# HISTORY 28 Mar 2016: Updated by: TOUCHUP-v1.15 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140829: Eukaryota_PTN000703549 has function phosphorelay response regulator activity (GO:0000156) 20140829: Eukaryota_PTN000703549 has function histidine phosphotransfer kinase activity (GO:0009927) # cellular_component 20140826: Embryophyta_PTN001232866 is found in nucleus (GO:0005634) 20140826: Viridiplantae_PTN001232738 is found in endoplasmic reticulum (GO:0005783) # biological_process 20140826: Viridiplantae_PTN001232738 participates in negative regulation of ethylene-activated signaling pathway (GO:0010105) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).