)|ensemblmetazoa:FBtr0346718(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0017069"(snRNA binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032259"(methylation)|go:"GO:0032502"(developmental process)|go:"GO:0040031"(snRNA modification)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR010675(Bicoid-interacting 3)|interpro:IPR024160|interpro:IPR025714|interpro:IPR029063|interpro:IPR039772	-	-	-	figure legend:1B, table 1|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/02/13	2014/10/16	rogid:Nt5CxfBC6SP6auZB0DEeSOXQHko7227	rogid:GAGF7zQJlQjvzZLj2MCRCKPJ64I7227	intact-crc:F1D81C3F05BECF9B|rigid:v5Hz8Ab0rKgaoJwmpj36nu5R+l0	false	sufficient binding region:1-343	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P09081	uniprotkb:Q7K480	intact:EBI-196628|intact:EBI-1628133|uniprotkb:Q5BI92|uniprotkb:Q86BA9|uniprotkb:Q86BP2|uniprotkb:Q8INR7|uniprotkb:Q8ST46|uniprotkb:Q8STB1|uniprotkb:Q8T9S9|uniprotkb:Q8T9T0|uniprotkb:Q8T9T1|uniprotkb:Q95TN3|uniprotkb:Q9UAM0|uniprotkb:Q9VI47|ensemblmetazoa:FBpp0081168	intact:EBI-180984|intact:EBI-1201723|intact:EBI-499029|uniprotkb:Q86LF5|uniprotkb:Q9NJV6|ensemblmetazoa:FBpp0085336|ensemblmetazoa:FBpp0085337|ensemblmetazoa:FBpp0307591|ensemblmetazoa:FBpp0312329	psi-mi:bcd_drome(display_long)|uniprotkb:bcd(gene name)|psi-mi:bcd(display_short)|uniprotkb:CG1034(orf name)|uniprotkb:PRD-4(gene name synonym)	psi-mi:mepce_drome(display_long)|uniprotkb:bin3(gene name)|psi-mi:bin3(display_short)|uniprotkb:Bicoid-interacting protein 3(gene name synonym)|uniprotkb:CG8276(orf name)	psi-mi:"MI:0018"(two hybrid)	Zhu et al. (2000)	pubmed:10717484|imex:IM-19912	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1201646|imex:IM-19912-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476825.1|refseq:NP_731111.1|refseq:NP_731113.2|refseq:NP_788587.1|refseq:NP_788588.1|flybase:FBgn0000166|ensemblmetazoa:FBgn0000166(gene)|ensemblmetazoa:FBtr0081668(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007355"(anterior region determination)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008358"(maternal determination of anterior/posterior axis, embryo)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048477"(oogenesis)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|rcsb pdb:1ZQ3	refseq:NP_523626.2|refseq:NP_724468.1|flybase:FBgn0263144|refseq:NP_001303336.1|refseq:NP_001260724.1|ensemblmetazoa:FBgn0263144(gene)|ensemblmetazoa:FBtr0085992(transcript)|ensemblmetazoa:FBtr0085993(transcript)|ensemblmetazoa:FBtr0336519(transcript)|ensemblmetazoa:FBtr0346718(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0017069"(snRNA binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032259"(methylation)|go:"GO:0032502"(developmental process)|go:"GO:0040031"(snRNA modification)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR010675(Bicoid-interacting 3)|interpro:IPR024160|interpro:IPR025714|interpro:IPR029063|interpro:IPR039772	-	-	-	figure legend:4A|comment:Region AA 61-948 of Bin3 interacts most strongly with Bicoid.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/02/13	2014/10/16	rogid:Nt5CxfBC6SP6auZB0DEeSOXQHko7227	rogid:GAGF7zQJlQjvzZLj2MCRCKPJ64I7227	intact-crc:638A14C69B0F5D81|rigid:v5Hz8Ab0rKgaoJwmpj36nu5R+l0	false	sufficient binding region:3-489(IPR001356)	sufficient binding region:472-763	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09081	uniprotkb:Q7K480	intact:EBI-196628|intact:EBI-1628133|uniprotkb:Q5BI92|uniprotkb:Q86BA9|uniprotkb:Q86BP2|uniprotkb:Q8INR7|uniprotkb:Q8ST46|uniprotkb:Q8STB1|uniprotkb:Q8T9S9|uniprotkb:Q8T9T0|uniprotkb:Q8T9T1|uniprotkb:Q95TN3|uniprotkb:Q9UAM0|uniprotkb:Q9VI47|ensemblmetazoa:FBpp0081168	intact:EBI-180984|intact:EBI-1201723|intact:EBI-499029|uniprotkb:Q86LF5|uniprotkb:Q9NJV6|ensemblmetazoa:FBpp0085336|ensemblmetazoa:FBpp0085337|ensemblmetazoa:FBpp0307591|ensemblmetazoa:FBpp0312329	psi-mi:bcd_drome(display_long)|uniprotkb:bcd(gene name)|psi-mi:bcd(display_short)|uniprotkb:CG1034(orf name)|uniprotkb:PRD-4(gene name synonym)	psi-mi:mepce_drome(display_long)|uniprotkb:bin3(gene name)|psi-mi:bin3(display_short)|uniprotkb:Bicoid-interacting protein 3(gene name synonym)|uniprotkb:CG8276(orf name)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2000)	pubmed:10717484|imex:IM-19912	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1201805|imex:IM-19912-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476825.1|refseq:NP_731111.1|refseq:NP_731113.2|refseq:NP_788587.1|refseq:NP_788588.1|flybase:FBgn0000166|ensemblmetazoa:FBgn0000166(gene)|ensemblmetazoa:FBtr0081668(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007355"(anterior region determination)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008358"(maternal determination of anterior/posterior axis, embryo)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048477"(oogenesis)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|rcsb pdb:1ZQ3	refseq:NP_523626.2|refseq:NP_724468.1|flybase:FBgn0263144|refseq:NP_001303336.1|refseq:NP_001260724.1|ensemblmetazoa:FBgn0263144(gene)|ensemblmetazoa:FBtr0085992(transcript)|ensemblmetazoa:FBtr0085993(transcript)|ensemblmetazoa:FBtr0336519(transcript)|ensemblmetazoa:FBtr0346718(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0017069"(snRNA binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032259"(methylation)|go:"GO:0032502"(developmental process)|go:"GO:0040031"(snRNA modification)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR010675(Bicoid-interacting 3)|interpro:IPR024160|interpro:IPR025714|interpro:IPR029063|interpro:IPR039772	-	-	-	figure legend:4B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/13	2014/10/16	rogid:Nt5CxfBC6SP6auZB0DEeSOXQHko7227	rogid:GAGF7zQJlQjvzZLj2MCRCKPJ64I7227	intact-crc:9F70F739639ED5E1|rigid:v5Hz8Ab0rKgaoJwmpj36nu5R+l0	false	35s radiolabel:?-?	sufficient binding region:132-948|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)