CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
SRC
SRC1
UniProt:P12931-1 SRC
PLC1
PLCG1
UniProt:P19174 PLCG1
PTP2C
PTPN11
SHPTP2
UniProt:Q06124 PTPN11
MKNK1
MNK1
UniProt:Q9BUB5 MKNK1
Active PLCG1 hydrolyses PIP2
DAG stimulates protein kinase C-delta
p-RAF binds 14-3-3 beta/alpha
Transient dissociation of 14-3-3 upon Ras binding
Stabilisation of RAS:RAF by 14-3-3
Stabilisation of RAF by further phosphorylation
Phosphorylated human RAF1 binds to RAS:GTP complex
Activated RAF1 complex binds MEK
RAF1 phosphorylates MEK1
RAF1 phosphorylates MEK2
Adenylate cyclase produces cAMP
cAMP induces dissociation of inactive PKA tetramers
PKA catalytic subunit translocates to the nucleus
PKA phosphorylates CREB
Dimerisation of CREB
Calmodulin binds CaMK IV
CamKIV enters the nucleus
CaMK IV autophosphorylation
CaMK IV phosphorylates CREB
Calmodulin activates Cam-PDE 1
cAMP hydrolysis by Cam-PDE 1
Inhibition of GRK2 by calmodulin
PKC phosphorylates GRK2
Calcium binds calmodulin
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1
FGFR1b binds to FGF
Autocatalytic phosphorylation of FGFR1b
FGFR1c binds to FGF
Autocatalytic phosphorylation of FGFR1c
FGFR2b binds to FGF
Autocatalytic phosphorylation of FGFR2b
FGFR2c binds to FGF
Autocatalytic phosphorylation of FGFR2c
FGFR3b binds to FGF
Autocatalytic phosphorylation of FGFR3b
FGFR3c binds to FGF
Autocatalytic phosphorylation of FGFR3c
FGFR4 binds to FGF
Autocatalytic phosphorylation of FGFR4
FGFR4 binds BetaKlotho-bound FGF19
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4
Autocatalytic phosphorylation of betaKlotho-bound FGFR4
FGFR1c binds to Klotho-bound FGF23
Autocatalytic phosphorylation of Klotho-bound FGFR1c
Activated FGFR binds FRS2alpha
Activated FGFR binds FRS2beta
Phosphorylation of FRS2-alpha by activated FGFR
Phosphorylation of FRS2-beta by activated FGFR
Activated FGFR and FRS2 bind to SHP2
Activated FGFR-alpha:p-FRS2 bind to SHP2
SHP2 is phosphorylated by activated FGFR
GRB2:SOS1 binds to p-FRS2:activated FGFR
Ras nucleotide exchange by GRB2:SOS1 bound to p-FRS2:activated FGFR
Activated FGFR binds PLC-gamma
PLC-gamma phosphorylation by FGFR
Activated PLC gamma release by activated FGFR
Activated FGFR recruits SHC1
SHC1 is phosphorylated
GRB2:SOS1 is recruited to activated FGFR through p-SHC1
Ras nucleotide exchange by GRB2:SOS1 through p-SHC
GRB2:GAB1:PI3Kreg binds directly to p-FRS2:activated FGFR
GRB2:GAB1:PI3Kreg binds to p-SHP2 on p-FRS2:activated FGFR
PI3K catalytic subunit is recruited by FGFR-associated PI3KR1
PI3K catalytic subunit binds to GRB2:GAB1:PI3Kreg (indirect)
FGFR-associated PI3K phosphorylates PIP2 to PIP3
FGFR associated PI3K phosphorylates PIP2 to PIP3
Activated ERK1/2 threonine-phosphorylate FRS2alpha.
p-CBL:GRB2 binds p-FRS2alpha:activated FGFR
CBL ubiquitinates FRS2 and FGFR
PPA2A dephosphorylates SPRY2
SPRY2 translocates to the plasma membrane
SRC phosphorylates SPRY2 on Y55 and Y227
SPRY2 binds GRB2
SPRY2 binds CBL
Phosphorylated SPRY2 is ubiquitinated by CBL
CBL dissociates from ubiquitinated p-SPRY2
SPRY2 is phosphorylated by phosphorylated MNK1
SPRY2 is serine phosphorylated in response to MAPK activation
B-RAF dissociates from S111/S120 p-SPRY2
SHP2 dephosphorylates SPRY2
p-MEK phosphorylates ERK
Dissociation of p-ERK from p-MEK
p-ERK dimerizes
PIP3 recruits PDPK1 to the membrane
PIP3 recruits AKT to the membrane
TORC2 (mTOR) phosphorylates AKT at S473
AKT binds PDPK1
PDPK1 phosphorylates AKT at T308
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
Release of calcium from intracellular stores by IP3 receptor activation
PI3K phosphorylates PIP2 to PIP3
AKT phosphorylates BAD
AKT phosphorylates GSK3
AKT phosphorylates caspase-9
AKT phosphorylates MDM2
AKT phosphorylates IKKalpha
AKT phosphorylates p21Cip1 and p27Kip1
AKT phosphorylates TSC2, inhibiting it
AKT phosphorylates AKT1S1 (PRAS40)
AKT translocates to the nucleus
AKT phosphorylates CREB1
AKT can phosphorylate forkhead box transcription factors
AKT can phosphorylate RSK
AKT can phosphorylate NR4A1 (NUR77)
PTEN dephosphorylates PIP3
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
PHLPP dephosphorylates S473 in AKT
PDPK1 binds PIP2
MIR26A microRNAs bind PTEN mRNA
PTEN mRNA translation negatively regulated by microRNAs
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
PIP3 activates AKT signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
ERK activation
ERK1 activation
ERK2 activation
RAF/MAP kinase cascade
RAF activation
MEK activation
RAF phosphorylates MEK
DAG and IP3 signaling
CaM pathway
Calmodulin induced events
PKA-mediated phosphorylation of CREB
PKA activation
CaMK IV-mediated phosphorylation of CREB
Cam-PDE 1 activation
Fibroblast Growth Factor Receptor (FGFR) signaling
Signaling by FGFR
FGFR ligand binding and activation
FGFR1 ligand binding and activation
FGFR1b ligand binding and activation
FGFR1c ligand binding and activation
FGFR2 ligand binding and activation
FGFR2b ligand binding and activation
FGFR2c ligand binding and activation
FGFR3 ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR4 ligand binding and activation
Klotho-mediated ligand binding
betaKlotho-mediated ligand binding
FGFR1c and Klotho ligand binding and activation
Downstream signaling of activated FGFR
FRS2-mediated cascade
Phospholipase C-mediated cascade
SHC-mediated cascade
PI-3K cascade
Negative regulation of FGFR signaling
Spry regulation of FGF signaling