CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
PRKACB
UniProt:P22694 PRKACB
COT
ESTF
MAP3K8
UniProt:P41279 MAP3K8
TAK1 phosphorylates MKK6
p-RAF binds 14-3-3 beta/alpha
Transient dissociation of 14-3-3 upon Ras binding
Stabilisation of RAS:RAF by 14-3-3
Stabilisation of RAF by further phosphorylation
Phosphorylated human RAF1 binds to RAS:GTP complex
Activated RAF1 complex binds MEK
RAF1 phosphorylates MEK1
RAF1 phosphorylates MEK2
Caspase-1 precursor is cleaved releasing p10 and p20 subunits
Formation of caspase-1 p10/p20 dimer
Caspase-1 active tetramer formation
Interleukin-1 family precursors are cleaved by caspase-1
Interleukin-1 family are secreted
Interleukin-1 receptor type 1 binds Interleukin 1
Interleukin-1 receptor type 2 binds Interleukin 1
IL1 receptor antagonist protein binds Interleukin 1 receptors
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform
IL1R1:IL1:IL1RAP binds MYD88 homodimer
IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4
The Interleukin 1 receptor complex binds Tollip
IRAK4 is activated by autophosphorylation
IRAK1 binds to MYD88 within the IL1R complex
IRAK4 phosphorylates IRAK1
IRAK4-activated IRAK1 autophosphorylates
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation
Hyperphosphorylated IRAK1 associates with TRAF6
p62:MEKK3 binds to TRAF6
TRAF6 binding leads to IRAK1:TRAF6 release
IRAK1 induces oligomerisation of TRAF6
TRAF6 auto-ubiquitinates with Lys63-linked polyubiquitin chains
Polyubiquitinated TRAF6 interacts with TAK1 complex
TAK1 is activated within the TAK1 complex
IRAK1 and 4 interact with Pellino1,2 and 3
IRAK1 and 4 can phosphorylate Pellino-1 and 2.
Pellino ubiquitinates IRAK1
NEMO binds polyubiquitinated IRAK1
The IKKB complex phosphorylates NFkB p105
The SCF betaTrCP complex binds p-NFkB p105
Beta-TrCP ubiquitinates then dissociates from p-NFKB p105
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex
TPL2 phosphorylates MEK1, SEK1
IL2RB associates with JAK1
IL2RG associates with JAK3
Interleukin-2 receptor alpha binds interleukin-2
Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta
Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit
Within the IL-2R complex JAK3 phosphorylates JAK1
JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
Phosphorylation of IL2RB Y338 enables SHC recruitment
Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment
SHC1 bound to IL2 receptor is phosphorylated
Phosphorylated SHC1 recruits GRB2:GAB2
SHC1 mediates cytokine-induced phosphorylation of GAB2
Gab2 binds the p85 subunit of Class 1A PI3 kinases
Phosphorylated SHC recruits GRB2:SOS1
SOS1 activates H-Ras
Phosphorylated SHC1 recruits SHIP
The SHC1:SHIP1 complex is stabilized by GRB2
Recruited STAT5 is phosphorylated
Phosphorylated STAT5 is released
Phosphorylated STAT5 forms dimers
STAT5 dimers translocate to the nucleus and bind to specific DNA sequences
Syk binds IL2RB
SYK is a substrate for JAK1
Pyk2 associates with Jak3
Pyk2 is activated following IL2 stimulation
The common beta chain IL3RB binds JAK2
GM-CSF receptor alpha subunit binds GM-CSF
GM-CSF receptor alpha:GM-CSF binds Bc
Interleukin-5 is a homodimer
Interleukin-5 receptor alpha subunit binds Interleukin-5
Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
Interleukin-3 receptor alpha subunit binds Interleukin-3
Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
The receptor is activated
JAK2 is phosphorylated, activated
STAT5 is recruited by JAK2
Activation of STAT5a/b by JAK2
p-STAT5 is released from the receptor complex
Tyrosine kinases phosphorylate the receptor
Recruitment of SHC1 is mediated by Y593 of the common beta chain
SHC1 bound to the common beta chain becomes tyrosine phosphorylated
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
CBL is tyrosine phosphorylated
CBL ubiquitinates PI3K
CBL binds CRK
CBL:CRKL binds RAPGEF1
CBL binds B-cell linker protein
CBL binds VAV
IL3 stimulation induces Vav binding to Tec kinase
SHP1 and SHP2 bind the common beta chain
SHP1 and SHP2 dephosphorylate Y628 of IL3RB
SHP2 can recruit GRB2
IL3RB is phosphorylated on Ser-585
p-S585-IL3RB binds 14-3-3 proteins
14-3-3 zeta binding allows recruitment of PI3K
JAKs associate with IL6RB (gp130)
Interleukin-6 binds to soluble IL-6 receptor
IL6:sIL6R binds sgp130
Interleukin-6 binds to IL-6 receptor alpha subunit
IL6:sIL6R binds to JAKs:IL6RB (gp130)
IL6:IL6RA binds JAKs:IL6RB (gp130)
Assembly of a hexameric IL-6 receptor
JAK activation
Phosphorylation of gp130
STATs bind gp130 phosphotyrosines
Tyrosine phosphorylation of STATs by IL6 receptor
Serine phosphorylation of STATs
Phosphorylated STATs are released
Phosphorylated STAT1, STAT3 form dimers
STAT1/3 dimers translocate to the nucleus
SHP2 binds gp130 phosphotyrosine-759
SHP2 is phosphorylated
SOCS3 binds gp130
SHP2 binds c-Cbl upon IL-6 stimulation
PPBSF is a complex of IL7 and HGFbeta
IL7RA associates with JAK1
Interleukin-7 binds IL7RA:JAK1
Interleukin-7:IL7RA:JAK1 binds Gc:JAK3
IL7RA is phosphorylated on Y449
p(Y449)-IL7RA mediates STAT5 activation
p85 binds p(Y449)-IL7RA
Activated TAK1 mediates phosphorylation of the IKK Complex
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
ERK activation
ERK1 activation
ERK2 activation
RAF/MAP kinase cascade
RAF activation
MEK activation
RAF phosphorylates MEK
Signaling by Interleukins
Interleukin-1 processing
Interleukin-1 signaling
Interleukin-2 signaling
Interleukin receptor SHC signaling
Interleukin-3, 5 and GM-CSF signaling
Regulation of signaling by CBL
Interleukin-6 signaling
Interleukin-7 signaling