Formation of Cyclin D:Cdk4/6 complexes
type: GO_0003674
BFO_0000050: Cyclin D associated events in G1
directly activates: Translocation of Cyclin D:Cdk4/6 complexes from the cytoplasm to the nucleus

Translocation of Cyclin D:Cdk4/6 complexes from the cytoplasm to the nucleus
type: GO_0003674
BFO_0000050: Cyclin D associated events in G1
directly activates: Phosphorylation of Cyclin D:Cdk4/6 complexes
directly activates: Catalysis824

Phosphorylation of Cyclin D:Cdk4/6 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin D associated events in G1
directly activates: Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes
directly activates: Catalysis825

Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Cyclin D associated events in G1
directly activates: Pathway449
directly activates: Pathway456
directly activates: TemplateReaction1
directly activates: TemplateReaction150
directly activates: TemplateReaction152
directly activates: TemplateReactionRegulation1
directly activates: TemplateReactionRegulation174
directly activates: TemplateReactionRegulation176

Association of INK4A with Cdk4/6
type: GO_0003674
BFO_0000050: Cyclin D associated events in G1

Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Cyclin D associated events in G1
directly activates: Dephosphorylation of p107 (RBL1) by PP2A
directly activates: Catalysis827

Dephosphorylation of p107 (RBL1) by PP2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Cyclin D associated events in G1
label: Dephosphorylation of p107 by PP2A

Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Cyclin D associated events in G1
directly activates: Dephosphorylation of p107 by PP2A
directly activates: Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
directly activates: Catalysis829

Dephosphorylation of p107 by PP2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Cyclin D associated events in G1
label: Dephosphorylation of p130 (RBL2) by PP2A

Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
type: GO_0003674
BFO_0000050: Cyclin D associated events in G1
directly activates: Ubiquitination of p130 (RBL2) by SCF (Skp2)
directly activates: Catalysis830

Ubiquitination of p130 (RBL2) by SCF (Skp2)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Cyclin D associated events in G1

G1 Phase
type: GO_0008150

Cyclin D associated events in G1
type: GO_0008150
BFO_0000050: G1 Phase