CPS1
label: UniProt:P31327 CPS1

NAGS
label: UniProt:Q8N159 NAGS

glutamate + acetyl CoA => N-acetyl glutamate + CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: NAGS
type: GO_0004042
BFO_0000050: Urea cycle
directly activates: 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate
directly activates: Catalysis2892
directly activates: Control482
directly activates: Modulation30

2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate
type: Restriction
  on property: enabled by
  some values from: CPS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004087
BFO_0000050: Urea cycle
directly activates: carbamoyl phosphate + ornithine => citrulline + orthophosphate
directly activates: Catalysis2893
label: 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]

carbamoyl phosphate + ornithine => citrulline + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004585
BFO_0000050: Urea cycle
directly activates: ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
directly activates: Catalysis2898

ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004055
BFO_0000050: Urea cycle
directly activates: BiochemicalReaction296
directly activates: argininosuccinate <=> fumarate + arginine
directly activates: Catalysis111
directly activates: Catalysis2895
directly activates: Control14

argininosuccinate <=> fumarate + arginine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004056
BFO_0000050: Urea cycle
directly activates: arginine + H2O => ornithine + urea [ARG1]
directly activates: Catalysis2896

arginine + H2O => ornithine + urea [ARG1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004053
BFO_0000050: Urea cycle
directly activates: ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
directly activates: Catalysis2898

arginine + H2O => ornithine + urea [ARG2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004053
BFO_0000050: Urea cycle

ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0000064
BFO_0000050: Urea cycle
directly activates: BiochemicalReaction5664
directly activates: carbamoyl phosphate + ornithine => citrulline + orthophosphate
directly activates: ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
directly activates: Catalysis2825
directly activates: Catalysis2893
directly activates: Catalysis2894

Urea cycle
type: GO_0008150
label: Urea synthesis