ESP1
label: ESPL1
label: KIAA0165
label: UniProt:Q14674 ESPL1

Association of Securin with Cdc20:APC/C complex
type: GO_0003674
BFO_0000050: Separation of Sister Chromatids
directly activates: Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
directly activates: Catalysis895

Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
type: GO_0042787
BFO_0000050: Separation of Sister Chromatids
directly activates: Degradation of multiubiquitinated Securin
directly activates: Catalysis896

Degradation of multiubiquitinated Securin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Separation of Sister Chromatids
directly activates: Autocleavage of ESPL1 (Separase)
directly activates: BiochemicalReaction2033
directly activates: Catalysis897

PTTG1 (Securin) sequesters ESPL1 (Separase)
type: GO_0003674
BFO_0000050: Separation of Sister Chromatids
label: Securin sequesters Separase

Autocleavage of ESPL1 (Separase)
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: enabled by
  some values from: ESP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008234
BFO_0000050: Separation of Sister Chromatids
label: Autocleavage of Separin

ESPL1 (Separase) cleaves centromeric cohesin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008234
BFO_0000050: Separation of Sister Chromatids

Separation of sister chromatids
type: GO_0003674
BFO_0000050: Separation of Sister Chromatids
directly activates: Deacetylation of cleaved cohesin
directly activates: Catalysis899

Deacetylation of cleaved cohesin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004407
BFO_0000050: Separation of Sister Chromatids

ANKLE2 binds VRK1 or VRK2
type: GO_0003674
BFO_0000050: Initiation of Nuclear Envelope Reformation

PP2A dephosphorylates BANF1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004722
BFO_0000050: Initiation of Nuclear Envelope Reformation
directly activates: BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins

BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins
type: GO_0003674
BFO_0000050: Initiation of Nuclear Envelope Reformation

Mitotic Anaphase
type: GO_0008150

Separation of Sister Chromatids
type: GO_0008150
BFO_0000050: Mitotic Anaphase

Nuclear Envelope Reassembly
type: GO_0008150
BFO_0000050: Mitotic Anaphase

Initiation of Nuclear Envelope Reformation
type: GO_0008150
BFO_0000050: Nuclear Envelope Reassembly