# HISTORY 08 May 2016: Updated by: TOUCHUP-v1.18 18 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150917: root_PTN001973695 contributes to function ubiquitin-protein transferase activity (GO:0004842) 20150917: Euteleostomi_PTN000697161 has function transcription factor binding (GO:0008134) 20150917: Euteleostomi_PTN000697969 has function interferon-gamma binding (GO:0019964) 20150917: Euteleostomi_PTN001229124 has function actin filament binding (GO:0051015) 20150917: Tetrapoda_PTN001229359 has function actin binding (GO:0003779) 20150917: Euteleostomi_PTN000697442 has function RNA polymerase II distal enhancer sequence-specific DNA binding (GO:0000980) 20150917: Euteleostomi_PTN000697442 has function transcription factor activity, sequence-specific DNA binding (GO:0003700) # cellular_component 20150917: root_PTN001973695 is found in Cul3-RING ubiquitin ligase complex (GO:0031463) 20150917: Euteleostomi_PTN000697969 is found in trans-Golgi network (GO:0005802) 20150917: Euteleostomi_PTN000697969 is found in PML body (GO:0016605) 20150917: Eumetazoa_PTN001561561 is found in polar microtubule (GO:0005827) 20150917: Chordata_PTN001973791 is found in Golgi membrane (GO:0000139) 20150917: Chordata_PTN001973791 is found in ER to Golgi transport vesicle (GO:0030134) 20150917: Amniota_PTN000698035 is found in neuronal cell body (GO:0043025) 20150917: Amniota_PTN000698035 is found in cytoplasm (GO:0005737) 20150917: Amniota_PTN000698035 is found in dendrite (GO:0030425) 20150917: Euteleostomi_PTN001229124 is found in actin cytoskeleton (GO:0015629) 20150917: Euteleostomi_PTN001229124 is found in dendrite cytoplasm (GO:0032839) 20150917: Eumetazoa_PTN001561551 is found in cytoplasm (GO:0005737) 20150917: Euteleostomi_PTN000697756 is found in endoplasmic reticulum (GO:0005783) 20150917: Euteleostomi_PTN000697756 is found in neuron projection (GO:0043005) 20150917: Euteleostomi_PTN000697756 is found in neuronal cell body (GO:0043025) 20150917: Euteleostomi_PTN000697893 is found in midbody (GO:0030496) 20150917: Euteleostomi_PTN000698246 is found in sarcoplasmic reticulum membrane (GO:0033017) 20150917: Euteleostomi_PTN000698246 is found in cytoskeleton (GO:0005856) 20150917: Euteleostomi_PTN000698246 is found in M band (GO:0031430) 20150917: Euteleostomi_PTN000697603 is found in centrosome (GO:0005813) 20150917: Euteleostomi_PTN000697603 is found in cytoplasm (GO:0005737) 20150917: Euteleostomi_PTN000697603 is found in mitotic spindle (GO:0072686) 20150917: Euteleostomi_PTN000697603 is found in polar microtubule (GO:0005827) 20150917: Euteleostomi_PTN000697002 is found in I band (GO:0031674) 20150917: Euteleostomi_PTN000697002 is found in A band (GO:0031672) 20150917: Euteleostomi_PTN000697193 is found in cytosol (GO:0005829) 20150917: Tetrapoda_PTN001229359 is found in actin cytoskeleton (GO:0015629) 20150917: Euteleostomi_PTN000697442 is found in nucleus (GO:0005634) 20150917: Embryophyta_PTN001229743 is found in nucleus (GO:0005634) # biological_process 20150917: Metazoa_PTN001973737 participates in protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787) 20150917: Euteleostomi_PTN000697161 participates in cytoplasmic sequestering of transcription factor (GO:0042994) 20150917: Euteleostomi_PTN000697161 participates in proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) 20150917: Euteleostomi_PTN000697161 participates in negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433) 20150917: Euteleostomi_PTN000697969 participates in protein K33-linked ubiquitination (GO:1990390) 20150917: Euteleostomi_PTN000697969 participates in Golgi to endosome transport (GO:0006895) 20150917: Euteleostomi_PTN000697969 participates in proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) 20150917: Euteleostomi_PTN000697969 participates in response to interferon-alpha (GO:0035455) 20150917: Eumetazoa_PTN001561561 participates in regulation of cytokinesis (GO:0032465) 20150917: Eumetazoa_PTN001561561 participates in chromosome passenger complex localization to spindle midzone (GO:0035853) 20150917: Chordata_PTN001973791 participates in protein monoubiquitination (GO:0006513) 20150917: Chordata_PTN001973791 participates in COPII vesicle coating (GO:0048208) 20150917: Amniota_PTN000698035 participates in dendrite development (GO:0016358) 20150917: Euteleostomi_PTN001229124 participates in brain development (GO:0007420) 20150917: Euteleostomi_PTN001229124 participates in actin cytoskeleton organization (GO:0030036) 20150917: Eumetazoa_PTN001561551 participates in fertilization (GO:0009566) 20150917: Eumetazoa_PTN001561551 participates in male gonad development (GO:0008584) 20150917: Eumetazoa_PTN001561551 participates in spermatid development (GO:0007286) 20150917: Bilateria_PTN001229449 participates in protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787) 20150917: Euteleostomi_PTN000698246 participates in sarcomere organization (GO:0045214) 20150917: Euteleostomi_PTN000698246 participates in skeletal muscle fiber development (GO:0048741) 20150917: Euteleostomi_PTN000698246 participates in regulation of skeletal muscle cell differentiation (GO:2001014) 20150917: Euteleostomi_PTN000698246 participates in regulation of myoblast proliferation (GO:2000291) 20150917: Euteleostomi_PTN000698246 participates in regulation of myoblast differentiation (GO:0045661) 20150917: Euteleostomi_PTN000697603 participates in protein monoubiquitination (GO:0006513) 20150917: Euteleostomi_PTN000697603 participates in mitotic spindle assembly checkpoint (GO:0007094) 20150917: Euteleostomi_PTN000697002 participates in negative regulation of protein ubiquitination (GO:0031397) 20150917: Euteleostomi_PTN000697002 participates in negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435) 20150917: Euteleostomi_PTN000697002 participates in skeletal muscle fiber development (GO:0048741) 20150917: Euteleostomi_PTN000697193 participates in renal sodium ion absorption (GO:0070294) 20150917: Euteleostomi_PTN000697193 participates in protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787) 20150917: Euteleostomi_PTN000697193 participates in protein K48-linked ubiquitination (GO:0070936) 20150917: Euteleostomi_PTN000697193 participates in ion homeostasis (GO:0050801) 20150917: Euteleostomi_PTN000697781 participates in proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) 20150917: Euteleostomi_PTN000697781 participates in regulation of microtubule-based process (GO:0032886) 20150917: Euteleostomi_PTN000697781 participates in protein polyubiquitination (GO:0000209) 20150917: Euteleostomi_PTN000697442 participates in transcription from RNA polymerase II promoter (GO:0006366) 20150917: Embryophyta_PTN001229743 participates in response to red light (GO:0010114) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).