#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P31785	uniprotkb:P05112	intact:EBI-80475|ensembl:ENSP00000363318|uniprotkb:Q5FC12	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:il2rg_human(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:p64(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Russell et al. (1993)	pubmed:8266078	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-367058	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0038111"(interleukin-7-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|rcsb pdb:1ILL|rcsb pdb:1ILM|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1ILN|rcsb pdb:1ITE|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3BPL|rcsb pdb:3QAZ|rcsb pdb:3QB7|rcsb pdb:4GS7|rcsb pdb:5M5E|rcsb pdb:6OEL|reactome:R-HSA-1266695|reactome:R-HSA-5673001|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|reactome:R-HSA-6785807|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-912526|refseq:NP_000197.1|dip:DIP-173N	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	-	-	-	comment:This interaction is dependent upon the expression of both IL4R and IL2Rgamma.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/06/11	2014/10/16	rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:6580C1F448F1D3CF|rigid:jx7tRKUYuJbYdV5XdDTG26TiTlc	false	-	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31785	uniprotkb:P24394	intact:EBI-80475|ensembl:ENSP00000363318|uniprotkb:Q5FC12	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	psi-mi:il2rg_human(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:p64(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Russell et al. (1993)	pubmed:8266078	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-367058	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0038111"(interleukin-7-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|rcsb pdb:1ILL|rcsb pdb:1ILM|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1ILN|rcsb pdb:1ITE|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3BPL|rcsb pdb:3QAZ|rcsb pdb:3QB7|rcsb pdb:4GS7|rcsb pdb:5M5E|rcsb pdb:6OEL|reactome:R-HSA-1266695|reactome:R-HSA-5673001|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|reactome:R-HSA-6785807|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-912526|refseq:NP_000197.1|dip:DIP-173N	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	-	-	-	comment:This interaction is dependent upon the expression of both IL4R and IL2Rgamma.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/06/11	2014/10/16	rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	intact-crc:6580C1F448F1D3CF|rigid:jx7tRKUYuJbYdV5XdDTG26TiTlc	false	-	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05112	uniprotkb:P24394	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Russell et al. (1993)	pubmed:8266078	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-367101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	-	-	-	comment:Cos-7 cells were affinity labelled with radio-labelled IL4.|comment:IL4 assumed to be human and expressed in E.coli. This is not absolutely clear in this paper.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/06/11	2014/10/16	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	intact-crc:0A1847C59B13A253|rigid:DtvGhEVCBmLTfHPis5cgG5lD46Q	false	radiolabel:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24394	uniprotkb:P31785	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	intact:EBI-80475|ensembl:ENSP00000363318|uniprotkb:Q5FC12	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:il2rg_human(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:p64(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Russell et al. (1993)	pubmed:8266078	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-367105	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0038111"(interleukin-7-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|rcsb pdb:1ILL|rcsb pdb:1ILM|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1ILN|rcsb pdb:1ITE|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3BPL|rcsb pdb:3QAZ|rcsb pdb:3QB7|rcsb pdb:4GS7|rcsb pdb:5M5E|rcsb pdb:6OEL|reactome:R-HSA-1266695|reactome:R-HSA-5673001|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|reactome:R-HSA-6785807|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-912526|refseq:NP_000197.1|dip:DIP-173N	-	-	-	comment:This interaction requires the expression of both IL4R and IL2Rgamma.Deletion analysis of IL2Rgamma showed that the SH2 domain and the 48 amino acids distal to the SH2 domain are not required for this interaction.|comment:IL4 assumed to be human and expressed in E.coli. This is not absolutely clear in this paper.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/06/11	2014/10/16	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606	intact-crc:EF9F93B641DDAA19|rigid:jx7tRKUYuJbYdV5XdDTG26TiTlc	false	-	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24394	uniprotkb:P05112	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Russell et al. (1993)	pubmed:8266078	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-367105	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	-	-	-	comment:This interaction requires the expression of both IL4R and IL2Rgamma.Deletion analysis of IL2Rgamma showed that the SH2 domain and the 48 amino acids distal to the SH2 domain are not required for this interaction.|comment:IL4 assumed to be human and expressed in E.coli. This is not absolutely clear in this paper.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/06/11	2014/10/16	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:EF9F93B641DDAA19|rigid:jx7tRKUYuJbYdV5XdDTG26TiTlc	false	-	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24394	uniprotkb:P31785	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	intact:EBI-80475|ensembl:ENSP00000363318|uniprotkb:Q5FC12	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:il2rg_human(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:p64(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Russell et al. (1993)	pubmed:8266078	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-367142	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0038111"(interleukin-7-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|rcsb pdb:1ILL|rcsb pdb:1ILM|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1ILN|rcsb pdb:1ITE|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3BPL|rcsb pdb:3QAZ|rcsb pdb:3QB7|rcsb pdb:4GS7|rcsb pdb:5M5E|rcsb pdb:6OEL|reactome:R-HSA-1266695|reactome:R-HSA-5673001|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|reactome:R-HSA-6785807|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-912526|refseq:NP_000197.1|dip:DIP-173N	-	-	-	comment:endogenous protein expression for il4r and IL2Rgamma in these cells.|disease:"Humans with mutated IL2Rgamma show severe combined immunodeficiency(XSCID)Cells from XSCID patients with truncated IL2Rgamma do not show cell-surface expression of this protein."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/06/11	2014/10/16	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606	intact-crc:F0465C68D9D7F8F8|rigid:jx7tRKUYuJbYdV5XdDTG26TiTlc	false	-	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24394	uniprotkb:P05112	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Russell et al. (1993)	pubmed:8266078	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-367142	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	-	-	-	comment:endogenous protein expression for il4r and IL2Rgamma in these cells.|disease:"Humans with mutated IL2Rgamma show severe combined immunodeficiency(XSCID)Cells from XSCID patients with truncated IL2Rgamma do not show cell-surface expression of this protein."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/06/11	2014/10/16	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:F0465C68D9D7F8F8|rigid:jx7tRKUYuJbYdV5XdDTG26TiTlc	false	-	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)