PLK
PLK1
UniProt:P53350 PLK1
ESP1
ESPL1
KIAA0165
UniProt:Q14674 ESPL1
GWL
MASTL
THC2
UniProt:Q96GX5 MASTL
Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB
GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi
Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65)
Activation of the Anaphase Promoting Complex (APC) by PLK1
PLK1 phosphorylates GORASP1
MAPK3-3 or MAPK1 phosphorylate GORASP2
GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking
CDK1 phosphorylates MASTL
MASTL (GWL) phosphorylates ARPP19
MASTL phosphorylates ENSA
p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D
CDK1:CCNB phosphorylates NEK9
PLK1 phosphorylates NEK9
NEK9 binds NEK6/NEK7 in the cytosol
NEK9 phosphorylates NEK6/NEK7
CDK1 phosphorylates NUP98
NEK6/NEK7 phosphorylates NUP98
VRK1/VRK2 phosphorylate BANF1
Kinetochore capture of astral microtubules
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms
Phosphorylation of cohesin by PLK1 at chromosomal arms
Resolution of sister chromatids
Deacetylation of cohesin
Kinetochore assembly
CDK1 phosphorylates CDCA5 (Sororin) at centromeres
Phosphorylation of cohesin by PLK1 at centromeres
PP2A-B56 dephosphorylates centromeric cohesin
CK2 phosphorylates condensin I subunits
Dephosphorylation of CK2-modified condensin I
CDK1 phosphorylates condensin I
Phosphorylated condensin I promotes condensation of prometaphase chromosomes
Down Regulation of Emi1 through Phosphorylation of Emi1
Association of Securin with Cdc20:APC/C complex
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
Degradation of multiubiquitinated Securin
PTTG1 (Securin) sequesters ESPL1 (Separase)
Securin sequesters Separase
Autocleavage of ESPL1 (Separase)
Autocleavage of Separin
ESPL1 (Separase) cleaves centromeric cohesin
Separation of sister chromatids
Deacetylation of cleaved cohesin
ANKLE2 binds VRK1 or VRK2
PP2A dephosphorylates BANF1
BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins
Regulation of KIF23 (MKLP1) by phosphorylation
Regulation of KIF20A (MKL2) by phosphorylation
Regulation of NUDC by phosphorylation
Cohesin binds PDS5 and WAPAL
Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2
M Phase
Mitotic Prophase
Golgi Cisternae Pericentriolar Stack Reorganization
MASTL Facilitates Mitotic Progression
Nuclear Envelope Breakdown
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
Clearance of Nuclear Envelope Membranes from Chromatin
Mitotic Prometaphase
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Mitotic Metaphase and Anaphase
Mitotic Metaphase
Mitotic Metaphase/Anaphase Transition
Mitotic Anaphase
Separation of Sister Chromatids
Nuclear Envelope Reassembly
Initiation of Nuclear Envelope Reformation
Mitotic Telophase/Cytokinesis
cell division
Cohesin Loading onto Chromatin