# HISTORY 25 Nov 2016: Saved by mfeuerma using Paint 2.28 on 25 Nov 2016 using PANTHER version UPL 11.0 # molecular_function 20161125: root_PTN000623091 has function cyclin-dependent protein serine/threonine kinase activity (GO:0004693) 20161125: Eukaryota_PTN001173068 has function cyclin-dependent protein kinase activating kinase activity (GO:0019912) 20161125: Eukaryota_PTN000756102 has LOST/MODIFIED function cyclin-dependent protein serine/threonine kinase activity (GO:0004693) 20161125: Eukaryota_PTN000756102 has function protein serine/threonine kinase activity (GO:0004674) 20161125: Eukaryota_PTN000623979 has function cyclin binding (GO:0030332) 20161125: Eukaryota_PTN000623455 has function RNA polymerase II carboxy-terminal domain kinase activity (GO:0008353) 20161125: Eukaryota_PTN000623455 has function cyclin binding (GO:0030332) 20161125: Eukaryota_PTN000623455 has function transcription factor binding (GO:0008134) 20161125: Eukaryota_PTN000623455 has function transcription regulatory region DNA binding (GO:0044212) 20161125: Eukaryota_PTN001936021 has function RNA polymerase II carboxy-terminal domain kinase activity (GO:0008353) 20161125: Eumetazoa_PTN001172735 has function cyclin binding (GO:0030332) 20161125: Eumetazoa_PTN001172753 has LOST/MODIFIED function cyclin-dependent protein serine/threonine kinase activity (GO:0004693) 20161125: Eumetazoa_PTN001172753 has function protein serine/threonine kinase activity (GO:0004674) 20161125: Eukaryota_PTN000623619 has LOST/MODIFIED function cyclin-dependent protein serine/threonine kinase activity (GO:0004693) 20161125: Eukaryota_PTN000623619 has function protein kinase activity (GO:0004672) # cellular_component 20161125: root_PTN000623091 is found in nucleus (GO:0005634) 20161125: Eukaryota_PTN001173068 is found in cytoplasm (GO:0005737) 20161125: Eukaryota_PTN000756102 is found in cytoplasm (GO:0005737) 20161125: Deuterostomia_PTN000624259 is found in dendrite cytoplasm (GO:0032839) 20161125: Eukaryota_PTN000623979 is found in cyclin-dependent protein kinase holoenzyme complex (GO:0000307) 20161125: Eukaryota_PTN000623979 is found in cytoplasm (GO:0005737) 20161125: Eukaryota_PTN000623455 is found in nucleoplasm (GO:0005654) 20161125: Eukaryota_PTN000623455 is found in cyclin/CDK positive transcription elongation factor complex (GO:0008024) 20161125: Eukaryota_PTN000623455 is found in chromosome (GO:0005694) 20161125: Eukaryota_PTN000756019 is found in cytoskeleton (GO:0005856) 20161125: Eukaryota_PTN000756019 is found in cytoplasm (GO:0005737) 20161125: Eukaryota_PTN000756019 is found in mitotic spindle (GO:0072686) 20161125: Eukaryota_PTN000623701 is found in cytoplasm (GO:0005737) 20161125: Eukaryota_PTN000623701 is found in cytosol (GO:0005829) 20161125: Eukaryota_PTN000623092 is found in mediator complex (GO:0016592) 20161125: Euteleostomi_PTN000623122 is NOT found in mediator complex (GO:0016592) 20161125: Euteleostomi_PTN000623122 is found in cytosol (GO:0005829) 20161125: Eukaryota_PTN000624096 is found in TFIIK complex (GO:0070985) 20161125: Eukaryota_PTN000624096 is found in cytoplasm (GO:0005737) 20161125: Eukaryota_PTN001936021 is found in cyclin-dependent protein kinase holoenzyme complex (GO:0000307) 20161125: Eukaryota_PTN002373304 is found in cytoplasm (GO:0005737) 20161125: Eukaryota_PTN001936021 is found in nuclear chromatin (GO:0000790) 20161125: Eumetazoa_PTN001172735 is found in cytosol (GO:0005829) 20161125: Eukaryota_PTN002373332 is found in Pho85-Pho80 CDK-cyclin complex (GO:1990860) 20161125: Euteleostomi_PTN000623740 co-localizes with synaptic vesicle (GO:0008021) 20161125: Euteleostomi_PTN000623740 is NOT found in nucleus (GO:0005634) # biological_process 20161125: root_PTN000623091 participates in protein phosphorylation (GO:0006468) 20161125: Eukaryota_PTN001173068 participates in positive regulation of cyclin-dependent protein kinase activity (GO:1904031) 20161125: Deuterostomia_PTN000624259 participates in regulation of dendrite development (GO:0050773) 20161125: Deuterostomia_PTN000624259 participates in positive regulation of axon extension (GO:0045773) 20161125: Eukaryota_PTN000623979 participates in mitotic cell cycle (GO:0000278) 20161125: Eukaryota_PTN000623979 participates in G1/S transition of mitotic cell cycle (GO:0000082) 20161125: Eukaryota_PTN000623979 participates in signal transduction (GO:0007165) 20161125: Eukaryota_PTN000623979 participates in regulation of mitotic cell cycle (GO:0007346) 20161125: Eukaryota_PTN000623979 participates in regulation of G2/M transition of mitotic cell cycle (GO:0010389) 20161125: Eukaryota_PTN000623979 participates in multicellular organism development (GO:0007275) 20161125: Eukaryota_PTN000623979 participates in regulation of gene expression (GO:0010468) 20161125: Eukaryota_PTN000623979 participates in response to organic substance (GO:0010033) 20161125: Eukaryota_PTN000623979 participates in positive regulation of cell proliferation (GO:0008284) 20161125: Eukaryota_PTN000623380 participates in regulation of mitotic cell cycle (GO:0007346) 20161125: Eukaryota_PTN000623380 participates in regulation of gene expression (GO:0010468) 20161125: Eukaryota_PTN000623455 participates in phosphorylation of RNA polymerase II C-terminal domain (GO:0070816) 20161125: Eukaryota_PTN000623455 participates in transcription elongation from RNA polymerase II promoter (GO:0006368) 20161125: Eukaryota_PTN000623455 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 20161125: Eukaryota_PTN000756019 participates in mitotic cell cycle phase transition (GO:0044772) 20161125: Eukaryota_PTN000756019 participates in cell differentiation (GO:0030154) 20161125: Eukaryota_PTN000756019 participates in histone phosphorylation (GO:0016572) 20161125: Eukaryota_PTN000756019 participates in cellular response to DNA damage stimulus (GO:0006974) 20161125: Eukaryota_PTN000756019 participates in microtubule cytoskeleton organization (GO:0000226) 20161125: Eukaryota_PTN000756019 participates in regulation of mitotic cell cycle (GO:0007346) 20161125: Eukaryota_PTN000756019 participates in regulation of meiotic cell cycle (GO:0051445) 20161125: Eukaryota_PTN000756019 participates in regulation of gene expression (GO:0010468) 20161125: Eukaryota_PTN000756019 participates in DNA repair (GO:0006281) 20161125: Nematostella vectensis_A7RGF7 does NOT participate in axonogenesis (GO:0007409) 20161125: Trichoplax adhaerens_B3RQV2 does NOT participate in axonogenesis (GO:0007409) 20161125: Monosiga brevicollis_A9UYZ3 does NOT participate in axonogenesis (GO:0007409) 20161125: Bilateria_PTN000623852 participates in axonogenesis (GO:0007409) 20161125: Bilateria_PTN000623852 participates in neuron apoptotic process (GO:0051402) 20161125: Bilateria_PTN000623852 participates in central nervous system development (GO:0007417) 20161125: Eukaryota_PTN000623701 participates in vesicle-mediated transport (GO:0016192) 20161125: Bilateria_PTN000623852 participates in synaptic vesicle transport (GO:0048489) 20161125: Eukaryota_PTN000623092 participates in regulation of mitotic cell cycle (GO:0007346) 20161125: Eukaryota_PTN000624096 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 20161125: Eukaryota_PTN001936021 participates in positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968) 20161125: Eukaryota_PTN002373332 participates in regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) 20161125: Amniota_PTN000624167 participates in positive regulation of dendrite morphogenesis (GO:0050775) 20161125: Amniota_PTN000624167 participates in negative regulation of axon extension (GO:0030517) 20161125: Amniota_PTN000624167 participates in dendrite extension (GO:0097484) 20161125: Eukaryota_PTN001936021 participates in phosphorylation of RNA polymerase II C-terminal domain (GO:0070816) 20161125: Euteleostomi_PTN000623740 participates in exocytosis (GO:0006887) 20161125: Euteleostomi_PTN000623740 participates in neuron projection development (GO:0031175) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).