Gene Ontology Definition Changes

77 / 52 direct

GO:0003708 : retinoic acid receptor activity

OLD: Combining with retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA\npolymerase II. Retinoic acid is one of the forms of vitamin A.
NEW: Combining with retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. Retinoic acid is one of the forms of vitamin A.

2 / 2 direct

GO:0003832 : beta-alanyl-dopamine hydrolase activity

OLD: Catalysis of the conversion of beta-alanyl dopamine to dopamine (3,4-dihydroxyphenylethylamine).
NEW: Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine.

3 / 3 direct

GO:0008823 : cupric reductase activity

OLD: Catalysis of the reaction: Cu+ + NAD+ = Cu2+ + NADH.
NEW: Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH.

15 / 15 direct

GO:0008849 : enterochelin esterase activity

OLD: Catalysis of the hydrolysis of the enterochelin group of ferric-enterochelin to yield ultimately three molecules of N-2,3-dihydroxybenzoylserine.
NEW: Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+.

969 / 545 direct

GO:0016706 : oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

OLD: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
NEW: Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.

8 / 8 direct

GO:0017099 : very-long-chain-acyl-CoA dehydrogenase activity

(was very long-chain-acyl-CoA dehydrogenase activity)

OLD: Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long-chain fatty acid residue.
NEW: Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue.

0 annotations

GO:0018602 : 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity

OLD: Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid = glyoxylate + 2,4-dichlorophenol.
NEW: Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2.

445 / 14 direct

GO:0030035 : microspike assembly

OLD: Formation of a microspike, a thin, stiff projection extended from the surface of a migrating cell.
NEW: Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell.

122 / 122 direct

GO:0030416 : methylamine metabolic process

OLD: The chemical reactions and pathways involving methylamine (CH3NH2), a flammable, explosive gas, used in tanning and in organic synthesis and produced naturally in some decaying fish, certain plants, and crude methanol.
NEW: The chemical reactions and pathways involving methylamine (CH3NH2).

106 / 1 direct

GO:0031543 : peptidyl-proline dioxygenase activity

OLD: Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a protein.
NEW: Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2.

1 / 1 direct

GO:0031964 : beta-alanyl-histamine hydrolase activity

OLD: Catalysis of the conversion of beta-alanyl-histamine to histamine.
NEW: Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine.

0 annotations

GO:0033761 : mugineic-acid 3-dioxygenase activity

OLD: Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2, and 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2.
NEW: Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2.

24 / 24 direct

GO:0043734 : DNA-N1-methyladenine dioxygenase activity

OLD: Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA and RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methylgroup on N1-methyladenine and N3-methylcytosine as formaldehyde.
NEW: Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA and RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.

431 / 216 direct

GO:0046847 : filopodium assembly

OLD: The assembly of a filopodium, a very long microspike extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or by the growth cone of a developing nerve cell axon.
NEW: The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

23 / 23 direct

GO:0050353 : trimethyllysine dioxygenase activity

OLD: Catalysis of the reaction: 2-oxoglutarate + N(6)<element>,N</element>(6)<element>,N</element>(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate.
NEW: Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate.

1 / 1 direct

GO:0080182 : histone H3-K4 trimethylation

OLD: The modification of histone H4 by addition of three methyl groups to lysine at position 4 of the histone.
NEW: The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.