Ontology Comparison Report

Files used:

file 1 (old): go-2011-06-25.obo; date: 24:06:2011 15:09; CVS revision: 1.2067
file 2 (new): go-2011-07-02.obo; date: 01:07:2011 14:52; CVS revision: 1.2074

New terms
Obsoletions
Term merges
Term changes
File Stats

New terms

ID	name	namespace
GO:0002189	ribose phosphate diphosphokinase complex	cellular_component
GO:0035915	pore complex assembly in other organism	biological_process
GO:0035916	modulation of calcium channel activity in other organism	biological_process
GO:0035917	negative regulation of calcium channel activity in other organism	biological_process
GO:0035918	negative regulation of voltage-gated calcium channel activity in other organism	biological_process
GO:0035919	negative regulation of low voltage-gated calcium channel activity in other organism	biological_process
GO:0035920	negative regulation of high voltage-gated calcium channel activity in other organism	biological_process
GO:0038021	leptin receptor activity	molecular_function
GO:0038022	olfactory receptor activity, G-protein coupled	molecular_function
GO:0097089	methyl-branched fatty acid metabolic process	biological_process
GO:2000794	regulation of epithelial cell proliferation involved in lung morphogenesis	biological_process
GO:2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis	biological_process
GO:2000796	Notch signaling pathway involved in negative regulation of venous endothelial cell fate commitment	biological_process
GO:2000797	regulation of amniotic stem cell differentiation	biological_process
GO:2000798	negative regulation of amniotic stem cell differentiation	biological_process
GO:2000799	positive regulation of amniotic stem cell differentiation	biological_process
GO:2000800	regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	biological_process
GO:2000801	negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	biological_process
GO:2000802	positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	biological_process
GO:2000803	endosomal signal transduction	biological_process

Obsoletions

None

Term merges

Old ID	Old name	Merged into	Merged term name
GO:0008095	inositol-1,4,5-trisphosphate receptor activity	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

Term changes

Changes in term-related data
File 1 (24:06:2011 15:09, 1.2067)	File 2 (01:07:2011 14:52, 1.2074)

GO:0004984 : olfactory receptor activity
def ~~Combining with airborne compounds to initiate a change in cell activity. These receptors are used for the sense of smell.~~ is_a ~~GO:0004930~~	def Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. synonym "odorant receptor activity" EXACT [PMID:19135896, PMID:21041441] is_a GO:0004888 relationship part_of GO:0050911

GO:0005044 : scavenger receptor activity
def ~~Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity.~~ synonym ~~"macrophage receptor activity" EXACT []~~	def Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand to initiate a change in cell activity. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). Following ligand binding, scavenger receptors can mediate intracellular signaling and/or ligand internalization. synonym "macrophage receptor activity" NARROW []

GO:0005044 : scavenger receptor activity

def
~~Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity.~~
synonym
~~"macrophage receptor activity" EXACT []~~

def
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand to initiate a change in cell activity. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). Following ligand binding, scavenger receptors can mediate intracellular signaling and/or ligand internalization.
synonym
"macrophage receptor activity" NARROW []

GO:0005220 : inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
def ~~Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate has been bound by the channel complex or one of its constituent parts.~~ is_a ~~GO:0008095~~	alt_id GO:0008095 def Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts. synonym "inositol-1,4,5-trisphosphate receptor activity" EXACT [] "InsP3 receptor" EXACT [GOC:bf] "IP3 receptor activity" EXACT [] is_a GO:0004872 relationship part_of GO:0048016

GO:0005220 : inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

def
~~Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate has been bound by the channel complex or one of its constituent parts.~~
is_a
~~GO:0008095~~

alt_id
GO:0008095
def
Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts.
synonym
"inositol-1,4,5-trisphosphate receptor activity" EXACT []
"InsP3 receptor" EXACT [GOC:bf]
"IP3 receptor activity" EXACT []
is_a
GO:0004872
relationship
part_of GO:0048016

GO:0007172 : signal complex assembly
def The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. Complex formation involves dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors. relationship ~~part_of GO:0007169~~	def The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. is_a GO:0009966

GO:0008527 : taste receptor activity
	relationship part_of GO:0050912

GO:0015469 : channel-forming toxin activity
consider ~~GO:0046931~~	consider GO:0035915

GO:0031585 : regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
name ~~regulation of inositol-1,4,5-triphosphate receptor activity~~ def ~~Any process that modulates the frequency, rate or extent of the activity of the IP3 receptor.~~ intersection_of ~~regulates GO:0008095~~ relationship ~~regulates GO:0008095~~	name regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity def Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. synonym "regulation of inositol-1,4,5-triphosphate receptor activity" EXACT [GOC:signaling] intersection_of regulates GO:0005220 relationship regulates GO:0005220

GO:0031585 : regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

name
~~regulation of inositol-1,4,5-triphosphate receptor activity~~
def
~~Any process that modulates the frequency, rate or extent of the activity of the IP3 receptor.~~
intersection_of
~~regulates GO:0008095~~
relationship
~~regulates GO:0008095~~

name
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
def
Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
synonym
"regulation of inositol-1,4,5-triphosphate receptor activity" EXACT [GOC:signaling]
intersection_of
regulates GO:0005220
relationship
regulates GO:0005220

GO:0031586 : negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
name ~~negative regulation of inositol-1,4,5-trisphosphate receptor activity~~ def ~~Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the IP3 receptor.~~ intersection_of ~~negatively_regulates GO:0008095~~ relationship ~~negatively_regulates GO:0008095~~	name negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity def Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. synonym "negative regulation of inositol 1,4,5-trisphosphate receptor activity" EXACT [GOC:signaling] intersection_of negatively_regulates GO:0005220 relationship negatively_regulates GO:0005220

GO:0031586 : negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

name
~~negative regulation of inositol-1,4,5-trisphosphate receptor activity~~
def
~~Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the IP3 receptor.~~
intersection_of
~~negatively_regulates GO:0008095~~
relationship
~~negatively_regulates GO:0008095~~

name
negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
def
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
synonym
"negative regulation of inositol 1,4,5-trisphosphate receptor activity" EXACT [GOC:signaling]
intersection_of
negatively_regulates GO:0005220
relationship
negatively_regulates GO:0005220

GO:0031587 : positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
name ~~positive regulation of inositol-1,4,5-trisphosphate receptor activity~~ def ~~Any process that activates or increases the frequency, rate or extent of the activity of the IP3 receptor.~~ intersection_of ~~positively_regulates GO:0008095~~ relationship ~~positively_regulates GO:0008095~~	name positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity def Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. synonym "positive regulation of inositol-1,4,5-trisphosphate receptor activity" EXACT [GOC:bf] intersection_of positively_regulates GO:0005220 relationship positively_regulates GO:0005220

GO:0031587 : positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

name
~~positive regulation of inositol-1,4,5-trisphosphate receptor activity~~
def
~~Any process that activates or increases the frequency, rate or extent of the activity of the IP3 receptor.~~
intersection_of
~~positively_regulates GO:0008095~~
relationship
~~positively_regulates GO:0008095~~

name
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
def
Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
synonym
"positive regulation of inositol-1,4,5-trisphosphate receptor activity" EXACT [GOC:bf]
intersection_of
positively_regulates GO:0005220
relationship
positively_regulates GO:0005220

GO:0033038 : bitter taste receptor activity
	relationship part_of GO:0001580

GO:0033039 : salty taste receptor activity
	relationship part_of GO:0001583

GO:0033040 : sour taste receptor activity
	relationship part_of GO:0001581

GO:0033041 : sweet taste receptor activity
	relationship part_of GO:0001582

GO:0033042 : umami taste receptor activity
	relationship part_of GO:0046535

GO:0033210 : leptin-mediated signaling pathway
def ~~A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor.~~	def A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. is_a GO:0044320

GO:0043113 : receptor clustering
relationship ~~part_of GO:0007172~~

GO:0046931 : pore complex assembly
synonym ~~"channel-forming toxin activity" RELATED []~~

GO:0060501 : positive regulation of epithelial cell proliferation involved in lung morphogenesis
	is_a GO:2000794

File Stats

Term counts for the old and new files
Ontology	Old file	New file	Change
molecular function	9023 9023 (100.0%) defined	9024 9024 (100.0%) defined	+1
cellular component	2855 2855 (100.0%) defined	2856 2856 (100.0%) defined	+1
biological process	20983 20982 (100.0%) defined	21000 20999 (100.0%) defined	+17
Obsolete	1559 (4.5% of total)	1559 (4.5% of total)	0 (0.0%)
Totals	32861 32860 (100.0%) defined 34420 inc. obsoletes	32880 32879 (100.0%) defined 34439 inc. obsoletes	+19 (+0.1%)