FARP2
label: KIAA0793
label: PLEKHC3
label: UniProt:O94887 FARP2

GSK3B
label: UniProt:P49841 GSK3B

Dimerization of LIMK1 by Hsp90
type: GO_0003674
BFO_0000050: Sema3A PAK dependent Axon repulsion
directly activates: Transphosphorylation of pLIMK1
directly activates: Catalysis432

Transphosphorylation of pLIMK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Sema3A PAK dependent Axon repulsion
directly activates: Phosphorylation of cofilin by LIMK-1
directly activates: Catalysis433

Phosphorylation of cofilin by LIMK-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Sema3A PAK dependent Axon repulsion

ROCK activation by Rho
type: GO_0003674
BFO_0000050: Sema4D induced cell migration and growth-cone collapse
directly activates: Myosin regulatory light chain phosphorylation by ROCK
directly activates: LIM kinase phosphorylation by ROCK
directly activates: Catalysis3170
directly activates: Catalysis3171

SEMA4D interacts with Plexin-B1:Met
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Sema4D mediated inhibition of cell attachment and migration
directly activates: Active Rac1 interacts with Plexin-B1:Sema4A

Active Rac1 interacts with Plexin-B1:Sema4A
type: GO_0003674
BFO_0000050: Sema4D mediated inhibition of cell attachment and migration
directly activates: Rnd1 interacts with Plexin-B1:Sema4D
label: Active Rac1 interacts with Plexin-B1:Sema4D

Rnd1 interacts with Plexin-B1:Sema4D
type: GO_0003674
BFO_0000050: Sema4D mediated inhibition of cell attachment and migration
directly activates: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
directly activates: p190RhoGAP binds Plexin-B1
directly activates: Catalysis3166

Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005096
BFO_0000050: Sema4D mediated inhibition of cell attachment and migration

p190RhoGAP binds Plexin-B1
type: GO_0003674
BFO_0000050: Sema4D mediated inhibition of cell attachment and migration
directly activates: Inactivation of Rho-GTP by p190RhoGAP
directly activates: Catalysis3167

Inactivation of Rho-GTP by p190RhoGAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005100
BFO_0000050: Sema4D mediated inhibition of cell attachment and migration

SEMA4D interacts with Plexin-B1:ErbB2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Sema4D induced cell migration and growth-cone collapse
directly activates: LARG and PDZ-RhoGEF binds to Plexin-B1

LARG and PDZ-RhoGEF binds to Plexin-B1
type: GO_0003674
BFO_0000050: Sema4D induced cell migration and growth-cone collapse
directly activates: Activation of Rho by LARG and PDZ-RhoGEF
directly activates: Catalysis3169

Activation of Rho by LARG and PDZ-RhoGEF
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005089
BFO_0000050: Sema4D induced cell migration and growth-cone collapse
directly activates: ROCK activation by Rho

Myosin regulatory light chain phosphorylation by ROCK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Sema4D induced cell migration and growth-cone collapse

LIM kinase phosphorylation by ROCK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Sema4D induced cell migration and growth-cone collapse

Plexin-A1-4 binds NRP1
type: GO_0003674
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
directly activates: Sema3A binds Nrp-1 bound to PlexinA

Sema3A binds Nrp-1 bound to PlexinA
type: GO_0003674
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
directly activates: Phosphorylation of Plexin-A
directly activates: Inhibition of integrin activation by sequestering PIP5KIgamma
directly activates: Catalysis3172

Phosphorylation of Plexin-A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
directly activates: Activation of Rac1 by FARP2
directly activates: Catalysis3173

Activation of Rac1 by FARP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: FARP2
type: Restriction
  on property: enabled by
  some values from: FARP2
type: GO_0030676
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
directly activates: Rac1 binds PlexinA

Rac1 binds PlexinA
type: GO_0003674
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
directly activates: Recruitment of Rnd1 to Plexin A

Recruitment of Rnd1 to Plexin A
type: GO_0003674
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
directly activates: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
directly activates: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
directly activates: Catalysis3166
directly activates: Catalysis3174

Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005096
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Inhibition of integrin activation by sequestering PIP5KIgamma
type: GO_0003674
BFO_0000050: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Activation of PAK by Rac1
type: GO_0003674
BFO_0000050: Sema3A PAK dependent Axon repulsion
directly activates: Autophosphorylation of PAK
directly activates: Catalysis3175

Autophosphorylation of PAK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Sema3A PAK dependent Axon repulsion
directly activates: Phosphorylation of LIMK-1 by PAK
directly activates: Catalysis3176

Phosphorylation of LIMK-1 by PAK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Sema3A PAK dependent Axon repulsion
directly activates: Dimerization of LIMK1 by Hsp90

Activation of Fyn
type: GO_0003674
BFO_0000050: CRMPs in Sema3A signaling
directly activates: Recruitment and activation of Cdk5
directly activates: Catalysis3177

Recruitment and activation of Cdk5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: CRMPs in Sema3A signaling
directly activates: Phosphorylation of CRMPs by Cdk5
directly activates: Catalysis3178

Phosphorylation of CRMPs by Cdk5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: CRMPs in Sema3A signaling
directly activates: Phosphorylation of CRMPs by GSK3beta
directly activates: Catalysis3179

Phosphorylation of CRMPs by GSK3beta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GSK3B
type: Restriction
  on property: enabled by
  some values from: GSK3B
type: GO_0004674
BFO_0000050: CRMPs in Sema3A signaling

Tyrosine phosphorylation of CRMPs by Fes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: CRMPs in Sema3A signaling

SEMA3E binds to PLXND1
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA4A binds to PLXND1
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA4D interacts with CD45
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA4D interacts with CD72
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA5A binds to PLXNB3
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA6A binds to PLXNA2 and PLXNA4
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA6D binds to PLXNA1:TREM2:DAP12
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA7A binds to PLXNC1
type: GO_0003674
BFO_0000050: Other semaphorin interactions

SEMA7A binds to integrin alpha1beta1
type: GO_0003674
BFO_0000050: Other semaphorin interactions

Semaphorin interactions
type: GO_0008150

Sema4D in semaphorin signaling
type: GO_0008150
BFO_0000050: Semaphorin interactions

Sema4D mediated inhibition of cell attachment and migration
type: GO_0008150
BFO_0000050: Sema4D in semaphorin signaling

Sema4D induced cell migration and growth-cone collapse
type: GO_0008150
BFO_0000050: Sema4D in semaphorin signaling

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
type: GO_0008150
BFO_0000050: Semaphorin interactions

Sema3A PAK dependent Axon repulsion
type: GO_0008150
BFO_0000050: Semaphorin interactions

CRMPs in Sema3A signaling
type: GO_0008150
BFO_0000050: Semaphorin interactions

Other semaphorin interactions
type: GO_0008150
BFO_0000050: Semaphorin interactions