UniProt:P15498 VAV1
label: VAV
label: VAV1

PLCG2
label: UniProt:P16885 PLCG2

UniProt:P52735 VAV2
label: VAV2

UniProt:Q9UKW4 VAV3
label: VAV3

Fyn/Lyn-mediated phosphorylation of FcR1 gamma
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: GPVI-mediated activation cascade
directly activates: Binding of Syk tyrosine kinase

Binding of Syk tyrosine kinase
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: Syk autophosphorylates
directly activates: Syk/Lck phosphorylate LAT
directly activates: Syk activation leads to SLP-76 activation
directly activates: Catalysis1020
directly activates: Catalysis1025

Syk autophosphorylates
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004715
BFO_0000050: GPVI-mediated activation cascade
directly activates: Syk is released
directly activates: GPVI stimulates PI3K beta, gamma

Syk is released
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: Syk binds Vav

Syk binds Vav
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: Syk phosphorylates Vav
directly activates: Catalysis1021

Syk phosphorylates Vav
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004715
BFO_0000050: GPVI-mediated activation cascade
directly activates: VAV1 is a GEF for Rho/Rac family kinases
directly activates: VAV2 is a GEF for Rho/Rac family kinases
directly activates: VAV3 is a GEF for Rho/Rac family kinases
directly activates: PIP3 stimulates Vav
directly activates: PIP2 inhibits Vav
directly activates: Catalysis1022
directly activates: Catalysis1023
directly activates: Catalysis1024

VAV1 is a GEF for Rho/Rac family kinases
type: Restriction
  on property: enabled by
  some values from: UniProt:P15498 VAV1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: GPVI-mediated activation cascade

VAV2 is a GEF for Rho/Rac family kinases
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: GPVI-mediated activation cascade
directly activates: BiochemicalReaction4379

VAV3 is a GEF for Rho/Rac family kinases
type: Restriction
  on property: enabled by
  some values from: UniProt:Q9UKW4 VAV3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: GPVI-mediated activation cascade
directly activates: BiochemicalReaction4379

Syk/Lck phosphorylate LAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: GPVI-mediated activation cascade

Syk activation leads to SLP-76 activation
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: SLP-76 stimulates PLC gamma 2
directly activates: p-SLP-76 binds VAV
directly activates: BiochemicalReaction649

SLP-76 stimulates PLC gamma 2
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: PLC gamma 2-mediated PIP2 hydrolysis
directly activates: Catalysis1026

p-SLP-76 binds VAV
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade

PLC gamma 2-mediated PIP2 hydrolysis
type: Restriction
  on property: enabled by
  some values from: PLCG2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004629
BFO_0000050: GPVI-mediated activation cascade
directly activates: BiochemicalReaction2349
directly activates: BiochemicalReaction2350
directly activates: BiochemicalReaction2351
directly activates: BiochemicalReaction2352
directly activates: BiochemicalReaction2353
directly activates: BiochemicalReaction2355
directly activates: BiochemicalReaction2356
directly activates: BiochemicalReaction715
directly activates: Catalysis1036
directly activates: Catalysis1038
directly activates: Control159

PIP3 stimulates Vav
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: VAV1 is a GEF for Rho/Rac family kinases
directly activates: VAV2 is a GEF for Rho/Rac family kinases
directly activates: VAV3 is a GEF for Rho/Rac family kinases
directly activates: Catalysis1022
directly activates: Catalysis1023
directly activates: Catalysis1024

PIP2 inhibits Vav
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: VAV1 is a GEF for Rho/Rac family kinases
directly activates: VAV2 is a GEF for Rho/Rac family kinases
directly activates: VAV3 is a GEF for Rho/Rac family kinases
directly activates: Catalysis1022
directly activates: Catalysis1023
directly activates: Catalysis1024

GPVI stimulates PI3K beta, gamma
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: PI3K alpha, beta, gamma convert PIP2 to PIP3
directly activates: Catalysis1027

PI3K alpha, beta, gamma convert PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0046934
BFO_0000050: GPVI-mediated activation cascade
directly activates: PIP3 stimulates Vav
directly activates: PIP2 inhibits Vav
directly activates: PIP3 recruits PDK1 and AKT to the membrane
directly activates: BiochemicalReaction679
directly activates: BiochemicalReaction680
directly activates: Control158

PIP3 recruits PDK1 and AKT to the membrane
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: PDK1 binds PKC zeta

PDK1 binds PKC zeta
type: GO_0003674
BFO_0000050: GPVI-mediated activation cascade
directly activates: PDK1 activates PKC zeta
directly activates: Catalysis1028

PDK1 activates PKC zeta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004676
BFO_0000050: GPVI-mediated activation cascade

GPVI-mediated activation cascade
type: GO_0008150