LIG1
UniProt:P18858 LIG1
UniProt:P30291 WEE1
WEE1
FEN1
RAD2
UniProt:P39748 FEN1
MCM8
UniProt:Q9UJA3 MCM8
Translocation of p21 to the nucleus
Translocation of p27 to the nucleoplasm
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
Association of Cks1 with SCF(Skp2) complex
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
Ubiquitination of phospho-p27/p21
Degradation of ubiquitinated p27/p21 by the 26S proteasome
Formation of Cyclin A:Cdk2 complexes
Translocation of Cyclin A:Cdk2 complexes to the nucleus
Phosphorylation of Cyclin A:Cdk2 at Tyr 15
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
CAK-mediated phosphorylation of Cyclin A:Cdk2
Cyclin A:Cdk2 mediated phosphorylation of p27/p21
Inactivation of Cyclin A:Cdk2 complexes by p27/p21
Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2
Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm
Ubiquitination of Cyclin D1
Proteasome mediated degradation of Cyclin D1
Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2
Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2
CDCA5 (Sororin) enables cohesion of sister chromosomal arms
CDCA5 (Sororin) enables cohesion of sister centromeres
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
Orc1 is phosphorylated by cyclin A/CDK2
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin
Ubiquitinated Orc1 enters the cytosol
Ubiquitinated Orc1 is degraded by the proteasome
Cdc6 protein is phosphorylated by CDK
Phosphorylated Cdc6 is exported from the nucleus
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
Ubiquitinated Cdc6 is degraded by the proteasome
Mcm4,6,7 trimer forms and associates with the replication fork
Rearrangement and mobilization of Mcm2-7
MCM2-7 mediated fork unwinding
MCM8 mediated fork unwinding
Formation of GINS complex
Multiple proteins are localized at replication fork
RFC binding displaces Pol Alpha
Loading of PCNA - Sliding Clamp Formation
RFC dissociates after sliding clamp formation
Formation of Processive Complex
Processive synthesis on the leading strand
Formation of Okazaki fragments
Formation of the Flap Intermediate
RPA binds to the Flap
Recruitment of Dna2 endonuclease
Removal of RNA primer and dissociation of RPA and Dna2
Removal of remaining Flap
Joining of adjacent Okazaki fragments
DNA replication initiation
Switching of origins to a post-replicative state
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
DNA strand elongation
Unwinding of DNA
Leading Strand Synthesis
Polymerase switching
Lagging Strand Synthesis
Processive synthesis on the lagging strand
Removal of the Flap Intermediate
SCF(Skp2)-mediated degradation of p27/p21
S Phase
Cyclin A:Cdk2-associated events at S phase entry
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D1
Establishment of Sister Chromatid Cohesion
Synthesis of DNA
Activation of Cdc25A by c-myc