CYP1ALPHA
label: CYP27B
label: CYP27B1
label: UniProt:O15528 CYP27B1

CYP24
label: CYP24A1
label: UniProt:Q07973 CYP24A1

CYP2R1
label: UniProt:Q6VVX0 CYP2R1

CYP26A2
label: CYP26B1
label: P450RAI2
label: UniProt:Q9NR63 CYP26B1

25-Hydroxylation of vitamin D3 in liver
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: GO_0030343
BFO_0000050: Vitamins
directly activates: BiochemicalReaction2542

Further hydroxylation of calcidiol in kidney to form calcitriol
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004498
BFO_0000050: Vitamins

CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: CYP24
type: GO_0030342
BFO_0000050: Vitamins

CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008401
BFO_0000050: Vitamins

CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP26A2
type: GO_0008401
BFO_0000050: Vitamins

CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008401
BFO_0000050: Vitamins

Vitamins
type: GO_0008150