# HISTORY
26 Apr 2016: Updated by: TOUCHUP-v1.15
19 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20140703: Opisthokonta_PTN001583233 has function single-stranded DNA exodeoxyribonuclease activity (GO:0008297) 

# cellular_component
20140703: Opisthokonta_PTN001583233 is found in mitochondrion (GO:0005739) 

# biological_process
20140703: Opisthokonta_PTN001583233 participates in mitochondrial DNA replication (GO:0006264) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
PTHR31340
A simple family, with only one paper available for human MGME1:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678843/
MGME1 was a PD-(D/E)XK-type nuclease localizes to mitochondria
The finding of mtDNA depletion and mtDNA deletions in skeletal muscle from the MGME1 patients suggested perturbed mtDNA maintenance as the primary cause of the mitochondrial disease. They also accumulate intermediates of stalled replication and show increased levels of 7S DNA, as do MGME1-depleted cells
MSA shows conserved Domain architecture; so propagate human annotations to the root node.
LN 7/3/2014

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).