PAI1
label: PLANH1
label: SERPINE1
label: UniProt:P05121 SERPINE1

AAP
label: PLI
label: SERPINF2
label: UniProt:P08697 SERPINF2

histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot

histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot
directly activates: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen

crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain)
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot
directly activates: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen
directly activates: BiochemicalReaction2420
directly activates: Catalysis1068

crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot
directly activates: crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin
directly activates: Catalysis1063

crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot
directly activates: fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
directly activates: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)
directly activates: alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin
directly activates: Catalysis1064
directly activates: Catalysis1065
directly activates: Catalysis1069

fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot

crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot
directly activates: crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen
directly activates: BiochemicalReaction2419
directly activates: Catalysis1067

crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot
directly activates: crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin
directly activates: Catalysis1066

crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot
directly activates: fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
directly activates: alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin
directly activates: Catalysis1064
directly activates: Catalysis1069

BiochemicalReaction2419
type: Restriction
  on property: enabled by
  some values from: PAI1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004867
BFO_0000050: Dissolution of Fibrin Clot
label: fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1

BiochemicalReaction2420
type: Restriction
  on property: enabled by
  some values from: PAI1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004867
BFO_0000050: Dissolution of Fibrin Clot
label: fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1

alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin
type: Restriction
  on property: enabled by
  some values from: AAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004867
BFO_0000050: Dissolution of Fibrin Clot

urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot
directly activates: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)
directly activates: Catalysis1070

plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein
type: GO_0003674
BFO_0000050: Dissolution of Fibrin Clot
directly activates: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)
directly activates: Catalysis1070

plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot
directly activates: fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
directly activates: urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR
directly activates: Catalysis1064
directly activates: Catalysis1071

urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot
directly activates: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)
directly activates: urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR
directly activates: urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR
directly activates: Catalysis1072
directly activates: Catalysis1073
directly activates: Catalysis1074

plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Dissolution of Fibrin Clot
directly activates: fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
directly activates: Catalysis1064

urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: PAI1
type: GO_0004867
BFO_0000050: Dissolution of Fibrin Clot

urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004867
BFO_0000050: Dissolution of Fibrin Clot

Dissolution of Fibrin Clot
type: GO_0008150