Gene Ontology: Ontology Comparison Report

Files used:

  • file 1 (old): go-2012-01-21.obo; date: 20:01:2012 15:15; CVS revision: 1.2535
  • file 2 (new): go-2012-01-28.obo; date: 27:01:2012 13:07; CVS revision: 1.2570

New terms

ID name namespace
GO:0001205 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription molecular_function
GO:0001206 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription molecular_function
GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0036096 3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing molecular_function
GO:0036097 pre-miRNA 3'-end processing biological_process
GO:0036098 male germ-line stem cell maintenance biological_process
GO:0036099 female germ-line stem cell maintenance biological_process
GO:0036100 leukotriene catabolic process biological_process
GO:0036101 leukotriene B4 catabolic process biological_process
GO:0036102 leukotriene B4 metabolic process biological_process
GO:0036103 Kdo2-lipid A metabolic process biological_process
GO:0036104 Kdo2-lipid A biosynthetic process biological_process
GO:0036105 peroxisome membrane class-1 targeting sequence binding molecular_function
GO:0036106 peroxisome membrane class-2 targeting sequence binding molecular_function
GO:0038066 p38MAPK cascade biological_process
GO:0038067 MAP kinase activity involved in cell wall biogenesis molecular_function
GO:0038068 MAP kinase kinase activity involved in cell wall biogenesis molecular_function
GO:0038069 MAP kinase phosphatase activity involved in regulation of cell wall biogenesis molecular_function
GO:0038070 MAP kinase kinase kinase activity involved in cell wall biogenesis molecular_function
GO:0038071 MAP kinase activity involved in conjugation with cellular fusion molecular_function
GO:0038072 MAP kinase kinase activity involved in conjugation with cellular fusion molecular_function
GO:0038073 MAP kinase kinase kinase activity involved in conjugation with cellular fusion molecular_function
GO:0038074 MAP kinase phosphatase activity involved in regulation of conjugation with cellular fusion molecular_function
GO:0038075 MAP kinase activity involved in innate immune response molecular_function
GO:0038076 MAP kinase kinase activity involved in innate immune response molecular_function
GO:0038077 MAP kinase kinase kinase activity involved in innate immune response molecular_function
GO:0038078 MAP kinase phosphatase activity involved in regulation of innate immune response molecular_function
GO:0038079 MAP kinase activity involved in osmosensory signaling pathway molecular_function
GO:0038080 MAP kinase kinase activity involved in osmosensory signaling pathway molecular_function
GO:0038081 MAP kinase kinase kinase activity involved in osmosensory signaling pathway molecular_function
GO:0038082 MAP kinase phosphatase activity involved in regulation of osmosensory signaling pathway molecular_function
GO:0044484 envenomation resulting in fibrinolysis in other organism biological_process
GO:0044485 envenomation resulting in fibrinogenolysis in other organism biological_process
GO:0044486 modulation of transmission of nerve impulse in other organism biological_process
GO:0044487 envenomation resulting in modulation of transmission of nerve impulse in other organism biological_process
GO:0061413 regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source biological_process
GO:0061414 positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source biological_process
GO:0061415 negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source biological_process
GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress biological_process
GO:0061417 negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress biological_process
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia biological_process
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia biological_process
GO:0061420 regulation of transcription from RNA polymerase II promoter in response to biotin starvation biological_process
GO:0061421 positive regulation of transcription by oleic acid biological_process
GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkalinity biological_process
GO:0061423 positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0097222 mitochondrial mRNA polyadenylation biological_process
GO:0097223 sperm part cellular_component
GO:0097224 sperm connecting piece cellular_component
GO:0097225 sperm midpiece cellular_component
GO:0097226 sperm mitochondrial sheath cellular_component
GO:0097227 sperm annulus cellular_component
GO:0097228 sperm principal piece cellular_component
GO:0097229 sperm end piece cellular_component
GO:0097230 cell motility in response to potassium ion biological_process
GO:0097231 cell motility in response to calcium ion biological_process
GO:0097232 lamellar body membrane cellular_component
GO:0097233 alveolar lamellar body membrane cellular_component
GO:0097234 epidermal lamellar body membrane cellular_component
GO:1900055 regulation of leaf senescence biological_process
GO:1900056 negative regulation of leaf senescence biological_process
GO:1900057 positive regulation of leaf senescence biological_process
GO:1900058 regulation of sulfate assimilation biological_process
GO:1900059 positive regulation of sulfate assimilation biological_process
GO:1900060 negative regulation of ceramide biosynthetic process biological_process
GO:1900061 positive regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling biological_process
GO:1900062 regulation of replicative cell aging biological_process
GO:1900063 regulation of peroxisome organization biological_process
GO:1900064 positive regulation of peroxisome organization biological_process
GO:1900065 regulation of ethanol catabolic process biological_process
GO:1900066 positive regulation of ethanol catabolic process biological_process
GO:1900067 regulation of cellular response to alkalinity biological_process
GO:1900068 negative regulation of cellular response to alkalinity biological_process
GO:1900069 regulation of cellular hyperosmotic salinity response biological_process
GO:1900070 negative regulation of cellular hyperosmotic salinity response biological_process
GO:1900071 regulation of sulfite transport biological_process
GO:1900072 positive regulation of sulfite transport biological_process
GO:1900073 regulation of neuromuscular synaptic transmission biological_process
GO:1900074 negative regulation of neuromuscular synaptic transmission biological_process
GO:1900075 positive regulation of neuromuscular synaptic transmission biological_process

Obsoletions

None

Term merges

None

Term changes

Changes in term-related data
File 1 (20:01:2012 15:15, 1.2535) File 2 (27:01:2012 13:07, 1.2570)
GO:0000161 : MAPK cascade involved in osmosensory signaling pathway
name
MAPKKK cascade involved in osmosensory signaling pathway
def
MAPKKK cascade involved in signal transduction in response to change in osmotic conditions.
 name
MAPK cascade involved in osmosensory signaling pathway
def
A MAPK cascade involved in signal transduction in response to change in osmotic conditions.
synonym
"High Osmolarity Glycerol (HOG) MAPK pathway" NARROW [PMID:20880736]
"Hog1 MAPK pathway" NARROW [PMID:20880736]
"MAPKKK cascade involved in osmosensory signaling pathway" EXACT [GOC:signaling]
GO:0000165 : MAPK cascade
name
MAPKKK cascade
def
A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK.
synonym
"ERK/MAPK cascade" EXACT []
"MAPK cascade" EXACT []
 name
MAPK cascade
def
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
comment
MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
synonym
"ERK/MAPK cascade" NARROW []
"MAPKKK cascade" EXACT [GOC:curators]
"mitogen-activated protein kinase cascade" EXACT [GOC:bf]
GO:0000167 : activation of MAPKKK activity involved in osmosensory signaling pathway
intersection_of
GO:0000185
part_of GO:0007231
relationship
part_of GO:0000161
 intersection_of
GO:0065007
positively_regulates GO:0038081
relationship
positively_regulates GO:0038081
GO:0000168 : activation of MAPKK activity involved in osmosensory signaling pathway
intersection_of
part_of GO:0007231
relationship
part_of GO:0000161
 intersection_of
GO:0065007
positively_regulates GO:0038080
relationship
positively_regulates GO:0038080
GO:0000169 : activation of MAPK activity involved in osmosensory signaling pathway
intersection_of
GO:0000187
part_of GO:0007231
relationship
part_of GO:0000161
 intersection_of
GO:0065007
positively_regulates GO:0038079
relationship
positively_regulates GO:0038079
GO:0000173 : inactivation of MAPK activity involved in osmosensory signaling pathway
intersection_of
GO:0000188
part_of GO:0007231
relationship
part_of GO:0000161
 intersection_of
GO:0065007
negatively_regulates GO:0007231
relationship
negatively_regulates GO:0038079
GO:0000185 : activation of MAPKKK activity
relationship
part_of GO:0043410
 synonym
"activation of MAP3K activity" EXACT [GOC:bf]
GO:0000186 : activation of MAPKK activity
relationship
part_of GO:0000165
 synonym
"activation of MAP2K activity" EXACT [GOC:bf]
GO:0000187 : activation of MAPK activity
relationship
part_of GO:0000165
 is_a
GO:0032147
GO:0000196 : MAPK cascade involved in cell wall biogenesis
name
MAPKKK cascade involved in cell wall biogenesis
def
A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.
 name
MAPK cascade involved in cell wall biogenesis
def
A MAPK cascade that contributes to cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.
synonym
"MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:signaling]
"Mpk1 cascade" NARROW [PMID:10523653]
"Slt2 cascade" NARROW [PMID:10523653]
GO:0000197 : activation of MAPKKK activity involved in cell wall biogenesis
intersection_of
part_of GO:0042546
relationship
part_of GO:0000196
 intersection_of
GO:0065007
positively_regulates GO:0038070
relationship
positively_regulates GO:0038070
GO:0000198 : activation of MAPKK activity involved in cell wall biogenesis
intersection_of
part_of GO:0042546
relationship
part_of GO:0000196
 intersection_of
GO:0065007
positively_regulates GO:0038068
relationship
positively_regulates GO:0038068
GO:0000199 : activation of MAPK activity involved in cell wall biogenesis
intersection_of
part_of GO:0042546
relationship
part_of GO:0000196
 intersection_of
GO:0065007
positively_regulates GO:0038067
relationship
positively_regulates GO:0038067
GO:0000200 : inactivation of MAPK activity involved in cell wall biogenesis
intersection_of
part_of GO:0042546
relationship
part_of GO:0000196
 intersection_of
GO:0065007
negatively_regulates GO:0038067
relationship
negatively_regulates GO:0038067
GO:0000436 : carbon catabolite activation of transcription from RNA polymerase II promoter
is_a
GO:0045991
GO:0000437 : carbon catabolite repression of transcription from RNA polymerase II promoter
is_a
GO:0045013
GO:0003151 : outflow tract morphogenesis
GO:0003678 : DNA helicase activity
relationship
part_of GO:0032508
GO:0003705 : sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
def
Functions to initiate or regulate RNA polymerase II transcription by binding a distal enhancer region of DNA.
 def
Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.
GO:0004518 : nuclease activity
relationship
part_of GO:0090305
GO:0004706 : JUN kinase kinase kinase activity
relationship
part_of GO:0007256
GO:0004707 : MAP kinase activity
synonym
"MAPK" RELATED [EC:2.7.11.24]
 synonym
"MAPK" RELATED [EC:2.7.11.24, PMID:20811974]
relationship
part_of GO:0000165
GO:0004708 : MAP kinase kinase activity
def
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
synonym
"MAPKK" RELATED [EC:2.7.12.2]
 def
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
synonym
"MAPKK" RELATED [EC:2.7.12.2, PMID:20811974]
relationship
part_of GO:0000165
part_of GO:0000187
GO:0004709 : MAP kinase kinase kinase activity
def
Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
synonym
"MAP3K" RELATED [EC:2.7.11.25]
 def
Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
synonym
"MAP3K" RELATED [EC:2.7.11.25, PMID:20811974]
relationship
part_of GO:0000165
part_of GO:0000186
GO:0004710 : MAPK/ERK kinase kinase activity
name
MAP/ERK kinase kinase activity
 name
MAPK/ERK kinase kinase activity
GO:0005052 : peroxisome matrix targeting signal-1 binding
synonym
"peroxisomal targeting signal 1 (PTS1) binding" EXACT [PMID:14709540]
"PTS1 binding" EXACT [PMID:14709540]
GO:0005053 : peroxisome matrix targeting signal-2 binding
synonym
"peroxisomal targeting signal 2 (PTS2) binding" EXACT [PMID:14709540]
"PTS2 binding" EXACT [PMID:14709540]
GO:0007243 : intracellular protein kinase cascade
def
A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.
 def
A series of reactions in which a signal is passed on to downstream proteins within the cell by sequential protein phosphorylation and activation of the cascade components.
GO:0007254 : JNK cascade
def
A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
 def
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
synonym
"c-Jun N-terminal kinase cascade" EXACT [PMID:20811974]
GO:0008349 : MAP kinase kinase kinase kinase activity
synonym
"MAP4K activity" EXACT [PMID:20811974]
relationship
part_of GO:0000165
part_of GO:0000185
GO:0008545 : JUN kinase kinase activity
relationship
part_of GO:0007257
GO:0010227 : floral organ abscission
GO:0021750 : vestibular nucleus development
relationship
part_of GO:0021550
GO:0021766 : hippocampus development
synonym
"hippocampal formation development" EXACT [ABA:HPF]
GO:0033328 : peroxisome membrane targeting sequence binding
synonym
"peroxisomal membrane protein (PMP) targeting signal (mPTS) binding" EXACT [PMID:14709540]
"PMP targeting signal (mPTS) binding" EXACT [PMID:14709540]
"PMP targeting signal binding" EXACT [PMID:14709540]
GO:0033549 : MAP kinase phosphatase activity
synonym
"MAPK phosphatase activity" EXACT [PMID:12184814]
relationship
part_of GO:0000188
GO:0033572 : transferrin transport
synonym
"melanotransferrin transport" EXACT [PRO:000001887]
 synonym
"melanotransferrin transport" EXACT [PR:000001887]
GO:0035419 : activation of MAPK activity involved in innate immune response
intersection_of
GO:0000187
part_of GO:0045087
relationship
part_of GO:0035420
 intersection_of
GO:0065007
positively_regulates GO:0038075
relationship
positively_regulates GO:0038075
GO:0035420 : MAPK cascade involved in innate immune response
name
MAPKKK cascade involved in innate immune response
def
A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.
 name
MAPK cascade involved in innate immune response
def
A MAPK cascade that contributes to an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.
synonym
"MAPKKK cascade involved in innate immune response" EXACT [GOC:signaling]
GO:0035421 : activation of MAPKK activity involved in innate immune response
intersection_of
part_of GO:0045087
relationship
part_of GO:0035420
 intersection_of
GO:0065007
positively_regulates GO:0038076
relationship
positively_regulates GO:0038076
GO:0035422 : activation of MAPKKK activity involved in innate immune response
intersection_of
GO:0000185
part_of GO:0045087
relationship
part_of GO:0035420
 intersection_of
GO:0065007
positively_regulates GO:0038077
relationship
positively_regulates GO:0038077
GO:0035423 : inactivation of MAPK activity involved in innate immune response
intersection_of
GO:0000188
part_of GO:0045087
relationship
part_of GO:0035420
 intersection_of
GO:0065007
negatively_regulates GO:0038075
relationship
negatively_regulates GO:0038075
GO:0035915 : pore formation in membrane of other organism
is_a
GO:0035821
 is_a
GO:0051673
GO:0038029 : epidermal growth factor receptor signaling pathway via MAPK cascade
name
epidermal growth factor receptor signaling pathway via MAPKKK cascade
 name
epidermal growth factor receptor signaling pathway via MAPK cascade
synonym
"epidermal growth factor receptor signaling pathway via MAPKKK cascade" EXACT [GOC:signaling]
GO:0038030 : non-canonical Wnt receptor signaling pathway via MAPK cascade
name
non-canonical Wnt receptor signaling pathway via MAPKKK cascade
 name
non-canonical Wnt receptor signaling pathway via MAPK cascade
synonym
"non-canonical Wnt receptor signaling pathway via MAPKKK cascade" EXACT [GOC:signaling]
GO:0042656 : JUN kinase kinase kinase kinase activity
relationship
part_of GO:0042655
GO:0042730 : fibrinolysis
def
An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots.
 def
A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.
GO:0043408 : regulation of MAPK cascade
name
regulation of MAPKKK cascade
def
Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
 name
regulation of MAPK cascade
def
Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
synonym
"regulation of MAP kinase cascade" EXACT [GOC:signaling]
"regulation of MAPKKK cascade" EXACT [GOC:signaling]
"regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling]
"regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling]
GO:0043409 : negative regulation of MAPK cascade
name
negative regulation of MAPKKK cascade
 name
negative regulation of MAPK cascade
synonym
"down regulation of MAPK cascade" EXACT [GOC:signaling]
"down-regulation of MAPK cascade" EXACT [GOC:signaling]
"downregulation of MAPK cascade" EXACT [GOC:signaling]
"inhibition of MAPK cascade" NARROW [GOC:signaling]
"negative regulation of MAP kinase cascade" EXACT [GOC:signaling]
"negative regulation of MAPKKK cascade" EXACT [GOC:signaling]
"negative regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling]
"negative regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling]
GO:0043410 : positive regulation of MAPK cascade
name
positive regulation of MAPKKK cascade
 name
positive regulation of MAPK cascade
synonym
"activation of MAPK cascade" NARROW [GOC:signaling]
"positive regulation of MAP kinase cascade" EXACT [GOC:signaling]
"positive regulation of MAPKKK cascade" EXACT [GOC:signaling]
"positive regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling]
"stimulation of MAPK cascade" EXACT [GOC:signaling]
"up-regulation of MAPK cascade" EXACT [GOC:signaling]
"upregulation of MAPK cascade" EXACT [GOC:signaling]
GO:0044469 : envenomation resulting in positive regulation of blood coagulation in other organism
is_a
GO:0044483
GO:0045210 : FasL biosynthetic process
synonym
"fas ligand biosynthetic process" EXACT [GOC:add, PRO:000000095]
 synonym
"fas ligand biosynthetic process" EXACT [GOC:add, PR:000000095]
GO:0045558 : TRAIL receptor 1 biosynthetic process
synonym
"tumor necrosis factor receptor superfamily member 10A biosynthetic process" EXACT [PRO:000002108]
 synonym
"tumor necrosis factor receptor superfamily member 10A biosynthetic process" EXACT [PR:000002108]
GO:0045559 : TRAIL receptor 2 biosynthetic process
synonym
"tumor necrosis factor receptor superfamily member 10B biosynthetic process" EXACT [PRO:000002109]
 synonym
"tumor necrosis factor receptor superfamily member 10B biosynthetic process" EXACT [PR:000002109]
GO:0046318 : negative regulation of glucosylceramide biosynthetic process
is_a
GO:0090155
 is_a
GO:1900060
GO:0048437 : floral organ development
GO:0048438 : floral whorl development
comment
Consider instead annotating to one of the more specific child terms, or to 'floral organ development ; GO:0048438' or one of its child terms.
synonym
"collective phyllome structure development" BROAD [GOC:PO_curators, PO:0025023]
GO:0048444 : floral organ morphogenesis
GO:0048449 : floral organ formation
GO:0048450 : floral organ structural organization
GO:0048457 : floral whorl morphogenesis
GO:0048458 : floral whorl formation
GO:0048459 : floral whorl structural organization
GO:0048497 : maintenance of floral organ identity
GO:0050051 : leukotriene-B4 20-monooxygenase activity
relationship
part_of GO:0036101
GO:0051403 : stress-activated MAPK cascade
synonym
"p38 MAPK signaling" EXACT []
"p38 MAPK signalling" EXACT []
 synonym
"p38 MAPK signaling" NARROW []
"p38 MAPK signalling" NARROW []
GO:0051673 : membrane disruption in other organism
is_a
GO:0051704
 is_a
GO:0035821
GO:0061404 : positive regulation of transcription from RNA polymerase II promoter in response to increased salt
is_a
GO:0061416
GO:0070371 : ERK1 and ERK2 cascade
def
A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases.
 def
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
synonym
"extracellular signal-regulated kinase 1/2 (ERK1/2) cascade" EXACT [PMID:20811974]
"extracellular signal-regulated kinase 1/2 cascade" EXACT [PMID:20811974]
GO:0070375 : ERK5 cascade
name
BMK cascade
def
A cascade of protein kinase activities, culminating in the phosphorylation and activation of big MAP kinase (BMK1/ERK5), which is a type of mitogen-activated protein (MAP) kinase.
synonym
"ERK5 cascade" EXACT [GOC:add]
 name
ERK5 cascade
def
An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
synonym
"big MAP kinase signaling cascade" EXACT [PMID:20811974]
"BMK cascade" EXACT [PMID:20811974]
"extracellular signal-regulated kinase 5 cascade" EXACT [PMID:20811974]
GO:0070376 : regulation of ERK5 cascade
name
regulation of BMK cascade
def
Any process that modulates the frequency, rate or extent of signal transduction mediated by the BMK cascade.
synonym
"regulation of ERK5 cascade" EXACT [GOC:add]
 name
regulation of ERK5 cascade
def
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.
synonym
"regulation of BMK cascade" EXACT [GOC:signaling]
GO:0070377 : negative regulation of ERK5 cascade
name
negative regulation of BMK cascade
def
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the BMK cascade.
synonym
"negative regulation of ERK5 cascade" EXACT [GOC:add]
 name
negative regulation of ERK5 cascade
def
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.
synonym
"negative regulation of BMK cascade" EXACT [GOC:signaling]
GO:0070378 : positive regulation of ERK5 cascade
name
positive regulation of BMK cascade
def
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the BMK cascade.
synonym
"positive regulation of ERK5 cascade" EXACT [GOC:add]
 name
positive regulation of ERK5 cascade
def
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.
synonym
"positive regulation of BMK cascade" EXACT [GOC:signaling]
GO:0071507 : MAPK cascade involved in conjugation with cellular fusion
name
MAPKKK cascade involved in conjugation with cellular fusion
def
A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of conjugation with cellular fusion.
 name
MAPK cascade involved in conjugation with cellular fusion
def
A MAPK cascade that contributes to conjugation with cellular fusion.
synonym
"Fus3 signaling cascade" NARROW [PMID:20880736]
"MAPK signaling in response to pheromone" RELATED [PMID:20880736]
"MAPKKK cascade involved in conjugation with cellular fusion" EXACT [GOC:signaling]
"pheromone MAPK module" RELATED [PMID:20880736]
GO:0071508 : activation of MAPK activity involved in conjugation with cellular fusion
intersection_of
part_of GO:0000747
relationship
part_of GO:0071507
 intersection_of
GO:0065007
positively_regulates GO:0038071
relationship
positively_regulates GO:0038071
GO:0071509 : activation of MAPKK activity involved in conjugation with cellular fusion
intersection_of
GO:0000186
part_of GO:0000747
relationship
part_of GO:0071507
 intersection_of
GO:0065007
positively_regulates GO:0038072
relationship
positively_regulates GO:0038072
GO:0071510 : activation of MAPKKK activity involved in conjugation with cellular fusion
intersection_of
part_of GO:0000747
relationship
part_of GO:0071507
 intersection_of
GO:0065007
positively_regulates GO:0038073
relationship
positively_regulates GO:0038073
GO:0071511 : inactivation of MAPK activity involved in conjugation with cellular fusion
intersection_of
GO:0000188
part_of GO:0000747
relationship
part_of GO:0071507
 intersection_of
GO:0065007
negatively_regulates GO:0038071
relationship
negatively_regulates GO:0038071
GO:0072535 : tumor necrosis factor (ligand) superfamily member 11 production
synonym
"TNFSF11 production" EXACT [GOC:mah, PRO:000002107]
 synonym
"TNFSF11 production" EXACT [GOC:mah, PR:000002107]
GO:1900007 : regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging
is_a
GO:0090342
 is_a
GO:1900062

Other Stanza Types

Stanzas Edited

Stanza type ID name
Typedef negatively_regulates negatively_regulates
Typedef positively_regulates positively_regulates
Typedef regulates regulates

File Stats

Term counts for the old and new files
Ontology Old file New file Change
molecular function 9212
9212 (100.0%) defined 		9233
9233 (100.0%) defined 		+21
cellular component 2950
2950 (100.0%) defined 		2960
2960 (100.0%) defined 		+10
biological process 21867
21867 (100.0%) defined 		21916
21916 (100.0%) defined 		+49
Obsolete 1611
(4.5% of total)		 1611
(4.5% of total)		 0 (0.0%)
Totals 34029
34029 (100.0%) defined
35640 inc. obsoletes 		34109
34109 (100.0%) defined
35720 inc. obsoletes 		+80 (+0.2%)

Ontology report info