TST
label: UniProt:Q16762 TST

MRDI
label: MRI1
label: UNQ6390/PRO21135
label: UniProt:Q9BV20 MRI1

DIC
label: SLC25A10
label: UniProt:Q9UBX3 SLC25A10

Sulfate is exported to the cytosol in exchange for dicarboxylate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: Restriction
  on property: enabled by
  some values from: DIC
type: GO_0005310
BFO_0000050: Sulfide oxidation to sulfate

MTR transfers CH3 group from MeCbl to HCYS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008705
BFO_0000050: Sulfur amino acid metabolism
directly activates: BiochemicalReaction5600
directly activates: Catalysis2771
label: Methionine is reformed

MTA is cleaved and phosphorylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017061
BFO_0000050: Methionine salvage pathway
directly activates: Methylthio-ribose-P = Methylthio-ribulose-P
directly activates: Catalysis2920

Methylthio-ribose-P = Methylthio-ribulose-P
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0046523
BFO_0000050: Methionine salvage pathway
directly activates: Dehydration of methylthio-ribulose-P
directly activates: Catalysis2922

Methylthio-ribulose-P = Methylthio-ribose-P
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MRDI
type: Restriction
  on property: enabled by
  some values from: MRDI
type: GO_0046523
BFO_0000050: Methionine salvage pathway

Dehydration of methylthio-ribulose-P
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019509
type: GO_0046570
BFO_0000050: Methionine salvage pathway
directly activates: Acireductone is created
directly activates: Catalysis2923

Acireductone is created
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0043874
BFO_0000050: Methionine salvage pathway
directly activates: Acireductone is oxidized to MOB
directly activates: Catalysis2924

Acireductone is oxidized to MOB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0010309
BFO_0000050: Methionine salvage pathway
directly activates: Transamination of MOB to methionine
directly activates: Catalysis2925

Transamination of MOB to methionine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008483
type: GO_0019509
BFO_0000050: Methionine salvage pathway

SAM is sythesized from methionine's reaction with ATP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004478
BFO_0000050: Sulfur amino acid metabolism
directly activates: BiochemicalReaction5755
directly activates: BiochemicalReaction5916
directly activates: BiochemicalReaction5917
directly activates: BiochemicalReaction5918
directly activates: BiochemicalReaction5919
directly activates: Catalysis2911
directly activates: Catalysis3054
directly activates: Catalysis3055
directly activates: Catalysis3056
directly activates: Catalysis3057

S-adenoylhomocysteine is hydrolyzed
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004013
BFO_0000050: Sulfur amino acid metabolism
directly activates: MTR transfers CH3 group from MeCbl to HCYS
directly activates: Remethylation of homocysteine via betaine degradation
directly activates: Cystathionine is formed from homocysteine and serine
directly activates: Catalysis2773
directly activates: Catalysis2953
directly activates: Catalysis2954

Remethylation of homocysteine via betaine degradation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047150
BFO_0000050: Sulfur amino acid metabolism

Cystathionine is formed from homocysteine and serine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004122
BFO_0000050: Cysteine formation from homocysteine
directly activates: Cleavage of cystathionine into cysteine
directly activates: Catalysis2955

Cleavage of cystathionine into cysteine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004123
BFO_0000050: Cysteine formation from homocysteine
directly activates: Cysteine is oxidized
directly activates: Catalysis2960

Glutamate and cysteine combine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004357
BFO_0000050: Sulfur amino acid metabolism
directly activates: BiochemicalReaction5921
directly activates: BiochemicalReaction5922
directly activates: Catalysis3059
directly activates: Catalysis3060
directly activates: Control489

A dipeptidase cleaves cysteinylglycine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004180
BFO_0000050: Sulfur amino acid metabolism
directly activates: Glutamate and cysteine combine
directly activates: BiochemicalReaction5922
directly activates: Catalysis2956
directly activates: Catalysis3060
directly activates: Control489

Homocysteine is degraded to oxobutanoate and H2S
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047982
BFO_0000050: Degradation of cysteine and homocysteine

Cysteine is degraded to serine and H2S
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0080146
BFO_0000050: Degradation of cysteine and homocysteine
directly activates: SQR oxidizes sulfide to bound persulfide
directly activates: Catalysis2965

Cysteine is oxidized
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017172
type: GO_0019448
BFO_0000050: Degradation of cysteine and homocysteine
directly activates: CSAD decarboxylates 3-sulfinoalanine to hypotaurine
directly activates: Catalysis2961

CSAD decarboxylates 3-sulfinoalanine to hypotaurine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004782
BFO_0000050: Degradation of cysteine and homocysteine
directly activates: Oxidation of hypotaurine to taurine
directly activates: Catalysis2962

Oxidation of hypotaurine to taurine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047822
BFO_0000050: Degradation of cysteine and homocysteine

Excess homocysteine yields homolanthionine and H2S
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016846
BFO_0000050: Degradation of cysteine and homocysteine

Excess cysteine yields lanthionine and H2S
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0080146
BFO_0000050: Degradation of cysteine and homocysteine

SQR oxidizes sulfide to bound persulfide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0070224
BFO_0000050: Sulfide oxidation to sulfate
directly activates: Persulfide sulfur is dioxygenated
directly activates: Persulfide sulfur is transferred onto sulfite
directly activates: Catalysis2966
directly activates: Catalysis2967

Persulfide sulfur is dioxygenated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0050313
BFO_0000050: Sulfide oxidation to sulfate
directly activates: Persulfide sulfur is transferred onto sulfite
directly activates: Sulfite is oxidized to sulfate
directly activates: Catalysis2967
directly activates: Catalysis2968

Persulfide sulfur is transferred onto sulfite
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: TST
type: Restriction
  on property: enabled by
  some values from: TST
type: Restriction
  on property: enabled by
  some values from: TST
type: Restriction
  on property: enabled by
  some values from: TST
type: GO_0016783
BFO_0000050: Sulfide oxidation to sulfate
directly activates: Thiosulfate can transfer its sulfate to glutathione

Thiosulfate can transfer its sulfate to glutathione
type: GO_0003674
BFO_0000050: Sulfide oxidation to sulfate

Sulfite is oxidized to sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008482
BFO_0000050: Sulfide oxidation to sulfate
directly activates: Sulfate is exported to the cytosol in exchange for dicarboxylate
directly activates: Thiosulfate can transfer its sulfate to glutathione
directly activates: Catalysis635

Methionine salvage pathway
type: GO_0008150
BFO_0000050: Sulfur amino acid metabolism

Sulfur amino acid metabolism
type: GO_0008150

Cysteine formation from homocysteine
type: GO_0008150
BFO_0000050: Sulfur amino acid metabolism

Degradation of cysteine and homocysteine
type: GO_0008150
BFO_0000050: Sulfur amino acid metabolism

Sulfide oxidation to sulfate
type: GO_0008150
BFO_0000050: Degradation of cysteine and homocysteine