UniProt:P15498 VAV1
VAV
VAV1
PLCG2
UniProt:P16885 PLCG2
UniProt:P52735 VAV2
VAV2
UniProt:Q9UKW4 VAV3
VAV3
Fyn/Lyn-mediated phosphorylation of FcR1 gamma
Binding of Syk tyrosine kinase
Syk autophosphorylates
Syk is released
Syk binds Vav
Syk phosphorylates Vav
VAV1 is a GEF for Rho/Rac family kinases
VAV2 is a GEF for Rho/Rac family kinases
VAV3 is a GEF for Rho/Rac family kinases
Syk/Lck phosphorylate LAT
Syk activation leads to SLP-76 activation
SLP-76 stimulates PLC gamma 2
p-SLP-76 binds VAV
PLC gamma 2-mediated PIP2 hydrolysis
PIP3 stimulates Vav
PIP2 inhibits Vav
GPVI stimulates PI3K beta, gamma
PI3K alpha, beta, gamma convert PIP2 to PIP3
PIP3 recruits PDK1 and AKT to the membrane
PDK1 binds PKC zeta
PDK1 activates PKC zeta
GPVI-mediated activation cascade