L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004088
BFO_0000050: Pyrimidine biosynthesis
directly activates: carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate
directly activates: Catalysis2668
label: bicarbonate and glutamine combine to form carbamoyl phosphate

carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004070
BFO_0000050: Pyrimidine biosynthesis
directly activates: N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O
directly activates: Catalysis2669
label: carbamoyl phosphate and L-aspartate combine to form N-Carbamoyl-L-aspartate

N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004151
BFO_0000050: Pyrimidine biosynthesis
directly activates: (S)-dihydroorotate + ubiquinone => orotate + ubiquinol
directly activates: Catalysis2670
label: condensation of N-Carbamoyl-L-aspartate to form (S)-Dihydroorotate (ring closure)

(S)-dihydroorotate + ubiquinone => orotate + ubiquinol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004152
BFO_0000050: Pyrimidine biosynthesis
directly activates: orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate
directly activates: Catalysis2671
label: oxidation of (S)-Dihydroorotate to form Orotate

orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004588
BFO_0000050: Pyrimidine biosynthesis
directly activates: BiochemicalReaction296
directly activates: decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
directly activates: Catalysis111
directly activates: Catalysis2672
directly activates: Control14
label: phosphoribosylation of orotate to form oritidine 5'-phosphate (OMP)

decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004590
BFO_0000050: Pyrimidine biosynthesis
directly activates: BiochemicalReaction5521
directly activates: Catalysis2707
label: orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2

dCMP + H2O => dUMP + NH4+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004132
BFO_0000050: Pyrimidine biosynthesis
directly activates: conversion of dUMP to dTMP
directly activates: BiochemicalReaction5523
directly activates: Catalysis2675
directly activates: Catalysis2709
label: deamination of dCMP to form dUMP

dUTP + H2O => dUMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004170
BFO_0000050: Pyrimidine biosynthesis
directly activates: conversion of dUMP to dTMP
directly activates: Catalysis2675
label: hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate

conversion of dUMP to dTMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004799
BFO_0000050: Pyrimidine biosynthesis
directly activates: BiochemicalReaction5523
directly activates: Catalysis2709
label: dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate

Pyrimidine biosynthesis
type: GO_0008150