Gene Ontology OBO file definition changes

7287 / 7287 direct

GO:0004984 : olfactory receptor activity

OLD: Combining with airborne compounds to initiate a change in cell activity. These receptors are used for the sense of smell.
NEW: Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.

438 / 438 direct

GO:0005044 : scavenger receptor activity

OLD: Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity.
NEW: Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand to initiate a change in cell activity. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). Following ligand binding, scavenger receptors can mediate intracellular signaling and/or ligand internalization.

39 / 39 direct

GO:0005220 : inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

OLD: Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate has been bound by the channel complex or one of its constituent parts.
NEW: Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts.

24 / 24 direct

GO:0007172 : signal complex assembly

OLD: The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. Complex formation involves dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors.
NEW: The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell.

2 / 2 direct

GO:0031585 : regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

(was regulation of inositol-1,4,5-triphosphate receptor activity)

OLD: Any process that modulates the frequency, rate or extent of the activity of the IP3 receptor.
NEW: Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.

0 annotations

GO:0031586 : negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

(was negative regulation of inositol-1,4,5-trisphosphate receptor activity)

OLD: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the IP3 receptor.
NEW: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.

0 annotations

GO:0031587 : positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

(was positive regulation of inositol-1,4,5-trisphosphate receptor activity)

OLD: Any process that activates or increases the frequency, rate or extent of the activity of the IP3 receptor.
NEW: Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.

9 / 9 direct

GO:0033210 : leptin-mediated signaling pathway

OLD: A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor.
NEW: A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.