Gene Ontology: Ontology Comparison Report

Files used:

  • file 1 (old): go-2012-01-07.obo; date: 06:01:2012 16:33; CVS revision: 1.2481
  • file 2 (new): go-2012-01-14.obo; date: 13:01:2012 15:54; CVS revision: 1.2512

New terms

ID name namespace
GO:0036089 cleavage furrow formation biological_process
GO:0036090 cleavage furrow ingression biological_process
GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress biological_process
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process biological_process
GO:0038059 IKKalpha-IKKalpha complex cellular_component
GO:0038060 nitric oxide-cGMP-mediated signaling pathway biological_process
GO:0044458 motile cilium assembly biological_process
GO:0044465 regulation of sensory perception of pain in another organism biological_process
GO:0052867 phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity molecular_function
GO:0052868 protein-lysine lysyltransferase activity molecular_function
GO:0061396 regulation of transcription from RNA polymerase II promoter in response to copper ion biological_process
GO:0061397 positive regulation of transcription from RNA polymerase II promoter in response to copper ion biological_process
GO:0061398 negative regulation of transcription from RNA polymerase II promoter in response to copper ion biological_process
GO:0061399 positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion biological_process
GO:0061400 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion biological_process
GO:0061401 positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment biological_process
GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidity biological_process
GO:0061403 positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress biological_process
GO:0061404 positive regulation of transcription from RNA polymerase II promoter in response to increased salt biological_process
GO:0061405 positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure biological_process
GO:0061406 positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation biological_process
GO:0061407 positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide biological_process
GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress biological_process
GO:0061409 positive regulation of transcription from RNA polymerase II promoter in response to freezing biological_process
GO:0061410 positive regulation of transcription from RNA polymerase II promoter in response to ethanol biological_process
GO:0061411 positive regulation of transcription from RNA polymerase II promoter in response to cold biological_process
GO:0061412 positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation biological_process
GO:0097210 response to gonadotropin-releasing hormone biological_process
GO:0097211 cellular response to gonadotropin-releasing hormone biological_process
GO:0097212 lysosomal membrane organization biological_process
GO:0097213 regulation of lysosomal membrane permeability biological_process
GO:0097214 positive regulation of lysosomal membrane permeability biological_process
GO:0097215 negative regulation of lysosomal membrane permeability biological_process
GO:0097216 guanosine tetraphosphate binding molecular_function
GO:0097217 sieve area cellular_component
GO:0097218 sieve plate cellular_component
GO:0097219 compound sieve plate cellular_component
GO:0097220 simple sieve plate cellular_component
GO:1900003 regulation of serine-type endopeptidase activity biological_process
GO:1900004 negative regulation of serine-type endopeptidase activity biological_process
GO:1900005 positive regulation of serine-type endopeptidase activity biological_process
GO:1900006 positive regulation of dendrite development biological_process
GO:1900007 regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging biological_process
GO:1900008 negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging biological_process
GO:1900009 positive regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging biological_process
GO:1900010 regulation of corticotropin-releasing hormone receptor activity biological_process
GO:1900011 negative regulation of corticotropin-releasing hormone receptor activity biological_process
GO:1900012 positive regulation of corticotropin-releasing hormone receptor activity biological_process
GO:1900015 regulation of cytokine production involved in inflammatory response biological_process
GO:1900016 negative regulation of cytokine production involved in inflammatory response biological_process
GO:1900017 positive regulation of cytokine production involved in inflammatory response biological_process
GO:1900018 phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex biological_process
GO:1900019 regulation of protein kinase C activity biological_process
GO:1900020 positive regulation of protein kinase C activity biological_process
GO:1900022 regulation of D-erythro-sphingosine kinase activity biological_process
GO:1900023 positive regulation of D-erythro-sphingosine kinase activity biological_process
GO:1900024 regulation of substrate adhesion-dependent cell spreading biological_process
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading biological_process
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading biological_process
GO:1900027 regulation of ruffle assembly biological_process
GO:1900028 negative regulation of ruffle assembly biological_process
GO:1900029 positive regulation of ruffle assembly biological_process
GO:1900030 regulation of pectin biosynthetic process biological_process
GO:1900032 regulation of trichome patterning biological_process
GO:1900033 negative regulation of trichome patterning biological_process
GO:2001289 lipid X metabolic process biological_process

Obsoletions

None

Term merges

None

Term changes

Changes in term-related data
File 1 (06:01:2012 16:33, 1.2481) File 2 (13:01:2012 15:54, 1.2512)
GO:0000155 : two-component sensor activity
relationship
part_of GO:0023014
GO:0003376 : sphingosine-1-phosphate signaling pathway
name
sphingolipid signaling pathway
def
A series of molecular signals mediated by a sphingolipid.
synonym
"sphingolipid signalling pathway" EXACT [GOC:mah]
is_a
GO:0007165
 name
sphingosine-1-phosphate signaling pathway
def
A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
comment
Sphingosine-1-phosphate (S1P) can act both as an extracellular ligand for cell surface G-protein coupled receptors, and as an intracellular second messenger. GO:0003376 describes a pathway where S1P acts as an extracellular ligand. Where S1P acts within the cell to transmit a signal, consider instead 'intracellular signal transduction ; GO:0035556' or 'G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) ; GO:0001789'.
synonym
"S1P receptor signaling pathway" EXACT [GOC:bf]
"S1P signaling pathway" EXACT [GOC:bf]
"S1P-activated G-protein coupled receptor signaling pathway" EXACT [GOC:bf]
"S1P-activated GPCR signaling pathway" EXACT [GOC:bf]
"S1P-stimulated signal transduction pathway" EXACT [PMID:22001186]
"sphingolipid signaling pathway" BROAD [GOC:bf]
"sphingolipid signalling pathway" BROAD [GOC:mah]
xref
Reactome:REACT_18416.2 "S1P-binding receptors bind S1P"
is_a
GO:0007186
GO:0003377 : regulation of apoptosis by sphingosine-1-phosphate signaling pathway
name
regulation of apoptosis by sphingolipid signaling pathway
def
A series of molecular signals mediated by a sphingolipid that modulates the rate, frequency, or extent of apoptosis.
synonym
"regulation of apoptosis by sphingolipid signalling pathway" EXACT [GOC:mah]
 name
regulation of apoptosis by sphingosine-1-phosphate signaling pathway
def
A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis.
synonym
"regulation of apoptosis by sphingolipid signaling pathway" BROAD [GOC:bf]
"regulation of apoptosis by sphingolipid signalling pathway" BROAD [GOC:mah]
GO:0003378 : regulation of inflammatory response by sphingosine-1-phosphate signaling pathway
name
regulation of inflammatory response by sphingolipid signaling pathway
def
A series of molecular signals mediated by a sphingolipid that modulates the rate, frequency, or extent of the inflammatory response.
synonym
"regulation of inflammatory response by sphingolipid signalling pathway" EXACT [GOC:mah]
 name
regulation of inflammatory response by sphingosine-1-phosphate signaling pathway
def
A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response.
synonym
"regulation of inflammatory response by sphingolipid signaling pathway" BROAD [GOC:bf]
"regulation of inflammatory response by sphingolipid signalling pathway" BROAD [GOC:mah]
GO:0004190 : aspartic-type endopeptidase activity
synonym
"aspartate protease activity" EXACT [GOC:mah, GOC:vw]
GO:0004430 : 1-phosphatidylinositol 4-kinase activity
relationship
part_of GO:0046854
GO:0004702 : receptor signaling protein serine/threonine kinase activity
relationship
part_of GO:0023014
GO:0004716 : receptor signaling protein tyrosine kinase activity
relationship
part_of GO:0023014
GO:0004728 : receptor signaling protein tyrosine phosphatase activity
relationship
part_of GO:0023014
GO:0004897 : ciliary neurotrophic factor receptor activity
def
Combining with ciliary neurotrophic factor to initiate a change in cell activity.
 def
Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal to initiate a change in cell activity.
GO:0004923 : leukemia inhibitory factor receptor activity
def
Combining with leukemia inhibitory factor to initiate a change in cell activity.
 def
Combining with leukemia inhibitory factor (LIF) and transmitting the signal to initiate a change in cell activity.
GO:0004967 : glucagon receptor activity
relationship
part_of GO:0071377
GO:0004968 : gonadotropin-releasing hormone receptor activity
def
Combining with gonadotropin-releasing hormone to initiate a change in cell activity.
 def
Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
synonym
"GnRH receptor activity" EXACT []
relationship
part_of GO:0097211
GO:0007166 : cell surface receptor signaling pathway
name
cell surface receptor linked signaling pathway
 name
cell surface receptor signaling pathway
synonym
"cell surface receptor linked signaling pathway" EXACT [GOC:bf]
GO:0007249 : I-kappaB kinase/NF-kappaB cascade
xref
REACTOME:REACT_13696.1 "NF-kB is activated and signals survival, Homo sapiens"
 xref
Reactome:REACT_13696.1 "NF-kB is activated and signals survival, Homo sapiens"
GO:0007250 : activation of NF-kappaB-inducing kinase activity
synonym
"positive regulation of NF-kappaB-inducing kinase activity" EXACT []
 synonym
"activation of NIK activity" EXACT [GOC:bf]
"positive regulation of NF-kappaB-inducing kinase activity" BROAD []
GO:0007263 : nitric oxide mediated signal transduction
def
A series of molecular signals mediated by nitric oxide (NO).
is_a
GO:0007165
 def
Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
synonym
"nitric oxide signaling" EXACT [GOC:bf]
is_a
GO:0019932
GO:0008385 : IkappaB kinase complex
synonym
"heterotrimeric IKK complex" EXACT [GOC:bf]
"trimeric IKK complex" EXACT [PMID:21173796]
GO:0015056 : corticotrophin-releasing factor receptor activity
relationship
part_of GO:0071376
GO:0016303 : 1-phosphatidylinositol-3-kinase activity
is_a
GO:0035004
relationship
part_of GO:0036092
GO:0016307 : phosphatidylinositol phosphate kinase activity
synonym
"phosphatidylinositol monophosphate kinase activity" EXACT [GOC:bf]
GO:0016316 : phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
relationship
part_of GO:0036092
GO:0016500 : protein-hormone receptor activity
relationship
has_part GO:0017046
GO:0016503 : pheromone receptor activity
relationship
has_part GO:0005550
GO:0019221 : cytokine-mediated signaling pathway
def
Any series of molecular signals generated as a consequence of a cytokine binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0019722 : calcium-mediated signaling
def
A series of molecular signals in which a cell uses calcium ions to convert a signal into a response.
 def
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
GO:0019932 : second-messenger-mediated signaling
def
A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell.
 def
Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell.
GO:0019933 : cAMP-mediated signaling
def
A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
 def
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
GO:0019934 : cGMP-mediated signaling
def
A series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
 def
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
GO:0019935 : cyclic-nucleotide-mediated signaling
def
A series of molecular signals in which a cell uses a cyclic nucleotide to convert an extracellular signal into a response.
 def
Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell.
GO:0023014 : signal transduction by phosphorylation
name
signal transduction via phosphorylation event
def
The process in which a signal is conveyed via the transfer of one or more phosphate groups.
 name
signal transduction by phosphorylation
def
A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.
synonym
"signal transduction via phosphorylation event" RELATED [GOC:bf]
is_a
GO:0016310
GO:0023015 : signal transduction by cis-phosphorylation
name
signal transduction via a cis-phosphorylation event
def
The process in which a signal is conveyed via the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule.
synonym
"signal transmission via auto-phosphorylation" EXACT []
 name
signal transduction by cis-phosphorylation
def
A process in which the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule transmits a signal. For example, ligand-binding can induce autophosphorylation of the activated receptor, creating binding sites for intracellular signaling molecules.
synonym
"signal transduction via a cis-phosphorylation event" RELATED [GOC:bf]
"signal transmission via auto-phosphorylation" RELATED []
GO:0023016 : signal transduction by trans-phosphorylation
name
signal transduction via a trans-phosphorylation event
def
The process in which a signal is conveyed via the transfer of one or more phosphate groups by a kinase to a residue in a different molecule.
 name
signal transduction by trans-phosphorylation
def
A process in which the transfer of one or more phosphate groups by a kinase to a residue in a different molecule transmits a signal.
synonym
"signal transduction via a trans-phosphorylation event" RELATED [GOC:bf]
GO:0023035 : CD40 signaling pathway
def
Any series of molecular signals generated as a consequence of the receptor CD40 binding to one of its physiological ligands.
 def
A series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0023045 : signal transduction by conformational transition
name
signal transduction via conformational transition
def
The process whereby a signal is passed on within a cell by triggering a conformational change in the molecule that is receiving the signal.
 name
signal transduction by conformational transition
def
A process where induction of a conformational change in a molecule transmits a signal to that molecule.
synonym
"signal transduction via conformational transition" RELATED [GOC:bf]
GO:0031530 : gonadotropin-releasing hormone receptor binding
def
Interacting selectively and non-covalently with a receptor for gonadotropin-releasing hormone, a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.
 def
Interacting selectively and non-covalently with a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.
synonym
"GnRH receptor binding" EXACT []
GO:0033173 : calcineurin-NFAT signaling cascade
name
calcineurin-NFAT signaling pathway
def
A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin.
synonym
"calcineurin-NFAT signalling pathway" EXACT []
 name
calcineurin-NFAT signaling cascade
def
Any intracellular signal transduction in which the signal is passed on within the by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).
synonym
"calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
"calcineurin-NFAT signalling pathway" RELATED []
GO:0033211 : adiponectin-mediated signaling pathway
def
A series of molecular signals generated as a consequence of adiponectin binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of adiponectin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035004 : phosphatidylinositol 3-kinase activity
def
Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
 def
Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring.
GO:0035005 : 1-phosphatidylinositol-4-phosphate 3-kinase activity
is_a
GO:0035004
GO:0035014 : phosphatidylinositol 3-kinase regulator activity
relationship
part_of GO:0043551
GO:0035689 : chemokine (C-C motif) ligand 5 signaling pathway
def
A series of molecular events generated as a consequence of the chemokine CCL5 binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of the chemokine CCL5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035722 : interleukin-12-mediated signaling pathway
def
A series of molecular signals generated as a consequence of interleukin-12 binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0038027 : apolipoprotein A-I-mediated signaling pathway
def
Any series of molecular signals initiated by the binding of apolipoprotein A-I to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0038036 : sphingosine-1-phosphate receptor activity
relationship
part_of GO:0003376
GO:0039537 : suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway
synonym
"suppression by virus of host RIG-I-like receptor (RLR) signaling pathway" RELATED [GOC:bf]
"suppression by virus of host RIG-I/MDA5 signaling pathway" RELATED [GOC:bf]
"suppression by virus of host RIG-like helicase signaling pathway" RELATED [GOC:bf]
"suppression by virus of host RIG-like receptor signaling pathway" RELATED [GOC:bf]
"suppression by virus of host RLR signaling pathway" RELATED [GOC:bf]
is_a
GO:0075111
GO:0043812 : phosphatidylinositol-4-phosphate phosphatase activity
is_a
GO:0034596
GO:0043813 : phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
relationship
part_of GO:0036092
GO:0046934 : phosphatidylinositol-4,5-bisphosphate 3-kinase activity
is_a
GO:0035004
GO:0048016 : inositol phosphate-mediated signaling
def
A series of molecular signals in which a cell uses a water-soluble inositol phosphate to convert a signal into a response. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6).
 def
Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6).
GO:0051448 : gonadotropin-releasing hormone binding
def
Interacting selectively and non-covalently with gonadotropin-releasing hormone, a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary and it is synthesized and released by the hypothalamus.
 def
Interacting selectively and non-covalently with gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
synonym
"GnRH binding" EXACT []
GO:0052742 : phosphatidylinositol kinase activity
relationship
part_of GO:0046854
GO:0052813 : phosphatidylinositol bisphosphate kinase activity
relationship
part_of GO:0046854
GO:0052866 : phosphatidylinositol phosphate phosphatase activity
synonym
"phosphoinositide phosphatase activity" EXACT []
GO:0060333 : interferon-gamma-mediated signaling pathway
def
A series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0061311 : cell surface receptor signaling pathway involved in heart development
name
cell surface receptor linked signaling pathway involved in heart development
def
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell contributing to the progression of the heart over time.
 name
cell surface receptor signaling pathway involved in heart development
def
Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time.
synonym
"cell surface receptor linked signaling pathway involved in heart development" EXACT [GOC:bf]
GO:0070098 : chemokine-mediated signaling pathway
def
A series of molecular signals generated as a consequence of a chemokine binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0070120 : ciliary neurotrophic factor-mediated signaling pathway
def
A series of molecular signals generated as a consequence of a ciliary neurotrophic factor binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0070498 : interleukin-1-mediated signaling pathway
def
A series of molecular signals generated as a consequence of interleukin-1 binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0070884 : regulation of calcineurin-NFAT signaling cascade
name
regulation of calcineurin-NFAT signaling pathway
def
Any process that modulates the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway.
synonym
"regulation of calcineurin-NFAT signalling pathway" EXACT [GOC:mah]
 name
regulation of calcineurin-NFAT signaling cascade
def
Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
synonym
"regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
"regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah]
GO:0070885 : negative regulation of calcineurin-NFAT signaling cascade
name
negative regulation of calcineurin-NFAT signaling pathway
def
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway.
synonym
"down regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
"down-regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
"downregulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
"inhibition of calcineurin-NFAT signaling pathway" NARROW [GOC:mah]
"negative regulation of calcineurin-NFAT signalling pathway" EXACT [GOC:mah]
 name
negative regulation of calcineurin-NFAT signaling cascade
def
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
synonym
"down regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
"down-regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
"downregulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
"inhibition of calcineurin-NFAT signaling cascade" NARROW [GOC:mah]
"negative regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
"negative regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah]
"termination of calcineurin-NFAT signaling cascade" NARROW [GOC:bf]
GO:0070886 : positive regulation of calcineurin-NFAT signaling cascade
name
positive regulation of calcineurin-NFAT signaling pathway
def
Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway.
synonym
"activation of calcineurin-NFAT signaling pathway" NARROW [GOC:mah]
"positive regulation of calcineurin-NFAT signalling pathway" EXACT [GOC:mah]
"stimulation of calcineurin-NFAT signaling pathway" NARROW [GOC:mah]
"up regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
"up-regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
"upregulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
 name
positive regulation of calcineurin-NFAT signaling cascade
def
Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.
synonym
"activation of calcineurin-NFAT signaling cascade" NARROW [GOC:mah]
"positive regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
"positive regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah]
"stimulation of calcineurin-NFAT signaling cascade" NARROW [GOC:mah]
"up regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
"up-regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
"upregulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
GO:2000819 : regulation of nucleotide-excision repair

File Stats

Term counts for the old and new files
Ontology Old file New file Change
molecular function 9205
9205 (100.0%) defined 		9208
9208 (100.0%) defined 		+3
cellular component 2944
2944 (100.0%) defined 		2949
2949 (100.0%) defined 		+5
biological process 21765
21765 (100.0%) defined 		21823
21823 (100.0%) defined 		+58
Obsolete 1609
(4.5% of total)		 1609
(4.5% of total)		 0 (0.0%)
Totals 33914
33914 (100.0%) defined
35523 inc. obsoletes 		33980
33980 (100.0%) defined
35589 inc. obsoletes 		+66 (+0.2%)

Ontology report info