#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P87060	uniprotkb:O14170	intact:EBI-1185389|uniprotkb:Q9P7P3|ensemblfungi:"SPBC1718.01.1:pep"	intact:EBI-1185414|ensemblfungi:"SPAC4D7.03.1:pep"	psi-mi:pop1_schpo(display_long)|uniprotkb:WD repeat-containing protein ste16(gene name synonym)|uniprotkb:pop1(gene name)|psi-mi:pop1(display_short)|uniprotkb:SPBC1718.01(orf name)|uniprotkb:SPBC2G2.18(orf name)|uniprotkb:ste16(gene name synonym)	psi-mi:pop2_schpo(display_long)|uniprotkb:Proteolysis factor sud1(gene name synonym)|uniprotkb:pop2(gene name)|psi-mi:pop2(display_short)|uniprotkb:sud1(gene name synonym)|uniprotkb:SPAC4D7.03(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wolf et al. (1999)	pubmed:10209119|imex:IM-19931	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1207488|imex:IM-19931-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_001713146.1|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|ensemblfungi:SPBC1718.01(gene)|ensemblfungi:SPBC1718.01.1(transcript)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR036047|interpro:IPR036322	refseq:NP_594956.1|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblfungi:SPAC4D7.03(gene)|ensemblfungi:SPAC4D7.03.1(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0070647"(protein modification by small protein conjugation or removal)|go:"GO:1903467"(negative regulation of mitotic DNA replication initiation)|interpro:IPR015943(WD40/YVTN repeat-like)|mint:O14170|interpro:IPR036047|interpro:IPR036322	-	-	-	figure legend:Figure 2a|comment:pop2 is able to interact with pop1 forming a heterodimer within the cell.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2007/02/23	2014/10/16	rogid:fpsox2UXaKWswVhuSnBBtqkY1/g284812	rogid:Te5GmNzUBSnfbMfLIGrHi+6u7/A284812	intact-crc:0E7F2A1F41338790|rigid:7aLKwbKho5Gj4yJu69yLS6/7RYw	false	his tag:?-?|myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87060	uniprotkb:O14170	intact:EBI-1185389|uniprotkb:Q9P7P3|ensemblfungi:"SPBC1718.01.1:pep"	intact:EBI-1185414|ensemblfungi:"SPAC4D7.03.1:pep"	psi-mi:pop1_schpo(display_long)|uniprotkb:WD repeat-containing protein ste16(gene name synonym)|uniprotkb:pop1(gene name)|psi-mi:pop1(display_short)|uniprotkb:SPBC1718.01(orf name)|uniprotkb:SPBC2G2.18(orf name)|uniprotkb:ste16(gene name synonym)	psi-mi:pop2_schpo(display_long)|uniprotkb:Proteolysis factor sud1(gene name synonym)|uniprotkb:pop2(gene name)|psi-mi:pop2(display_short)|uniprotkb:sud1(gene name synonym)|uniprotkb:SPAC4D7.03(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wolf et al. (1999)	pubmed:10209119|imex:IM-19931	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1207596|imex:IM-19931-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_001713146.1|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|ensemblfungi:SPBC1718.01(gene)|ensemblfungi:SPBC1718.01.1(transcript)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR036047|interpro:IPR036322	refseq:NP_594956.1|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblfungi:SPAC4D7.03(gene)|ensemblfungi:SPAC4D7.03.1(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0070647"(protein modification by small protein conjugation or removal)|go:"GO:1903467"(negative regulation of mitotic DNA replication initiation)|interpro:IPR015943(WD40/YVTN repeat-like)|mint:O14170|interpro:IPR036047|interpro:IPR036322	-	-	-	figure legend:Figure 2B|comment:"The n-terminal region of pop2 (AA 2-241), even without the f-box is able to bind with pop1, however deletion of the pop2 n-terminal regions AA 171-703 and AA 345-703 prevents interaction with pop1 suggesting that there maybe an independent pop1-binding-domain in the region AA 2-171."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2007/02/23	2014/10/16	rogid:fpsox2UXaKWswVhuSnBBtqkY1/g284812	rogid:Te5GmNzUBSnfbMfLIGrHi+6u7/A284812	intact-crc:B456E80184D2DF90|rigid:7aLKwbKho5Gj4yJu69yLS6/7RYw	false	ha tag:?-?	myc tag:?-?|necessary binding region:2-171	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41411	uniprotkb:O14170	intact:EBI-1207853|ensemblfungi:"SPBC14C8.07c.1:pep"	intact:EBI-1185414|ensemblfungi:"SPAC4D7.03.1:pep"	psi-mi:cdc18_schpo(display_long)|uniprotkb:cdc18(gene name)|psi-mi:cdc18(display_short)|uniprotkb:SPBC14C8.07c(orf name)	psi-mi:pop2_schpo(display_long)|uniprotkb:Proteolysis factor sud1(gene name synonym)|uniprotkb:pop2(gene name)|psi-mi:pop2(display_short)|uniprotkb:sud1(gene name synonym)|uniprotkb:SPAC4D7.03(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wolf et al. (1999)	pubmed:10209119|imex:IM-19931	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1207868|imex:IM-19931-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_595910.1|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR016314(Cell division control, Cdc6)|reactome:R-SPO-68689|reactome:R-SPO-68962|reactome:R-SPO-69017|interpro:IPR027417|reactome:R-SPO-176187|ensemblfungi:SPBC14C8.07c(gene)|ensemblfungi:SPBC14C8.07c.1(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0140530"(MCM complex loading)|go:"GO:1902985"(mitotic pre-replicative complex assembly)|go:"GO:1903468"(positive regulation of DNA replication initiation)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR036388|interpro:IPR036390|reactome:R-SPO-68949|interpro:IPR041083|reactome:R-SPO-68827|reactome:R-SPO-68867	refseq:NP_594956.1|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblfungi:SPAC4D7.03(gene)|ensemblfungi:SPAC4D7.03.1(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0070647"(protein modification by small protein conjugation or removal)|go:"GO:1903467"(negative regulation of mitotic DNA replication initiation)|interpro:IPR015943(WD40/YVTN repeat-like)|mint:O14170|interpro:IPR036047|interpro:IPR036322	-	-	-	figure legend:Figure 3D|comment:Interaction between Pop2p and GFP-Cdc18p was detected in lysates from wild-type cells, but was undetectable in lysates from pop1-deleted mutants, suggesting that Pop1p-Pop2p heterooligomers cooperate in substrate binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2007/02/23	2014/10/16	rogid:jB9IGO2TuHbrQngQUhh0PiIudgg284812	rogid:Te5GmNzUBSnfbMfLIGrHi+6u7/A284812	intact-crc:99A7ACECF61C1FA2|rigid:w1yjQ3yWHfRWdkdH1W485nufVMM	false	green fluorescent protein tag:?-?|myc tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41411	uniprotkb:P87060	intact:EBI-1207853|ensemblfungi:"SPBC14C8.07c.1:pep"	intact:EBI-1185389|uniprotkb:Q9P7P3|ensemblfungi:"SPBC1718.01.1:pep"	psi-mi:cdc18_schpo(display_long)|uniprotkb:cdc18(gene name)|psi-mi:cdc18(display_short)|uniprotkb:SPBC14C8.07c(orf name)	psi-mi:pop1_schpo(display_long)|uniprotkb:WD repeat-containing protein ste16(gene name synonym)|uniprotkb:pop1(gene name)|psi-mi:pop1(display_short)|uniprotkb:SPBC1718.01(orf name)|uniprotkb:SPBC2G2.18(orf name)|uniprotkb:ste16(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wolf et al. (1999)	pubmed:10209119|imex:IM-19931	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1207868|imex:IM-19931-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_595910.1|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR016314(Cell division control, Cdc6)|reactome:R-SPO-68689|reactome:R-SPO-68962|reactome:R-SPO-69017|interpro:IPR027417|reactome:R-SPO-176187|ensemblfungi:SPBC14C8.07c(gene)|ensemblfungi:SPBC14C8.07c.1(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0140530"(MCM complex loading)|go:"GO:1902985"(mitotic pre-replicative complex assembly)|go:"GO:1903468"(positive regulation of DNA replication initiation)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR036388|interpro:IPR036390|reactome:R-SPO-68949|interpro:IPR041083|reactome:R-SPO-68827|reactome:R-SPO-68867	refseq:XP_001713146.1|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|ensemblfungi:SPBC1718.01(gene)|ensemblfungi:SPBC1718.01.1(transcript)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR036047|interpro:IPR036322	-	-	-	figure legend:Figure 3D|comment:Interaction between Pop2p and GFP-Cdc18p was detected in lysates from wild-type cells, but was undetectable in lysates from pop1-deleted mutants, suggesting that Pop1p-Pop2p heterooligomers cooperate in substrate binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2007/02/23	2014/10/16	rogid:jB9IGO2TuHbrQngQUhh0PiIudgg284812	rogid:fpsox2UXaKWswVhuSnBBtqkY1/g284812	intact-crc:99A7ACECF61C1FA2|rigid:w1yjQ3yWHfRWdkdH1W485nufVMM	false	green fluorescent protein tag:?-?|myc tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)