format-version: 1.2
subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation"
subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation"
subsetdef: goslim_agr "AGR slim"
subsetdef: goslim_aspergillus "Aspergillus GO slim"
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_chembl "ChEMBL protein targets summary"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_metagenomics "Metagenomics GO slim"
subsetdef: goslim_mouse "Mouse GO slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_pombe "Fission yeast GO slim"
subsetdef: goslim_synapse "synapse GO slim"
subsetdef: goslim_yeast "Yeast GO slim"
synonymtypedef: syngo_official_label "label approved by the SynGO project"
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
ontology: go/subsets/goslim_synapse

[Term]
id: GO:0001504
name: neurotransmitter uptake
namespace: biological_process
def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
subset: goslim_synapse
synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "neurotransmitter import into glial cell" NARROW []
synonym: "neurotransmitter import into neuron" NARROW []
synonym: "neurotransmitter recycling" BROAD []
xref: Reactome:REACT_106095 "Neurotransmitter uptake and Metabolism In Glial Cells, Gallus gallus"
xref: Reactome:REACT_106673 "Neurotransmitter uptake and Metabolism In Glial Cells, Bos taurus"
xref: Reactome:REACT_107830 "Neurotransmitter uptake and Metabolism In Glial Cells, Arabidopsis thaliana"
xref: Reactome:REACT_114027 "Neurotransmitter uptake and Metabolism In Glial Cells, Staphylococcus aureus N315"
xref: Reactome:REACT_13594 "Neurotransmitter uptake and Metabolism In Glial Cells, Homo sapiens"
xref: Reactome:REACT_29399 "Neurotransmitter uptake and Metabolism In Glial Cells, Drosophila melanogaster"
xref: Reactome:REACT_30311 "Neurotransmitter uptake and Metabolism In Glial Cells, Rattus norvegicus"
xref: Reactome:REACT_82534 "Neurotransmitter uptake and Metabolism In Glial Cells, Caenorhabditis elegans"
xref: Reactome:REACT_88126 "Neurotransmitter uptake and Metabolism In Glial Cells, Escherichia coli"
xref: Reactome:REACT_89424 "Neurotransmitter uptake and Metabolism In Glial Cells, Sus scrofa"
xref: Reactome:REACT_92363 "Neurotransmitter uptake and Metabolism In Glial Cells, Canis familiaris"
xref: Reactome:REACT_93291 "Neurotransmitter uptake and Metabolism In Glial Cells, Taeniopygia guttata"
xref: Reactome:REACT_94616 "Neurotransmitter uptake and Metabolism In Glial Cells, Schizosaccharomyces pombe"
xref: Reactome:REACT_97761 "Neurotransmitter uptake and Metabolism In Glial Cells, Saccharomyces cerevisiae"
xref: Reactome:REACT_98224 "Neurotransmitter uptake and Metabolism In Glial Cells, Oryza sativa"
xref: Reactome:REACT_98482 "Neurotransmitter uptake and Metabolism In Glial Cells, Xenopus tropicalis"
xref: Reactome:REACT_98978 "Neurotransmitter uptake and Metabolism In Glial Cells, Danio rerio"
xref: Reactome:REACT_99735 "Neurotransmitter uptake and Metabolism In Glial Cells, Mus musculus"

[Term]
id: GO:0007268
name: chemical synaptic transmission
namespace: biological_process
def: "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]
subset: goslim_synapse
synonym: "neurotransmission" RELATED [GOC:dph]
synonym: "signal transmission across a synapse" BROAD []
synonym: "synaptic transmission" BROAD []
xref: Reactome:REACT_102443 "Transmission across Chemical Synapses, Mycobacterium tuberculosis"
xref: Reactome:REACT_102748 "Neuronal System, Saccharomyces cerevisiae"
xref: Reactome:REACT_102963 "Transmission across Chemical Synapses, Canis familiaris"
xref: Reactome:REACT_104470 "Transmission across Chemical Synapses, Rattus norvegicus"
xref: Reactome:REACT_104894 "Neuronal System, Xenopus tropicalis"
xref: Reactome:REACT_105301 "Transmission across Chemical Synapses, Caenorhabditis elegans"
xref: Reactome:REACT_106168 "Transmission across Chemical Synapses, Escherichia coli"
xref: Reactome:REACT_106459 "Transmission across Chemical Synapses, Mus musculus"
xref: Reactome:REACT_107151 "Neuronal System, Sus scrofa"
xref: Reactome:REACT_107221 "Transmission across Chemical Synapses, Schizosaccharomyces pombe"
xref: Reactome:REACT_112265 "Transmission across Chemical Synapses, Staphylococcus aureus N315"
xref: Reactome:REACT_113444 "Neuronal System, Staphylococcus aureus N315"
xref: Reactome:REACT_13477 "Transmission across Chemical Synapses, Homo sapiens"
xref: Reactome:REACT_13685 "Neuronal System, Homo sapiens"
xref: Reactome:REACT_29254 "Neuronal System, Danio rerio"
xref: Reactome:REACT_29595 "Neuronal System, Caenorhabditis elegans"
xref: Reactome:REACT_29683 "Transmission across Chemical Synapses, Drosophila melanogaster"
xref: Reactome:REACT_30050 "Transmission across Chemical Synapses, Gallus gallus"
xref: Reactome:REACT_30266 "Transmission across Chemical Synapses, Sus scrofa"
xref: Reactome:REACT_31284 "Transmission across Chemical Synapses, Saccharomyces cerevisiae"
xref: Reactome:REACT_33322 "Neuronal System, Taeniopygia guttata"
xref: Reactome:REACT_33434 "Neuronal System, Escherichia coli"
xref: Reactome:REACT_78038 "Neuronal System, Rattus norvegicus"
xref: Reactome:REACT_78840 "Transmission across Chemical Synapses, Taeniopygia guttata"
xref: Reactome:REACT_79078 "Transmission across Chemical Synapses, Arabidopsis thaliana"
xref: Reactome:REACT_80052 "Neuronal System, Schizosaccharomyces pombe"
xref: Reactome:REACT_82334 "Transmission across Chemical Synapses, Bos taurus"
xref: Reactome:REACT_82746 "Neuronal System, Arabidopsis thaliana"
xref: Reactome:REACT_86563 "Neuronal System, Mus musculus"
xref: Reactome:REACT_86628 "Neuronal System, Canis familiaris"
xref: Reactome:REACT_88599 "Neuronal System, Bos taurus"
xref: Reactome:REACT_88891 "Neuronal System, Mycobacterium tuberculosis"
xref: Reactome:REACT_89065 "Neuronal System, Gallus gallus"
xref: Reactome:REACT_89149 "Neuronal System, Dictyostelium discoideum"
xref: Reactome:REACT_89785 "Neuronal System, Drosophila melanogaster"
xref: Reactome:REACT_90781 "Transmission across Chemical Synapses, Danio rerio"
xref: Reactome:REACT_93592 "Transmission across Chemical Synapses, Xenopus tropicalis"
xref: Reactome:REACT_98546 "Transmission across Chemical Synapses, Dictyostelium discoideum"
xref: Reactome:REACT_99535 "Transmission across Chemical Synapses, Oryza sativa"
xref: Reactome:REACT_99952 "Neuronal System, Oryza sativa"
xref: Wikipedia:Neurotransmission
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0007269
name: neurotransmitter secretion
namespace: biological_process
alt_id: GO:0010554
def: "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." [CHEBI:25512, GOC:dph]
comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
subset: goslim_synapse
synonym: "neurotransmitter release" EXACT []
synonym: "neurotransmitter secretory pathway" EXACT []
xref: Reactome:REACT_100716 "Neurotransmitter Release Cycle, Bos taurus"
xref: Reactome:REACT_102134 "Neurotransmitter Release Cycle, Arabidopsis thaliana"
xref: Reactome:REACT_102586 "Neurotransmitter Release Cycle, Xenopus tropicalis"
xref: Reactome:REACT_102743 "Neurotransmitter Release Cycle, Rattus norvegicus"
xref: Reactome:REACT_105010 "Neurotransmitter Release Cycle, Oryza sativa"
xref: Reactome:REACT_105885 "Neurotransmitter Release Cycle, Taeniopygia guttata"
xref: Reactome:REACT_110862 "Neurotransmitter Release Cycle, Sus scrofa"
xref: Reactome:REACT_11184 "Botulinum neurotoxicity, Homo sapiens"
xref: Reactome:REACT_113329 "Neurotransmitter Release Cycle, Staphylococcus aureus N315"
xref: Reactome:REACT_115061 "Neurotransmitter Release Cycle, Dictyostelium discoideum"
xref: Reactome:REACT_13723 "Neurotransmitter Release Cycle, Homo sapiens"
xref: Reactome:REACT_29477 "Neurotransmitter Release Cycle, Danio rerio"
xref: Reactome:REACT_29495 "Neurotransmitter Release Cycle, Drosophila melanogaster"
xref: Reactome:REACT_29928 "Neurotransmitter Release Cycle, Mus musculus"
xref: Reactome:REACT_77375 "Neurotransmitter Release Cycle, Mycobacterium tuberculosis"
xref: Reactome:REACT_85993 "Neurotransmitter Release Cycle, Canis familiaris"
xref: Reactome:REACT_91316 "Neurotransmitter Release Cycle, Caenorhabditis elegans"
xref: Reactome:REACT_95406 "Neurotransmitter Release Cycle, Gallus gallus"
xref: Reactome:REACT_99398 "Neurotransmitter Release Cycle, Escherichia coli"
is_a: GO:0099643 ! signal release from synapse
relationship: occurs_in GO:0098793 ! presynapse
relationship: part_of GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0007416
name: synapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a synapse.  This process ends when the synapse is mature (functional)." [GOC:mah]
subset: goslim_synapse
synonym: "synapse biogenesis" EXACT [GOC:mah]
synonym: "synaptogenesis" EXACT [GOC:mah]
xref: Wikipedia:Synaptogenesis
is_a: GO:0050808 ! synapse organization

[Term]
id: GO:0008021
name: synaptic vesicle
namespace: cellular_component
def: "A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]
comment: This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles.
subset: goslim_synapse
synonym: "docked vesicle" NARROW [NIF_Subcellular:sao403156667]
xref: NIF_Subcellular:sao1071221672
xref: Wikipedia:Synaptic_vesicle
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0008039
name: synaptic target recognition
namespace: biological_process
def: "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
subset: goslim_synapse
synonym: "neuronal targeting" EXACT []

[Term]
id: GO:0008088
name: axo-dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axon cargo transport" NARROW []
synonym: "axonal transport" NARROW []
synonym: "axoplasmic transport" NARROW []
xref: Wikipedia:Axoplasmic_transport

[Term]
id: GO:0008089
name: anterograde axonal transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "anterograde axon cargo transport" EXACT []
is_a: GO:0098930 ! axonal transport

[Term]
id: GO:0008090
name: retrograde axonal transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "retrograde axon cargo transport" EXACT []
is_a: GO:0098930 ! axonal transport

[Term]
id: GO:0010807
name: regulation of synaptic vesicle priming
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511]
subset: goslim_synapse
is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis
relationship: regulates GO:0016082 ! synaptic vesicle priming

[Term]
id: GO:0014069
name: postsynaptic density
namespace: cellular_component
alt_id: GO:0097481
alt_id: GO:0097483
def: "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
subset: goslim_synapse
synonym: "neuronal postsynaptic density" EXACT [GO:0097481]
synonym: "post synaptic density" EXACT []
synonym: "post-synaptic density" EXACT []
synonym: "postsynaptic density of dendrite" NARROW []
xref: NIF_Subcellular:sao1196688972
xref: Wikipedia:Postsynaptic_density
is_a: GO:0099572 ! postsynaptic specialization
created_by: paola
creation_date: 2013-07-02T09:44:28Z

[Term]
id: GO:0016079
name: synaptic vesicle exocytosis
namespace: biological_process
def: "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
subset: goslim_synapse
is_a: GO:0048489 ! synaptic vesicle transport
is_a: GO:0099643 ! signal release from synapse
relationship: part_of GO:0007269 ! neurotransmitter secretion
relationship: part_of GO:0099504 ! synaptic vesicle cycle

[Term]
id: GO:0016081
name: synaptic vesicle docking
namespace: biological_process
def: "The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component.  Synaptic vesicle tethering is the first step in this process." [PMID:15217342]
comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission (dos, pvn, fk synapse project 2015).
subset: goslim_synapse
synonym: "synaptic vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb]
synonym: "synaptic vesicle docking involved in exocytosis" EXACT []
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0016082
name: synaptic vesicle priming
namespace: biological_process
def: "A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane." [GOC:mah, PMID:15217342, PMID:23060190]
comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission.  (dos, pvn, fk synapse project 2015)
subset: goslim_synapse
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0016182
name: synaptic vesicle budding from endosome
namespace: biological_process
def: "Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes." [GOC:curators, PMID:10099709, PMID:24596248]
subset: goslim_synapse
synonym: "endosome to synaptic vesicle budding" RELATED [GOC:mah]
synonym: "synaptic vesicle budding involved in synaptic vesicle exocytosis" EXACT [GOC:mah]
is_a: GO:0099003 ! vesicle-mediated transport in synapse
relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome
relationship: part_of GO:0048489 ! synaptic vesicle transport
relationship: part_of GO:0099532 ! synaptic vesicle endosomal processing

[Term]
id: GO:0016183
name: synaptic vesicle coating
namespace: biological_process
def: "The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles." [GOC:curators, PMID:10099709, PMID:20448150]
subset: goslim_synapse
relationship: part_of GO:0016185 ! synaptic vesicle budding from presynaptic endocytic zone membrane

[Term]
id: GO:0016185
name: synaptic vesicle budding from presynaptic endocytic zone membrane
namespace: biological_process
def: "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:curators, PMID:10099709, PMID:20448150]
subset: goslim_synapse
synonym: "synaptic vesicle budding from pre-synaptic membrane" EXACT []
synonym: "synaptic vesicle budding involved in synaptic vesicle endocytosis" EXACT [GOC:mah]
relationship: part_of GO:0048488 ! synaptic vesicle endocytosis
relationship: part_of GO:0048489 ! synaptic vesicle transport

[Term]
id: GO:0016189
name: synaptic vesicle to endosome fusion
namespace: biological_process
def: "Fusion of a synaptic vesicle with an endosome." [GOC:curators, PMID:10099709]
comment: This covers fusion of synaptic vesicles trafficked to the synapse as well as fusion of endocytosed vesicles as part of recycling.  It is there for not  part of the synaptic vesicle cycle.
subset: goslim_synapse
relationship: part_of GO:0099532 ! synaptic vesicle endosomal processing

[Term]
id: GO:0016191
name: synaptic vesicle uncoating
namespace: biological_process
def: "The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane." [GOC:curators, PMID:10099709, PMID:24596248]
subset: goslim_synapse
synonym: "synaptic vesicle coat depolymerization" EXACT []
synonym: "synaptic vesicle coat protein depolymerization" EXACT []
relationship: part_of GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:0019896
name: axonal transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai]
subset: goslim_synapse
synonym: "axon transport of mitochondria" EXACT []
is_a: GO:0098930 ! axonal transport

[Term]
id: GO:0030285
name: integral component of synaptic vesicle membrane
namespace: cellular_component
def: "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
subset: goslim_synapse
synonym: "integral to synaptic vesicle membrane" NARROW []
is_a: GO:0098563 ! intrinsic component of synaptic vesicle membrane

[Term]
id: GO:0030672
name: synaptic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]
subset: goslim_synapse
relationship: part_of GO:0008021 ! synaptic vesicle

[Term]
id: GO:0031629
name: synaptic vesicle fusion to presynaptic active zone membrane
namespace: biological_process
def: "Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [ISBN:0071120009]
subset: goslim_synapse
synonym: "synaptic vesicle fusion" BROAD []
synonym: "synaptic vesicle fusion to pre-synaptic membrane" EXACT []
synonym: "synaptic vesicle fusion to presynaptic membrane" EXACT []
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0031630
name: regulation of synaptic vesicle fusion to presynaptic active zone membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah]
subset: goslim_synapse
synonym: "regulation of synaptic vesicle fusion to pre-synaptic membrane" EXACT []
synonym: "regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis
relationship: regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane

[Term]
id: GO:0034592
name: synaptic vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the synaptic vesicle membrane." [GOC:rph]
subset: goslim_synapse
relationship: part_of GO:0008021 ! synaptic vesicle

[Term]
id: GO:0036466
name: synaptic vesicle recycling via endosome
namespace: biological_process
alt_id: GO:0099090
def: "Synaptic vesicle recycling where vesicles endocytose via clathrin-coated pits, re-acidify, and refill with neurotransmitters after passing through an endosomal intermediate." [GOC:bf, GOC:dos, GOC:pad, GOC:PARL, PMID:15217342]
subset: goslim_synapse
synonym: "recycling endosome localization within postsynapse" EXACT []
relationship: occurs_in GO:0098794 ! postsynapse
relationship: part_of GO:0099504 ! synaptic vesicle cycle
created_by: rebeccafoulger
creation_date: 2014-06-26T11:07:46Z

[Term]
id: GO:0042135
name: neurotransmitter catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl]
subset: goslim_synapse
synonym: "neurotransmitter breakdown" EXACT []
synonym: "neurotransmitter catabolism" EXACT []
synonym: "neurotransmitter degradation" EXACT []

[Term]
id: GO:0042136
name: neurotransmitter biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl]
subset: goslim_synapse
synonym: "neurotransmitter anabolism" EXACT []
synonym: "neurotransmitter biosynthesis" EXACT []
synonym: "neurotransmitter biosynthesis and storage" BROAD []
synonym: "neurotransmitter biosynthetic process and storage" BROAD []
synonym: "neurotransmitter formation" EXACT []
synonym: "neurotransmitter synthesis" EXACT []
xref: Reactome:REACT_101731 "Neurotransmitter Clearance In The Synaptic Cleft, Sus scrofa"
xref: Reactome:REACT_107523 "Neurotransmitter Clearance In The Synaptic Cleft, Schizosaccharomyces pombe"
xref: Reactome:REACT_108610 "Neurotransmitter Clearance In The Synaptic Cleft, Mycobacterium tuberculosis"
xref: Reactome:REACT_108742 "Neurotransmitter Clearance In The Synaptic Cleft, Caenorhabditis elegans"
xref: Reactome:REACT_110245 "Neurotransmitter Clearance In The Synaptic Cleft, Xenopus tropicalis"
xref: Reactome:REACT_112396 "Neurotransmitter Clearance In The Synaptic Cleft, Escherichia coli"
xref: Reactome:REACT_115066 "Neurotransmitter Clearance In The Synaptic Cleft, Dictyostelium discoideum"
xref: Reactome:REACT_13583 "Neurotransmitter Clearance In The Synaptic Cleft, Homo sapiens"
xref: Reactome:REACT_28513 "Neurotransmitter Clearance In The Synaptic Cleft, Taeniopygia guttata"
xref: Reactome:REACT_77139 "Neurotransmitter Clearance In The Synaptic Cleft, Rattus norvegicus"
xref: Reactome:REACT_81660 "Neurotransmitter Clearance In The Synaptic Cleft, Arabidopsis thaliana"
xref: Reactome:REACT_82622 "Neurotransmitter Clearance In The Synaptic Cleft, Bos taurus"
xref: Reactome:REACT_83009 "Neurotransmitter Clearance In The Synaptic Cleft, Gallus gallus"
xref: Reactome:REACT_89303 "Neurotransmitter Clearance In The Synaptic Cleft, Oryza sativa"
xref: Reactome:REACT_93349 "Neurotransmitter Clearance In The Synaptic Cleft, Danio rerio"
xref: Reactome:REACT_99114 "Neurotransmitter Clearance In The Synaptic Cleft, Drosophila melanogaster"
xref: Reactome:REACT_99596 "Neurotransmitter Clearance In The Synaptic Cleft, Mus musculus"
xref: Reactome:REACT_99804 "Neurotransmitter Clearance In The Synaptic Cleft, Canis familiaris"

[Term]
id: GO:0042734
name: presynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]
subset: goslim_synapse
synonym: "pre-synaptic membrane" EXACT []
synonym: "presynaptic plasma membrane" EXACT []
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0043083
name: synaptic cleft
namespace: cellular_component
def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, http://synapses.mcg.edu/anatomy/chemical/synapse.stm]
subset: goslim_synapse
xref: NIF_Subcellular:sao243541954
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0043197
name: dendritic spine
namespace: cellular_component
def: "A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse.  They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \"thin\", \"stubby\", \"mushroom\", and \"branched\", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]
subset: goslim_synapse
synonym: "branched dendritic spine" NARROW [NIF_Subcellular:sao-965204139]
synonym: "dendrite spine" EXACT []
synonym: "mushroom dendritic spine" NARROW [NIF_Subcellular:sao-876577163]
synonym: "sessile dendritic spine" NARROW [NIF_Subcellular:sao1536532595]
synonym: "stubby dendritic spine" NARROW [NIF_Subcellular:sao317384566]
synonym: "thin dendritic spine" NARROW [NIF_Subcellular:sao1232858786]
xref: NIF_Subcellular:sao1799103720
xref: Wikipedia:Dendritic_spine
is_a: GO:0098794 ! postsynapse

[Term]
id: GO:0045202
name: synapse
namespace: cellular_component
def: "The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
subset: goslim_agr
subset: goslim_mouse
subset: goslim_pir
subset: goslim_synapse
synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124]
synonym: "mixed synapse" NARROW [NIF_Subcellular:sao1506103497]
synonym: "synaptic junction" EXACT []
xref: NIF_Subcellular:sao914572699
xref: Wikipedia:Chemical_synapse

[Term]
id: GO:0045211
name: postsynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
subset: goslim_synapse
synonym: "post-synaptic membrane" EXACT []
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0048488
name: synaptic vesicle endocytosis
namespace: biological_process
alt_id: GO:0008099
def: "A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]
comment: Changed parent as requested in https://github.com/geneontology/synapse/issues/230
subset: goslim_synapse
synonym: "synaptic vesicle retrieval" RELATED []
is_a: GO:0140238 ! presynaptic endocytosis
relationship: part_of GO:0099504 ! synaptic vesicle cycle

[Term]
id: GO:0048489
name: synaptic vesicle transport
namespace: biological_process
alt_id: GO:0016181
def: "The directed movement of synaptic vesicles." [GOC:jid, GOC:lmg, GOC:pr]
subset: goslim_synapse
synonym: "synaptic vesicle fission" RELATED []
synonym: "synaptic vesicle fusion" RELATED []
synonym: "synaptic vesicle trafficking" RELATED [PMID:15217342]
is_a: GO:0099003 ! vesicle-mediated transport in synapse

[Term]
id: GO:0048490
name: anterograde synaptic vesicle transport
namespace: biological_process
def: "The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse." [GOC:jid, GOC:lmg]
subset: goslim_synapse
synonym: "anterograde axonal transport of synaptic vesicle" EXACT []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0099517 ! synaptic vesicle transport along microtubule

[Term]
id: GO:0048491
name: retrograde synaptic vesicle transport
namespace: biological_process
def: "The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body." [GOC:jid, GOC:lmg, PMID:24762653]
subset: goslim_synapse
synonym: "retrograde axonal transport of synaptic vesicle" EXACT []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0099517 ! synaptic vesicle transport along microtubule

[Term]
id: GO:0048786
name: presynaptic active zone
namespace: cellular_component
def: "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
subset: goslim_synapse
synonym: "pre-synaptic active zone" EXACT []
synonym: "pre-synaptic active zone component" NARROW [NIF_Subcellular:sao1911631652]
synonym: "presynaptic specialization" EXACT []
xref: NIF_Subcellular:sao792027222
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0048787
name: presynaptic active zone membrane
namespace: cellular_component
def: "The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters." [PMID:12812759, PMID:12923177, PMID:3152289]
subset: goslim_synapse
synonym: "active zone plasma membrane" EXACT [NIF_Subcellular:sao2038461087]
synonym: "active zone pre-synaptic plasma membrane" EXACT []
synonym: "active zone presynaptic plasma membrane" EXACT []
synonym: "pre-synaptic active zone membrane" EXACT []
xref: NIF_Subcellular:sao2038461087
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0042734 ! presynaptic membrane
relationship: part_of GO:0048786 ! presynaptic active zone

[Term]
id: GO:0048790
name: maintenance of presynaptic active zone structure
namespace: biological_process
def: "A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]
subset: goslim_synapse
synonym: "maintenance of pre-synaptic active zone structure" EXACT []
is_a: GO:0099558 ! maintenance of synapse structure
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0050804
name: modulation of chemical synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.  Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai]
subset: goslim_synapse
synonym: "modulation of synaptic transmission" BROAD []
synonym: "regulation of chemical synaptic transmission" EXACT []
synonym: "regulation of synaptic transmission" EXACT []
relationship: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0050807
name: regulation of synapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_synapse
synonym: "regulation of synapse organisation" EXACT [GOC:mah]
synonym: "regulation of synapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of synapse structure" EXACT []
relationship: regulates GO:0050808 ! synapse organization

[Term]
id: GO:0050808
name: synapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
subset: goslim_synapse
synonym: "synapse development" RELATED [GOC:aruk]
synonym: "synapse morphogenesis" RELATED [GOC:BHF]
synonym: "synapse organisation" EXACT [GOC:curators]
synonym: "synapse organization and biogenesis" RELATED [GOC:mah]

[Term]
id: GO:0051580
name: regulation of neurotransmitter uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai]
subset: goslim_synapse
synonym: "regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of neurotransmitter reuptake" EXACT []
relationship: regulates GO:0001504 ! neurotransmitter uptake

[Term]
id: GO:0051963
name: regulation of synapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
subset: goslim_synapse
synonym: "regulation of synapse biogenesis" EXACT []
synonym: "regulation of synaptogenesis" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0060074
name: synapse maturation
namespace: biological_process
def: "The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development." [GOC:dph, GOC:ef]
subset: goslim_synapse
synonym: "synaptic maturation" EXACT []
is_a: GO:0050808 ! synapse organization

[Term]
id: GO:0060078
name: regulation of postsynaptic membrane potential
namespace: biological_process
def: "Any process that modulates the potential difference across a post-synaptic membrane." [GOC:dph, GOC:ef]
subset: goslim_synapse
synonym: "regulation of post-synaptic membrane potential" EXACT []

[Term]
id: GO:0090128
name: regulation of synapse maturation
namespace: biological_process
def: "Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb]
subset: goslim_synapse
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0060074 ! synapse maturation
created_by: tanyaberardini
creation_date: 2009-12-07T03:00:58Z

[Term]
id: GO:0097060
name: synaptic membrane
namespace: cellular_component
def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104]
subset: goslim_synapse
relationship: part_of GO:0045202 ! synapse
created_by: paola
creation_date: 2011-06-07T11:22:09Z

[Term]
id: GO:0097091
name: synaptic vesicle clustering
namespace: biological_process
def: "The process that results in grouping synaptic vesicles in presynaptic structures." [GOC:ans, GOC:pr, PMID:19900895, PMID:7568108]
comment: Updated definition as requested by SynGO group, see https://github.com/geneontology/synapse/issues/163.
subset: goslim_synapse
relationship: part_of GO:0099504 ! synaptic vesicle cycle
created_by: paola
creation_date: 2011-07-04T01:48:24Z

[Term]
id: GO:0097104
name: postsynaptic membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:BHF, GOC:sjp, PMID:21424692]
subset: goslim_synapse
synonym: "post-synaptic membrane assembly" EXACT []
relationship: part_of GO:0007416 ! synapse assembly
relationship: part_of GO:0099173 ! postsynapse organization
created_by: paola
creation_date: 2011-07-27T01:26:49Z

[Term]
id: GO:0097105
name: presynaptic membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a  specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction." [GOC:BHF, GOC:pr, GOC:sjp, PMID:15797875, PMID:18550748]
comment: Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron.
subset: goslim_synapse
synonym: "pre-synaptic membrane assembly" EXACT []
relationship: part_of GO:0099054 ! presynapse assembly
created_by: paola
creation_date: 2011-07-27T01:30:45Z

[Term]
id: GO:0097107
name: postsynaptic density assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273]
subset: goslim_synapse
synonym: "post synaptic density assembly" EXACT []
synonym: "post-synaptic density assembly" EXACT []
synonym: "PSD assembly" EXACT []
is_a: GO:0098698 ! postsynaptic specialization assembly
created_by: paola
creation_date: 2011-07-27T05:21:39Z

[Term]
id: GO:0097401
name: synaptic vesicle lumen acidification
namespace: biological_process
def: "The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading." [GOC:dsf, PMID:21172605, PMID:22875945]
subset: goslim_synapse
synonym: "synaptic vesicle lumen pH reduction" EXACT []
synonym: "synaptic vesicle proton loading" EXACT syngo_official_label []
relationship: part_of GO:0099504 ! synaptic vesicle cycle
created_by: paola
creation_date: 2012-10-25T09:03:34Z

[Term]
id: GO:0097444
name: spine apparatus
namespace: cellular_component
def: "A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material.  The endomembrane component is continuous with the smooth endoplasmic reticulum." [NIF_Subcellular:sao725931194, PMID:20400711, PMID:8987748]
subset: goslim_synapse
synonym: "dense material" NARROW [NIF_Subcellular:sao1004601938]
xref: NIF_Subcellular:sao725931194
relationship: part_of GO:0043197 ! dendritic spine
created_by: paola
creation_date: 2012-12-06T14:05:58Z

[Term]
id: GO:0097471
name: mossy fiber rosette
namespace: cellular_component
def: "A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes." [http://en.wikipedia.org/wiki/Mossy_fiber_(cerebellum), NIF_Subcellular:nlx_subcell_091021]
subset: goslim_synapse
synonym: "cerebellar mossy fiber to granule cell synapse" EXACT syngo_official_label []
xref: NIF_Subcellular:nlx_subcell_091021
is_a: GO:0045202 ! synapse
relationship: has_part GO:0014069 ! postsynaptic density
created_by: paola
creation_date: 2013-02-21T07:42:52Z

[Term]
id: GO:0098563
name: intrinsic component of synaptic vesicle membrane
namespace: cellular_component
def: "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0030672 ! synaptic vesicle membrane

[Term]
id: GO:0098674
name: extrinsic component of neuronal dense core vesicle membrane
namespace: cellular_component
def: "The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0099012 ! neuronal dense core vesicle membrane
created_by: dos
creation_date: 2017-01-17T16:20:56Z

[Term]
id: GO:0098675
name: intrinsic component of neuronal dense core vesicle membrane
namespace: cellular_component
def: "The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to neuronal dense core granule membrane" EXACT []
relationship: part_of GO:0099012 ! neuronal dense core vesicle membrane
created_by: dos
creation_date: 2017-01-17T16:22:44Z

[Term]
id: GO:0098683
name: cochlear hair cell ribbon synapse
namespace: cellular_component
def: "A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density." [PMID:15626493]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
created_by: dos
creation_date: 2017-02-05T16:16:49Z

[Term]
id: GO:0098684
name: photoreceptor ribbon synapse
namespace: cellular_component
def: "A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell.  These contain a plate-like synaptic ribbon." [PMID:15626493]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
created_by: dos
creation_date: 2017-02-05T16:26:27Z

[Term]
id: GO:0098685
name: Schaffer collateral - CA1 synapse
namespace: cellular_component
def: "A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell." [PMID:16399689]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
created_by: dos
creation_date: 2017-02-05T16:29:43Z

[Term]
id: GO:0098686
name: hippocampal mossy fiber to CA3 synapse
namespace: cellular_component
def: "One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell." [DOI:10.1002/1096-9861, PMID:13869693, PMID:23264762]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
relationship: has_part GO:0043197 ! dendritic spine
relationship: has_part GO:0098793 ! presynapse
created_by: dos
creation_date: 2017-02-05T16:29:58Z

[Term]
id: GO:0098688
name: parallel fiber to Purkinje cell synapse
namespace: cellular_component
def: "An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells." [PMID:16623829, PMID:3209740]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
created_by: dos
creation_date: 2017-02-21T18:32:05Z

[Term]
id: GO:0098690
name: glycinergic synapse
namespace: cellular_component
def: "A synapse that uses glycine as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
created_by: dos
creation_date: 2017-03-07T14:50:33Z

[Term]
id: GO:0098691
name: dopaminergic synapse
namespace: cellular_component
def: "A synapse that uses dopamine as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
created_by: dos
creation_date: 2017-03-07T14:51:52Z

[Term]
id: GO:0098693
name: regulation of synaptic vesicle cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle." [GOC:dos]
subset: goslim_synapse
relationship: regulates GO:0099504 ! synaptic vesicle cycle
created_by: dos
creation_date: 2017-03-21T16:06:48Z

[Term]
id: GO:0098694
name: regulation of synaptic vesicle budding from presynaptic endocytic zone membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:1900242 ! regulation of synaptic vesicle endocytosis
relationship: regulates GO:0016185 ! synaptic vesicle budding from presynaptic endocytic zone membrane
created_by: dos
creation_date: 2017-04-04T17:03:29Z

[Term]
id: GO:0098695
name: inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
namespace: molecular_function
def: "Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GOC:dos]
subset: goslim_synapse
synonym: "IP3 receptor activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT []
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2017-04-04T17:07:09Z

[Term]
id: GO:0098696
name: regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane." [GOC:dos]
subset: goslim_synapse
relationship: regulates GO:0099645 ! neurotransmitter receptor localization to postsynaptic specialization membrane
created_by: dos
creation_date: 2017-04-04T16:33:38Z

[Term]
id: GO:0098697
name: ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels
namespace: molecular_function
def: "Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2017-04-04T17:11:38Z

[Term]
id: GO:0098698
name: postsynaptic specialization assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099084 ! postsynaptic specialization organization
relationship: part_of GO:0007416 ! synapse assembly
created_by: dos
creation_date: 2017-04-04T17:22:01Z

[Term]
id: GO:0098699
name: structural constituent of presynaptic actin cytoskeleton
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099181 ! structural constituent of presynapse
relationship: part_of GO:0099140 ! presynaptic actin cytoskeleton organization
created_by: dos
creation_date: 2017-06-09T18:33:07Z

[Term]
id: GO:0098700
name: neurotransmitter loading into synaptic vesicle
namespace: biological_process
def: "The active transport of neurotransmitters into a synaptic vesicle.  This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps." [GOC:bf, GOC:pad, GOC:PARL, PMID:10099709, PMID:15217342]
subset: goslim_synapse
synonym: "neurotransmitter import into synaptic vesicle" EXACT []
synonym: "neurotransmitter uptake into synaptic vesicle" EXACT [PMID:15217342]
synonym: "synaptic vesicle neurotransmitter loading" EXACT syngo_official_label []
relationship: part_of GO:0099504 ! synaptic vesicle cycle

[Term]
id: GO:0098793
name: presynapse
namespace: cellular_component
def: "The part of a synapse that is part of the presynaptic cell." [GOC:dos]
subset: goslim_synapse
synonym: "presynaptic terminal" EXACT []
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0098794
name: postsynapse
namespace: cellular_component
def: "The part of a synapse that is part of the post-synaptic cell." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0098810
name: neurotransmitter reuptake
namespace: biological_process
def: "The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0001504 ! neurotransmitter uptake
relationship: occurs_in GO:0098793 ! presynapse

[Term]
id: GO:0098814
name: spontaneous synaptic transmission
namespace: biological_process
def: "The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential." [PMID:20200227]
comment: This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs).
subset: goslim_synapse
synonym: "basal synaptic transmission" EXACT [PMID:16899074]
is_a: GO:0007268 ! chemical synaptic transmission
relationship: has_part GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0098820
name: trans-synaptic protein complex
namespace: cellular_component
def: "A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes." [PMID:20200227]
subset: goslim_synapse

[Term]
id: GO:0098830
name: presynaptic endosome
namespace: cellular_component
def: "An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone.  This organelle is believed to be involved in regeneration of synaptic vesicles." [PMID:20200227, PMID:25939282]
comment: As of 2015, there is still controversy over the nature of presynaptic endosomes and their relationship to regular endosomes.  See Jahne et al., 2015 (PMID:25939282) for details.
subset: goslim_synapse
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0098831
name: presynaptic active zone cytoplasmic component
namespace: cellular_component
def: "A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles." [GOC:dos]
subset: goslim_synapse
synonym: "cortex of presynaptic active zone" EXACT []
synonym: "presynaptic zone cortex" EXACT []
relationship: part_of GO:0048786 ! presynaptic active zone

[Term]
id: GO:0098833
name: presynaptic endocytic zone
namespace: cellular_component
def: "A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis.  It is especially enriched in endocytic proteins following intense activity." [PMID:17455288]
comment: May be identical to periactive zone?
subset: goslim_synapse
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0098834
name: presynaptic endocytic zone cytoplasmic component
namespace: cellular_component
def: "The cytoplasmic component of the presynaptic endocytic zone." [GOC:dos]
subset: goslim_synapse
synonym: "cortex of presynaptic endocytic zone" EXACT []
relationship: part_of GO:0098833 ! presynaptic endocytic zone

[Term]
id: GO:0098835
name: presynaptic endocytic zone membrane
namespace: cellular_component
def: "The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0042734 ! presynaptic membrane
relationship: part_of GO:0098833 ! presynaptic endocytic zone

[Term]
id: GO:0098837
name: postsynaptic recycling endosome
namespace: cellular_component
def: "A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane.  In some cases at least, this recycling is activated by postsynaptic signalling and so can play a role in long term potentiation." [PMID:20820847]
subset: goslim_synapse
synonym: "postsynaptic endosomal recycling compartment" BROAD [PMID:20820847]
synonym: "postsynaptic recycling outpost" EXACT [PMID:20820847]
is_a: GO:0098845 ! postsynaptic endosome

[Term]
id: GO:0098839
name: postsynaptic density membrane
namespace: cellular_component
def: "The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099634 ! postsynaptic specialization membrane
relationship: part_of GO:0014069 ! postsynaptic density

[Term]
id: GO:0098842
name: postsynaptic early endosome
namespace: cellular_component
def: "An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling." [PMID:19603039, PMID:20820847, PMID:24727350]
comment: Commonly used markers for postsynaptic early endosomes include RAB5A and EEA1.
subset: goslim_synapse
is_a: GO:0098845 ! postsynaptic endosome

[Term]
id: GO:0098843
name: postsynaptic endocytic zone
namespace: cellular_component
def: "A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins." [PMID:17880892]
subset: goslim_synapse
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0098844
name: postsynaptic endocytic zone membrane
namespace: cellular_component
def: "The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone.  This region of membrane is associated with stable clathrin puncta." [PMID:17880892]
subset: goslim_synapse
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0098843 ! postsynaptic endocytic zone

[Term]
id: GO:0098845
name: postsynaptic endosome
namespace: cellular_component
def: "An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse." [PMID:20820847]
subset: goslim_synapse
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0098850
name: extrinsic component of synaptic vesicle membrane
namespace: cellular_component
def: "The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0030672 ! synaptic vesicle membrane

[Term]
id: GO:0098871
name: postsynaptic actin cytoskeleton
namespace: cellular_component
def: "The actin cytoskeleton that is part of a postsynapse" [GOC:dos]
subset: goslim_synapse
is_a: GO:0099571 ! postsynaptic cytoskeleton

[Term]
id: GO:0098872
name: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT []
synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
is_a: GO:0099583 ! neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

[Term]
id: GO:0098877
name: neurotransmitter receptor transport to plasma membrane
namespace: biological_process
def: "The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099637 ! neurotransmitter receptor transport

[Term]
id: GO:0098879
name: structural constituent of postsynaptic specialization
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a postsynaptic specialization." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099186 ! structural constituent of postsynapse
relationship: part_of GO:0098880 ! maintenance of postsynaptic specialization structure

[Term]
id: GO:0098880
name: maintenance of postsynaptic specialization structure
namespace: biological_process
def: "A process which maintains the organization and the arrangement of proteins in the presynaptic specialization." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099084 ! postsynaptic specialization organization
is_a: GO:0099558 ! maintenance of synapse structure

[Term]
id: GO:0098881
name: exocytic insertion of neurotransmitter receptor to plasma membrane
namespace: biological_process
def: "The exocytic fusion of neurotransmitter receptor containing vesicles with a plasma-membrane resulting in the integration of NT receptors with the plasma-membrane. This process includes tethering and docking steps that prepare vesicles for fusion." [PMID:19503082]
subset: goslim_synapse
synonym: "neurotransmitter receptor insertion" EXACT []
relationship: part_of GO:0098877 ! neurotransmitter receptor transport to plasma membrane

[Term]
id: GO:0098882
name: structural constituent of presynaptic active zone
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a presynaptic active zone." [GOC:dos]
subset: goslim_synapse
synonym: "structural constituent of active zone" EXACT syngo_official_label []
is_a: GO:0099181 ! structural constituent of presynapse
relationship: part_of GO:0048790 ! maintenance of presynaptic active zone structure
relationship: part_of GO:0099181 ! structural constituent of presynapse

[Term]
id: GO:0098883
name: synapse pruning
namespace: biological_process
def: "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared." [GOC:dos, PMID:12062020, PMID:18083105, PMID:22632716, PMID:29844190]
subset: goslim_synapse
synonym: "synapse clearance" EXACT [GOC:aruk, GOC:bc, PMID:22632716]
synonym: "synapse disassembly" EXACT syngo_official_label [PMID:12062020]
synonym: "synapse elimination" EXACT [GOC:aruk, GOC:bc, PMID:18083105, PMID:29844190]
synonym: "synapse removal" EXACT [GOC:aruk, GOC:bc, PMID:22632716]
is_a: GO:0050808 ! synapse organization

[Term]
id: GO:0098884
name: postsynaptic neurotransmitter receptor internalization
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle." [GOC:dos]
comment: Added parent as requested in https://github.com/geneontology/synapse/issues/230.
subset: goslim_synapse
synonym: "postsynaptic neurotransmitter receptor endocytosis" EXACT syngo_official_label []
is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels
is_a: GO:0140239 ! postsynaptic endocytosis

[Term]
id: GO:0098885
name: modification of postsynaptic actin cytoskeleton
namespace: biological_process
def: "Any process that modifies the structure of a postsynaptic actin cytoskeleton." [GOC:dos]
comment: This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones.
subset: goslim_synapse
synonym: "postsynaptic actin cytoskeleton remodelling" EXACT []
is_a: GO:0099010 ! modification of postsynaptic structure

[Term]
id: GO:0098887
name: neurotransmitter receptor transport, endosome to postsynaptic membrane
namespace: biological_process
def: "The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles." [GOC:dos]
subset: goslim_synapse
synonym: "postsynaptic neurotransmitter receptor endosomal trafficking" BROAD []
is_a: GO:0098969 ! neurotransmitter receptor transport to postsynaptic membrane
is_a: GO:0099639 ! neurotransmitter receptor transport, endosome to plasma membrane

[Term]
id: GO:0098888
name: extrinsic component of presynaptic membrane
namespace: cellular_component
def: "The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
synonym: "extrinsic component of presynaptic plasma membrane" EXACT []
is_a: GO:0099243 ! extrinsic component of synaptic membrane
relationship: part_of GO:0042734 ! presynaptic membrane

[Term]
id: GO:0098889
name: intrinsic component of presynaptic membrane
namespace: cellular_component
def: "The component of the presynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to presynaptic membrane" NARROW []
is_a: GO:0099240 ! intrinsic component of synaptic membrane
relationship: part_of GO:0042734 ! presynaptic membrane

[Term]
id: GO:0098890
name: extrinsic component of postsynaptic membrane
namespace: cellular_component
def: "The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0099243 ! extrinsic component of synaptic membrane
relationship: part_of GO:0045211 ! postsynaptic membrane

[Term]
id: GO:0098891
name: extrinsic component of presynaptic active zone membrane
namespace: cellular_component
def: "The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098888 ! extrinsic component of presynaptic membrane
relationship: part_of GO:0048787 ! presynaptic active zone membrane

[Term]
id: GO:0098892
name: extrinsic component of postsynaptic specialization membrane
namespace: cellular_component
def: "The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098890 ! extrinsic component of postsynaptic membrane
relationship: part_of GO:0099634 ! postsynaptic specialization membrane

[Term]
id: GO:0098893
name: extrinsic component of postsynaptic endocytic zone
namespace: cellular_component
def: "The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098890 ! extrinsic component of postsynaptic membrane
relationship: part_of GO:0098844 ! postsynaptic endocytic zone membrane

[Term]
id: GO:0098894
name: extrinsic component of presynaptic endocytic zone membrane
namespace: cellular_component
def: "The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098888 ! extrinsic component of presynaptic membrane
relationship: part_of GO:0098835 ! presynaptic endocytic zone membrane

[Term]
id: GO:0098895
name: postsynaptic endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a postsynaptic endosome." [GOC:pz]
subset: goslim_synapse
relationship: part_of GO:0098845 ! postsynaptic endosome

[Term]
id: GO:0098896
name: postsynaptic early endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a postsynaptic early endosome." [GOC:pz]
subset: goslim_synapse
is_a: GO:0098895 ! postsynaptic endosome membrane
relationship: part_of GO:0098842 ! postsynaptic early endosome

[Term]
id: GO:0098897
name: spine apparatus membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the spine apparatus." [GOC:mah]
subset: goslim_synapse
relationship: part_of GO:0097444 ! spine apparatus

[Term]
id: GO:0098899
name: spine apparatus lumen
namespace: cellular_component
def: "The volume enclosed by the spine apparatus membrane." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0097444 ! spine apparatus

[Term]
id: GO:0098918
name: structural constituent of synapse
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a synapse." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0098919
name: structural constituent of postsynaptic density
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a postsynaptic density." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098879 ! structural constituent of postsynaptic specialization
relationship: part_of GO:0099562 ! maintenance of postsynaptic density structure

[Term]
id: GO:0098920
name: retrograde trans-synaptic signaling by lipid
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099541 ! trans-synaptic signaling by lipid

[Term]
id: GO:0098921
name: retrograde trans-synaptic signaling by endocannabinoid
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an  endocannabinoid ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098920 ! retrograde trans-synaptic signaling by lipid
is_a: GO:0099542 ! trans-synaptic signaling by endocannabinoid

[Term]
id: GO:0098923
name: retrograde trans-synaptic signaling by soluble gas
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099543 ! trans-synaptic signaling by soluble gas

[Term]
id: GO:0098924
name: retrograde trans-synaptic signaling by nitric oxide
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098923 ! retrograde trans-synaptic signaling by soluble gas
is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide

[Term]
id: GO:0098925
name: retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
namespace: biological_process
def: "Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0098924 ! retrograde trans-synaptic signaling by nitric oxide
is_a: GO:0099555 ! trans-synaptic signaling by nitric oxide, modulating synaptic transmission

[Term]
id: GO:0098926
name: postsynaptic signal transduction
namespace: biological_process
def: "Signal transduction in which the initial step occurs in a postsynapse." [GOC:dos]
comment: Do not directly annotate. This term is intended for automatically grouping annotations to signal transduction classes extended with has_start_location/occurs_in postsynapse or one of its parts.
subset: gocheck_do_not_manually_annotate
subset: goslim_synapse
synonym: "postsynaptic signaling pathway" EXACT syngo_official_label []
relationship: part_of GO:0099536 ! synaptic signaling

[Term]
id: GO:0098928
name: presynaptic signal transduction
namespace: biological_process
def: "Signal transduction in which the initial step occurs in a presynapse." [GOC:dos]
comment: Do not directly annotate. This term intended for grouping.  Annotate to either a subclass or to some other subclass of signal transduction  extended with has_start_location/occurs_in presynapse or one of its parts.  Such extensions will result in automatic annotation to this term.
subset: gocheck_do_not_manually_annotate
subset: goslim_synapse
synonym: "presynaptic signaling pathway" EXACT syngo_official_label []

[Term]
id: GO:0098929
name: extrinsic component of spine apparatus membrane
namespace: cellular_component
def: "The component of the spine apparatus membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0098897 ! spine apparatus membrane

[Term]
id: GO:0098930
name: axonal transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axon cargo transport" EXACT []
synonym: "axoplasmic transport" EXACT []
xref: Wikipedia:Axoplasmic_transport
is_a: GO:0008088 ! axo-dendritic transport

[Term]
id: GO:0098934
name: retrograde dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098935 ! dendritic transport

[Term]
id: GO:0098935
name: dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in dendrites." [ISBN:0815316194]
subset: goslim_synapse
synonym: "dendrite cargo transport" EXACT []
is_a: GO:0008088 ! axo-dendritic transport

[Term]
id: GO:0098936
name: intrinsic component of postsynaptic membrane
namespace: cellular_component
def: "The component of the postsynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to postsynaptic membrane" NARROW []
is_a: GO:0099240 ! intrinsic component of synaptic membrane
relationship: part_of GO:0045211 ! postsynaptic membrane

[Term]
id: GO:0098937
name: anterograde dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites." [ISBN:0815316194]
subset: goslim_synapse
is_a: GO:0098935 ! dendritic transport

[Term]
id: GO:0098938
name: actin cytoskeleton of dendritic spine
namespace: cellular_component
def: "The actin cytoskeleton that is part of a dendritic spine." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098871 ! postsynaptic actin cytoskeleton
relationship: part_of GO:0043197 ! dendritic spine

[Term]
id: GO:0098939
name: dendritic transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in nerve cell dendrites." [GOC:ai]
subset: goslim_synapse
is_a: GO:0098935 ! dendritic transport

[Term]
id: GO:0098940
name: anterograde trans-synaptic signaling by nitric oxide
namespace: biological_process
def: "Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide

[Term]
id: GO:0098941
name: anterograde trans-synaptic signaling by trans-synaptic protein complex
namespace: biological_process
def: "Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex

[Term]
id: GO:0098942
name: retrograde trans-synaptic signaling by trans-synaptic protein complex
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex

[Term]
id: GO:0098943
name: neurotransmitter receptor transport, postsynaptic endosome to lysosome
namespace: biological_process
def: "The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation." [GOC:dos]
subset: goslim_synapse
synonym: "postsynaptic neurotransmitter receptor endosomal trafficking" BROAD []
is_a: GO:0099637 ! neurotransmitter receptor transport

[Term]
id: GO:0098944
name: postsynaptic recycling endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a postsynaptic recycling endosome." [GOC:pz]
subset: goslim_synapse
is_a: GO:0098895 ! postsynaptic endosome membrane
relationship: part_of GO:0098837 ! postsynaptic recycling endosome

[Term]
id: GO:0098945
name: intrinsic component of presynaptic active zone membrane
namespace: cellular_component
def: "The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to presynaptic acive zone membrane" NARROW []
is_a: GO:0098889 ! intrinsic component of presynaptic membrane
relationship: part_of GO:0048787 ! presynaptic active zone membrane

[Term]
id: GO:0098946
name: intrinsic component of presynaptic endocytic zone membrane
namespace: cellular_component
def: "The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to presynaptic acive zone membrane" NARROW []
is_a: GO:0098889 ! intrinsic component of presynaptic membrane
relationship: part_of GO:0098835 ! presynaptic endocytic zone membrane

[Term]
id: GO:0098947
name: intrinsic component of postsynaptic endocytic zone membrane
namespace: cellular_component
def: "The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to postsynaptic acive zone membrane" NARROW []
is_a: GO:0098936 ! intrinsic component of postsynaptic membrane
relationship: part_of GO:0098844 ! postsynaptic endocytic zone membrane

[Term]
id: GO:0098948
name: intrinsic component of postsynaptic specialization membrane
namespace: cellular_component
def: "The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to postsynaptic specialization membrane" NARROW []
is_a: GO:0098936 ! intrinsic component of postsynaptic membrane
relationship: part_of GO:0099634 ! postsynaptic specialization membrane

[Term]
id: GO:0098949
name: intrinsic component of postsynaptic endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to postsynaptic endosome membrane" NARROW []
relationship: part_of GO:0098895 ! postsynaptic endosome membrane

[Term]
id: GO:0098950
name: intrinsic component of postsynaptic early endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to postsynaptic early endosome membrane" NARROW []
is_a: GO:0098949 ! intrinsic component of postsynaptic endosome membrane
relationship: part_of GO:0098896 ! postsynaptic early endosome membrane

[Term]
id: GO:0098951
name: intrinsic component of postsynaptic recycling endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to postsynaptic recycling endosome membrane" EXACT []
is_a: GO:0098949 ! intrinsic component of postsynaptic endosome membrane
relationship: part_of GO:0098944 ! postsynaptic recycling endosome membrane

[Term]
id: GO:0098952
name: intrinsic component of spine apparatus membrane
namespace: cellular_component
def: "The component of the spine apparatus membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to spine apparatus membrane" EXACT []
relationship: part_of GO:0098897 ! spine apparatus membrane

[Term]
id: GO:0098954
name: presynaptic endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a presynaptic endosome." [GOC:pz]
subset: goslim_synapse
relationship: part_of GO:0098830 ! presynaptic endosome

[Term]
id: GO:0098955
name: intrinsic component of presynaptic endosome membrane
namespace: cellular_component
def: "The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to presynaptic endosome membrane" EXACT []
relationship: part_of GO:0098954 ! presynaptic endosome membrane

[Term]
id: GO:0098957
name: anterograde axonal transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [GOC:dos]
subset: goslim_synapse
synonym: "anterograde axon transport of mitochondria" EXACT []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0019896 ! axonal transport of mitochondrion

[Term]
id: GO:0098958
name: retrograde axonal transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse." [GOC:dos]
subset: goslim_synapse
synonym: "retrograde axon transport of mitochondria" EXACT []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0019896 ! axonal transport of mitochondrion

[Term]
id: GO:0098959
name: retrograde dendritic transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "retrograde dendrite transport of mitochondria" EXACT []
is_a: GO:0098939 ! dendritic transport of mitochondrion

[Term]
id: GO:0098961
name: dendritic transport of ribonucleoprotein complex
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites." [GOC:dos]
subset: goslim_synapse
synonym: "dendritic transport of RNP complex" EXACT []
is_a: GO:0098935 ! dendritic transport
is_a: GO:0099640 ! axo-dendritic protein transport

[Term]
id: GO:0098962
name: regulation of postsynaptic neurotransmitter receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0099601 ! regulation of neurotransmitter receptor activity
relationship: regulates GO:0099565 ! chemical synaptic transmission, postsynaptic

[Term]
id: GO:0098963
name: dendritic transport of messenger ribonucleoprotein complex
namespace: biological_process
def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites." [GOC:dos]
subset: goslim_synapse
synonym: "dendritic transport of mRNA RNP complex" EXACT []
is_a: GO:0098961 ! dendritic transport of ribonucleoprotein complex

[Term]
id: GO:0098964
name: anterograde dendritic transport of messenger ribonucleoprotein complex
namespace: biological_process
def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "anterograde dendritic transport of mRNA RNP complex" EXACT []
is_a: GO:0098937 ! anterograde dendritic transport
is_a: GO:0098963 ! dendritic transport of messenger ribonucleoprotein complex

[Term]
id: GO:0098965
name: extracellular matrix of synaptic cleft
namespace: cellular_component
def: "The portion of the extracellular matrix that lies within the synaptic cleft." [GOC:dos]
subset: goslim_synapse
synonym: "ECM of synaptic cleft" EXACT []
synonym: "synaptic cleft ECM" EXACT []
relationship: part_of GO:0043083 ! synaptic cleft
relationship: part_of GO:0099535 ! synapse-associated extracellular matrix

[Term]
id: GO:0098966
name: perisynaptic extracellular matrix
namespace: cellular_component
def: "The portion of the extracellular matrix that lies within the perisynaptic space." [GOC:dos]
subset: goslim_synapse
synonym: "extrasynaptic extracellular matrix" EXACT []
synonym: "perisynaptic ECM" EXACT []
relationship: part_of GO:0099535 ! synapse-associated extracellular matrix
relationship: part_of GO:0099544 ! perisynaptic space

[Term]
id: GO:0098967
name: exocytic insertion of neurotransmitter receptor to postsynaptic membrane
namespace: biological_process
def: "The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception.  This process includes tethering and docking steps that prepare vesicles for fusion." [PMID:19503082]
subset: goslim_synapse
is_a: GO:0098881 ! exocytic insertion of neurotransmitter receptor to plasma membrane
is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels
relationship: part_of GO:0098969 ! neurotransmitter receptor transport to postsynaptic membrane

[Term]
id: GO:0098968
name: neurotransmitter receptor transport postsynaptic membrane to endosome
namespace: biological_process
def: "Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099637 ! neurotransmitter receptor transport

[Term]
id: GO:0098969
name: neurotransmitter receptor transport to postsynaptic membrane
namespace: biological_process
def: "The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098877 ! neurotransmitter receptor transport to plasma membrane
is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels

[Term]
id: GO:0098970
name: postsynaptic neurotransmitter receptor diffusion trapping
namespace: biological_process
def: "The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization." [PMID:18832033]
subset: goslim_synapse
is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels
is_a: GO:0099628 ! neurotransmitter receptor diffusion trapping
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: occurs_in GO:0099634 ! postsynaptic specialization membrane

[Term]
id: GO:0098971
name: anterograde dendritic transport of neurotransmitter receptor complex
namespace: biological_process
def: "The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098937 ! anterograde dendritic transport

[Term]
id: GO:0098972
name: anterograde dendritic transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098937 ! anterograde dendritic transport
is_a: GO:0098939 ! dendritic transport of mitochondrion

[Term]
id: GO:0098973
name: structural constituent of postsynaptic actin cytoskeleton
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099186 ! structural constituent of postsynapse
relationship: part_of GO:0098974 ! postsynaptic actin cytoskeleton organization

[Term]
id: GO:0098974
name: postsynaptic actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099188 ! postsynaptic cytoskeleton organization

[Term]
id: GO:0098978
name: glutamatergic synapse
namespace: cellular_component
def: "A synapse that uses glutamate as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0098981
name: cholinergic synapse
namespace: cellular_component
def: "A synapse that uses acetylcholine as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0098982
name: GABA-ergic synapse
namespace: cellular_component
def: "A synapse that uses GABA as a neurotransmitter.  These synapses are typically inhibitory." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0098987
name: regulation of modification of synapse structure, modulating synaptic transmission
namespace: biological_process
def: "Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:1905244 ! regulation of modification of synaptic structure
intersection_of: GO:1905244 ! regulation of modification of synaptic structure
intersection_of: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0098990
name: AMPA selective glutamate receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:dos, ISBN:9780071120005]
subset: goslim_synapse

[Term]
id: GO:0098991
name: kainate selective glutamate receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:9780071120005]
subset: goslim_synapse

[Term]
id: GO:0098992
name: neuronal dense core vesicle
namespace: cellular_component
def: "A dense core vesicle (granule) that is part of a neuron.  These vesicles typically contain neuropeptides.  They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals." [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176]
subset: goslim_synapse

[Term]
id: GO:0098993
name: anchored component of synaptic vesicle membrane
namespace: cellular_component
def: "The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098563 ! intrinsic component of synaptic vesicle membrane

[Term]
id: GO:0098998
name: extrinsic component of postsynaptic early endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098999 ! extrinsic component of postsynaptic endosome membrane
relationship: part_of GO:0098896 ! postsynaptic early endosome membrane

[Term]
id: GO:0098999
name: extrinsic component of postsynaptic endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
relationship: part_of GO:0098895 ! postsynaptic endosome membrane

[Term]
id: GO:0099003
name: vesicle-mediated transport in synapse
namespace: biological_process
def: "Any vesicle-mediated transport that occurs in a synapse" [GOC:dos]
subset: goslim_synapse
relationship: occurs_in GO:0045202 ! synapse

[Term]
id: GO:0099005
name: extrinsic component of postsynaptic recycling endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098999 ! extrinsic component of postsynaptic endosome membrane
relationship: part_of GO:0098944 ! postsynaptic recycling endosome membrane

[Term]
id: GO:0099007
name: extrinsic component of presynaptic endosome membrane
namespace: cellular_component
def: "The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
relationship: part_of GO:0098954 ! presynaptic endosome membrane

[Term]
id: GO:0099010
name: modification of postsynaptic structure
namespace: biological_process
def: "Any process that modifies the structure of a postsynapse." [GOC:dos]
comment: This class does not cover assembly or disassembly of postsynapses, only the modification/remodelling of existing ones.
subset: goslim_synapse
synonym: "synapse remodelling" BROAD []
is_a: GO:0099563 ! modification of synaptic structure

[Term]
id: GO:0099012
name: neuronal dense core vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a neuronal dense core vesicle." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0098992 ! neuronal dense core vesicle

[Term]
id: GO:0099013
name: neuronal dense core vesicle lumen
namespace: cellular_component
def: "The volume enclosed by a neuronal dense core vesicle membrane." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0098992 ! neuronal dense core vesicle

[Term]
id: GO:0099025
name: anchored component of postsynaptic membrane
namespace: cellular_component
def: "The component of the postsynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098936 ! intrinsic component of postsynaptic membrane
is_a: GO:0099144 ! anchored component of synaptic membrane

[Term]
id: GO:0099026
name: anchored component of presynaptic membrane
namespace: cellular_component
def: "The component of the presynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
synonym: "anchored component of presynaptic plasma membrane" EXACT []
is_a: GO:0098889 ! intrinsic component of presynaptic membrane
is_a: GO:0099144 ! anchored component of synaptic membrane

[Term]
id: GO:0099027
name: anchored component of presynaptic endocytic zone membrane
namespace: cellular_component
def: "The component of the presynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098946 ! intrinsic component of presynaptic endocytic zone membrane
is_a: GO:0099026 ! anchored component of presynaptic membrane

[Term]
id: GO:0099028
name: anchored component of postynaptic endocytic zone membrane
namespace: cellular_component
def: "The component of the postynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098947 ! intrinsic component of postsynaptic endocytic zone membrane
is_a: GO:0099025 ! anchored component of postsynaptic membrane

[Term]
id: GO:0099029
name: anchored component of presynaptic active zone membrane
namespace: cellular_component
def: "The component of the presynaptic active zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098945 ! intrinsic component of presynaptic active zone membrane
is_a: GO:0099026 ! anchored component of presynaptic membrane

[Term]
id: GO:0099030
name: anchored component of postsynaptic specialization membrane
namespace: cellular_component
def: "The component of the postsynaptic specialization membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098948 ! intrinsic component of postsynaptic specialization membrane
is_a: GO:0099025 ! anchored component of postsynaptic membrane

[Term]
id: GO:0099031
name: anchored component of postsynaptic density membrane
namespace: cellular_component
def: "The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099030 ! anchored component of postsynaptic specialization membrane
is_a: GO:0099146 ! intrinsic component of postsynaptic density membrane

[Term]
id: GO:0099032
name: anchored component of postsynaptic early endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic early endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098950 ! intrinsic component of postsynaptic early endosome membrane
is_a: GO:0099034 ! anchored component of postsynaptic endosome membrane

[Term]
id: GO:0099033
name: anchored component of postsynaptic recycling endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic recycling endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098951 ! intrinsic component of postsynaptic recycling endosome membrane
is_a: GO:0099034 ! anchored component of postsynaptic endosome membrane

[Term]
id: GO:0099034
name: anchored component of postsynaptic endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098949 ! intrinsic component of postsynaptic endosome membrane

[Term]
id: GO:0099035
name: anchored component of spine apparatus membrane
namespace: cellular_component
def: "The component of the spine apparatus membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098952 ! intrinsic component of spine apparatus membrane

[Term]
id: GO:0099036
name: anchored component of neuronal dense core vesicle membrane
namespace: cellular_component
def: "The component of the neuronal dense core vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098675 ! intrinsic component of neuronal dense core vesicle membrane

[Term]
id: GO:0099037
name: anchored component of presynaptic endosome membrane
namespace: cellular_component
def: "The component of the presynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098955 ! intrinsic component of presynaptic endosome membrane

[Term]
id: GO:0099054
name: presynapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a presynapse." [GOC:bf, GOC:dos, GOC:PARL, PMID:24449494]
subset: goslim_synapse
synonym: "presynapse biogenesis" EXACT [GOC:mah]
synonym: "presynaptic terminal assembly" EXACT [PMID:24449494]
is_a: GO:0099172 ! presynapse organization
relationship: part_of GO:0007416 ! synapse assembly

[Term]
id: GO:0099055
name: integral component of postsynaptic membrane
namespace: cellular_component
def: "The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098936 ! intrinsic component of postsynaptic membrane
is_a: GO:0099699 ! integral component of synaptic membrane

[Term]
id: GO:0099056
name: integral component of presynaptic membrane
namespace: cellular_component
def: "The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
synonym: "integral component of presynaptic plasma membrane" EXACT []
is_a: GO:0098889 ! intrinsic component of presynaptic membrane
is_a: GO:0099699 ! integral component of synaptic membrane

[Term]
id: GO:0099057
name: integral component of presynaptic endocytic zone membrane
namespace: cellular_component
def: "The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098946 ! intrinsic component of presynaptic endocytic zone membrane
is_a: GO:0099056 ! integral component of presynaptic membrane

[Term]
id: GO:0099058
name: integral component of postsynaptic endocytic zone membrane
namespace: cellular_component
def: "The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098947 ! intrinsic component of postsynaptic endocytic zone membrane
is_a: GO:0099055 ! integral component of postsynaptic membrane

[Term]
id: GO:0099059
name: integral component of presynaptic active zone membrane
namespace: cellular_component
def: "The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098945 ! intrinsic component of presynaptic active zone membrane
is_a: GO:0099056 ! integral component of presynaptic membrane

[Term]
id: GO:0099060
name: integral component of postsynaptic specialization membrane
namespace: cellular_component
def: "The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098948 ! intrinsic component of postsynaptic specialization membrane
is_a: GO:0099055 ! integral component of postsynaptic membrane

[Term]
id: GO:0099061
name: integral component of postsynaptic density membrane
namespace: cellular_component
def: "The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099060 ! integral component of postsynaptic specialization membrane
is_a: GO:0099146 ! intrinsic component of postsynaptic density membrane

[Term]
id: GO:0099062
name: integral component of postsynaptic early endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098950 ! intrinsic component of postsynaptic early endosome membrane
is_a: GO:0099064 ! integral component of postsynaptic endosome membrane

[Term]
id: GO:0099063
name: integral component of postsynaptic recycling endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098951 ! intrinsic component of postsynaptic recycling endosome membrane
is_a: GO:0099064 ! integral component of postsynaptic endosome membrane

[Term]
id: GO:0099064
name: integral component of postsynaptic endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098949 ! intrinsic component of postsynaptic endosome membrane

[Term]
id: GO:0099065
name: integral component of spine apparatus membrane
namespace: cellular_component
def: "The component of the spine apparatus membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098952 ! intrinsic component of spine apparatus membrane

[Term]
id: GO:0099066
name: integral component of neuronal dense core vesicle membrane
namespace: cellular_component
def: "The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098675 ! intrinsic component of neuronal dense core vesicle membrane

[Term]
id: GO:0099067
name: integral component of presynaptic endosome membrane
namespace: cellular_component
def: "The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098955 ! intrinsic component of presynaptic endosome membrane

[Term]
id: GO:0099072
name: regulation of postsynaptic membrane neurotransmitter receptor levels
namespace: biological_process
def: "Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse

[Term]
id: GO:0099082
name: retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629]
subset: goslim_synapse
is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide

[Term]
id: GO:0099083
name: retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission
namespace: biological_process
def: "Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide
is_a: GO:0099551 ! trans-synaptic signaling by neuropeptide, modulating synaptic transmission

[Term]
id: GO:0099084
name: postsynaptic specialization organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane." [GOC:BHF, GOC:sjp, PMID:21525273, PMID:26834556]
subset: goslim_synapse
synonym: "post synaptic specialization organization" EXACT []
synonym: "post-synaptic specialization organization" EXACT []
synonym: "postsynaptic specialization organisation" EXACT []
relationship: part_of GO:0099173 ! postsynapse organization
created_by: paola
creation_date: 2011-07-27T05:17:12Z

[Term]
id: GO:0099087
name: anterograde axonal transport of messenger ribonucleoprotein complex
namespace: biological_process
def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse." [GOC:dos, PMID:26586091]
subset: goslim_synapse
synonym: "anterograde axonal transport of mRNA RNP complex" EXACT []
is_a: GO:0099088 ! axonal transport of messenger ribonucleoprotein complex
is_a: GO:0099641 ! anterograde axonal protein transport

[Term]
id: GO:0099088
name: axonal transport of messenger ribonucleoprotein complex
namespace: biological_process
def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in axons." [GOC:dos, PMID:26586091]
subset: goslim_synapse
synonym: "axonal transport of mRNA RNP complex" EXACT []
is_a: GO:0098930 ! axonal transport
is_a: GO:0099640 ! axo-dendritic protein transport

[Term]
id: GO:0099089
name: establishment of endoplasmic reticulum localization to postsynapse
namespace: biological_process
def: "The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine." [GOC:dos, PMID:21151132]
subset: goslim_synapse
synonym: "establishment of ER localization to postsynapse" EXACT [GOC:dos]

[Term]
id: GO:0099091
name: postsynaptic specialization, intracellular component
namespace: cellular_component
def: "A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0099572 ! postsynaptic specialization

[Term]
id: GO:0099092
name: postsynaptic density, intracellular component
namespace: cellular_component
def: "A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099091 ! postsynaptic specialization, intracellular component
relationship: part_of GO:0014069 ! postsynaptic density

[Term]
id: GO:0099102
name: G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential." [GOC:dos, PMID:9429760]
subset: goslim_synapse
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0099108
name: potassium channel activator activity involved in G protein-coupled receptor signaling pathway
namespace: molecular_function
def: "Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling." [PMID:9429760]
comment: Examples include G-protein beta-gamma complexes that bind to and activate potassium channels.
subset: goslim_synapse
synonym: "potassium channel activator activity involved in G-protein coupled receptor signaling pathway" EXACT []

[Term]
id: GO:0099113
name: negative regulation of presynaptic cytosolic calcium concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099140
name: presynaptic actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0099172 ! presynapse organization
created_by: dos
creation_date: 2017-06-09T18:34:19Z

[Term]
id: GO:0099143
name: presynaptic actin cytoskeleton
namespace: cellular_component
def: "The actin cytoskeleton that is part of a presynapse" [GOC:dos]
subset: goslim_synapse
is_a: GO:0099569 ! presynaptic cytoskeleton
created_by: dos
creation_date: 2017-06-09T18:36:19Z

[Term]
id: GO:0099144
name: anchored component of synaptic membrane
namespace: cellular_component
def: "The component of the synaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099240 ! intrinsic component of synaptic membrane
created_by: dos
creation_date: 2017-05-25T17:25:19Z

[Term]
id: GO:0099145
name: regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse
relationship: regulates GO:0098967 ! exocytic insertion of neurotransmitter receptor to postsynaptic membrane
created_by: dos
creation_date: 2017-06-09T18:49:26Z

[Term]
id: GO:0099146
name: intrinsic component of postsynaptic density membrane
namespace: cellular_component
def: "The component of the postsynaptic density membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to postsynaptic specialization membrane" NARROW []
is_a: GO:0098948 ! intrinsic component of postsynaptic specialization membrane
relationship: part_of GO:0098839 ! postsynaptic density membrane
created_by: dos
creation_date: 2017-07-05T10:43:24Z

[Term]
id: GO:0099147
name: extrinsic component of postsynaptic density membrane
namespace: cellular_component
def: "The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098892 ! extrinsic component of postsynaptic specialization membrane
relationship: part_of GO:0098839 ! postsynaptic density membrane
created_by: dos
creation_date: 2017-07-05T10:44:43Z

[Term]
id: GO:0099148
name: regulation of synaptic vesicle docking
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle docking." [GOC:dos]
subset: goslim_synapse
is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis
relationship: regulates GO:0016081 ! synaptic vesicle docking
created_by: dos
creation_date: 2017-07-05T13:10:10Z

[Term]
id: GO:0099149
name: regulation of postsynaptic neurotransmitter receptor internalization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse." [GOC:ai]
subset: goslim_synapse
synonym: "regulation of postsynaptic neurotransmitter receptor endocytosis" EXACT syngo_official_label []
relationship: regulates GO:0098884 ! postsynaptic neurotransmitter receptor internalization
created_by: dos
creation_date: 2017-07-05T13:13:49Z

[Term]
id: GO:0099150
name: regulation of postsynaptic specialization assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization." [GOC:dos]
subset: goslim_synapse
is_a: GO:0150052 ! regulation of postsynapse assembly
relationship: regulates GO:0098698 ! postsynaptic specialization assembly
created_by: dos
creation_date: 2017-07-05T13:20:48Z

[Term]
id: GO:0099151
name: regulation of postsynaptic density assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099150 ! regulation of postsynaptic specialization assembly
relationship: regulates GO:0097107 ! postsynaptic density assembly
created_by: dos
creation_date: 2017-07-05T13:20:48Z

[Term]
id: GO:0099152
name: regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles." [GOC:dos, PMID:20098723]
subset: goslim_synapse
relationship: regulates GO:0098887 ! neurotransmitter receptor transport, endosome to postsynaptic membrane
created_by: dos
creation_date: 2017-08-25T15:01:11Z

[Term]
id: GO:0099154
name: serotonergic synapse
namespace: cellular_component
def: "A synapse that uses serotonin as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
created_by: dos
creation_date: 2017-07-05T14:22:05Z

[Term]
id: GO:0099157
name: trans-synaptic signalling via exosome
namespace: biological_process
def: "Transynaptic signaling in which the ligand is carried across the synapse by an exosome." [GOC:dos, PMID:19837038]
subset: goslim_synapse
synonym: "exosome mediated transynaptic signalling" EXACT []
is_a: GO:0099537 ! trans-synaptic signaling
created_by: dos
creation_date: 2017-07-05T16:49:44Z

[Term]
id: GO:0099158
name: regulation of recycling endosome localization within postsynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse." [GOC:dos, PMID:20098723]
subset: goslim_synapse
is_a: GO:0098693 ! regulation of synaptic vesicle cycle
relationship: regulates GO:0036466 ! synaptic vesicle recycling via endosome
created_by: dos
creation_date: 2017-08-25T15:37:50Z

[Term]
id: GO:0099159
name: regulation of modification of postsynaptic structure
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of modification of postsynaptic structure." [GOC:dos]
subset: goslim_synapse
synonym: "regulation of postsynapse remodelling" EXACT []
is_a: GO:1905244 ! regulation of modification of synaptic structure
relationship: regulates GO:0099010 ! modification of postsynaptic structure
created_by: dos
creation_date: 2017-08-25T15:47:55Z

[Term]
id: GO:0099160
name: postsynaptic intermediate filament cytoskeleton
namespace: cellular_component
def: "The intermediate filament cytoskeleton that is part of a postsynapse" [GOC:dos, PMID:25869803]
subset: goslim_synapse
is_a: GO:0099571 ! postsynaptic cytoskeleton
created_by: dos
creation_date: 2017-08-28T15:26:08Z

[Term]
id: GO:0099161
name: regulation of presynaptic dense core granule exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis." [GOC:dos, PMID:17881523]
subset: goslim_synapse
synonym: "regulation of presynaptic dense core vesicle exocytosis" EXACT syngo_official_label []
relationship: regulates GO:0099525 ! presynaptic dense core vesicle exocytosis
created_by: dos
creation_date: 2017-09-10T10:59:08Z

[Term]
id: GO:0099162
name: regulation of neurotransmitter loading into synaptic vesicle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles." [GOC:dos, PMID:25176177]
subset: goslim_synapse
synonym: "regulation of neurotransmitter uptake into synaptic vesicle" EXACT [PMID:15217342]
synonym: "regulation of synaptic vesicle neurotransmitter loading" EXACT syngo_official_label []
is_a: GO:0098693 ! regulation of synaptic vesicle cycle
relationship: regulates GO:0098700 ! neurotransmitter loading into synaptic vesicle
created_by: dos
creation_date: 2017-09-10T11:07:57Z

[Term]
id: GO:0099163
name: synaptic signaling by nitric oxide
namespace: biological_process
def: "Cell-cell signaling to or from a synapse, mediated by nitric oxide." [GOC:dos, PMID:19038221]
subset: goslim_synapse
is_a: GO:0099536 ! synaptic signaling

[Term]
id: GO:0099164
name: postsynaptic specialization membrane of symmetric synapse
namespace: cellular_component
def: "The membrane component of the postsynaptic specialization of a symmetic synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099634 ! postsynaptic specialization membrane
relationship: part_of GO:0099629 ! postsynaptic specialization of symmetric synapse
created_by: dos
creation_date: 2017-09-10T11:50:44Z

[Term]
id: GO:0099165
name: postsynaptic specialization of symmetric synapse, intracellular component
namespace: cellular_component
def: "A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.  This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099091 ! postsynaptic specialization, intracellular component
relationship: part_of GO:0099629 ! postsynaptic specialization of symmetric synapse
created_by: dos
creation_date: 2017-09-10T11:54:15Z

[Term]
id: GO:0099166
name: intrinsic component of postsynaptic specialization membrane of symmetric synapse
namespace: cellular_component
def: "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos]
subset: goslim_synapse
synonym: "intrinsic to postsynaptic specialization membrane of symmetric synapse" NARROW []
is_a: GO:0098948 ! intrinsic component of postsynaptic specialization membrane
relationship: part_of GO:0099164 ! postsynaptic specialization membrane of symmetric synapse
created_by: dos
creation_date: 2017-09-10T11:56:47Z

[Term]
id: GO:0099167
name: integral component of postsynaptic specialization membrane of symmetric synapse
namespace: cellular_component
def: "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099060 ! integral component of postsynaptic specialization membrane
is_a: GO:0099166 ! intrinsic component of postsynaptic specialization membrane of symmetric synapse
created_by: dos
creation_date: 2017-09-10T11:58:46Z

[Term]
id: GO:0099168
name: extrinsic component of postsynaptic specialization membrane of symmetric synapse
namespace: cellular_component
def: "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098892 ! extrinsic component of postsynaptic specialization membrane
relationship: part_of GO:0099164 ! postsynaptic specialization membrane of symmetric synapse
created_by: dos
creation_date: 2017-09-10T12:00:26Z

[Term]
id: GO:0099169
name: anchored component of postsynaptic specialization membrane of symmetric synapse
namespace: cellular_component
def: "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099030 ! anchored component of postsynaptic specialization membrane
is_a: GO:0099166 ! intrinsic component of postsynaptic specialization membrane of symmetric synapse
created_by: dos
creation_date: 2017-09-10T12:01:53Z

[Term]
id: GO:0099170
name: postsynaptic modulation of chemical synaptic transmission
namespace: biological_process
def: "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission." [GOC:dos]
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: occurs_in GO:0098794 ! postsynapse
relationship: occurs_in GO:0098794 ! postsynapse
created_by: dos
creation_date: 2017-09-11T17:09:17Z

[Term]
id: GO:0099171
name: presynaptic modulation of chemical synaptic transmission
namespace: biological_process
def: "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission." [GOC:dos]
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: occurs_in GO:0098793 ! presynapse
relationship: occurs_in GO:0098793 ! presynapse
created_by: dos
creation_date: 2017-09-11T17:09:31Z

[Term]
id: GO:0099172
name: presynapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse." [GOC:dos]
subset: goslim_synapse
synonym: "presynapse development" EXACT []
synonym: "presynapse morphogenesis" RELATED [GOC:BHF]
synonym: "presynapse organisation" EXACT [GOC:curators]
synonym: "presynapse organization and biogenesis" RELATED [GOC:mah]
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0099173
name: postsynapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "postsynapse development" EXACT []
synonym: "postsynapse morphogenesis" RELATED [GOC:BHF]
synonym: "postsynapse organisation" EXACT [GOC:curators]
synonym: "postsynapse organization and biogenesis" RELATED [GOC:mah]
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0099174
name: regulation of presynapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a presynapse." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_synapse
synonym: "regulation of presynapse organisation" EXACT [GOC:mah]
synonym: "regulation of presynapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of presynapse structure" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0099172 ! presynapse organization

[Term]
id: GO:0099175
name: regulation of postsynapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_synapse
synonym: "regulation of postsynapse organisation" EXACT [GOC:mah]
synonym: "regulation of postsynapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of postsynapse structure" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0099173 ! postsynapse organization

[Term]
id: GO:0099176
name: regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex." [GOC:dos, PMID:23209303]
subset: goslim_synapse
synonym: "regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
relationship: regulates GO:0098942 ! retrograde trans-synaptic signaling by trans-synaptic protein complex

[Term]
id: GO:0099179
name: regulation of synaptic membrane adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes." [GOC:dos]
subset: goslim_synapse
synonym: "regulation of synapse adhesion between pre- and post-synapse" EXACT [] {synonymtypedef="syngo_official_label"}
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0099560 ! synaptic membrane adhesion

[Term]
id: GO:0099180
name: zinc ion import into synaptic vesicle
namespace: biological_process
def: "The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle." [PMID:9990090]
subset: goslim_synapse
synonym: "zinc import into synaptic vesicle" EXACT []
synonym: "Zn2+ import into synaptic vesicle" EXACT []

[Term]
id: GO:0099181
name: structural constituent of presynapse
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a presynapse." [GOC:dos, PMID:23751498]
subset: goslim_synapse
is_a: GO:0098918 ! structural constituent of synapse
relationship: part_of GO:0099172 ! presynapse organization
created_by: dos
creation_date: 2017-12-20T13:42:46Z

[Term]
id: GO:0099182
name: presynaptic intermediate filament cytoskeleton
namespace: cellular_component
def: "The intermediate filament cytoskeleton that is part of a presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099569 ! presynaptic cytoskeleton
created_by: dos
creation_date: 2017-12-01T18:10:21Z

[Term]
id: GO:0099183
name: trans-synaptic signaling by BDNF, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099191 ! trans-synaptic signaling by BDNF
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission
created_by: dos
creation_date: 2017-12-01T18:25:24Z

[Term]
id: GO:0099184
name: structural constituent of postsynaptic intermediate filament cytoskeleton
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099186 ! structural constituent of postsynapse
relationship: part_of GO:0099185 ! postsynaptic intermediate filament cytoskeleton organization
created_by: dos
creation_date: 2017-12-20T13:45:35Z

[Term]
id: GO:0099185
name: postsynaptic intermediate filament cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of  cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099188 ! postsynaptic cytoskeleton organization
created_by: dos
creation_date: 2017-12-20T13:47:30Z

[Term]
id: GO:0099186
name: structural constituent of postsynapse
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098918 ! structural constituent of synapse
relationship: part_of GO:0099173 ! postsynapse organization
created_by: dos
creation_date: 2017-12-20T14:54:33Z

[Term]
id: GO:0099188
name: postsynaptic cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0099173 ! postsynapse organization
created_by: dos
creation_date: 2017-12-20T15:06:57Z

[Term]
id: GO:0099189
name: postsynaptic spectrin-associated cytoskeleton
namespace: cellular_component
def: "The portion of the spectrin-associated cytoskeleton contained within the postsynapse." [GOC:dos, PMID:28576936]
subset: goslim_synapse
is_a: GO:0099571 ! postsynaptic cytoskeleton
created_by: dos
creation_date: 2017-12-20T15:29:09Z

[Term]
id: GO:0099190
name: postsynaptic spectrin-associated cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse." [GOC:dos, PMID:28576936]
subset: goslim_synapse
is_a: GO:0099188 ! postsynaptic cytoskeleton organization
created_by: dos
creation_date: 2017-12-20T15:34:26Z

[Term]
id: GO:0099191
name: trans-synaptic signaling by BDNF
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft." [GOC:dos]
subset: goslim_synapse
synonym: "trans-synaptic signaling by brain-derived neurotrophic factor" EXACT []
is_a: GO:0099537 ! trans-synaptic signaling
created_by: dos
creation_date: 2017-12-20T15:48:33Z

[Term]
id: GO:0099192
name: cerebellar Golgi cell to granule cell synapse
namespace: cellular_component
def: "A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell." [PMID:26134650]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
created_by: dos
creation_date: 2017-12-20T16:12:25Z

[Term]
id: GO:0099240
name: intrinsic component of synaptic membrane
namespace: cellular_component
def: "The component of the synaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: goslim_synapse
synonym: "intrinsic to synaptic membrane" NARROW []
relationship: part_of GO:0097060 ! synaptic membrane
created_by: dos
creation_date: 2017-05-25T17:23:21Z

[Term]
id: GO:0099243
name: extrinsic component of synaptic membrane
namespace: cellular_component
def: "The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0097060 ! synaptic membrane
created_by: dos
creation_date: 2017-05-25T17:24:23Z

[Term]
id: GO:0099502
name: calcium-dependent activation of synaptic vesicle fusion
namespace: biological_process
def: "The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane." [PMID:23060190]
subset: goslim_synapse
is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis
relationship: positively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane

[Term]
id: GO:0099504
name: synaptic vesicle cycle
namespace: biological_process
def: "A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters." [PMID:15217342]
subset: goslim_synapse
relationship: occurs_in GO:0098793 ! presynapse

[Term]
id: GO:0099505
name: regulation of presynaptic membrane potential
namespace: biological_process
def: "Any process that modulates the potential difference across a presynaptic membrane." [GOC:dph, GOC:ef]
subset: goslim_synapse
synonym: "regulation of pre-synaptic membrane potential" EXACT []

[Term]
id: GO:0099506
name: synaptic vesicle transport along actin filament
namespace: biological_process
def: "The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099514 ! synaptic vesicle cytoskeletal transport

[Term]
id: GO:0099507
name: ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential." [GOC:dos, PMID:15145529, PMID:19558451]
subset: goslim_synapse
synonym: "ligand gated ion channel activity involved in regulation of presynaptic membrane potential" EXACT []
synonym: "ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT []
synonym: "ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential" EXACT []
synonym: "ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT []
relationship: occurs_in GO:0042734 ! presynaptic membrane
relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential

[Term]
id: GO:0099508
name: voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse." [GOC:dos]
subset: goslim_synapse
synonym: "voltage gated ion channel activity involved in regulation of presynaptic membrane potential" EXACT []
synonym: "voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT []
synonym: "voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential" EXACT []
synonym: "voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT []
relationship: occurs_in GO:0042734 ! presynaptic membrane
relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential

[Term]
id: GO:0099509
name: regulation of presynaptic cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that regulates the concentration of calcium in the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
synonym: "regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
relationship: occurs_in GO:0098793 ! presynapse

[Term]
id: GO:0099511
name: voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
namespace: molecular_function
def: "Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel." [GOC:dos]
subset: goslim_synapse

[Term]
id: GO:0099514
name: synaptic vesicle cytoskeletal transport
namespace: biological_process
def: "The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0048489 ! synaptic vesicle transport

[Term]
id: GO:0099517
name: synaptic vesicle transport along microtubule
namespace: biological_process
def: "The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099514 ! synaptic vesicle cytoskeletal transport

[Term]
id: GO:0099520
name: ion antiporter activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential" [GOC:dos]
subset: goslim_synapse
synonym: "ion antiporter activity involved in regulation of pre-synaptic membrane potential" EXACT []
relationship: occurs_in GO:0042734 ! presynaptic membrane
relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential

[Term]
id: GO:0099521
name: ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential." [GOC:dos, PMID:17220883]
subset: goslim_synapse
synonym: "ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential" EXACT []
synonym: "ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential" EXACT []
relationship: occurs_in GO:0042734 ! presynaptic membrane
relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential

[Term]
id: GO:0099523
name: presynaptic cytosol
namespace: cellular_component
def: "The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0099524
name: postsynaptic cytosol
namespace: cellular_component
def: "The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0099525
name: presynaptic dense core vesicle exocytosis
namespace: biological_process
def: "The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels." [PMID:17553987, PMID:24653208]
subset: goslim_synapse
is_a: GO:0099003 ! vesicle-mediated transport in synapse
is_a: GO:0099643 ! signal release from synapse
relationship: occurs_in GO:0098793 ! presynapse

[Term]
id: GO:0099526
name: presynapse to nucleus signaling pathway
namespace: biological_process
def: "A series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications)." [GOC:dos, PMID:24317321, PMID:25652077]
comment: This class does not cover the cellular machinery (motor proteins, cargo-recognition proteins) that transports the signaling protein along the cytoskeleton towards the nucleus. For these cases, annotate to the appropriate transport/trafficking term.
subset: goslim_synapse
synonym: "presynaptic signaling to nucleus" EXACT []
is_a: GO:0098928 ! presynaptic signal transduction

[Term]
id: GO:0099527
name: postsynapse to nucleus signaling pathway
namespace: biological_process
def: "A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications)." [GOC:dos, PMID:24317321, PMID:25652077]
subset: goslim_synapse
synonym: "postsynaptic signaling to nucleus" EXACT []
is_a: GO:0098926 ! postsynaptic signal transduction

[Term]
id: GO:0099529
name: neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel.)" [GOC:dos]
subset: goslim_synapse
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential
relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic

[Term]
id: GO:0099530
name: G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse
synonym: "G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential" EXACT []
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0099531
name: presynaptic process involved in chemical synaptic transmission
namespace: biological_process
def: "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." [GOC:dos]
subset: gocheck_do_not_annotate
subset: goslim_synapse
relationship: occurs_in GO:0098793 ! presynapse
relationship: part_of GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099532
name: synaptic vesicle endosomal processing
namespace: biological_process
def: "The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles." [GOC:dos]
comment: This covers processing of synaptic vesicles trafficked to synapse as well as  of endocytosed vesicles as part of recycling.  It is there for not part of the synaptic vesicle cycle.
subset: goslim_synapse
synonym: "synaptic vesicle processing via endosome" EXACT []
is_a: GO:0099003 ! vesicle-mediated transport in synapse
relationship: part_of GO:0099504 ! synaptic vesicle cycle

[Term]
id: GO:0099533
name: positive regulation of presynaptic cytosolic calcium concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099534
name: calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations." [PMID:24442513, PMID:26190970]
subset: goslim_synapse
synonym: "calcium ion binding involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "presynaptic calcium ion buffering" EXACT []
synonym: "regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering" EXACT []
relationship: occurs_in GO:0099523 ! presynaptic cytosol
relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099535
name: synapse-associated extracellular matrix
namespace: cellular_component
def: "The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft." [GOC:dos]
subset: goslim_synapse
synonym: "extra-synaptic extracellular matrix" EXACT []

[Term]
id: GO:0099536
name: synaptic signaling
namespace: biological_process
def: "Cell-cell signaling to, from or or within a synapse." [GOC:dos]
subset: goslim_synapse

[Term]
id: GO:0099537
name: trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling in either direction across the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099536 ! synaptic signaling

[Term]
id: GO:0099538
name: synaptic signaling via neuropeptide
namespace: biological_process
def: "Cell-cell signaling to or from a synapse, mediated by a peptide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099536 ! synaptic signaling

[Term]
id: GO:0099539
name: neuropeptide secretion from presynapse
namespace: biological_process
def: "The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration." [PMID:17553987, PMID:24653208]
subset: goslim_synapse
synonym: "neuropeptide secretion from presynapse via dense core granule exocytosis" EXACT []
is_a: GO:0099525 ! presynaptic dense core vesicle exocytosis
relationship: part_of GO:0099538 ! synaptic signaling via neuropeptide

[Term]
id: GO:0099540
name: trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling
is_a: GO:0099538 ! synaptic signaling via neuropeptide

[Term]
id: GO:0099541
name: trans-synaptic signaling by lipid
namespace: biological_process
def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099542
name: trans-synaptic signaling by endocannabinoid
namespace: biological_process
def: "Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099541 ! trans-synaptic signaling by lipid

[Term]
id: GO:0099543
name: trans-synaptic signaling by soluble gas
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099544
name: perisynaptic space
namespace: cellular_component
def: "The extracellular region immediately adjacent to to a synapse." [GOC:dos]
subset: goslim_synapse
synonym: "extrasynaptic space" EXACT syngo_official_label []

[Term]
id: GO:0099545
name: trans-synaptic signaling by trans-synaptic complex
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099546
name: protein catabolic process, modulating synaptic transmission
namespace: biological_process
def: "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission." [GOC:dos, PMID:23083742]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0140246 ! protein catabolic process at synapse

[Term]
id: GO:0099547
name: regulation of translation at synapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0140243 ! regulation of translation at synapse

[Term]
id: GO:0099548
name: trans-synaptic signaling by nitric oxide
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099163 ! synaptic signaling by nitric oxide
is_a: GO:0099543 ! trans-synaptic signaling by soluble gas

[Term]
id: GO:0099549
name: trans-synaptic signaling by carbon monoxide
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099543 ! trans-synaptic signaling by soluble gas

[Term]
id: GO:0099550
name: trans-synaptic signaling, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0099537 ! trans-synaptic signaling
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099551
name: trans-synaptic signaling by neuropeptide, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission

[Term]
id: GO:0099552
name: trans-synaptic signaling by lipid, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099541 ! trans-synaptic signaling by lipid
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission

[Term]
id: GO:0099553
name: trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099542 ! trans-synaptic signaling by endocannabinoid
is_a: GO:0099552 ! trans-synaptic signaling by lipid, modulating synaptic transmission

[Term]
id: GO:0099554
name: trans-synaptic signaling by soluble gas, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099543 ! trans-synaptic signaling by soluble gas
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission

[Term]
id: GO:0099555
name: trans-synaptic signaling by nitric oxide, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide
is_a: GO:0099554 ! trans-synaptic signaling by soluble gas, modulating synaptic transmission

[Term]
id: GO:0099556
name: trans-synaptic signaling by carbon monoxide, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099549 ! trans-synaptic signaling by carbon monoxide
is_a: GO:0099554 ! trans-synaptic signaling by soluble gas, modulating synaptic transmission

[Term]
id: GO:0099557
name: trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:19029886]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission

[Term]
id: GO:0099558
name: maintenance of synapse structure
namespace: biological_process
def: "A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds." [GOC:dos, PMID:24449494, PMID:25611509]
subset: goslim_synapse
synonym: "synaptic maintenance" EXACT []
is_a: GO:0050808 ! synapse organization

[Term]
id: GO:0099559
name: maintenance of alignment of postsynaptic density and presynaptic active zone
namespace: biological_process
def: "The process by which alignment between postsynaptic density and presynaptic active zone is maintained." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099558 ! maintenance of synapse structure

[Term]
id: GO:0099560
name: synaptic membrane adhesion
namespace: biological_process
def: "The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]
subset: goslim_synapse
synonym: "synapse adhesion between pre- and post-synapse" EXACT syngo_official_label []
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0099561
name: synaptic membrane adhesion to extracellular matrix
namespace: biological_process
def: "The binding of a synaptic membrane to the extracellular matrix via adhesion molecules." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0099562
name: maintenance of postsynaptic density structure
namespace: biological_process
def: "A process which maintains the organization and the arrangement of proteins in the presynaptic density." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098880 ! maintenance of postsynaptic specialization structure

[Term]
id: GO:0099563
name: modification of synaptic structure
namespace: biological_process
def: "Any process that modifies the structure/morphology of a synapse." [GOC:dos]
comment: This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones.
subset: goslim_synapse
synonym: "synapse remodelling" EXACT []
is_a: GO:0050808 ! synapse organization

[Term]
id: GO:0099564
name: modification of synaptic structure, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission via modification of the structure of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0099563 ! modification of synaptic structure

[Term]
id: GO:0099565
name: chemical synaptic transmission, postsynaptic
namespace: biological_process
def: "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol." [GOC:dos]
subset: gocheck_do_not_annotate
subset: goslim_synapse
synonym: "postsynaptic process involved in chemical synaptic transmission" RELATED syngo_official_label []
relationship: occurs_in GO:0098794 ! postsynapse
relationship: part_of GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099566
name: regulation of postsynaptic cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that regulates the concentration of calcium in the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
synonym: "regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
relationship: occurs_in GO:0098794 ! postsynapse

[Term]
id: GO:0099567
name: calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations." [PMID:24442513, PMID:26190970]
subset: goslim_synapse
synonym: "calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "postsynaptic calcium ion buffering" EXACT []
synonym: "regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering" RELATED []
relationship: occurs_in GO:0099524 ! postsynaptic cytosol
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099569
name: presynaptic cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton contained within the presynapse." [GOC:dos]
subset: goslim_synapse
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0099571
name: postsynaptic cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton contained within the postsynapse." [GOC:dos, PMID:19889835]
subset: goslim_synapse
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0099572
name: postsynaptic specialization
namespace: cellular_component
def: "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028]
subset: goslim_synapse
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0099573
name: glutamatergic postsynaptic density
namespace: cellular_component
def: "The post-synaptic specialization of a glutamatergic excitatory synapse." [GOC:dos]
subset: goslim_synapse
synonym: "postsynaptic specialization, glutamatergic neuron-to-neuron synapse" EXACT syngo_official_label []
is_a: GO:0014069 ! postsynaptic density

[Term]
id: GO:0099574
name: regulation of protein catabolic process at synapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating protein degradation at the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0140250 ! regulation protein catabolic process at synapse

[Term]
id: GO:0099575
name: regulation of protein catabolic process at presynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission

[Term]
id: GO:0099576
name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission

[Term]
id: GO:0099577
name: regulation of translation at presynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission
is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission
is_a: GO:0140244 ! regulation of translation at presynapse

[Term]
id: GO:0099578
name: regulation of translation at postsynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission
is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission
is_a: GO:0140245 ! regulation of translation at postsynapse

[Term]
id: GO:0099579
name: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential." [GOC:dos]
subset: goslim_synapse
synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential" EXACT []
is_a: GO:0099529 ! neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
is_a: GO:0099530 ! G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

[Term]
id: GO:0099580
name: ion antiporter activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential" [GOC:dos]
subset: goslim_synapse
synonym: "ion antiporter activity involved in regulation of post-synaptic membrane potential" EXACT []
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0099581
name: ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential." [GOC:dos]
subset: goslim_synapse
synonym: "ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential" EXACT []
synonym: "ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential" EXACT []
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0099582
name: neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
synonym: "neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
relationship: occurs_in GO:0042734 ! presynaptic membrane
relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099583
name: neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
synonym: "neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099585
name: release of sequestered calcium ion into presynaptic cytosol
namespace: biological_process
def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration

[Term]
id: GO:0099586
name: release of sequestered calcium ion into postsynaptic cytosol
namespace: biological_process
def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099588 ! positive regulation of postsynaptic cytosolic calcium concentration

[Term]
id: GO:0099588
name: positive regulation of postsynaptic cytosolic calcium concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099601
name: regulation of neurotransmitter receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos]
subset: goslim_synapse

[Term]
id: GO:0099626
name: voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
namespace: molecular_function
def: "Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels." [GOC:dos, PMID:15548655]
subset: goslim_synapse
synonym: "voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
is_a: GO:0099511 ! voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
relationship: occurs_in GO:0098793 ! presynapse
relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099628
name: neurotransmitter receptor diffusion trapping
namespace: biological_process
def: "The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane." [PMID:18832033]
subset: goslim_synapse

[Term]
id: GO:0099629
name: postsynaptic specialization of symmetric synapse
namespace: cellular_component
def: "A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses." [PMID:18832033]
subset: goslim_synapse
synonym: "postsynaptic density of inhibitory synapse" EXACT [PMID:18832033]
is_a: GO:0099572 ! postsynaptic specialization

[Term]
id: GO:0099631
name: postsynaptic endocytic zone cytoplasmic component
namespace: cellular_component
def: "The cytoplasmic component of the postsynaptic endocytic zone." [GOC:dos]
subset: goslim_synapse
synonym: "postsynaptic endocytic zone cytoplasmic component" EXACT []
relationship: part_of GO:0098843 ! postsynaptic endocytic zone

[Term]
id: GO:0099634
name: postsynaptic specialization membrane
namespace: cellular_component
def: "The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0099572 ! postsynaptic specialization

[Term]
id: GO:0099635
name: voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
namespace: molecular_function
def: "Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels.  This is the first step in synaptic transmission" [GOC:dos]
subset: goslim_synapse
is_a: GO:0099626 ! voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
relationship: part_of GO:0099703 ! induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099637
name: neurotransmitter receptor transport
namespace: biological_process
def: "The directed movement of neurotransmitter receptors." [GOC:dos]
subset: goslim_synapse

[Term]
id: GO:0099639
name: neurotransmitter receptor transport, endosome to plasma membrane
namespace: biological_process
def: "The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098877 ! neurotransmitter receptor transport to plasma membrane

[Term]
id: GO:0099640
name: axo-dendritic protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules in neuron projections." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axonal protein transport" NARROW []
is_a: GO:0008088 ! axo-dendritic transport

[Term]
id: GO:0099641
name: anterograde axonal protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons." [GOC:dos]
subset: goslim_synapse
synonym: "anterograde axon cargo transport" BROAD []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0099640 ! axo-dendritic protein transport

[Term]
id: GO:0099642
name: retrograde axonal protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "retrograde axon cargo transport" BROAD []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0099640 ! axo-dendritic protein transport

[Term]
id: GO:0099643
name: signal release from synapse
namespace: biological_process
def: "Any signal release from a synapse." [GOC:dos]
subset: goslim_synapse
relationship: occurs_in GO:0045202 ! synapse
relationship: part_of GO:0099536 ! synaptic signaling

[Term]
id: GO:0099645
name: neurotransmitter receptor localization to postsynaptic specialization membrane
namespace: biological_process
def: "A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density)." [GOC:dos]
subset: goslim_synapse
synonym: "neurotransmitter receptor localisation in postsynaptic specialization membrane" EXACT [GOC:TermGenie]
is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels

[Term]
id: GO:0099646
name: neurotransmitter receptor transport, plasma membrane to endosome
namespace: biological_process
def: "Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099637 ! neurotransmitter receptor transport

[Term]
id: GO:0099699
name: integral component of synaptic membrane
namespace: cellular_component
def: "The component of the synaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099240 ! intrinsic component of synaptic membrane
created_by: dos
creation_date: 2017-05-25T17:22:18Z

[Term]
id: GO:0099703
name: induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
namespace: biological_process
def: "The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse.  This is the first step in synaptic transmission." [GOC:dos, ISBN:9780071120005]
subset: goslim_synapse
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission
is_a: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration
is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis
intersection_of: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration
intersection_of: positively_regulates GO:0016079 ! synaptic vesicle exocytosis
relationship: part_of GO:0007268 ! chemical synaptic transmission
relationship: positively_regulates GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0140231
name: anterograde axonal transport of neurotransmitter receptor complex
namespace: biological_process
def: "The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons." [PMID:28680963]
subset: goslim_synapse
is_a: GO:0008089 ! anterograde axonal transport
created_by: pg
creation_date: 2018-07-09T09:41:37Z

[Term]
id: GO:0140232
name: intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential." [PMID:21358644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. New term as requested here: https://github.com/geneontology/synapse/issues/231
subset: goslim_synapse
synonym: "intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential" EXACT []
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential
created_by: pg
creation_date: 2018-07-09T11:30:40Z

[Term]
id: GO:0140233
name: intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential." [GOC:pvn]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. New term as requested here: https://github.com/geneontology/synapse/issues/231
subset: goslim_synapse
synonym: "intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential" EXACT []
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential
created_by: pg
creation_date: 2018-07-09T11:31:18Z

[Term]
id: GO:0140235
name: RNA polyadenylation at postsynapse
namespace: biological_process
def: "A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse." [PMID:22727665]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
relationship: occurs_in GO:0098794 ! postsynapse
created_by: pg
creation_date: 2018-07-13T12:03:28Z

[Term]
id: GO:0140236
name: translation at presynapse
namespace: biological_process
def: "Translation that occurs at the presynapse." [PMID:27321671]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/216
subset: goslim_synapse
is_a: GO:0140241 ! translation at synapse
relationship: occurs_in GO:0098793 ! presynapse
created_by: pg
creation_date: 2018-07-13T13:00:33Z

[Term]
id: GO:0140237
name: translation at presynapse, modulating chemical synaptic transmission
namespace: biological_process
def: "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission." [PMID:27321671]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/216
subset: goslim_synapse
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission
is_a: GO:0140236 ! translation at presynapse
created_by: pg
creation_date: 2018-07-13T13:07:23Z

[Term]
id: GO:0140238
name: presynaptic endocytosis
namespace: biological_process
def: "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:24719103]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Term request: https://github.com/geneontology/synapse/issues/230
subset: goslim_synapse
is_a: GO:0099003 ! vesicle-mediated transport in synapse
relationship: occurs_in GO:0098793 ! presynapse
created_by: pg
creation_date: 2018-07-15T07:33:55Z

[Term]
id: GO:0140239
name: postsynaptic endocytosis
namespace: biological_process
def: "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:12839988]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Term request: https://github.com/geneontology/synapse/issues/230
subset: goslim_synapse
is_a: GO:0099003 ! vesicle-mediated transport in synapse
relationship: occurs_in GO:0098794 ! postsynapse
created_by: pg
creation_date: 2018-07-15T07:38:27Z

[Term]
id: GO:0140240
name: perforant pathway to dendrate granule cell synapse
namespace: cellular_component
def: "A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus." [PMID:22727665, PMID:29199135]
comment: New term request https://github.com/geneontology/synapse/issues/234
subset: goslim_synapse
synonym: "perforant pathway to DG granule cell synapse" EXACT []
is_a: GO:0045202 ! synapse
created_by: pg
creation_date: 2018-07-15T08:21:43Z

[Term]
id: GO:0140241
name: translation at synapse
namespace: biological_process
def: "Translation that occurs at the synapse." [PMID:23083742]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210.
subset: goslim_synapse
relationship: occurs_in GO:0045202 ! synapse
created_by: pg
creation_date: 2018-07-15T09:23:12Z

[Term]
id: GO:0140242
name: translation at postsynapse
namespace: biological_process
def: "Translation that occurs at the postsynapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210.
subset: goslim_synapse
is_a: GO:0140241 ! translation at synapse
relationship: occurs_in GO:0098794 ! postsynapse
created_by: pg
creation_date: 2018-07-15T09:26:27Z

[Term]
id: GO:0140243
name: regulation of translation at synapse
namespace: biological_process
def: "Any process that regulates translation occurring at the synapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210.
subset: goslim_synapse
relationship: occurs_in GO:0045202 ! synapse
created_by: pg
creation_date: 2018-07-15T09:38:26Z

[Term]
id: GO:0140244
name: regulation of translation at presynapse
namespace: biological_process
def: "Any process that regulates translation occurring at the presynapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210.
subset: goslim_synapse
is_a: GO:0140243 ! regulation of translation at synapse
relationship: occurs_in GO:0098793 ! presynapse
created_by: pg
creation_date: 2018-07-15T09:38:33Z

[Term]
id: GO:0140245
name: regulation of translation at postsynapse
namespace: biological_process
def: "Any process that regulates translation occurring at the postsynapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210.
subset: goslim_synapse
is_a: GO:0140243 ! regulation of translation at synapse
relationship: occurs_in GO:0098794 ! postsynapse
created_by: pg
creation_date: 2018-07-15T09:38:54Z

[Term]
id: GO:0140246
name: protein catabolic process at synapse
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse." [PMID:17062563]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204.
subset: goslim_synapse
relationship: occurs_in GO:0045202 ! synapse
created_by: pg
creation_date: 2018-07-15T10:12:51Z

[Term]
id: GO:0140247
name: protein catabolic process at presynapse
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse." [PMID:27764673]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204.
subset: goslim_synapse
is_a: GO:0140246 ! protein catabolic process at synapse
relationship: occurs_in GO:0098793 ! presynapse
created_by: pg
creation_date: 2018-07-15T10:23:49Z

[Term]
id: GO:0140249
name: protein catabolic process at postsynapse
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse." [PMID:17062563]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204.
subset: goslim_synapse
is_a: GO:0140246 ! protein catabolic process at synapse
relationship: occurs_in GO:0098794 ! postsynapse
created_by: pg
creation_date: 2018-07-15T10:25:04Z

[Term]
id: GO:0140250
name: regulation protein catabolic process at synapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse." [PMID:23083742]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204.
subset: goslim_synapse
relationship: occurs_in GO:0045202 ! synapse
created_by: pg
creation_date: 2018-07-15T10:34:56Z

[Term]
id: GO:0140251
name: regulation protein catabolic process at presynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse." [PMID:27764673]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204.
subset: goslim_synapse
is_a: GO:0140250 ! regulation protein catabolic process at synapse
relationship: occurs_in GO:0098793 ! presynapse
created_by: pg
creation_date: 2018-07-15T10:35:39Z

[Term]
id: GO:0140252
name: regulation protein catabolic process at postsynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse." [PMID:17062563]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204.
subset: goslim_synapse
is_a: GO:0140250 ! regulation protein catabolic process at synapse
relationship: occurs_in GO:0098794 ! postsynapse
created_by: pg
creation_date: 2018-07-15T10:35:56Z

[Term]
id: GO:0150035
name: regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission." [GOC:aruk, GOC:bc, PMID:19448629]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: regulates GO:0099183 ! trans-synaptic signaling by BDNF, modulating synaptic transmission
created_by: BarbaraCzub
creation_date: 2018-04-17T13:56:34Z

[Term]
id: GO:0150036
name: regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission." [GOC:aruk, GOC:bc, PMID:27296803]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: regulates GO:0099553 ! trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
created_by: BarbaraCzub
creation_date: 2018-04-18T09:54:49Z

[Term]
id: GO:0150037
name: regulation of calcium-dependent activation of synaptic vesicle fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion." [GOC:aruk, GOC:bc, PMID:27052163]
subset: goslim_synapse
is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane
relationship: regulates GO:0099502 ! calcium-dependent activation of synaptic vesicle fusion
created_by: BarbaraCzub
creation_date: 2018-04-18T12:47:38Z

[Term]
id: GO:0150038
name: postsynaptic dense core vesicle exocytosis
namespace: biological_process
def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels." [GOC:aruk, GOC:bc, PMID:19448629]
subset: goslim_synapse
is_a: GO:0099003 ! vesicle-mediated transport in synapse
relationship: occurs_in GO:0098794 ! postsynapse
created_by: BarbaraCzub
creation_date: 2018-04-18T14:32:16Z

[Term]
id: GO:0150043
name: structural constituent of synapse-associated extracellular matrix
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft." [GOC:aruk, GOC:bc, PMID:17189701]
subset: goslim_synapse
synonym: "extra-synaptic extracellular matrix structural constituent" EXACT []
synonym: "structural constituent of extra-synaptic extracellular matrix" EXACT []
synonym: "synapse-associated extracellular matrix structural constituent" EXACT []
relationship: occurs_in GO:0099535 ! synapse-associated extracellular matrix
created_by: BarbaraCzub
creation_date: 2018-04-19T13:42:40Z

[Term]
id: GO:0150044
name: regulation of postsynaptic dense core vesicle exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis." [GOC:aruk, GOC:bc, PMID:19448629]
subset: goslim_synapse
relationship: regulates GO:0150038 ! postsynaptic dense core vesicle exocytosis
created_by: BarbaraCzub
creation_date: 2018-04-20T13:34:32Z

[Term]
id: GO:0150045
name: regulation of synaptic signaling by nitric oxide
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide." [GOC:aruk, GOC:bc, PMID:26311509]
subset: goslim_synapse
relationship: regulates GO:0099163 ! synaptic signaling by nitric oxide
created_by: BarbaraCzub
creation_date: 2018-04-23T09:42:25Z

[Term]
id: GO:0150047
name: G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential." [GOC:aruk, GOC:bc, PMID:11498050]
subset: goslim_synapse
synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential" EXACT []
relationship: occurs_in GO:0042734 ! presynaptic membrane
relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential
created_by: BarbaraCzub
creation_date: 2018-04-23T10:51:20Z

[Term]
id: GO:0150048
name: cerebellar granule cell to Purkinje cell synapse
namespace: cellular_component
def: "A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum." [GOC:aruk, GOC:bc, PMID:12427822]
subset: goslim_synapse
synonym: "cerebellar parallel fiber to Purkinje cell synapse" EXACT []
is_a: GO:0098978 ! glutamatergic synapse
relationship: has_part GO:0014069 ! postsynaptic density
created_by: BarbaraCzub
creation_date: 2018-04-23T14:44:40Z

[Term]
id: GO:0150050
name: postsynaptic septin cytoskeleton
namespace: cellular_component
def: "The portion of the septin cytoskeleton contained within the postsynapse." [GOC:aruk, GOC:bc, PMID:28065648]
subset: goslim_synapse
is_a: GO:0099571 ! postsynaptic cytoskeleton
created_by: BarbaraCzub
creation_date: 2018-04-26T14:45:52Z

[Term]
id: GO:0150051
name: postsynaptic Golgi apparatus
namespace: cellular_component
def: "The network of the Golgi apparatus structures located within the postsynapse." [GOC:aruk, GOC:bc, PMID:23838184]
subset: goslim_synapse
synonym: "Golgi outpost" RELATED [GOC:aruk, GOC:bc, PMID:21215635]
relationship: part_of GO:0098794 ! postsynapse
created_by: BarbaraCzub
creation_date: 2018-05-08T15:42:56Z

[Term]
id: GO:0150052
name: regulation of postsynapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:aruk, GOC:bc, PMID:16394100, PMID:16672654, PMID:28185854]
subset: goslim_synapse
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:0099175 ! regulation of postsynapse organization
created_by: BarbaraCzub
creation_date: 2018-05-08T16:38:55Z

[Term]
id: GO:0150053
name: cerebellar climbing fiber to Purkinje cell synapse
namespace: cellular_component
def: "A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata." [GOC:aruk, GOC:bc, PMID:19597563, PMID:23811844, PMID:5044254]
subset: goslim_synapse
synonym: "cerebellar climbing fibre to Purkinje cell synapse" EXACT []
is_a: GO:0098978 ! glutamatergic synapse
relationship: has_part GO:0014069 ! postsynaptic density
created_by: BarbaraCzub
creation_date: 2018-05-09T09:57:20Z

[Term]
id: GO:0150054
name: regulation of postsynaptic neurotransmitter receptor diffusion trapping
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping." [GOC:aruk, GOC:bc, PMID:20935643]
subset: goslim_synapse
relationship: regulates GO:0098970 ! postsynaptic neurotransmitter receptor diffusion trapping
created_by: BarbaraCzub
creation_date: 2018-05-10T14:26:59Z

[Term]
id: GO:1900242
name: regulation of synaptic vesicle endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie]
subset: goslim_synapse
synonym: "regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
is_a: GO:0098693 ! regulation of synaptic vesicle cycle
relationship: regulates GO:0048488 ! synaptic vesicle endocytosis
created_by: rl
creation_date: 2012-03-28T01:40:26Z

[Term]
id: GO:1901546
name: regulation of synaptic vesicle lumen acidification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie]
subset: goslim_synapse
synonym: "regulation of proton loading" EXACT syngo_official_label []
synonym: "regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
is_a: GO:0098693 ! regulation of synaptic vesicle cycle
relationship: regulates GO:0097401 ! synaptic vesicle lumen acidification
created_by: dsf
creation_date: 2012-10-26T16:09:24Z

[Term]
id: GO:1903742
name: regulation of anterograde synaptic vesicle transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901]
subset: goslim_synapse
relationship: regulates GO:0048490 ! anterograde synaptic vesicle transport
created_by: kmv
creation_date: 2014-12-12T16:28:27Z

[Term]
id: GO:1904315
name: transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]
subset: goslim_synapse
synonym: "ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential" NARROW [GOC:TermGenie]
synonym: "ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential" NARROW [GOC:TermGenie]
is_a: GO:0099529 ! neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
created_by: dos
creation_date: 2015-06-10T18:02:07Z

[Term]
id: GO:1905030
name: voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, ISBN:9780071120005]
subset: goslim_synapse
synonym: "voltage gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage gated ion channel activity involved in regulation of postsynaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie]
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential
created_by: dos
creation_date: 2016-03-04T15:51:54Z

[Term]
id: GO:1905054
name: calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:15919193, PMID:23918386]
subset: goslim_synapse
synonym: "calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-17T12:12:53Z

[Term]
id: GO:1905055
name: calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:22972962, PMID:23255722]
subset: goslim_synapse
synonym: "calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-17T14:35:35Z

[Term]
id: GO:1905056
name: calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium-transporting ATPase activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:22972962]
subset: goslim_synapse
synonym: "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-17T14:35:25Z

[Term]
id: GO:1905057
name: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
namespace: molecular_function
def: "Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:20734177]
subset: goslim_synapse
synonym: "depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
is_a: GO:0099511 ! voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-18T12:31:48Z

[Term]
id: GO:1905058
name: calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:23639769]
subset: goslim_synapse
synonym: "calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-18T12:31:59Z

[Term]
id: GO:1905059
name: calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium-transporting ATPase activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:20678993]
subset: goslim_synapse
synonym: "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-18T12:32:08Z

[Term]
id: GO:1905060
name: calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:18024055]
subset: goslim_synapse
synonym: "calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels" EXACT syngo_official_label []
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-18T12:32:17Z

[Term]
id: GO:1905244
name: regulation of modification of synaptic structure
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of modification of synaptic structure." [GO_REF:0000058, GOC:TermGenie, PMID:25164660]
subset: goslim_synapse
synonym: "regulation of synapse remodelling" EXACT [GOC:TermGenie]
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0099563 ! modification of synaptic structure
created_by: dos
creation_date: 2016-06-09T09:43:40Z

[Term]
id: GO:1905274
name: regulation of modification of postsynaptic actin cytoskeleton
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton." [GO_REF:0000058, GOC:TermGenie, PMID:21068295]
subset: goslim_synapse
synonym: "regulation of postsynaptic actin cytoskeleton remodelling" EXACT [GOC:TermGenie]
is_a: GO:0099159 ! regulation of modification of postsynaptic structure
relationship: regulates GO:0098885 ! modification of postsynaptic actin cytoskeleton
created_by: dos
creation_date: 2016-06-16T22:34:25Z

[Term]
id: GO:1905539
name: regulation of postsynapse to nucleus signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway." [GO_REF:0000058, GOC:TermGenie, ISBN:9780071120005]
subset: goslim_synapse
synonym: "regulation of postsynaptic signaling to nucleus" EXACT [GOC:TermGenie]
relationship: regulates GO:0099527 ! postsynapse to nucleus signaling pathway
created_by: dos
creation_date: 2016-10-07T17:03:38Z

[Term]
id: GO:1905606
name: regulation of presynapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
subset: goslim_synapse
synonym: "regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:0099174 ! regulation of presynapse organization
relationship: regulates GO:0099054 ! presynapse assembly
created_by: bc
creation_date: 2016-10-27T16:08:13Z

[Term]
id: GO:1905743
name: calcium import into the mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration
namespace: biological_process
def: "Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474]
subset: goslim_synapse
synonym: "calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration" EXACT [GOC:TermGenie]
synonym: "mitochondrial calcium uptake involved in negative regulation of presynaptic cytosolic calcium concentration" EXACT []
relationship: part_of GO:0099113 ! negative regulation of presynaptic cytosolic calcium concentration
created_by: dosumis
creation_date: 2016-12-06T10:53:17Z

[Term]
id: GO:1905806
name: regulation of synapse pruning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
subset: goslim_synapse
synonym: "regulation of synapse clearance" EXACT []
synonym: "regulation of synapse disassembly" EXACT syngo_official_label []
synonym: "regulation of synapse elimination" EXACT []
synonym: "regulation of synapse removal" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0098883 ! synapse pruning
created_by: tberardini
creation_date: 2017-01-11T22:03:15Z

[Term]
id: GO:1990048
name: anterograde neuronal dense core vesicle transport
namespace: biological_process
def: "The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse." [GOC:kmv, PMID:23358451]
subset: goslim_synapse
synonym: "anterograde dense core granule trafficking" EXACT []
synonym: "anterograde dense core granule transport" EXACT []
is_a: GO:0008089 ! anterograde axonal transport

[Term]
id: GO:1990049
name: retrograde neuronal dense core vesicle transport
namespace: biological_process
def: "The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body." [GOC:kmv, PMID:23358451, PMID:24762653]
subset: goslim_synapse
synonym: "retrograde dense core granule trafficking" EXACT []
synonym: "retrograde dense core granule transport" EXACT []
is_a: GO:0008090 ! retrograde axonal transport
created_by: pr
creation_date: 2013-02-19T13:31:44Z

[Term]
id: GO:2000300
name: regulation of synaptic vesicle exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0098693 ! regulation of synaptic vesicle cycle
relationship: regulates GO:0016079 ! synaptic vesicle exocytosis
created_by: dph
creation_date: 2011-01-03T08:20:40Z

[Typedef]
id: ends_during
name: ends_during
namespace: external
xref: RO:0002093

[Typedef]
id: happens_during
name: happens_during
namespace: external
xref: RO:0002092
is_transitive: true
is_a: ends_during ! ends_during

[Typedef]
id: has_part
name: has_part
namespace: external
xref: BFO:0000051
is_transitive: true

[Typedef]
id: negatively_regulates
name: negatively regulates
namespace: external
xref: RO:0002212
is_a: regulates ! regulates
transitive_over: part_of ! part of

[Typedef]
id: never_in_taxon
name: never_in_taxon
namespace: external
xref: RO:0002161
expand_assertion_to: "Class: ?X DisjointWith: RO_0002162 some ?Y" []
is_metadata_tag: true
is_class_level: true

[Typedef]
id: occurs_in
name: occurs in
namespace: external
xref: BFO:0000066
holds_over_chain: part_of occurs_in
transitive_over: part_of ! part of

[Typedef]
id: part_of
name: part of
namespace: external
xref: BFO:0000050
is_transitive: true
inverse_of: has_part ! has_part

[Typedef]
id: positively_regulates
name: positively regulates
namespace: external
xref: RO:0002213
holds_over_chain: negatively_regulates negatively_regulates
is_a: regulates ! regulates
transitive_over: part_of ! part of

[Typedef]
id: regulates
name: regulates
namespace: external
xref: RO:0002211
is_transitive: true
transitive_over: part_of ! part of

[Typedef]
id: starts_during
name: starts_during
namespace: external
xref: RO:0002091