# HISTORY 06 May 2016: Saved by suzi using Paint 2.0-beta18 18 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20160205: Tetrapoda_PTN000335136 has function phosphatidylinositol-4,5-bisphosphate binding (GO:0005546) 20160205: Euteleostomi_PTN000277596 has function SUMO-specific protease activity (GO:0016929) 20160208: Euteleostomi_PTN000062869 has function dynein binding (GO:0045502) 20160229: Euteleostomi_PTN000687489 has function transforming growth factor beta binding (GO:0050431) 20160229: Euteleostomi_PTN000687444 has function transmembrane signaling receptor activity (GO:0004888) 20160229: Theria _PTN000687448 has function lipopeptide binding (GO:0071723) 20160205: Theria _PTN000687448 has function Toll-like receptor 2 binding (GO:0035663) 20160208: node_PTN001555329 has function G-protein coupled receptor activity (GO:0004930) 20160208: Bilateria_PTN000687652 has function receptor activity (GO:0004872) 20160205: Tetrapoda_PTN000687294 has function single-stranded RNA binding (GO:0003727) 20160229: Mammalia_PTN000687407 has function lipopolysaccharide binding (GO:0001530) 20160229: Mammalia_PTN000687407 has function lipopolysaccharide receptor activity (GO:0001875) 20160229: Euteleostomi_PTN000063014 has function cytoskeletal protein binding (GO:0008092) 20160229: Euteleostomi_PTN000687556 has function receptor activity (GO:0004872) 20160229: Ecdysozoa_PTN001222848 has function neurotrophin receptor activity (GO:0005030) 20160229: Euteleostomi_PTN000687728 has function double-stranded RNA binding (GO:0003725) 20160229: Euteleostomi_PTN000687728 has function receptor activity (GO:0004872) 20160229: Tetrapoda_PTN000687767 has function insulin-like growth factor binding (GO:0005520) 20160229: Opisthokonta_PTN001970896 has function double-stranded RNA binding (GO:0003725) # cellular_component 20160205: Tetrapoda_PTN000335136 is found in dendritic spine (GO:0043197) 20160208: Euteleostomi_PTN000062869 is found in axoneme (GO:0005930) 20160208: Tetrapoda_PTN001555458 is found in plasma membrane (GO:0005886) 20160229: Euteleostomi_PTN000687444 is found in integral component of plasma membrane (GO:0005887) 20160229: Boreoeutheria_PTN000687459 is found in Toll-like receptor 1-Toll-like receptor 2 protein complex (GO:0035354) 20160205: Boreoeutheria_PTN000687466 is found in Toll-like receptor 2-Toll-like receptor 6 protein complex (GO:0035355) 20160208: node_PTN001555329 is found in plasma membrane (GO:0005886) 20160205: Euteleostomi_PTN000062770 is found in cytoplasm (GO:0005737) 20160205: Euteleostomi_PTN000062770 is found in cilium (GO:0005929) 20160208: Bilateria_PTN000687652 is found in integral component of plasma membrane (GO:0005887) 20160229: Euteleostomi_PTN000063014 is found in microtubule cytoskeleton (GO:0015630) 20160229: Euteleostomi_PTN000687556 is found in intrinsic component of plasma membrane (GO:0031226) 20160229: Bilateria_PTN000757746 is found in integral component of plasma membrane (GO:0005887) 20160229: Euteleostomi_PTN000687728 is found in integral component of plasma membrane (GO:0005887) 20160229: Tetrapoda_PTN000687767 is found in insulin-like growth factor ternary complex (GO:0042567) # biological_process 20160205: Tetrapoda_PTN000335136 participates in positive regulation of synapse structural plasticity (GO:0051835) 20160205: Euteleostomi_PTN000277596 participates in protein desumoylation (GO:0016926) 20160205: Euteleostomi_PTN000277596 participates in regulation of kinetochore assembly (GO:0090234) 20160208: Tetrapoda_PTN001555458 participates in cell surface receptor signaling pathway (GO:0007166) 20160229: Euteleostomi_PTN000687444 participates in toll-like receptor signaling pathway (GO:0002224) 20160205: Theria _PTN000687448 participates in cellular response to bacterial lipopeptide (GO:0071221) 20160205: Theria _PTN000687448 participates in defense response to bacterium (GO:0042742) 20160205: Boreoeutheria_PTN000687459 participates in cellular response to triacyl bacterial lipopeptide (GO:0071727) 20160205: Boreoeutheria_PTN000687466 participates in cellular response to diacyl bacterial lipopeptide (GO:0071726) 20160208: node_PTN001555329 participates in adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188) 20160205: Euteleostomi_PTN000062770 participates in cilium movement (GO:0003341) 20160229: Bilateria_PTN000687652 participates in inflammatory response (GO:0006954) 20160208: Bilateria_PTN000687652 participates in toll-like receptor signaling pathway (GO:0002224) 20160205: Tetrapoda_PTN000687294 participates in toll-like receptor 7 signaling pathway (GO:0034154) 20160205: Tetrapoda_PTN000687294 participates in defense response to virus (GO:0051607) 20160229: Amniota_PTN000687406 participates in defense response to Gram-negative bacterium (GO:0050829) 20160229: Euteleostomi_PTN000063014 participates in regulation of phosphatase activity (GO:0010921) 20160229: Euteleostomi_PTN000687556 participates in toll-like receptor signaling pathway (GO:0002224) 20160229: Ecdysozoa_PTN001222848 participates in axon guidance (GO:0007411) 20160229: Euteleostomi_PTN000687728 participates in toll-like receptor signaling pathway (GO:0002224) 20160229: Euteleostomi_PTN000687728 participates in defense response to virus (GO:0051607) 20160229: Euteleostomi_PTN000687728 participates in response to dsRNA (GO:0043331) 20160229: Amniota_PTN000687657 participates in defense response to other organism (GO:0098542) 20160229: Amniota_PTN000687657 participates in immune response (GO:0006955) 20160229: Opisthokonta_PTN001970896 participates in defense response to other organism (GO:0098542) 20160229: Opisthokonta_PTN001970896 participates in toll-like receptor signaling pathway (GO:0002224) 20160229: Arthropoda_PTN001222964 does NOT participate in inflammatory response (GO:0006954) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).