LIG1
label: UniProt:P18858 LIG1

UniProt:P30291 WEE1
label: WEE1

FEN1
label: RAD2
label: UniProt:P39748 FEN1

C20orf154
label: MCM8
label: UniProt:Q9UJA3 MCM8

Translocation of p21 to the nucleus
type: GO_0003674
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: BiochemicalReaction1840
directly activates: Inactivation of Cyclin A:Cdk2 complexes by p27/p21
directly activates: Catalysis808
directly activates: Catalysis845

Translocation of p27 to the nucleoplasm
type: GO_0003674
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: BiochemicalReaction1840
directly activates: Inactivation of Cyclin A:Cdk2 complexes by p27/p21
directly activates: Catalysis808
directly activates: Catalysis845

Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

Association of Cks1 with SCF(Skp2) complex
type: GO_0003674
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
type: GO_0003674
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: Ubiquitination of phospho-p27/p21
directly activates: Catalysis832

Ubiquitination of phospho-p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: Degradation of ubiquitinated p27/p21 by the 26S proteasome
directly activates: Catalysis833

Degradation of ubiquitinated p27/p21 by the 26S proteasome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004175
BFO_0000050: SCF(Skp2)-mediated degradation of p27/p21
directly activates: BiochemicalReaction1903
directly activates: CAK-mediated phosphorylation of Cyclin A:Cdk2
directly activates: Catalysis838
directly activates: Catalysis843

Formation of Cyclin A:Cdk2 complexes
type: GO_0003674
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Translocation of Cyclin A:Cdk2 complexes to the nucleus

Translocation of Cyclin A:Cdk2 complexes to the nucleus
type: GO_0003674
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Phosphorylation of Cyclin A:Cdk2 at Tyr 15
directly activates: Inactivation of Cyclin A:Cdk2 complexes by p27/p21
directly activates: Catalysis841
directly activates: Catalysis845

Phosphorylation of Cyclin A:Cdk2 at Tyr 15
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
directly activates: Catalysis842

Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: CAK-mediated phosphorylation of Cyclin A:Cdk2
directly activates: Catalysis843

CAK-mediated phosphorylation of Cyclin A:Cdk2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2
directly activates: BiochemicalReaction2015
directly activates: Catalysis846

Cyclin A:Cdk2 mediated phosphorylation of p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry

Inactivation of Cyclin A:Cdk2 complexes by p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004861
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
directly activates: Cyclin A:Cdk2 mediated phosphorylation of p27/p21
directly activates: Catalysis831
directly activates: Catalysis844

Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry

Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Ubiquitin-dependent degradation of Cyclin D1

Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm
type: GO_0003674
BFO_0000050: Ubiquitin-dependent degradation of Cyclin D1

Relocalization of nuclearly localized Cyclin D1 to the cytoplasm
type: GO_0003674
BFO_0000050: Ubiquitin-dependent degradation of Cyclin D1

Ubiquitination of Cyclin D1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Ubiquitin-dependent degradation of Cyclin D1
directly activates: Proteasome mediated degradation of Cyclin D1
directly activates: Catalysis849

Proteasome mediated degradation of Cyclin D1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Ubiquitin-dependent degradation of Cyclin D1

Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0008080
BFO_0000050: Establishment of Sister Chromatid Cohesion
directly activates: CDCA5 (Sororin) enables cohesion of sister chromosomal arms

Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0008080
BFO_0000050: Establishment of Sister Chromatid Cohesion
directly activates: CDCA5 (Sororin) enables cohesion of sister centromeres

CDCA5 (Sororin) enables cohesion of sister chromosomal arms
type: GO_0003674
BFO_0000050: Establishment of Sister Chromatid Cohesion
directly activates: BiochemicalReaction1986
directly activates: Catalysis885

CDCA5 (Sororin) enables cohesion of sister centromeres
type: GO_0003674
BFO_0000050: Establishment of Sister Chromatid Cohesion
directly activates: BiochemicalReaction1990

The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
BFO_0000050: DNA replication initiation
directly activates: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
directly activates: Catalysis6

The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: DNA replication initiation
directly activates: BiochemicalReaction1906
directly activates: RFC binding displaces Pol Alpha

Orc1 is phosphorylated by cyclin A/CDK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Orc1 removal from chromatin
directly activates: Phosphorylated Orc1 is ubiquitinated while still associated with chromatin

Phosphorylated Orc1 is ubiquitinated while still associated with chromatin
type: GO_0003674
BFO_0000050: Orc1 removal from chromatin
directly activates: Ubiquitinated Orc1 enters the cytosol

Ubiquitinated Orc1 enters the cytosol
type: GO_0003674
BFO_0000050: Orc1 removal from chromatin
directly activates: Ubiquitinated Orc1 is degraded by the proteasome
directly activates: Catalysis8

Ubiquitinated Orc1 is degraded by the proteasome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Orc1 removal from chromatin

Cdc6 protein is phosphorylated by CDK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: CDK-mediated phosphorylation and removal of Cdc6
directly activates: Phosphorylated Cdc6 is exported from the nucleus

Phosphorylated Cdc6 is exported from the nucleus
type: GO_0003674
BFO_0000050: CDK-mediated phosphorylation and removal of Cdc6
directly activates: Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
directly activates: Catalysis10

Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: CDK-mediated phosphorylation and removal of Cdc6
directly activates: Ubiquitinated Cdc6 is degraded by the proteasome
directly activates: Catalysis11

Ubiquitinated Cdc6 is degraded by the proteasome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: CDK-mediated phosphorylation and removal of Cdc6

Mcm4,6,7 trimer forms and associates with the replication fork
type: GO_0003674
BFO_0000050: Switching of origins to a post-replicative state
label: Rearrangement and mobilization of Mcm2-7

MCM2-7 mediated fork unwinding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004386
BFO_0000050: Unwinding of DNA

MCM8 mediated fork unwinding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: enabled by
  some values from: C20orf154
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004386
BFO_0000050: Unwinding of DNA

Formation of GINS complex
type: GO_0003674
BFO_0000050: Unwinding of DNA
directly activates: MCM8 mediated fork unwinding
directly activates: Catalysis13

Multiple proteins are localized at replication fork
type: GO_0003674
BFO_0000050: Unwinding of DNA

RFC binding displaces Pol Alpha
type: GO_0003674
BFO_0000050: Polymerase switching
directly activates: Loading of PCNA - Sliding Clamp Formation

Loading of PCNA - Sliding Clamp Formation
type: GO_0003674
BFO_0000050: Polymerase switching
directly activates: RFC dissociates after sliding clamp formation

RFC dissociates after sliding clamp formation
type: GO_0003674
BFO_0000050: Polymerase switching
directly activates: Formation of Processive Complex

Formation of Processive Complex
type: GO_0003674
BFO_0000050: Polymerase switching

Processive synthesis on the leading strand
type: GO_0003674
BFO_0000050: Leading Strand Synthesis

Formation of Okazaki fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Processive synthesis on the lagging strand
directly activates: Formation of the Flap Intermediate

Formation of the Flap Intermediate
type: GO_0003674
BFO_0000050: Processive synthesis on the lagging strand
directly activates: RPA binds to the Flap
directly activates: Removal of the Flap Intermediate

RPA binds to the Flap
type: GO_0003674
BFO_0000050: Removal of the Flap Intermediate
directly activates: Recruitment of Dna2 endonuclease

Recruitment of Dna2 endonuclease
type: GO_0003674
BFO_0000050: Removal of the Flap Intermediate
directly activates: Removal of RNA primer and dissociation of RPA and Dna2

Removal of RNA primer and dissociation of RPA and Dna2
type: GO_0003674
BFO_0000050: Removal of the Flap Intermediate
directly activates: Removal of remaining Flap
directly activates: Catalysis15

Removal of remaining Flap
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0017108
BFO_0000050: Removal of the Flap Intermediate

Joining of adjacent Okazaki fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003909
BFO_0000050: Processive synthesis on the lagging strand

DNA replication initiation
type: GO_0008150
BFO_0000050: Synthesis of DNA

Switching of origins to a post-replicative state
type: GO_0008150
BFO_0000050: Synthesis of DNA

Orc1 removal from chromatin
type: GO_0008150
BFO_0000050: Switching of origins to a post-replicative state

CDK-mediated phosphorylation and removal of Cdc6
type: GO_0008150
BFO_0000050: Switching of origins to a post-replicative state

DNA strand elongation
type: GO_0008150
BFO_0000050: Synthesis of DNA

Unwinding of DNA
type: GO_0008150
BFO_0000050: DNA strand elongation

Leading Strand Synthesis
type: GO_0008150
BFO_0000050: DNA strand elongation

Polymerase switching
type: GO_0008150
BFO_0000050: Leading Strand Synthesis
BFO_0000050: Lagging Strand Synthesis

Lagging Strand Synthesis
type: GO_0008150
BFO_0000050: DNA strand elongation

Processive synthesis on the lagging strand
type: GO_0008150
BFO_0000050: Lagging Strand Synthesis

Removal of the Flap Intermediate
type: GO_0008150
BFO_0000050: Processive synthesis on the lagging strand

SCF(Skp2)-mediated degradation of p27/p21
type: GO_0008150
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry

S Phase
type: GO_0008150

Cyclin A:Cdk2-associated events at S phase entry
type: GO_0008150
BFO_0000050: S Phase

Ubiquitin-dependent degradation of Cyclin D
type: GO_0008150
BFO_0000050: S Phase

Ubiquitin-dependent degradation of Cyclin D1
type: GO_0008150
BFO_0000050: Ubiquitin-dependent degradation of Cyclin D

Establishment of Sister Chromatid Cohesion
type: GO_0008150
BFO_0000050: S Phase

Synthesis of DNA
type: GO_0008150
BFO_0000050: S Phase

Activation of Cdc25A by c-myc
type: GO_0003674
BFO_0000050: Cyclin A:Cdk2-associated events at S phase entry
directly activates: BiochemicalReaction1902
directly activates: Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
directly activates: Catalysis837
directly activates: Catalysis842