Gene Ontology Ontology Comparison Report ========================== Files used: - file 1 (old): go-2011-07-16.obo; date: 15:07:2011 15:41; CVS revision: 1.2091 - file 2 (new): go-2011-07-23.obo; date: 22:07:2011 17:11; CVS revision: 1.2104 NEW TERMS ========= ID name namespace GO:0035925 mRNA 3'-UTR AU-rich region binding molecular_function GO:0035926 chemokine (C-C motif) ligand 2 secretion biological_process GO:0035927 RNA import into mitochondrion biological_process GO:0035928 rRNA import into mitochondrion biological_process GO:0035929 steroid hormone secretion biological_process GO:0035930 corticosteroid hormone secretion biological_process GO:0035931 mineralocorticoid secretion biological_process GO:0035932 aldosterone secretion biological_process GO:0035933 glucocorticoid secretion biological_process GO:0035934 corticosterone secretion biological_process GO:0035935 androgen secretion biological_process GO:0035936 testosterone secretion biological_process GO:0035937 estrogen secretion biological_process GO:0035938 estradiol secretion biological_process GO:0035939 microsatellite binding molecular_function GO:0035940 negative regulation of peptidase activity in other organism biological_process GO:0072688 SHREC complex localization biological_process GO:2000826 regulation of heart morphogenesis biological_process GO:2000827 mitochondrial RNA surveillance biological_process OBSOLETIONS =========== None TERM MERGES =========== None TERM CHANGES ============ GO:0001559 : regulation of cell growth by detection of nuclear:cytoplasmic ratio - is_a: GO:0001558 + is_a: GO:0061387 GO:0005109 : frizzled binding GO:0005110 : frizzled-2 binding - is_a: GO:0001664 + is_a: GO:0005109 GO:0009549 : cellulose microfibril - def: Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls where it is found as microfibrils laid down in orthogonal layers. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell. + def: A microfibril composed of cellulose arranged in orthogonal layers. Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell. - is_a: GO:0001527 - relationship: part_of GO:0009530 - relationship: part_of GO:0009531 + relationship: part_of GO:0009505 GO:0016031 : tRNA import into mitochondrion - name: cytoplasmic tRNA import into mitochondrion + name: tRNA import into mitochondrion - def: The directed movement of cytoplasmic tRNA into a mitochondrion. + def: The directed movement of tRNA, transfer ribonucleic acid, from the cytoplasm into a mitochondrion. - synonym: "mitochondrial import of cytoplasmic tRNA" EXACT [] + synonym: "mitochondrial import of cytoplasmic tRNA" NARROW [] + synonym: "cytoplasmic tRNA import into mitochondrion" NARROW [GOC:bf] + synonym: "nuclear-encoded tRNA import into mitochondrion" NARROW [GOC:bf] - is_a: GO:0006839 + is_a: GO:0035927 GO:0016049 : cell growth - relationship: part_of GO:0008361 GO:0017091 : AU-rich element binding - def: Interacting selectively and non-covalently with AU-rich elements within the 3' untranslated region of mRNAs. + def: Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases. + synonym: "Adenylate/uridylate-rich element binding" EXACT [PMID:8578590] GO:0019517 : L-threonine catabolic process to D-lactate - name: threonine catabolic process to D-lactate + name: L-threonine catabolic process to D-lactate - def: The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate. + def: The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate. - synonym: "threonine catabolic process to pyruvate" RELATED [GOC:mah] - synonym: "threonine catabolism to D-lactate" EXACT [GOC:mah] - synonym: "threonine degradation to D-lactate" EXACT [] - synonym: "threonine catabolic process to methylglyoxal" EXACT [MetaCyc:THRDLCTCAT-PWY] - synonym: "threonine breakdown to D-lactate" EXACT [] + synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah] + synonym: "L-threonine catabolism to D-lactate" EXACT [GOC:bf, GOC:mah] + synonym: "L-threonine catabolic process to (R)-lactate" BROAD [CHEBI:16004, GOC:bf] + synonym: "L-threonine catabolic process to methylglyoxal" EXACT [MetaCyc:THRDLCTCAT-PWY] + synonym: "L-threonine breakdown to D-lactate" EXACT [GOC:bf] + synonym: "threonine catabolic process to D-lactate" BROAD [GOC:bf] + synonym: "L-threonine degradation to D-lactate" EXACT [GOC:bf] GO:0019518 : L-threonine catabolic process to glycine - name: threonine catabolic process to glycine + name: L-threonine catabolic process to glycine - def: The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound glycine. + def: The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine. - synonym: "threonine catabolic process to pyruvate" RELATED [GOC:mah] - synonym: "threonine degradation to glycine" EXACT [GOC:mah] - synonym: "threonine catabolism to glycine" EXACT [GOC:mah] - synonym: "threonine breakdown to glycine" EXACT [GOC:mah] + synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah] + synonym: "threonine catabolic process to glycine" BROAD [GOC:bf] + synonym: "L-threonine breakdown to glycine" EXACT [GOC:bf, GOC:mah] + synonym: "L-threonine degradation to glycine" EXACT [GOC:bf, GOC:mah] + synonym: "L-threonine catabolism to glycine" EXACT [GOC:bf, GOC:mah] GO:0030307 : positive regulation of cell growth - relationship: part_of GO:0045793 GO:0030308 : negative regulation of cell growth - relationship: part_of GO:0045792 GO:0030516 : regulation of axon extension - is_a: GO:0001558 + is_a: GO:0061387 GO:0030947 : regulation of vascular endothelial growth factor receptor signaling pathway + is_a: GO:0090287 GO:0030948 : negative regulation of vascular endothelial growth factor receptor signaling pathway + is_a: GO:0090288 GO:0042701 : progesterone secretion - is_a: GO:0060986 + is_a: GO:0035929 GO:0043400 : cortisol secretion + synonym: "hydrocortisone secretion" EXACT [CHEBI:17650] - is_a: GO:0060986 + is_a: GO:0035933 GO:0045025 : mitochondrial degradosome - def: The mitochondrial degradosome (mtEXO) is a three-protein complex which has a 3' to 5' exoribonuclease activity and participates in intron-independent turnover and processing of mitochondrial transcripts. + def: A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer. + synonym: "mtEXO" EXACT [PMID:10397341, PMID:9829834] GO:0045457 : ecdysteroid secretion - is_a: GO:0060986 + is_a: GO:0035929 GO:0048670 : regulation of collateral sprouting - is_a: GO:0001558 + is_a: GO:0061387 GO:0048686 : regulation of sprouting of injured axon - is_a: GO:0001558 + is_a: GO:0061387 GO:0051523 : cell growth mode switching, monopolar to bipolar - is_a: GO:0051510 + is_a: GO:0051519 + is_a: GO:0061389 GO:0051524 : cell growth mode switching, bipolar to monopolar - name: cell growth mode switch, bipolar to monopolar + name: cell growth mode switching, bipolar to monopolar + is_a: GO:0061389 GO:0051754 : meiotic sister chromatid cohesion, centromeric + is_a: GO:0051177 - relationship: part_of GO:0051177 GO:0051760 : meiotic sister chromatid cohesion, arms - is_a: GO:0022402 + is_a: GO:0051177 - relationship: part_of GO:0051177 GO:0051963 : regulation of synapse assembly - name: regulation of synaptogenesis + name: regulation of synapse assembly - def: Any process that modulates the frequency, rate or extent of synaptogenesis, the formation of a synapse. + def: Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. + synonym: "regulation of synapse biogenesis" EXACT [] + synonym: "regulation of synaptogenesis" EXACT [] GO:0051964 : negative regulation of synapse assembly - name: negative regulation of synaptogenesis + name: negative regulation of synapse assembly - def: Any process that stops, prevents, or reduces the frequency, rate or extent of synaptogenesis, the formation of a synapse. + def: Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. - synonym: "inhibition of synaptogenesis" NARROW [] - synonym: "down-regulation of synaptogenesis" EXACT [] - synonym: "down regulation of synaptogenesis" EXACT [] - synonym: "downregulation of synaptogenesis" EXACT [] + synonym: "negative regulation of synaptogenesis" EXACT [] + synonym: "inhibition of synapse assembly" NARROW [] + synonym: "negative regulation of synapse biogenesis" EXACT [] + synonym: "down regulation of synapse assembly" EXACT [] + synonym: "down-regulation of synapse assembly" EXACT [] + synonym: "downregulation of synapse assembly" EXACT [] GO:0051965 : positive regulation of synapse assembly - name: positive regulation of synaptogenesis + name: positive regulation of synapse assembly - def: Any process that activates, maintains or increases the frequency, rate or extent of synaptogenesis, the formation of a synapse. + def: Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. - synonym: "activation of synaptogenesis" NARROW [] - synonym: "stimulation of synaptogenesis" NARROW [] - synonym: "up-regulation of synaptogenesis" EXACT [] - synonym: "up regulation of synaptogenesis" EXACT [] - synonym: "upregulation of synaptogenesis" EXACT [] + synonym: "activation of synapse assembly" NARROW [] + synonym: "stimulation of synapse assembly" NARROW [] + synonym: "positive regulation of synaptogenesis" EXACT [] + synonym: "positive regulation of synapse biogenesis" EXACT [] + synonym: "upregulation of synapse assembly" EXACT [] + synonym: "up regulation of synapse assembly" EXACT [] + synonym: "up-regulation of synapse assembly" EXACT [] GO:0052149 : modulation by symbiont of host peptidase activity - name: modulation by symbiont of host protease activity + name: modulation by symbiont of host peptidase activity - def: The process in which an organism effects a change in host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction. + def: The process in which an organism effects a change in host peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction. + synonym: "modulation by symbiont of host protease activity" EXACT [GOC:bf] GO:0052180 : negative regulation of peptidase activity in other organism involved in symbiotic interaction - is_a: GO:0010466 + is_a: GO:0035940 GO:0052198 : modulation of peptidase activity in other organism involved in symbiotic interaction - name: modulation of protease activity in other organism involved in symbiotic interaction + name: modulation of peptidase activity in other organism involved in symbiotic interaction - def: The process in which an organism effects a change in protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction. + def: The process in which an organism effects a change in peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction. + synonym: "modulation of protease activity in other organism involved in symbiotic interaction" EXACT [GOC:bf] GO:0052427 : modulation by host of symbiont peptidase activity - name: modulation by host of symbiont protease activity + name: modulation by host of symbiont peptidase activity - def: The process in which an organism effects a change in symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. + def: The process in which an organism effects a change in symbiont peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. + synonym: "modulation by host of symbiont protease activity" EXACT [GOC:bf] GO:0060386 : synapse assembly involved in innervation - name: synaptogenesis involved in innervation + name: synapse assembly involved in innervation - def: The biosynthesis of a synapse within a target tissue in which a nerve is invading. + def: The assembly of a synapse within a target tissue in which a nerve is invading. + synonym: "synapse biogenesis involved in innervation" EXACT [] + synonym: "synaptogenesis involved in innervation" EXACT [] GO:0061387 : regulation of extent of cell growth + relationship: part_of GO:0008361 GO:0070689 : L-threonine catabolic process to propionate - name: threonine catabolic process to propionate + name: L-threonine catabolic process to propionate - def: The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound propionate. + def: The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate. - synonym: "threonine breakdown to propionate" EXACT [GOC:mah] - synonym: "threonine degradation to propionate" EXACT [GOC:mah] - synonym: "threonine catabolism to propionate" EXACT [GOC:mah] + synonym: "L-threonine breakdown to propionate" EXACT [GOC:bf, GOC:mah] + synonym: "L-threonine catabolism to propionate" EXACT [GOC:bf, GOC:mah] + synonym: "L-threonine degradation to propionate" EXACT [GOC:bf, GOC:mah] + synonym: "threonine catabolic process to propionate" BROAD [GOC:bf] GO:0070690 : L-threonine catabolic process to acetyl-CoA - name: threonine catabolic process to acetyl-CoA + name: L-threonine catabolic process to acetyl-CoA - def: The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound acetyl-Coenzyme A. + def: The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) into glycine and acetaldehyde, with acetaldehyde being subsequently converted to acetyl-CoA. - synonym: "threonine degradation to acetyl-CoA" EXACT [GOC:mah] - synonym: "threonine breakdown to acetyl-CoA" EXACT [GOC:mah] - synonym: "threonine catabolism to acetyl-CoA" EXACT [GOC:mah] + synonym: "L-threonine breakdown to acetyl-CoA" EXACT [GOC:bf, GOC:mah] + synonym: "threonine catabolic process to acetyl-CoA" BROAD [GOC:bf] + synonym: "L-threonine catabolism to acetyl-CoA" EXACT [GOC:bf, GOC:mah] + synonym: "L-threonine degradation to acetyl-CoA" EXACT [GOC:bf, GOC:mah] GO:0071961 : mitotic sister chromatid cohesion, arms - is_a: GO:0022402 + is_a: GO:0007064 - relationship: part_of GO:0007064 GO:0071962 : mitotic sister chromatid cohesion, centromeric + is_a: GO:0007064 - relationship: part_of GO:0007064 GO:2000804 : regulation of termination of RNA polymerase II transcription, poly(A)-coupled + is_a: GO:0006357 GO:2000823 : regulation of androgen receptor activity + is_a: GO:0060765 FILE STATS ========== Term counts for the old and new files Ontology Old file New file Change molecular function 9028 9030 +2 (9028 defined) (9030 defined) cellular component 2858 2858 (2858 defined) (2858 defined) biological process 21036 21053 +17 (21035 defined) (21052 defined) Obsolete 1560 1560 0 (4.5% of total) (4.5% of total) (0.0%) Totals 32922 32941 +19 (+0.1%) 32921 (100.0%) defined 32940 (100.0%) defined 34482 inc. obs 34501 inc. obs