CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
FUR
FURIN
PACE
PCSK3
UniProt:P09958 FURIN
SRC
SRC1
UniProt:P12931-1 SRC
PLC1
PLCG1
UniProt:P19174 PLCG1
Active PLCG1 hydrolyses PIP2
DAG stimulates protein kinase C-delta
p-RAF binds 14-3-3 beta/alpha
Transient dissociation of 14-3-3 upon Ras binding
Stabilisation of RAS:RAF by 14-3-3
Stabilisation of RAF by further phosphorylation
Phosphorylated human RAF1 binds to RAS:GTP complex
Activated RAF1 complex binds MEK
RAF1 phosphorylates MEK1
RAF1 phosphorylates MEK2
Adenylate cyclase produces cAMP
cAMP induces dissociation of inactive PKA tetramers
PKA catalytic subunit translocates to the nucleus
PKA phosphorylates CREB
Dimerisation of CREB
Calmodulin binds CaMK IV
CamKIV enters the nucleus
CaMK IV autophosphorylation
CaMK IV phosphorylates CREB
Calmodulin activates Cam-PDE 1
cAMP hydrolysis by Cam-PDE 1
Inhibition of GRK2 by calmodulin
PKC phosphorylates GRK2
Calcium binds calmodulin
Translocation of PDGF from ER to Golgi
Processing of classical PDGFs
Release of novel PDGFs as latent factors
Extracellular processing of novel PDGFs
PDGF binds to extracellular matrix proteins
PDGF dimer binds two receptors simultaneously
Autophosphorylation of PDGF beta receptors
Autophosphorylation of PDGF alpha receptors
Autophosphorylation of PDGF alpha/beta receptors
PI3-kinase binds to the active receptor
PI3K catalyses the phosphorylation of PIP2 to PIP3
PLC-gamma binds to the active receptor
Phosphorylation of PLCgamma by PDGFR
Activated PLC gamma dissociates from the PDGF receptor
SH2 domain of Src binds to the active receptor
Activation of Src
SHP2 binds to the active receptor
GAP binds to PDGF-beta receptors only
Grb2/Sos1 complex binds to the active receptor
Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos)
STAT binds to the active receptor
Crk binds to the active PDGF receptor
p130Cas and C3G bind PDGFR bound Crk
Nck binds to the active PDGF receptor
Grb7 binds to the active PDGF receptor
PIP3 recruits PDPK1 to the membrane
PIP3 recruits AKT to the membrane
TORC2 (mTOR) phosphorylates AKT at S473
AKT binds PDPK1
PDPK1 phosphorylates AKT at T308
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
Release of calcium from intracellular stores by IP3 receptor activation
PI3K phosphorylates PIP2 to PIP3
AKT phosphorylates BAD
AKT phosphorylates GSK3
AKT phosphorylates caspase-9
AKT phosphorylates MDM2
AKT phosphorylates IKKalpha
AKT phosphorylates p21Cip1 and p27Kip1
AKT phosphorylates TSC2, inhibiting it
AKT phosphorylates AKT1S1 (PRAS40)
AKT translocates to the nucleus
AKT phosphorylates CREB1
AKT can phosphorylate forkhead box transcription factors
AKT can phosphorylate RSK
AKT can phosphorylate NR4A1 (NUR77)
PTEN dephosphorylates PIP3
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
PHLPP dephosphorylates S473 in AKT
PDPK1 binds PIP2
MIR26A microRNAs bind PTEN mRNA
PTEN mRNA translation negatively regulated by microRNAs
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
Signaling by PDGF
Downstream signal transduction
PIP3 activates AKT signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
ERK activation
ERK1 activation
ERK2 activation
RAF/MAP kinase cascade
RAF activation
MEK activation
RAF phosphorylates MEK
DAG and IP3 signaling
CaM pathway
Calmodulin induced events
PKA-mediated phosphorylation of CREB
PKA activation
CaMK IV-mediated phosphorylation of CREB
Cam-PDE 1 activation