#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q811P8 uniprotkb:P47870 intact:EBI-6949116|ensembl:ENSMUSP00000133898|intact:MINT-268399|uniprotkb:B9EHJ8|uniprotkb:Q6A010 intact:EBI-6949072|ensembl:ENSP00000274547|ensembl:ENSP00000377531|intact:MINT-268409|uniprotkb:A8K1A0|uniprotkb:D1LYT1|uniprotkb:Q4FZB2|uniprotkb:Q16323|uniprotkb:D1LYT0|uniprotkb:A8K115 psi-mi:rhg32_mouse(display_long)|uniprotkb:RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling(gene name synonym)|uniprotkb:Rics(gene name synonym)|uniprotkb:p200RhoGAP(gene name synonym)|uniprotkb:p250GAP(gene name synonym)|uniprotkb:Arhgap32(gene name)|psi-mi:Arhgap32(display_short)|uniprotkb:Brain-specific Rho GTPase-activating protein(gene name synonym)|uniprotkb:GAB-associated Cdc42/Rac GTPase-activating protein(gene name synonym)|uniprotkb:GC-GAP(gene name synonym)|uniprotkb:Grit(gene name synonym)|uniprotkb:Kiaa0712(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 32(gene name synonym)|uniprotkb:Rho/Cdc42/Rac GTPase-activating protein RICS(gene name synonym) psi-mi:gbrb2_human(display_long)|uniprotkb:GABRB2(gene name)|psi-mi:GABRB2(display_short)|uniprotkb:"GABA(A) receptor subunit beta-2"(gene name synonym) psi-mi:"MI:0018"(two hybrid) Zhao et al. (2003) pubmed:12819203|mint:MINT-5216483 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6949158|mint:MINT-18010 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000041444(gene)|ensembl:ENSMUST00000174641(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001650"(fibrillar center)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005938"(cell cortex)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0043197"(dendritic spine)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036028|interpro:IPR036871|interpro:IPR042139|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-9035034|refseq:NP_796353.3|refseq:NP_001182561.1|mint:MINT-735860(identity) ensembl:ENSG00000145864(gene)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060384"(innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0090102"(cochlea development)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR002289(Gamma-aminobutyric-acid A receptor, beta subunit)|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|ensembl:ENST00000274547(transcript)|ensembl:ENST00000393959(transcript)|go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005237"(inhibitory extracellular ligand-gated ion channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|rcsb pdb:6D6T|rcsb pdb:6D6U|rcsb pdb:6X3S|rcsb pdb:6X3T|rcsb pdb:6X3U|rcsb pdb:6X3V|rcsb pdb:6X3W|rcsb pdb:6X3X|rcsb pdb:6X3Z|rcsb pdb:6X40|reactome:R-HSA-1236394|reactome:R-HSA-977443|refseq:NP_068711.1|refseq:NP_000804.1|mint:MINT-735852(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel|comment:"Stoichiometry: 1.0" figure legend:F1A|comment:- 160.80.34.218|comment:homomint|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2003/07/07 2014/10/16 rogid:4ZVZeciVms1xmC18riIhaDt9wMY10090 rogid:E5RyMQHTXlCmzSgIHjnYK4Zlivc9606 intact-crc:EBCFEBC14CDE8626|rigid:gazRjSQaX2bW7z71VfG6V8UCXMU false tag:?-?(MINT-735861) tag:?-?(MINT-735855)|binding-associated region:?-?(MINT-735853) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q811P8 uniprotkb:P47870 intact:EBI-6949116|ensembl:ENSMUSP00000133898|intact:MINT-268399|uniprotkb:B9EHJ8|uniprotkb:Q6A010 intact:EBI-6949072|ensembl:ENSP00000274547|ensembl:ENSP00000377531|intact:MINT-268409|uniprotkb:A8K1A0|uniprotkb:D1LYT1|uniprotkb:Q4FZB2|uniprotkb:Q16323|uniprotkb:D1LYT0|uniprotkb:A8K115 psi-mi:rhg32_mouse(display_long)|uniprotkb:RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling(gene name synonym)|uniprotkb:Rics(gene name synonym)|uniprotkb:p200RhoGAP(gene name synonym)|uniprotkb:p250GAP(gene name synonym)|uniprotkb:Arhgap32(gene name)|psi-mi:Arhgap32(display_short)|uniprotkb:Brain-specific Rho GTPase-activating protein(gene name synonym)|uniprotkb:GAB-associated Cdc42/Rac GTPase-activating protein(gene name synonym)|uniprotkb:GC-GAP(gene name synonym)|uniprotkb:Grit(gene name synonym)|uniprotkb:Kiaa0712(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 32(gene name synonym)|uniprotkb:Rho/Cdc42/Rac GTPase-activating protein RICS(gene name synonym) psi-mi:gbrb2_human(display_long)|uniprotkb:GABRB2(gene name)|psi-mi:GABRB2(display_short)|uniprotkb:"GABA(A) receptor subunit beta-2"(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Zhao et al. (2003) pubmed:12819203|mint:MINT-5216483 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6949285|mint:MINT-18011 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000041444(gene)|ensembl:ENSMUST00000174641(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001650"(fibrillar center)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005938"(cell cortex)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0043197"(dendritic spine)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036028|interpro:IPR036871|interpro:IPR042139|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-9035034|refseq:NP_796353.3|refseq:NP_001182561.1|mint:MINT-735872(identity) ensembl:ENSG00000145864(gene)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060384"(innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0090102"(cochlea development)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR002289(Gamma-aminobutyric-acid A receptor, beta subunit)|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|ensembl:ENST00000274547(transcript)|ensembl:ENST00000393959(transcript)|go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005237"(inhibitory extracellular ligand-gated ion channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|rcsb pdb:6D6T|rcsb pdb:6D6U|rcsb pdb:6X3S|rcsb pdb:6X3T|rcsb pdb:6X3U|rcsb pdb:6X3V|rcsb pdb:6X3W|rcsb pdb:6X3X|rcsb pdb:6X3Z|rcsb pdb:6X40|reactome:R-HSA-1236394|reactome:R-HSA-977443|refseq:NP_068711.1|refseq:NP_000804.1|mint:MINT-735878(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel|comment:"Stoichiometry: 1.0" comment:- 160.80.34.218|comment:homomint|comment:mint taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2003/07/07 2014/10/16 rogid:4ZVZeciVms1xmC18riIhaDt9wMY10090 rogid:E5RyMQHTXlCmzSgIHjnYK4Zlivc9606 intact-crc:DD5EECF93AF0F4F2|rigid:gazRjSQaX2bW7z71VfG6V8UCXMU false tag:?-?(MINT-735873) tag:?-?(MINT-735879) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:A7KAX9 uniprotkb:Q13480 intact:EBI-308663|uniprotkb:Q86YL6|intact:EBI-1210177|uniprotkb:O94820|uniprotkb:Q8IUG4|uniprotkb:Q9BWG3|ensembl:ENSP00000310561|uniprotkb:I7H0B0 intact:EBI-517684|uniprotkb:Q4W5G2|uniprotkb:Q6P1W2|uniprotkb:A8K152|ensembl:ENSP00000262994 psi-mi:rhg32_human(display_long)|uniprotkb:ARHGAP32(gene name)|psi-mi:ARHGAP32(display_short)|uniprotkb:GRIT(gene name synonym)|uniprotkb:KIAA0712(gene name synonym)|uniprotkb:RICS(gene name synonym)|uniprotkb:Brain-specific Rho GTPase-activating protein(gene name synonym)|uniprotkb:GAB-associated Cdc42/Rac GTPase-activating protein(gene name synonym)|uniprotkb:GC-GAP(gene name synonym)|uniprotkb:GTPase regulator interacting with TrkA(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 32(gene name synonym)|uniprotkb:Rho/Cdc42/Rac GTPase-activating protein RICS(gene name synonym)|uniprotkb:RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling(gene name synonym)|uniprotkb:p200RhoGAP(gene name synonym)|uniprotkb:p250GAP(gene name synonym) psi-mi:gab1_human(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 1(gene name synonym)|uniprotkb:GRB2-associated binder 1(gene name synonym)|uniprotkb:GAB1(gene name)|psi-mi:GAB1(display_short) psi-mi:"MI:0019"(coimmunoprecipitation) Zhao et al. (2003) pubmed:12819203|mint:MINT-5216483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6949495|mint:MINT-18900 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005938"(cell cortex)|ensembl:ENSP00000310561|ensembl:ENST00000392657|ensembl:ENSP00000376425|ensembl:ENST00000527272|ensembl:ENSP00000432862|ensembl:ENSG00000134909(gene)|ensembl:ENST00000310343(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001650"(fibrillar center)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036028|interpro:IPR036871|interpro:IPR042139|mint:A7KAX9|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034|rcsb pdb:3IUG|refseq:NP_001136157.1|refseq:NP_055530.2|go:"GO:0007264"(small GTPase mediated signal transduction)|mint:MINT-735889(identity) ensembl:ENSP00000262994|ensembl:ENST00000262995|ensembl:ENSP00000262995|refseq:NP_002030.2|refseq:NP_997006.1|ensembl:ENSG00000109458(gene)|ensembl:ENST00000262994(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0090668"(endothelial cell chemotaxis to vascular endothelial growth factor)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q13480|rcsb pdb:4QSY|reactome:R-HSA-109704|reactome:R-HSA-1236382|reactome:R-HSA-1257604|reactome:R-HSA-180292|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8865999|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-9664565|reactome:R-HSA-9665348|mint:MINT-735895(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4|comment:homomint|comment:mint taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2003/07/07 2014/10/16 rogid:V51KfHcAYYMGvIsWaG5hNqZ49Yk9606 rogid:AIK39gZJknpy3vQK/GraIpBbgzU9606 intact-crc:CA63227CF5225747|rigid:09/SdJh2SKhfwDiNcdbC/1uSUNw false tag:?-?(MINT-735890) tag:?-?(MINT-735896) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)