Gene Ontology Ontology Comparison Report ========================== Files used: - file 1 (old): go-2012-01-21.obo; date: 20:01:2012 15:15; CVS revision: 1.2535 - file 2 (new): go-2012-01-28.obo; date: 27:01:2012 13:07; CVS revision: 1.2570 NEW TERMS ========= ID name namespace GO:0001205 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription molecular_function GO:0001206 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription molecular_function GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter biological_process GO:0036096 3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing molecular_function GO:0036097 pre-miRNA 3'-end processing biological_process GO:0036098 male germ-line stem cell maintenance biological_process GO:0036099 female germ-line stem cell maintenance biological_process GO:0036100 leukotriene catabolic process biological_process GO:0036101 leukotriene B4 catabolic process biological_process GO:0036102 leukotriene B4 metabolic process biological_process GO:0036103 Kdo2-lipid A metabolic process biological_process GO:0036104 Kdo2-lipid A biosynthetic process biological_process GO:0036105 peroxisome membrane class-1 targeting sequence binding molecular_function GO:0036106 peroxisome membrane class-2 targeting sequence binding molecular_function GO:0038066 p38MAPK cascade biological_process GO:0038067 MAP kinase activity involved in cell wall biogenesis molecular_function GO:0038068 MAP kinase kinase activity involved in cell wall biogenesis molecular_function GO:0038069 MAP kinase phosphatase activity involved in regulation of cell wall biogenesis molecular_function GO:0038070 MAP kinase kinase kinase activity involved in cell wall biogenesis molecular_function GO:0038071 MAP kinase activity involved in conjugation with cellular fusion molecular_function GO:0038072 MAP kinase kinase activity involved in conjugation with cellular fusion molecular_function GO:0038073 MAP kinase kinase kinase activity involved in conjugation with cellular fusion molecular_function GO:0038074 MAP kinase phosphatase activity involved in regulation of conjugation with cellular fusion molecular_function GO:0038075 MAP kinase activity involved in innate immune response molecular_function GO:0038076 MAP kinase kinase activity involved in innate immune response molecular_function GO:0038077 MAP kinase kinase kinase activity involved in innate immune response molecular_function GO:0038078 MAP kinase phosphatase activity involved in regulation of innate immune response molecular_function GO:0038079 MAP kinase activity involved in osmosensory signaling pathway molecular_function GO:0038080 MAP kinase kinase activity involved in osmosensory signaling pathway molecular_function GO:0038081 MAP kinase kinase kinase activity involved in osmosensory signaling pathway molecular_function GO:0038082 MAP kinase phosphatase activity involved in regulation of osmosensory signaling pathway molecular_function GO:0044484 envenomation resulting in fibrinolysis in other organism biological_process GO:0044485 envenomation resulting in fibrinogenolysis in other organism biological_process GO:0044486 modulation of transmission of nerve impulse in other organism biological_process GO:0044487 envenomation resulting in modulation of transmission of nerve impulse in other organism biological_process GO:0061413 regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source biological_process GO:0061414 positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source biological_process GO:0061415 negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source biological_process GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress biological_process GO:0061417 negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress biological_process GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia biological_process GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia biological_process GO:0061420 regulation of transcription from RNA polymerase II promoter in response to biotin starvation biological_process GO:0061421 positive regulation of transcription by oleic acid biological_process GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkalinity biological_process GO:0061423 positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter biological_process GO:0097222 mitochondrial mRNA polyadenylation biological_process GO:0097223 sperm part cellular_component GO:0097224 sperm connecting piece cellular_component GO:0097225 sperm midpiece cellular_component GO:0097226 sperm mitochondrial sheath cellular_component GO:0097227 sperm annulus cellular_component GO:0097228 sperm principal piece cellular_component GO:0097229 sperm end piece cellular_component GO:0097230 cell motility in response to potassium ion biological_process GO:0097231 cell motility in response to calcium ion biological_process GO:0097232 lamellar body membrane cellular_component GO:0097233 alveolar lamellar body membrane cellular_component GO:0097234 epidermal lamellar body membrane cellular_component GO:1900055 regulation of leaf senescence biological_process GO:1900056 negative regulation of leaf senescence biological_process GO:1900057 positive regulation of leaf senescence biological_process GO:1900058 regulation of sulfate assimilation biological_process GO:1900059 positive regulation of sulfate assimilation biological_process GO:1900060 negative regulation of ceramide biosynthetic process biological_process GO:1900061 positive regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling biological_process GO:1900062 regulation of replicative cell aging biological_process GO:1900063 regulation of peroxisome organization biological_process GO:1900064 positive regulation of peroxisome organization biological_process GO:1900065 regulation of ethanol catabolic process biological_process GO:1900066 positive regulation of ethanol catabolic process biological_process GO:1900067 regulation of cellular response to alkalinity biological_process GO:1900068 negative regulation of cellular response to alkalinity biological_process GO:1900069 regulation of cellular hyperosmotic salinity response biological_process GO:1900070 negative regulation of cellular hyperosmotic salinity response biological_process GO:1900071 regulation of sulfite transport biological_process GO:1900072 positive regulation of sulfite transport biological_process GO:1900073 regulation of neuromuscular synaptic transmission biological_process GO:1900074 negative regulation of neuromuscular synaptic transmission biological_process GO:1900075 positive regulation of neuromuscular synaptic transmission biological_process OBSOLETIONS =========== None TERM MERGES =========== None TERM CHANGES ============ GO:0000161 : MAPK cascade involved in osmosensory signaling pathway - name: MAPKKK cascade involved in osmosensory signaling pathway + name: MAPK cascade involved in osmosensory signaling pathway - def: MAPKKK cascade involved in signal transduction in response to change in osmotic conditions. + def: A MAPK cascade involved in signal transduction in response to change in osmotic conditions. + synonym: "High Osmolarity Glycerol (HOG) MAPK pathway" NARROW [PMID:20880736] + synonym: "Hog1 MAPK pathway" NARROW [PMID:20880736] + synonym: "MAPKKK cascade involved in osmosensory signaling pathway" EXACT [GOC:signaling] GO:0000165 : MAPK cascade - name: MAPKKK cascade + name: MAPK cascade - def: A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK. + def: An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. + comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier. - synonym: "MAPK cascade" EXACT [] - synonym: "ERK/MAPK cascade" EXACT [] + synonym: "MAPKKK cascade" EXACT [GOC:curators] + synonym: "ERK/MAPK cascade" NARROW [] + synonym: "mitogen-activated protein kinase cascade" EXACT [GOC:bf] GO:0000167 : activation of MAPKKK activity involved in osmosensory signaling pathway - intersection_of: GO:0000185 - intersection_of: part_of GO:0007231 + intersection_of: positively_regulates GO:0038081 + intersection_of: GO:0065007 - relationship: part_of GO:0000161 + relationship: positively_regulates GO:0038081 GO:0000168 : activation of MAPKK activity involved in osmosensory signaling pathway - intersection_of: part_of GO:0007231 + intersection_of: positively_regulates GO:0038080 + intersection_of: GO:0065007 - relationship: part_of GO:0000161 + relationship: positively_regulates GO:0038080 GO:0000169 : activation of MAPK activity involved in osmosensory signaling pathway - intersection_of: part_of GO:0007231 - intersection_of: GO:0000187 + intersection_of: positively_regulates GO:0038079 + intersection_of: GO:0065007 - relationship: part_of GO:0000161 + relationship: positively_regulates GO:0038079 GO:0000173 : inactivation of MAPK activity involved in osmosensory signaling pathway - intersection_of: GO:0000188 - intersection_of: part_of GO:0007231 + intersection_of: negatively_regulates GO:0007231 + intersection_of: GO:0065007 - relationship: part_of GO:0000161 + relationship: negatively_regulates GO:0038079 GO:0000185 : activation of MAPKKK activity + synonym: "activation of MAP3K activity" EXACT [GOC:bf] - relationship: part_of GO:0043410 GO:0000186 : activation of MAPKK activity + synonym: "activation of MAP2K activity" EXACT [GOC:bf] - relationship: part_of GO:0000165 GO:0000187 : activation of MAPK activity + is_a: GO:0032147 - relationship: part_of GO:0000165 GO:0000196 : MAPK cascade involved in cell wall biogenesis - name: MAPKKK cascade involved in cell wall biogenesis + name: MAPK cascade involved in cell wall biogenesis - def: A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells. + def: A MAPK cascade that contributes to cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells. + synonym: "MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:signaling] + synonym: "Mpk1 cascade" NARROW [PMID:10523653] + synonym: "Slt2 cascade" NARROW [PMID:10523653] GO:0000197 : activation of MAPKKK activity involved in cell wall biogenesis - intersection_of: part_of GO:0042546 + intersection_of: positively_regulates GO:0038070 + intersection_of: GO:0065007 - relationship: part_of GO:0000196 + relationship: positively_regulates GO:0038070 GO:0000198 : activation of MAPKK activity involved in cell wall biogenesis - intersection_of: part_of GO:0042546 + intersection_of: positively_regulates GO:0038068 + intersection_of: GO:0065007 - relationship: part_of GO:0000196 + relationship: positively_regulates GO:0038068 GO:0000199 : activation of MAPK activity involved in cell wall biogenesis - intersection_of: part_of GO:0042546 + intersection_of: positively_regulates GO:0038067 + intersection_of: GO:0065007 - relationship: part_of GO:0000196 + relationship: positively_regulates GO:0038067 GO:0000200 : inactivation of MAPK activity involved in cell wall biogenesis - intersection_of: part_of GO:0042546 + intersection_of: negatively_regulates GO:0038067 + intersection_of: GO:0065007 - relationship: part_of GO:0000196 + relationship: negatively_regulates GO:0038067 GO:0000436 : carbon catabolite activation of transcription from RNA polymerase II promoter + is_a: GO:0045991 GO:0000437 : carbon catabolite repression of transcription from RNA polymerase II promoter + is_a: GO:0045013 GO:0003151 : outflow tract morphogenesis GO:0003678 : DNA helicase activity + relationship: part_of GO:0032508 GO:0003705 : sequence-specific distal enhancer binding RNA polymerase II transcription factor activity - def: Functions to initiate or regulate RNA polymerase II transcription by binding a distal enhancer region of DNA. + def: Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. GO:0004518 : nuclease activity + relationship: part_of GO:0090305 GO:0004706 : JUN kinase kinase kinase activity + relationship: part_of GO:0007256 GO:0004707 : MAP kinase activity - synonym: "MAPK" RELATED [EC:2.7.11.24] + synonym: "MAPK" RELATED [EC:2.7.11.24, PMID:20811974] + relationship: part_of GO:0000165 GO:0004708 : MAP kinase kinase activity - def: Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase. + def: Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. - synonym: "MAPKK" RELATED [EC:2.7.12.2] + synonym: "MAPKK" RELATED [EC:2.7.12.2, PMID:20811974] + relationship: part_of GO:0000165 + relationship: part_of GO:0000187 GO:0004709 : MAP kinase kinase kinase activity - def: Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. + def: Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. - synonym: "MAP3K" RELATED [EC:2.7.11.25] + synonym: "MAP3K" RELATED [EC:2.7.11.25, PMID:20811974] + relationship: part_of GO:0000165 + relationship: part_of GO:0000186 GO:0004710 : MAPK/ERK kinase kinase activity - name: MAP/ERK kinase kinase activity + name: MAPK/ERK kinase kinase activity GO:0005052 : peroxisome matrix targeting signal-1 binding + synonym: "peroxisomal targeting signal 1 (PTS1) binding" EXACT [PMID:14709540] + synonym: "PTS1 binding" EXACT [PMID:14709540] GO:0005053 : peroxisome matrix targeting signal-2 binding + synonym: "PTS2 binding" EXACT [PMID:14709540] + synonym: "peroxisomal targeting signal 2 (PTS2) binding" EXACT [PMID:14709540] GO:0007243 : intracellular protein kinase cascade - def: A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. + def: A series of reactions in which a signal is passed on to downstream proteins within the cell by sequential protein phosphorylation and activation of the cascade components. GO:0007254 : JNK cascade - def: A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress. + def: An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. + synonym: "c-Jun N-terminal kinase cascade" EXACT [PMID:20811974] GO:0008349 : MAP kinase kinase kinase kinase activity + synonym: "MAP4K activity" EXACT [PMID:20811974] + relationship: part_of GO:0000165 + relationship: part_of GO:0000185 GO:0008545 : JUN kinase kinase activity + relationship: part_of GO:0007257 GO:0010227 : floral organ abscission GO:0021750 : vestibular nucleus development + relationship: part_of GO:0021550 GO:0021766 : hippocampus development + synonym: "hippocampal formation development" EXACT [ABA:HPF] GO:0033328 : peroxisome membrane targeting sequence binding + synonym: "peroxisomal membrane protein (PMP) targeting signal (mPTS) binding" EXACT [PMID:14709540] + synonym: "PMP targeting signal (mPTS) binding" EXACT [PMID:14709540] + synonym: "PMP targeting signal binding" EXACT [PMID:14709540] GO:0033549 : MAP kinase phosphatase activity + synonym: "MAPK phosphatase activity" EXACT [PMID:12184814] + relationship: part_of GO:0000188 GO:0033572 : transferrin transport - synonym: "melanotransferrin transport" EXACT [PRO:000001887] + synonym: "melanotransferrin transport" EXACT [PR:000001887] GO:0035419 : activation of MAPK activity involved in innate immune response - intersection_of: part_of GO:0045087 - intersection_of: GO:0000187 + intersection_of: positively_regulates GO:0038075 + intersection_of: GO:0065007 - relationship: part_of GO:0035420 + relationship: positively_regulates GO:0038075 GO:0035420 : MAPK cascade involved in innate immune response - name: MAPKKK cascade involved in innate immune response + name: MAPK cascade involved in innate immune response - def: A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens. + def: A MAPK cascade that contributes to an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens. + synonym: "MAPKKK cascade involved in innate immune response" EXACT [GOC:signaling] GO:0035421 : activation of MAPKK activity involved in innate immune response - intersection_of: part_of GO:0045087 + intersection_of: positively_regulates GO:0038076 + intersection_of: GO:0065007 - relationship: part_of GO:0035420 + relationship: positively_regulates GO:0038076 GO:0035422 : activation of MAPKKK activity involved in innate immune response - intersection_of: GO:0000185 - intersection_of: part_of GO:0045087 + intersection_of: positively_regulates GO:0038077 + intersection_of: GO:0065007 - relationship: part_of GO:0035420 + relationship: positively_regulates GO:0038077 GO:0035423 : inactivation of MAPK activity involved in innate immune response - intersection_of: GO:0000188 - intersection_of: part_of GO:0045087 + intersection_of: negatively_regulates GO:0038075 + intersection_of: GO:0065007 - relationship: part_of GO:0035420 + relationship: negatively_regulates GO:0038075 GO:0035915 : pore formation in membrane of other organism - is_a: GO:0035821 + is_a: GO:0051673 GO:0038029 : epidermal growth factor receptor signaling pathway via MAPK cascade - name: epidermal growth factor receptor signaling pathway via MAPKKK cascade + name: epidermal growth factor receptor signaling pathway via MAPK cascade + synonym: "epidermal growth factor receptor signaling pathway via MAPKKK cascade" EXACT [GOC:signaling] GO:0038030 : non-canonical Wnt receptor signaling pathway via MAPK cascade - name: non-canonical Wnt receptor signaling pathway via MAPKKK cascade + name: non-canonical Wnt receptor signaling pathway via MAPK cascade + synonym: "non-canonical Wnt receptor signaling pathway via MAPKKK cascade" EXACT [GOC:signaling] GO:0042656 : JUN kinase kinase kinase kinase activity + relationship: part_of GO:0042655 GO:0042730 : fibrinolysis - def: An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots. + def: A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. GO:0043408 : regulation of MAPK cascade - name: regulation of MAPKKK cascade + name: regulation of MAPK cascade - def: Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. + def: Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. + synonym: "regulation of MAPKKK cascade" EXACT [GOC:signaling] + synonym: "regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling] + synonym: "regulation of MAP kinase cascade" EXACT [GOC:signaling] + synonym: "regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling] GO:0043409 : negative regulation of MAPK cascade - name: negative regulation of MAPKKK cascade + name: negative regulation of MAPK cascade + synonym: "negative regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling] + synonym: "down regulation of MAPK cascade" EXACT [GOC:signaling] + synonym: "negative regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling] + synonym: "negative regulation of MAP kinase cascade" EXACT [GOC:signaling] + synonym: "inhibition of MAPK cascade" NARROW [GOC:signaling] + synonym: "down-regulation of MAPK cascade" EXACT [GOC:signaling] + synonym: "negative regulation of MAPKKK cascade" EXACT [GOC:signaling] + synonym: "downregulation of MAPK cascade" EXACT [GOC:signaling] GO:0043410 : positive regulation of MAPK cascade - name: positive regulation of MAPKKK cascade + name: positive regulation of MAPK cascade + synonym: "positive regulation of MAP kinase cascade" EXACT [GOC:signaling] + synonym: "positive regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling] + synonym: "positive regulation of MAPKKK cascade" EXACT [GOC:signaling] + synonym: "activation of MAPK cascade" NARROW [GOC:signaling] + synonym: "up-regulation of MAPK cascade" EXACT [GOC:signaling] + synonym: "stimulation of MAPK cascade" EXACT [GOC:signaling] + synonym: "upregulation of MAPK cascade" EXACT [GOC:signaling] GO:0044469 : envenomation resulting in positive regulation of blood coagulation in other organism + is_a: GO:0044483 GO:0045210 : FasL biosynthetic process - synonym: "fas ligand biosynthetic process" EXACT [GOC:add, PRO:000000095] + synonym: "fas ligand biosynthetic process" EXACT [GOC:add, PR:000000095] GO:0045558 : TRAIL receptor 1 biosynthetic process - synonym: "tumor necrosis factor receptor superfamily member 10A biosynthetic process" EXACT [PRO:000002108] + synonym: "tumor necrosis factor receptor superfamily member 10A biosynthetic process" EXACT [PR:000002108] GO:0045559 : TRAIL receptor 2 biosynthetic process - synonym: "tumor necrosis factor receptor superfamily member 10B biosynthetic process" EXACT [PRO:000002109] + synonym: "tumor necrosis factor receptor superfamily member 10B biosynthetic process" EXACT [PR:000002109] GO:0046318 : negative regulation of glucosylceramide biosynthetic process - is_a: GO:0090155 + is_a: GO:1900060 GO:0048437 : floral organ development GO:0048438 : floral whorl development + comment: Consider instead annotating to one of the more specific child terms, or to 'floral organ development ; GO:0048438' or one of its child terms. + synonym: "collective phyllome structure development" BROAD [GOC:PO_curators, PO:0025023] GO:0048444 : floral organ morphogenesis GO:0048449 : floral organ formation GO:0048450 : floral organ structural organization GO:0048457 : floral whorl morphogenesis GO:0048458 : floral whorl formation GO:0048459 : floral whorl structural organization GO:0048497 : maintenance of floral organ identity GO:0050051 : leukotriene-B4 20-monooxygenase activity + relationship: part_of GO:0036101 GO:0051403 : stress-activated MAPK cascade - synonym: "p38 MAPK signaling" EXACT [] - synonym: "p38 MAPK signalling" EXACT [] + synonym: "p38 MAPK signalling" NARROW [] + synonym: "p38 MAPK signaling" NARROW [] GO:0051673 : membrane disruption in other organism - is_a: GO:0051704 + is_a: GO:0035821 GO:0061404 : positive regulation of transcription from RNA polymerase II promoter in response to increased salt + is_a: GO:0061416 GO:0070371 : ERK1 and ERK2 cascade - def: A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases. + def: An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. + synonym: "extracellular signal-regulated kinase 1/2 cascade" EXACT [PMID:20811974] + synonym: "extracellular signal-regulated kinase 1/2 (ERK1/2) cascade" EXACT [PMID:20811974] GO:0070375 : ERK5 cascade - name: BMK cascade + name: ERK5 cascade - def: A cascade of protein kinase activities, culminating in the phosphorylation and activation of big MAP kinase (BMK1/ERK5), which is a type of mitogen-activated protein (MAP) kinase. + def: An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. - synonym: "ERK5 cascade" EXACT [GOC:add] + synonym: "big MAP kinase signaling cascade" EXACT [PMID:20811974] + synonym: "BMK cascade" EXACT [PMID:20811974] + synonym: "extracellular signal-regulated kinase 5 cascade" EXACT [PMID:20811974] GO:0070376 : regulation of ERK5 cascade - name: regulation of BMK cascade + name: regulation of ERK5 cascade - def: Any process that modulates the frequency, rate or extent of signal transduction mediated by the BMK cascade. + def: Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade. - synonym: "regulation of ERK5 cascade" EXACT [GOC:add] + synonym: "regulation of BMK cascade" EXACT [GOC:signaling] GO:0070377 : negative regulation of ERK5 cascade - name: negative regulation of BMK cascade + name: negative regulation of ERK5 cascade - def: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the BMK cascade. + def: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK5 cascade. - synonym: "negative regulation of ERK5 cascade" EXACT [GOC:add] + synonym: "negative regulation of BMK cascade" EXACT [GOC:signaling] GO:0070378 : positive regulation of ERK5 cascade - name: positive regulation of BMK cascade + name: positive regulation of ERK5 cascade - def: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the BMK cascade. + def: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade. - synonym: "positive regulation of ERK5 cascade" EXACT [GOC:add] + synonym: "positive regulation of BMK cascade" EXACT [GOC:signaling] GO:0071507 : MAPK cascade involved in conjugation with cellular fusion - name: MAPKKK cascade involved in conjugation with cellular fusion + name: MAPK cascade involved in conjugation with cellular fusion - def: A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of conjugation with cellular fusion. + def: A MAPK cascade that contributes to conjugation with cellular fusion. + synonym: "pheromone MAPK module" RELATED [PMID:20880736] + synonym: "MAPK signaling in response to pheromone" RELATED [PMID:20880736] + synonym: "Fus3 signaling cascade" NARROW [PMID:20880736] + synonym: "MAPKKK cascade involved in conjugation with cellular fusion" EXACT [GOC:signaling] GO:0071508 : activation of MAPK activity involved in conjugation with cellular fusion - intersection_of: part_of GO:0000747 + intersection_of: positively_regulates GO:0038071 + intersection_of: GO:0065007 - relationship: part_of GO:0071507 + relationship: positively_regulates GO:0038071 GO:0071509 : activation of MAPKK activity involved in conjugation with cellular fusion - intersection_of: GO:0000186 - intersection_of: part_of GO:0000747 + intersection_of: positively_regulates GO:0038072 + intersection_of: GO:0065007 - relationship: part_of GO:0071507 + relationship: positively_regulates GO:0038072 GO:0071510 : activation of MAPKKK activity involved in conjugation with cellular fusion - intersection_of: part_of GO:0000747 + intersection_of: positively_regulates GO:0038073 + intersection_of: GO:0065007 - relationship: part_of GO:0071507 + relationship: positively_regulates GO:0038073 GO:0071511 : inactivation of MAPK activity involved in conjugation with cellular fusion - intersection_of: GO:0000188 - intersection_of: part_of GO:0000747 + intersection_of: negatively_regulates GO:0038071 + intersection_of: GO:0065007 - relationship: part_of GO:0071507 + relationship: negatively_regulates GO:0038071 GO:0072535 : tumor necrosis factor (ligand) superfamily member 11 production - synonym: "TNFSF11 production" EXACT [GOC:mah, PRO:000002107] + synonym: "TNFSF11 production" EXACT [GOC:mah, PR:000002107] GO:1900007 : regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging - is_a: GO:0090342 + is_a: GO:1900062 OTHER STANZA TYPES ================== Stanzas Edited ============== Stanza type ID Name Typedef negatively_regulates negatively_regulates Typedef positively_regulates positively_regulates Typedef regulates regulates FILE STATS ========== Term counts for the old and new files Ontology Old file New file Change molecular function 9212 9233 +21 (9212 defined) (9233 defined) cellular component 2950 2960 +10 (2950 defined) (2960 defined) biological process 21867 21916 +49 (21867 defined) (21916 defined) Obsolete 1611 1611 0 (4.5% of total) (4.5% of total) (0.0%) Totals 34029 34109 +80 (+0.2%) 34029 (100.0%) defined 34109 (100.0%) defined 35640 inc. obs 35720 inc. obs