PLA2G6
PLPLA9
UniProt:O60733 PLA2G6
MSK1
RPS6KA5
UniProt:O75582 RPS6KA5
ABL
ABL1
JTK7
UniProt:P00519 ABL1
CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
JTK8
LYN
UniProt:P07948 LYN
PLC1
PLCG1
UniProt:P19174 PLCG1
RNF81
RO52
SSA1
TRIM21
UniProt:P19474 TRIM21
OTUD7C
TNFAIP3
UniProt:P21580 TNFAIP3
CTSS
UniProt:P25774 CTSS
MAPKAPK2
UniProt:P49137 MAPKAPK2
MAP2K6
MEK6
MKK6
PRKMK6
SKK3
UniProt:P52564 MAP2K6
ART1
UniProt:P52961 ART1
PAK1
UniProt:Q13153 PAK1
BMK1
ERK5
MAPK7
PRKM7
UniProt:Q13164 MAPK7
MAP3K1
MAPKKK1
MEKK
MEKK1
UniProt:Q13233 MAP3K1
OTUD5
UniProt:Q96G74 OTUD5
ITCH
UniProt:Q96J02 ITCH
CYLD
CYLD1
HSPC057
KIAA0849
UniProt:Q9NQC7 CYLD
RNF85
TRAF6
UniProt:Q9Y4K3 TRAF6
TLR1:TLR2 is recruited to ligand:CD14
TLR6/2 ligand associates with CD14 and CD36 within lipid rafts
TLR6:TLR2 is recruited to ligand:CD14:CD36
Ficolin-1 binds to molecular patterns on the target cell surface
Ficolin-2 binds to molecular patterns on the target cell surface
Ficolin-3 binds to molecular patterns on the target cell surface
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa
Activation of MASPs
Activation of C1R
Activation of C1S
Conversion of C4 into C4a and C4b
C4b binds to cell surface
Conversion of C2 into C2a and C2b
Formation of Classical C3 convertase (C4b:C2a complex)
Spontaneous hydrolysis of C3 thioester
Factor B binds to C3(H2O)
Factor D cleaves C3(H2O)-bound Factor B
C3(H2O):Factor Bb cleaves C3 to C3b and C3a
C3b binds to cell surface
Factor B binds to surface-associated C3b
Factor D cleaves C3b-bound Factor B
Properdin stabilizes C3b:Bb bound to cell surfaces
Formation of alternative pathway C5 convertase
Formation of C5b:C6 complex
Formation of C5b:C6:C7 complex
C7 allows complex to insert into membrane under attack
Formation of C5b:C6:C7:C8 complex
Creation of the Membrane Attack Complex (MAC)
Cleavage of C3 by C3 convertases
Formation of classic pathway C5 convertase
Activation of C5
C3 convertases spontaneously dissociate
Factor H binds to C3b
Factor H binds host cell surface markers
Factor H binds to membrane-associated C3b
Factor H binds to C3bBb
Factor H displaces Bb
Complement factor I complex formation
Complement factor I binds to extracellular Factor H:C3b
Factor I inactivates plasma Factor H-bound C3b
Complement factor I binds to membrane-associated Factor H:C3b
Factor I inactivates Factor H-boundC3b
iC3b proteolysis
CR1 binds C3bBb/C4bC2a
Displacement of C2a/Bb by CR1
MCP binds C3b, C4b
Complement factor I binds to MCP, CR1:C4b, C3b
Factor I inactivates MCP/CR1-bound C4b/C3b
DAF binds C3bBb, C4bC2a
DAF accelerates C3bBb/C4bC2a dissociation
C4b-binding protein binds C4b
Complement factor I binds C4BP
Complement factor I inactivates C4BP-bound C4b
C4b binding protein binds C4bC2a
C4b binding protein displaces C2a
C4b binding protein binds Protein S
CD59 inhibits MAC formation
Formation of soluble VTN:C5b-C9
Vitronectin(VTN) binds to C5b:C6:C7
Hydrolysis of internal thioester in C4b
iE-DAP elicits a NOD1 response
MDP elicits a NOD2 response
Activated NOD1 oligomerizes
Activated NOD2 oligomerizes
Activated NOD oligomer recruites RIP2 (RICK)
RIP2 binds NEMO
RIP2 induces K63-linked ubiquitination of NEMO
CYLD deubiquitinates NEMO
RIP2 is K63 polyubiquitinated
A20 deubiquitinates RIP2
K63 polyubiquitinated RIP2 associates with the TAK1 complex
TAK1 is activated
TAK1 phosphorylates MKK6
NOD1 induced apoptosis is mediated by RIP2 and CARD8
CARD9 binds RIP2 (and NOD2)
Activation of p38 MAPK
ATP binds to P2X7
P2X7 forms oligomeric non-selective cation channels
P2X7 mediates loss of intracellular K+
P2X7 mediates membrane pores that include pannexin-1
SGT1 binds HSP90
SGT1:HSP90 binds inactive NLRP3
TXNIP binds reduced thioredoxin
ROS oxidize thioredoxin
TXNIP is released from oxidized thioredoxin
TXNIP binds NLRP3
NLRP3 activation by small molecules
NLRP3 activation by elicitor proteins
NLRP3 oligomerizes via NACHT domains
ASC is recruited via a PYD-PYD interaction
The CARD domain of ASC recruits Procaspase-1
PSTPIP1 binds Pyrin
Pyrin binds ASC
Bcl-2 and Bcl-XL bind NLRP1
NLRP1 senses MDP
MDP:NLRP1 binds ATP
NLRP1 oligomerizes
IPAF is activated
IPAF binds procaspase-1
AIM2 binds dsDNA
AIM2 oligomerizes
dsDNA:AIM2 clusters bind ASC
dsDNA:AIM2:ASC cluster binds procaspase-1
The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B
Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor
AGER binds ERK1/2
AGER-1,2,3 bind AGEs
dsRNA binds to RIG-I
K-63-linked polyubiquitination of RIG-I
dsRNA binds to MDA5
RIG-I/MDA5 interacts with IPS-1
Recruitment of TRAF3 to IPS-1
TBK1/IKK epsilon complex interacts with IPS-1 bound TRAF3
Recruitment of IRF3/7Â
Phosphorylation and release of IRF3/IRF7
Dimerization of Phospho IRF3 or phospho IRF7
Translocation of phosphorylated IRF3/7 dimers into nucleus
Interaction of CBP/p300 with p-IRF3 dimer
IRF3:CBP/p300 complex binds the promoters of IFN-beta
IPS-1 interacts with RIP-1 and FADD
Recruitment of caspase-8 and -10 to FADD complex
Dimerzation of procaspase-8/10
Processing of caspases
Recruitment of IKK complex
Recruitment of TRAF6/TRAF2 to IPS-1
Recruitment of TANK to TRAF6
Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
Recruitment of IRF7 to TRAF6
Phosphorylation and release of IRF7
p-IRF7 dimer interacts with coactivator CBP/p300
Formation of VAF (virus-activated factor) complex
VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes
Interaction of MEKK1 with TRAF6
Activation of IKK by MEKK1
RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1
Interaction of PIN1 with p-IRF3
PIN1 mediated IRF3 degradation
Inhibition of RIG-I/MDA5 signaling by ATG5-ATG12 conjugate
CYLD mediated deubiquitination of RIG-I
Negative regulation of RIG-I/MDA5 signaling by DUBA
Negative regulation of RIG-I/MDA5 signaling by TRIAD3A
NLRX1 inhibits IPS-1-RIG-I interaction.
ISGylation of RIG-I
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination
NLRC5 interacts with RIG-I/MDA5 and inhibit IPS-1 binding
Interaction of PCBP2 with MAVS/IPS-1
Recruitment of AIP4 and K-48 ubiquitination of MAVS/IPS-1
Pre-pro-defensins are cleaved to remove the signal peptide
Pro-HNP1-4 are cleaved to biologically active defensin
HNP1-4 are stored in primary neutrophil granules
HNP1-4 are released into phagocytic vacuoles
pro-defensin alpha 5 is stored in Paneth cell granules
pro-defensin alpha 5 is secreted
pro-HD5 is cleaved by trypsin
Alpha-defensins form biologically active dimers
Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids
Alpha-defensin dimers multimerize to form a pore complex
HNP1-3 bind gp120
HNP1-3 bind CD4
ADP-Ribosylation of HNP-1
Beta-defensins are secreted
Beta-defensins bind microbial membranes causing disruption
Beta-defensins 1, 4A and 103 bind CCR6
Beta-defensins 4A and 103 bind CCR2
Beta defensin 103 activates TLR1:TLR2
Binding of defensins to lipid II
ZBP1 binds cytosolic DNA
Recruitment TBK1 to dsDNA:ZBP1 followed by its activation
Recruitment of IRF3 to activated ZBP1:TBK1
Phosphorylation and release of IRF3
p-T,4S-IRF3 is dimerized
Dimerized phospho-IRF3 migrates to the nucleus
ZBP1(DAI) recruits RIP1 and RIP3
RIP1 facilitates IKK complex phosphorylation
cGAS binds cytosolic DNA
cGAS produces cyclic GMP-AMP
IFI16 binds cytosolic dsDNA
DDX41 binds dsDNA or c-di-NMP
STING dimerization
STING binds c-di-GMP
STING binds cyclic GMP-AMP
STING recruits TBK1 and IRF3
TBK1 is phosphorylated within STING:TBK1:IRF3 complex
IRF3 is phosphorylated by TBK1
STING recruits TBK1 and STAT6
TBK1 is phosphorylated within STING:TBK1:STAT6 complex
TBK1 phosphorylates STAT6 at Ser407
p-S407-STAT6 is phosphorylated at Tyr641
p-S407,Y641-STAT6 is dimerized
p-S407,Y641-STAT6 dimer migrates to the nucleus
RNA polymerase III transcribes microbial dsDNA to dsRNA
LRR FLII-interacting protein 1 binds dsDNA
LRR FLII-interacting protein 1 associates with beta-catenin
Phosphorylation of beta-catenin at Ser552
Beta-catenin migrates to the nucleus
Beta-catenin enhances association of IRF3 with CBP/p300
DHX36 binds DNA
DHX9 binds DNA
DHX36 or DHX9 binds MyD88
DNA-PK binds microbial dsDNA
MRE11 binds cytosolic DNA
DDX41 ubiquitination by TRIM21
STING binds TRIM32 or TRIM56
STING ubiquitination by TRIM32 or TRIM56
NLRP4 and DTX4 associate with p-S172-TBK1
p-S172-TBK1 is ubiquitinated by DTX4
TREX1 binds retroviral-derived DNA
Viral DNA cleavage by TREX1
Cross-linking of FCGRIA with IgG-coated Ag
Cross-linking of FCGRIIA with IgG-coated Ag
Cross-linking of FCGRIIIA with IgG-coated Ag
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts
Recruitment of SYK to phosphorylated ITAMs
Phosphorylation of SYK by Src kinases
Recruitment of VAV1 to p-6Y-SYK
Phosphorylation of VAV
Activation of RAC1 by VAV
Recruitment of CRKII:DOCK180:ELMO complex to FCGR
Activation of RAC1 by CRKII:DOCK180:ELMO
WAVE Regulatory Complex (WRC) interacts with RAC1 and PIP3 and gets activated
ERK2 phosphorylates WAVE2 and ABI
ABL phosphorylates WAVE2
Activation of CDC42 by unknown mechanism
Activation of WASP and N-WASP by CDC42
Activation of WASP/N-WASP by WIP family and SH3 domain proteins
Phosphorylation of WASP/N-WASP
WAVE2 or WASP/N-WASP activate the ARP2/3 complex
Attachment of preexisting mother filament and initiation of branching
Detachment of WASP/WAVE
Branching and elongation of mother and daughter filaments
RAC and CDC42 activate PAK
Autophosphorylation of PAK1
Phosphorylation of LIMK1 by PAK
Dimerization of LIMK1 by Hsp90
Transphosphorylation of pLIMK1
Phosphorylation of cofilin by LIMK-1
Extension of pseudopodia by myosin-X in a PI3K dependent manner
Role of myosins in phagosome formation
PI3K binds to p-6Y-SYK
PI3K phosphorylates PIP2 to PIP3
Recruitment of PLCgamma to membrane
Phosphorylation and activation of PLCG
Release of PLCG from FCGR
Active PLCG1 hydrolyses PIP2
DAG stimulates protein kinase C-delta
Hydrolysis of PC to PA by PLD
Conversion of PA into DAG by PAP-1
Production of AA by iPLA2 upon FCGR activation
Dimerization of DAP12
Interaction of DAP12 and KIR2DS1
Interaction of DAP12 and KIR2DS2
Interaction of DAP12 and KIR2DS4
Interaction of DAP12 and KIR2DS5
Interaction of DAP12 and KIR3DS1
Interaction of DAP12 and MDL-1
DAP12 interacts with NKG2C
Interaction of DAP12 and NKG2D
Interaction of DAP12 and NKp44
Interaction of DAP12 and SIRP beta
Interaction of DAP12 and TREM1
Interaction of DAP12 and TREM2
Interaction of SIGLEC14/15/16 and DAP12
Interaction of DAP12 and IREM2
Interaction of DAP12 and CLM7
Phosphorylation of DAP12
Recruitment of SYK to p-DAP12
Phosphorylation of SYK
p85 regulatory unit of PI3K binds p-6Y-SYK
Phosphorylation of LAT by p-SYK
Recruitment of GRB2:SOS to p-5Y-LAT
Recruitment of GADS:SLP-76 to p-5Y-LAT
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
SOS mediated nucleotide exchange of RAS (SHC)
p-RAF binds 14-3-3 beta/alpha
Transient dissociation of 14-3-3 upon Ras binding
Stabilisation of RAS:RAF by 14-3-3
Stabilisation of RAF by further phosphorylation
Phosphorylated human RAF1 binds to RAS:GTP complex
Activated RAF1 complex binds MEK
RAF1 phosphorylates MEK1
RAF1 phosphorylates MEK2
Phosphorylation of SLP-76 by p-SYK
Recruitment of VAV and BTK to p-SLP-76
Phosphorylation of BTK by p-SYK
Phosphorylation of PLC-gamma by p-BTK/p-SYK
Release of p-PLCG1
Adenylate cyclase produces cAMP
cAMP induces dissociation of inactive PKA tetramers
PKA catalytic subunit translocates to the nucleus
PKA phosphorylates CREB
Dimerisation of CREB
Calmodulin binds CaMK IV
CamKIV enters the nucleus
CaMK IV autophosphorylation
CaMK IV phosphorylates CREB
Calmodulin activates Cam-PDE 1
cAMP hydrolysis by Cam-PDE 1
Inhibition of GRK2 by calmodulin
PKC phosphorylates GRK2
Phosphorylation and activation of VAV2/VAV3 by SYK
Activation of RAC1 by VAV2/3
Allergen dependent IgE bound FCERI aggregation
Autophosphorylation of LYN kinase
Phosphorylation of beta and gamma subunits by LYN
Recruitment of SYK to p-FCERI gamma subunit
Phosphorylation of SHC by SYK kinase
Interaction of GRB2:SOS complex with p-SHC1
Recruitment of VAV to p-SLP-76
Phosphorylation and activation of VAV
Recruitment of PAK to the membrane by binding active RAC1
Autophosphorylation of PAK
Autophosphorylation and activation of MEKK1
Phosphorylation of MEK4 by MEKK1
Phosphorylation of MEK7 by MEKK1
Recruitment of TEC kinases to p-SLP-76
Phosphorylation of TEC kinases by p-SYK
Autophosphorylation of BTK/ITK
Phosphorylation of PLC-gamma
Hydrolysis of PIP2 by PLCG
Activation of Calcineurin
Calcineurin binds and dephosphorylates NFAT
Translocation of CaN:CaM:NFAT to nucleus
RasGRP interacts with DAG and Ca2+
DAG recruits PKC-theta to plasma membrane
Phosphorylation of PKC-theta
Autophosphorylation of PKC-theta
Phosphorylation of CARMA1 by PKC-theta
Oligomerization of p-CARMA1
Interaction of BCL10:MALT1 with CARMA1 to form CBM complex
Oligomerization of BCL10 and MALT1
Recruitment of TRAF6 to CBM complex by binding to MALT1
Oligomerization of TRAF6
Auto-ubiquitination of TRAF6
Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
Activation of TAK1 complex bound to pUb-TRAF6
Phosphorylation of IKK-beta by TAK1
Released NF-kB complex is transported to the nucleus
Phosphorylation of NTAL by p-SYK/Lyn
Recruitment of GRB2:SOS to p-10Y-NTAL
Recruitment of GAB2 to PM and FCERI by binding to GRB2
Phoshorylation of GAB2 by SYK/FYN
PI3K associates with phosphorylated GAB2
Phosphorylation of PIP2 to PIP3 by PI3K
Calcium binds calmodulin
Translocation of PDK1 to Plasma membrane
Ubiquitination of NEMO by TRAF6
Activation of NF-kB complex
PIP3 recruits PDPK1 to the membrane
PIP3 recruits AKT to the membrane
TORC2 (mTOR) phosphorylates AKT at S473
AKT binds PDPK1
PDPK1 phosphorylates AKT at T308
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
Release of calcium from intracellular stores by IP3 receptor activation
AKT phosphorylates BAD
AKT phosphorylates GSK3
AKT phosphorylates caspase-9
AKT phosphorylates MDM2
AKT phosphorylates IKKalpha
AKT phosphorylates p21Cip1 and p27Kip1
AKT phosphorylates TSC2, inhibiting it
AKT phosphorylates AKT1S1 (PRAS40)
AKT translocates to the nucleus
AKT phosphorylates CREB1
AKT can phosphorylate forkhead box transcription factors
AKT can phosphorylate RSK
AKT can phosphorylate NR4A1 (NUR77)
PTEN dephosphorylates PIP3
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
PHLPP dephosphorylates S473 in AKT
PDPK1 binds PIP2
MIR26A microRNAs bind PTEN mRNA
PTEN mRNA translation negatively regulated by microRNAs
TLR folding by chaperones GP96 and CNPY3
Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex
Full-length TLR3/7/8/9 binds to UNC93B1
Endosomal TLRs pass through the Golgi
UNC93B1 delivers endosomal full-length TLRs to endolysosome
TLR processing at low pH
TLR9 processing at neutral pH
Ligand binds to TLR10
MyD88 forms a complex with the activated TLR receptor
MyD88 oligomerization within the complex of activated TLR:MyD88
IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor
IRAK4 autophosphorylation within the complex activated TLR:MyD88
IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex
Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR
TRAF6 binds to hp- IRAK1 or p-IRAK2
Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex
Pellino binds hp-IRAK1:TRAF6
IRAK1 phosphorylates Pellino
Pellino ubiquitinates hp-IRAK1
NEMO subunit of IKK complex binds to activated IRAK1
IRAK2 induces TRAF6 oligomerization
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2
Activated TRAF6 synthesizes unanchored polyubiquitin chains
Activated TRAF6:p-IRAK2 interacts with TAK1 complex
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
TRAF6 binds MEKK1
Activated TAK1 mediates phosphorylation of the IKK Complex
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex
Released NFkB complex is transported to nucleus
Activated TAK1 phosphorylates MKK4/MKK7
Phosphorylation of human JNKs by activated MKK4/MKK7
Activated human JNKs migrate to nucleoplasm
activated human TAK1 phosphorylates MKK3/MKK6
phosphorylated MKK3/MKK6 migrates to nucleus
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
Active p38 MAPK phosphorylates MAPKAPK2 or 3
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
ERK1/2 activates ELK1
ERK1/2 phosphorylates MSK1
p38MAPK phosphorylates MSK1
ERK1/2/5 activate RSK1/2/3
ERK5 activates the transcription factor MEF2
ERKs are inactivated by protein phosphatase 2A
ERKs are inactivated by dual-specific phosphatases (DUSPs)
MSK1 activates CREB
MSK1 activates ATF1
RSK1/2/3 phosphorylates CREB at Serine 133
MAPKAPK2 phosphorylates CREB at Serine 133
Phosphorylated MAPKs phosphorylate ATF-2
Activated JNKs phosphorylate c-JUN
c-FOS activation by phospho ERK1/2
Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.
Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
Viral dsRNA binds the Toll-Like Receptor 3 (TLR3)
TRAM:TLR4:MD2:LPS:CD14 recruits TRIF (TICAM1)
Viral dsRNA:TLR3 recruits TRIF (TICAM1)
Negative regulator SARM binds to TRIF
TRAF3 binds to TRIF:activated TLR3/4 complex
Auto-ubiquitination of TRAF3
Recruitment of TBK1/IKK epsilon to K63-poly-Ub-TRAF3:TRIF:activated TLR3/TLR4 followed by their phosphorylation
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
Dimerization of phosphorylated IRF3/IRF7
Dimerized phospho-IRF3/IRF7 is transported to the nucleus
TRIF:activated TLR3/TLR4 complex recruits RIP1
K63-linked ubiquitination of RIP1 bound to the activated TLR complex
Nemo subunit of IKK complex binds polyubiquinated RIP1
TLR3/4-induced ripoptosome assembly
Caspase-8 processing
RIP3 binds TRIF to mediate necroptosis
Activated TLR3/4:TRIF recruits TRAF6
Auto ubiquitination of TRAF6 bound to the activated TLR complex
Activated TLR:TRIF:K63-pUb-TRAF6 recruits TAK1complex
Activation of TAK1 complex bound to activated TLR
Phosphorylated TAK1 leaves activated TLR receptor complex
Flagellin binds to TLR5
Ligand binds to TLR7 or TLR8
MyD88 interacts with the activated TLR receptor 7, 8 or 9
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9.
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation
IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
Dimerization of p-IRF7
Translocation of p-IRF7:p-IRF7 to nucleus
Engulfed CpG DNA binds to endosomal full-length TLR9
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer
Engulfed CpG DNA binds to endosomal C-ter TLR9
Rab5-mediated recruitment of class III PI3K to TLR9
Association of LBP with LPS
GPI-bound CD14 binds LPS
Secreted CD14 binds LPS
Transfer of LPS onto TLR4
CD14:LPS binds CR3
MAL(TIRAP) binds PIP2-rich regions in the plasma membrane
Endocytosis of TLR4:MD2:LPS:CD14
Endocytosis of TRAM (TICAM2)
TLR4:MD2:LPS:CD14 recruits TRAM (TICAM2)
Activated TLR2/4 interacts with MAL(TIRAP)
Activated TLR2/4:MAL interacts with BTK
MAL is phosphorylated by BTK
MyD88 forms a complex with MAL:activated TLR2/4
MyD88 oligomerization within the complex of activated TLR:Mal:MyD88
IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:Mal
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:Mal complex
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
Multiple IRAK1 autophosphorylation steps
TRAF6 binds to hp- IRAK1
TRAF6 binds to p-IRAK2
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex
TLR1/2 ligand binds to CD14
PIP3 activates AKT signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
Innate Immune System
Toll-Like Receptors Cascades
Trafficking and processing of endosomal TLR
Toll Like Receptor 10 (TLR10) Cascade
MyD88 cascade initiated on plasma membrane
IRAK1 recruits IKK complex
IRAK2 mediated activation of TAK1 complex
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
MAP kinase activation in TLR cascade
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
activated TAK1 mediates p38 MAPK activation
ERK activation
ERK1 activation
ERK2 activation
MAPK targets/ Nuclear events mediated by MAP kinases
ERK/MAPK targets
ERKs are inactivated
CREB phosphorylation
Activation of the AP-1 family of transcription factors
Toll Like Receptor 3 (TLR3) Cascade
MyD88-independent cascade
TRIF-mediated TLR3/TLR4 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRIF-mediated programmed cell death
TRAF6 mediated induction of TAK1 complex
Toll Like Receptor 5 (TLR5) Cascade
Toll Like Receptor 7/8 (TLR7/8) Cascade
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Toll Like Receptor 9 (TLR9) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Transfer of LPS from LBP carrier to CD14
Activated TLR4 signalling
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor 2 (TLR2) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Complement cascade
Initial triggering of complement
Creation of C4 and C2 activators
Lectin pathway of complement activation
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Classical antibody-mediated complement activation
Alternative complement activation
Terminal pathway of complement
Activation of C3 and C5
Regulation of Complement cascade
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
NOD1/2 Signaling Pathway
Inflammasomes
The NLRP3 inflammasome
The NLRP1 inflammasome
The IPAF inflammasome
The AIM2 inflammasome
Advanced glycosylation endproduct receptor signaling
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
TRAF3-dependent IRF activation pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
Negative regulators of RIG-I/MDA5 signaling
Defensins
Alpha-defensins
Beta defensins
Cytosolic sensors of pathogen-associated DNA
ZBP1(DAI) mediated induction of type I IFNs
IRF3 mediated activation of type 1 IFN
RIP-mediated NFkB activation via ZBP1
STING mediated induction of host immune responses
IRF3-mediated induction of type I IFN
STAT6-mediated induction of chemokines
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Regulation of innate immune responses to cytosolic DNA
Regulation by TREX1
Fcgamma receptor (FCGR) dependent phagocytosis
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 interactions
DAP12 signaling
RAF/MAP kinase cascade
RAF activation
MEK activation
RAF phosphorylates MEK
DAG and IP3 signaling
CaM pathway
Calmodulin induced events
PKA-mediated phosphorylation of CREB
PKA activation
CaMK IV-mediated phosphorylation of CREB
Cam-PDE 1 activation
Fc epsilon receptor (FCERI) signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
Role of LAT2/NTAL/LAB on calcium mobilization
Expression of IFN-beta
Expression of Interferon-alpha and beta