ontology: go/extensions/x-signaling remark: THIS FILE IS READ ONLY. See: http://wiki.geneontology.org/index.php/Ontology_extensions [Term] id: GO:0000165 ! MAPKKK cascade !def: "A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK." [GOC:bf, GOC:mtg_signaling_feb11, PMID:9561267] intersection_of: GO:0007243 ! intracellular protein kinase cascade intersection_of: ends_with GO:0004707 ! MAP kinase activity intersection_of: has_part GO:0004708 ! MAP kinase kinase activity intersection_of: starts_with GO:0004709 ! MAP kinase kinase kinase activity !intersection_of: has_part GO:0000185 ! activation of MAPKKK activity !intersection_of: has_part GO:0000186 ! activation of MAPKK activity !intersection_of: has_part GO:0000187 ! activation of MAPK activity !intersection_of: has_part GO:0000188 ! inactivation of MAPK activity !intersection_of: has_part GO:0000189 ! nuclear translocation of MAPK !intersection_of: has_part GO:0051389 ! inactivation of MAPKK activity !intersection_of: has_part GO:0051390 ! inactivation of MAPKKK activity [Term] id: GO:0007249 ! I-kappaB kinase/NF-kappaB cascade !def: "A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase." [GOC:jl, PMID:12773372] intersection_of: GO:0007243 ! protein kinase cascade intersection_of: starts_with GO:0051059 ! NF-kappaB binding [Term] id: GO:0007219 ! Notch signaling pathway def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell." [GOC:go_curators] intersection_of: GO:0007166 ! cell surface receptor linked signal transduction intersection_of: starts_with GO:0005112 ! Notch binding intersection_of: has_part GO:0007220 ! Notch receptor processing intersection_of: precedes GO:0007221 ! positive regulation of transcription of Notch receptor target [Term] id: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway def: "The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand." [GOC:ceb] intersection_of: GO:0007167 ! enzyme linked receptor protein signaling pathway intersection_of: starts_with GO:0030971 ! receptor tyrosine kinase binding intersection_of: has_part GO:0007171 ! activation of transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0008286 ! insulin receptor signaling pathway def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway intersection_of: starts_with GO:0005158 ! insulin receptor binding !intersection_of: has_part GO:0005009 ! insulin receptor activity !intersection_of: has_part GO:0004713 ! protein tyrosine kinase activity [Term] id: GO:0007173 ! epidermal growth factor receptor signaling pathway def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands." [GOC:ceb] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathwa intersection_of: starts_with GO:0005154 ! epidermal growth factor receptor binding intersection_of: has_part GO:0005006 ! epidermal growth factor receptor activity intersection_of: has_part GO:0007174 ! epidermal growth factor ligand processing intersection_of: has_part GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway [Term] id: GO:0001973 ! adenosine receptor signaling pathway def: "The series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] intersection_of: GO:0007186 ! G-protein coupled receptor protein signaling pathway intersection_of: starts_with GO:0031685 ! adenosine receptor binding [Term] id: GO:0003376 ! sphingolipid signaling pathway def: "A series of molecular signals mediated by a sphingolipid." [GOC:ascb_2009, GOC:dph, GOC:tb] intersection_of: GO:0007242 ! intracellular signaling cascade intersection_of: starts_with GO:0046625 ! sphingolipid binding [Term] id: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway def: "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:mah] intersection_of: GO:0007167 ! enzyme linked receptor protein signaling pathway intersection_of: starts_with GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding [Term] id: GO:0007179 ! transforming growth factor beta receptor signaling pathway def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands." [GOC:mah] intersection_of: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: starts_with GO:0005160 ! transforming growth factor beta receptor binding [Term] id: GO:0007212 ! dopamine receptor signaling pathway def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:mah] intersection_of: GO:0007186 ! G-protein coupled receptor protein signaling pathway intersection_of: starts_with GO:0050780 ! dopamine receptor binding [Term] id: GO:0007213 ! muscarinic acetylcholine receptor signaling pathway def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to one of its physiological ligands; muscarinic acetylcholine receptors activate inhibitory G proteins and can be activated by the fungal alkaloid muscarine." [GOC:mah, ISBN:0815316194] intersection_of: GO:0007186 ! G-protein coupled receptor protein signaling pathway intersection_of: starts_with GO:0031789 ! muscarinic acetylcholine receptor binding [Term] id: GO:0007214 ! gamma-aminobutyric acid signaling pathway def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor." [GOC:mah] intersection_of: GO:0007186 ! G-protein coupled receptor protein signaling pathway intersection_of: starts_with GO:0016917 ! GABA receptor activity [Term] id: GO:0007215 ! glutamate signaling pathway def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor." [GOC:mah, PMID:9131252] intersection_of: GO:0007166 ! cell surface receptor linked signal transduction intersection_of: starts_with GO:0016595 ! glutamate binding [Term] id: GO:0007216 ! metabotropic glutamate receptor signaling pathway def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor coupled to effectors through GTP-binding proteins." [GOC:mah, PMID:9131252] intersection_of: GO:0007186 ! G-protein coupled receptor protein signaling pathway intersection_of: starts_with GO:0035256 ! metabotropic glutamate receptor binding [Term] id: GO:0007218 ! neuropeptide signaling pathway def: "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] intersection_of: GO:0007186 ! G-protein coupled receptor protein signaling pathway intersection_of: starts_with GO:0042923 ! neuropeptide binding ! comment: syn: Hh. actually starts further upstream.. [Term] id: GO:0007224 ! smoothened signaling pathway def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] intersection_of: GO:0007166 ! cell surface receptor linked signal transduction intersection_of: starts_with GO:0005119 ! smoothened binding [Term] id: GO:0008063 ! Toll signaling pathway def: "The series of molecular signals initiated by binding of a ligand to an extracellular ligand to the Toll receptor on the surface of the target cell." [GOC:go_curators] intersection_of: GO:0007166 ! cell surface receptor linked signal transduction intersection_of: starts_with GO:0005121 ! Toll binding [Term] id: GO:0008293 ! torso signaling pathway def: "The series of molecular signals generated as a consequence of the torso transmembrane receptor tyrosine kinase binding to its physiological ligand." [GOC:go_curators] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway intersection_of: starts_with GO:0005122 ! torso binding [Term] id: GO:0008314 ! gurken receptor signaling pathway def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to the ligand Gurken." [GOC:bf] intersection_of: GO:0007173 ! epidermal growth factor receptor signaling pathway intersection_of: starts_with GO:0008317 ! gurken receptor binding [Term] id: GO:0008543 ! fibroblast growth factor receptor signaling pathway def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway intersection_of: starts_with GO:0005104 ! fibroblast growth factor receptor binding [Term] id: GO:0016055 ! Wnt receptor signaling pathway def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] intersection_of: GO:0007166 ! cell surface receptor linked signal transduction intersection_of: starts_with GO:0005109 ! frizzled binding [Term] id: GO:0030518 ! steroid hormone receptor signaling pathway def: "Any series of molecular signals generated as a consequence of a steroid hormone binding to its receptor." [GOC:mah] intersection_of: GO:0030522 ! intracellular receptor-mediated signaling pathway intersection_of: starts_with GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0030520 ! estrogen receptor signaling pathway def: "Any series of molecular signals generated as a consequence of an estrogen binding to its receptor." [GOC:mah] intersection_of: GO:0030518 ! steroid hormone receptor signaling pathway intersection_of: starts_with GO:0030331 ! estrogen receptor binding [Term] id: GO:0030521 ! androgen receptor signaling pathway def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor." [GOC:mah] intersection_of: GO:0030518 ! steroid hormone receptor signaling pathway intersection_of: starts_with GO:0050681 ! androgen receptor binding [Term] id: GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway def: "The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:mah] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway intersection_of: starts_with GO:0031546 ! brain-derived neurotrophic factor receptor binding [Term] id: GO:0031959 ! mineralocorticoid receptor signaling pathway def: "Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724] intersection_of: GO:0031958 ! corticosteroid receptor signaling pathway intersection_of: starts_with GO:0031962 ! mineralocorticoid receptor binding [Term] id: GO:0031989 ! bombesin receptor signaling pathway def: "The series of molecular signals generated as a consequence of a bombesin receptor binding to one of its physiological ligands." [GOC:mah] intersection_of: GO:0007186 ! G-protein coupled receptor protein signaling pathway intersection_of: starts_with GO:0031705 ! bombesin receptor binding [Term] id: GO:0032924 ! activin receptor signaling pathway def: "A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor." [GOC:rl] intersection_of: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: starts_with GO:0070697 ! activin receptor binding [Term] id: GO:0035235 ! ionotropic glutamate receptor signaling pathway def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor, followed by the movement of ions through a channel in the receptor complex." [ISBN:0198506732] intersection_of: GO:0007215 ! glutamate signaling pathway intersection_of: starts_with GO:0035255 ! ionotropic glutamate receptor binding [Term] id: GO:0042921 ! glucocorticoid receptor signaling pathway def: "Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor." [GOC:mah] intersection_of: GO:0031958 ! corticosteroid receptor signaling pathway intersection_of: starts_with GO:0035259 ! glucocorticoid receptor binding [Term] id: GO:0045500 ! sevenless signaling pathway def: "The series of molecular signals generated as a consequence of the sevenless receptor binding to one of its physiological ligands." [GOC:bf] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway intersection_of: starts_with GO:0005118 ! sevenless binding [Term] id: GO:0048008 ! platelet-derived growth factor receptor signaling pathway def: "The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands." [GOC:ceb] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway intersection_of: starts_with GO:0005161 ! platelet-derived growth factor receptor binding [Term] id: GO:0048009 ! insulin-like growth factor receptor signaling pathway def: "The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands." [GOC:ceb] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway intersection_of: starts_with GO:0005159 ! insulin-like growth factor receptor binding [Term] id: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway def: "The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands." [GOC:ceb] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway intersection_of: starts_with GO:0005172 ! vascular endothelial growth factor receptor binding [Term] id: GO:0048011 ! nerve growth factor receptor signaling pathway def: "The series of molecular signals generated as a consequence of the nerve growth factor receptor binding to one of its physiological ligands." [GOC:ceb] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway intersection_of: starts_with GO:0005163 ! nerve growth factor receptor binding [Term] id: GO:0048012 ! hepatocyte growth factor receptor signaling pathway def: "The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands." [GOC:ceb] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway intersection_of: starts_with GO:0005171 ! hepatocyte growth factor receptor binding [Term] id: GO:0048013 ! ephrin receptor signaling pathway def: "The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin." [GOC:ceb] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway intersection_of: starts_with GO:0046875 ! ephrin receptor binding [Term] id: GO:0048384 ! retinoic acid receptor signaling pathway def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands." [GOC:dgh] intersection_of: GO:0030522 ! intracellular receptor-mediated signaling pathway intersection_of: starts_with GO:0042974 ! retinoic acid receptor binding [Term] id: GO:0050847 ! progesterone receptor signaling pathway def: "Any series of molecular signals generated as a consequence of a progesterone binding to its receptor." [GOC:ai, GOC:mah, PMID:14744870] intersection_of: GO:0030518 ! steroid hormone receptor signaling pathway intersection_of: starts_with GO:0033142 ! progesterone receptor binding [Term] id: GO:0050852 ! T cell receptor signaling pathway def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell." [GOC:add] intersection_of: GO:0050851 ! antigen receptor-mediated signaling pathway intersection_of: starts_with GO:0042608 ! T cell receptor binding [Term] id: GO:0060183 ! apelin receptor signaling pathway def: "The series of molecular signals generated as a consequence of an apelin receptor binding to one of its physiological ligands." [GOC:dph] intersection_of: GO:0007186 ! G-protein coupled receptor protein signaling pathway intersection_of: starts_with GO:0031704 ! apelin receptor binding [Term] id: GO:0060396 ! growth hormone receptor signaling pathway def: "The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph, PMID:11445442] intersection_of: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway intersection_of: starts_with GO:0005131 ! growth hormone receptor binding [Term] id: GO:0070493 ! thrombin receptor signaling pathway def: "The series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah, PMID:1672265] intersection_of: GO:0007186 ! G-protein coupled receptor protein signaling pathway intersection_of: starts_with GO:0031872 ! type 1 proteinase activated receptor binding [Term] id: GO:0070561 ! vitamin D receptor signaling pathway def: "The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah, PMID:12637589] intersection_of: GO:0030522 ! intracellular receptor-mediated signaling pathway intersection_of: starts_with GO:0042809 ! vitamin D receptor binding [Term] id: GO:0007186 ! G-protein coupled receptor protein signaling pathway def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:mah] intersection_of: GO:0007166 ! cell surface receptor linked signal transduction intersection_of: starts_with GO:0001664 ! G-protein-coupled receptor binding [Typedef] id: has_part xref: BFO:0000051 [Typedef] id: starts_with xref: RO:0002224 [Typedef] id: ends_with xref: RO:0002230 [Typedef] id: precedes xref: BFO:0000063