Notch 4-ligand complex is cleaved to produce NEXT4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008237
BFO_0000050: Signaling by NOTCH4
directly activates: NEXT4 is cleaved to produce NICD4
directly activates: Catalysis1439

NEXT4 is cleaved to produce NICD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004190
BFO_0000050: Signaling by NOTCH4
directly activates: NICD4 traffics to the nucleus

NICD4 traffics to the nucleus
type: GO_0003674
BFO_0000050: Signaling by NOTCH4

Notch 4 heterodimer binds with a Notch ligand in the extracellular space
type: GO_0003674
BFO_0000050: Signaling by NOTCH4
directly activates: Notch 4-ligand complex is cleaved to produce NEXT4
directly activates: Catalysis560

Signaling by NOTCH4
type: GO_0008150