ABCC8
label: HRINS
label: SUR
label: SUR1
label: UniProt:Q09428 ABCC8

Rearrangement of the heterotrimeric G(s) complex
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Glucagon-like Peptide-1
directly activates: BiochemicalReaction1770
directly activates: Activation of Adenylyl Cyclase by G(s):GTP

Binding of Glucagon-like Peptide-1 by Glucagon-like Peptide-1 Receptor
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Glucagon-like Peptide-1
directly activates: BiochemicalReaction4341
directly activates: Activation of G(s) by GLP-1R

Activation of Protein kinase C, alpha type by Diacylglycerol
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Acetylcholine
directly activates: Phosphorylation of MARCKS by Protein kinase C, alpha type
directly activates: Catalysis2568
directly activates: TemplateReaction109

Binding of Adrenaline or Noradrenaline by Alpha-2A/2C Adrenergic Receptors
type: GO_0003674
BFO_0000050: Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
directly activates: Activation of Gi/o Heterotrimeric G Proteins by Alpha Adrenergic Receptors Alpha-2A/2C
directly activates: Control418

Activation of Gi/o Heterotrimeric G Proteins by Alpha Adrenergic Receptors Alpha-2A/2C
type: GO_0003674
BFO_0000050: Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
directly activates: Dissociation of Gi/o Heterotrimeric G-protein Complex

Dissociation of Gi/o Heterotrimeric G-protein Complex
type: GO_0003674
BFO_0000050: Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
directly activates: Closing (Inhibition) of L-type Calcium Channels in Pancreatic Beta Cells
directly activates: Opening of Potassium Channels in Pancreatic Beta Cells in Response to Epinephrine
directly activates: Inhibition of Adenylate Cyclase by G-beta:G-gamma
directly activates: Control419
directly activates: Control420

Closing (Inhibition) of L-type Calcium Channels in Pancreatic Beta Cells
type: GO_0003674
BFO_0000050: Inhibition of Insulin Secretion by Adrenaline/Noradrenaline

Opening of Potassium Channels in Pancreatic Beta Cells in Response to Epinephrine
type: GO_0003674
BFO_0000050: Inhibition of Insulin Secretion by Adrenaline/Noradrenaline

Inhibition of Adenylate Cyclase by G-beta:G-gamma
type: GO_0003674
BFO_0000050: Inhibition of Insulin Secretion by Adrenaline/Noradrenaline

Binding of Acetylcholine by Muscarinic Acetylcholine Receptor M3
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Acetylcholine
directly activates: Activation of Gq by Muscarinic Acetylcholine Receptor M3
directly activates: Catalysis2566

Activation of Gq by Muscarinic Acetylcholine Receptor M3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Regulation of Insulin Secretion by Acetylcholine
directly activates: Dissociation of Gq alpha:GTP Complex from G beta:G gamma Complex

Dissociation of Gq alpha:GTP Complex from G beta:G gamma Complex
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Acetylcholine
BFO_0000050: Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
directly activates: Activation of Phospholipase C Beta by Gq alpha

Activation of Phospholipase C Beta by Gq alpha
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Acetylcholine
BFO_0000050: Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
directly activates: Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1
directly activates: Catalysis2567

Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004629
BFO_0000050: Regulation of Insulin Secretion by Acetylcholine
BFO_0000050: Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
directly activates: Activation of Protein kinase C, alpha type by Diacylglycerol
directly activates: IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel

Phosphorylation of MARCKS by Protein kinase C, alpha type
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Regulation of Insulin Secretion by Acetylcholine

Binding of fatty acid ligands by Free fatty acid receptor 1 (GPR40)
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
directly activates: Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex
directly activates: Catalysis2569

Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
directly activates: Dissociation of Gq alpha:GTP Complex from G beta:G gamma Complex

Activation of G(s) by GLP-1R
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Glucagon-like Peptide-1
directly activates: Rearrangement of the heterotrimeric G(s) complex

Activation of Adenylyl Cyclase by G(s):GTP
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Glucagon-like Peptide-1
directly activates: Production of Cyclic AMP by Activated Adenylyl Cyclase
directly activates: Catalysis2570

Production of Cyclic AMP by Activated Adenylyl Cyclase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004016
BFO_0000050: Regulation of Insulin Secretion by Glucagon-like Peptide-1
directly activates: cAMP induces dissociation of active PKA catalytic subunits from the PKA:AKAP79:IQGAP1 Complex
directly activates: Activation of Epac1 by cAMP
directly activates: Activation of Epac2 by cAMP

cAMP induces dissociation of active PKA catalytic subunits from the PKA:AKAP79:IQGAP1 Complex
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Glucagon-like Peptide-1
directly activates: Closing of Potassium voltage-gated channels by PKA
directly activates: Opening of ER calcium channels by activated PKA
directly activates: Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels)
directly activates: Catalysis2573
directly activates: Control421
directly activates: Control422
directly activates: Control425
directly activates: Control426
directly activates: Control427

Closing of Potassium voltage-gated channels by PKA
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Glucagon-like Peptide-1
directly activates: Calcium Influx through Voltage-gated Calcium Channels
directly activates: Catalysis2574

Opening of ER calcium channels by activated PKA
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Glucagon-like Peptide-1
directly activates: Exocytosis of Insulin
directly activates: Catalysis2575
directly activates: Control428
directly activates: Control429
directly activates: Control430
directly activates: Control431

Activation of Epac1 by cAMP
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Glucagon-like Peptide-1
directly activates: Exchange of GDP for GTP by Rap1A
directly activates: Control423
directly activates: Control424

Activation of Epac2 by cAMP
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Glucagon-like Peptide-1
directly activates: Exchange of GDP for GTP by Rap1A
directly activates: Control423
directly activates: Control424

Exchange of GDP for GTP by Rap1A
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion by Glucagon-like Peptide-1

Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005355
BFO_0000050: Regulation of Insulin Secretion

ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0015207
BFO_0000050: Regulation of Insulin Secretion
directly activates: Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels)
directly activates: BiochemicalReaction5430
directly activates: Catalysis2573
directly activates: Control425
directly activates: Control426
directly activates: Control427

Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ABCC8
type: GO_0005524
BFO_0000050: Regulation of Insulin Secretion
directly activates: Calcium Influx through Voltage-gated Calcium Channels
directly activates: Catalysis2574

Calcium Influx through Voltage-gated Calcium Channels
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005245
BFO_0000050: Regulation of Insulin Secretion
directly activates: Exocytosis of Insulin
directly activates: Catalysis2575
directly activates: Control428
directly activates: Control429
directly activates: Control430
directly activates: Control431

Exocytosis of Insulin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0000149
BFO_0000050: Regulation of Insulin Secretion

IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
type: GO_0003674
BFO_0000050: Regulation of Insulin Secretion
directly activates: Release of calcium from intracellular stores by IP3 receptor activation
directly activates: Catalysis272
directly activates: Control50

Release of calcium from intracellular stores by IP3 receptor activation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0005261
BFO_0000050: Regulation of Insulin Secretion
directly activates: BiochemicalReaction242
directly activates: Exocytosis of Insulin
directly activates: BiochemicalReaction717
directly activates: BiochemicalReaction722
directly activates: Catalysis2575
directly activates: Catalysis273
directly activates: Control428
directly activates: Control429
directly activates: Control430
directly activates: Control431
directly activates: Pathway1104

Regulation of Insulin Secretion
type: GO_0008150

Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
type: GO_0008150
BFO_0000050: Regulation of Insulin Secretion

Regulation of Insulin Secretion by Acetylcholine
type: GO_0008150
BFO_0000050: Regulation of Insulin Secretion

Regulation of Insulin Secretion by Free Fatty Acids
type: GO_0008150
BFO_0000050: Regulation of Insulin Secretion

Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
type: GO_0008150
BFO_0000050: Regulation of Insulin Secretion by Free Fatty Acids

Regulation of Insulin Secretion by Glucagon-like Peptide-1
type: GO_0008150
BFO_0000050: Regulation of Insulin Secretion