ABCC8
HRINS
SUR
SUR1
UniProt:Q09428 ABCC8
Rearrangement of the heterotrimeric G(s) complex
Binding of Glucagon-like Peptide-1 by Glucagon-like Peptide-1 Receptor
Activation of Protein kinase C, alpha type by Diacylglycerol
Binding of Adrenaline or Noradrenaline by Alpha-2A/2C Adrenergic Receptors
Activation of Gi/o Heterotrimeric G Proteins by Alpha Adrenergic Receptors Alpha-2A/2C
Dissociation of Gi/o Heterotrimeric G-protein Complex
Closing (Inhibition) of L-type Calcium Channels in Pancreatic Beta Cells
Opening of Potassium Channels in Pancreatic Beta Cells in Response to Epinephrine
Inhibition of Adenylate Cyclase by G-beta:G-gamma
Binding of Acetylcholine by Muscarinic Acetylcholine Receptor M3
Activation of Gq by Muscarinic Acetylcholine Receptor M3
Dissociation of Gq alpha:GTP Complex from G beta:G gamma Complex
Activation of Phospholipase C Beta by Gq alpha
Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1
Phosphorylation of MARCKS by Protein kinase C, alpha type
Binding of fatty acid ligands by Free fatty acid receptor 1 (GPR40)
Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex
Activation of G(s) by GLP-1R
Activation of Adenylyl Cyclase by G(s):GTP
Production of Cyclic AMP by Activated Adenylyl Cyclase
cAMP induces dissociation of active PKA catalytic subunits from the PKA:AKAP79:IQGAP1 Complex
Closing of Potassium voltage-gated channels by PKA
Opening of ER calcium channels by activated PKA
Activation of Epac1 by cAMP
Activation of Epac2 by cAMP
Exchange of GDP for GTP by Rap1A
Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2
ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix
Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels)
Calcium Influx through Voltage-gated Calcium Channels
Exocytosis of Insulin
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
Release of calcium from intracellular stores by IP3 receptor activation
Regulation of Insulin Secretion
Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
Regulation of Insulin Secretion by Acetylcholine
Regulation of Insulin Secretion by Free Fatty Acids
Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
Regulation of Insulin Secretion by Glucagon-like Peptide-1