# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
18 Mar 2016: Updated by: TOUCHUP-v1.14
27 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20140924: Eumetazoa_PTN001200938 has function peptide binding (GO:0042277) 
20140924: Eumetazoa_PTN001200938 has function G-protein coupled receptor activity (GO:0004930) 
20140924: Bilateria_PTN000659780 has function neuropeptide binding (GO:0042923) 
20140924: Euteleostomi_PTN000757064 has function somatostatin receptor activity (GO:0004994) 
20140924: Euteleostomi_PTN000659883 has function somatostatin receptor activity (GO:0004994) 
20140924: Euteleostomi_PTN000659951 has function dynorphin receptor activity (GO:0038048) 
20140924: Euteleostomi_PTN000659833 has function enkephalin receptor activity (GO:0038046) 
20140924: Euteleostomi_PTN000659803 has function somatostatin receptor activity (GO:0004994) 
20140924: Euteleostomi_PTN000659858 has function nociceptin receptor activity (GO:0001626) 
20140924: Euteleostomi_PTN000660027 has function prostaglandin D receptor activity (GO:0004956) 
20140924: Euteleostomi_PTN000659928 has function morphine receptor activity (GO:0038047) 
20140924: Euteleostomi_PTN000659928 has function G-protein beta-subunit binding (GO:0031681) 
20140924: Euteleostomi_PTN000659928 has function G-protein alpha-subunit binding (GO:0001965) 
20140924: Euteleostomi_PTN000659928 has function beta-endorphin receptor activity (GO:0004979) 
20140924: Euteleostomi_PTN000660084 has function somatostatin receptor activity (GO:0004994) 

# cellular_component
20140924: Eumetazoa_PTN001200938 is found in neuron projection (GO:0043005) 
20140924: Eumetazoa_PTN001200938 is found in integral component of plasma membrane (GO:0005887) 

# biological_process
20140925: Eumetazoa_PTN001200938 participates in G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) 
20140924: Bilateria_PTN000659780 participates in neuropeptide signaling pathway (GO:0007218) 
20140924: Chordata_PTN000659782 participates in synaptic transmission (GO:0007268) 
20140925: Euteleostomi_PTN000757064 participates in negative regulation of cell proliferation (GO:0008285) 
20140925: Euteleostomi_PTN000757064 participates in cellular response to estradiol stimulus (GO:0071392) 
20140925: Euteleostomi_PTN000659883 participates in negative regulation of cell proliferation (GO:0008285) 
20140925: Euteleostomi_PTN000659883 participates in cellular response to glucocorticoid stimulus (GO:0071385) 
20140924: Euteleostomi_PTN000659951 participates in sensory perception of pain (GO:0019233) 
20140924: Euteleostomi_PTN000659833 participates in sensory perception of pain (GO:0019233) 
20140925: Euteleostomi_PTN000659803 participates in cellular response to glucocorticoid stimulus (GO:0071385) 
20140925: Euteleostomi_PTN000659803 participates in negative regulation of cell proliferation (GO:0008285) 
20140925: Euteleostomi_PTN000659803 participates in cellular response to estradiol stimulus (GO:0071392) 
20140924: Euteleostomi_PTN000659858 participates in opioid receptor signaling pathway (GO:0038003) 
20140924: Euteleostomi_PTN000659858 participates in sensory perception of pain (GO:0019233) 
20140924: Euteleostomi_PTN000659928 participates in sensory perception of pain (GO:0019233) 
20140925: Euteleostomi_PTN000659928 participates in cellular response to morphine (GO:0071315) 
20140925: Euteleostomi_PTN000660084 participates in cellular response to glucocorticoid stimulus (GO:0071385) 
20140925: Euteleostomi_PTN000660084 participates in regulation of insulin secretion (GO:0050796) 
20140925: Euteleostomi_PTN000660084 participates in negative regulation of cell proliferation (GO:0008285) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Annotated by PG and VH

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).