# HISTORY
27 Mar 2016: Updated by: TOUCHUP-v1.15
18 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function

# cellular_component
20131010: Deuterostomia_PTN001197580 is found in cytoplasm (GO:0005737) 
20131010: Deuterostomia_PTN001197580 is found in nucleus (GO:0005634) 

# biological_process
20131010: Eukaryota_PTN001197575 participates in regulation of canonical Wnt signaling pathway (GO:0060828) 
20131010: Deuterostomia_PTN001197580 participates in positive regulation of JNK cascade (GO:0046330) 
20131010: Deuterostomia_PTN001197580 participates in negative regulation of canonical Wnt signaling pathway (GO:0090090) 
20131010: Euteleostomi_PTN000653899 participates in patterning of blood vessels (GO:0001569) 
20131010: Euteleostomi_PTN000653899 participates in positive regulation of endothelial cell proliferation (GO:0001938) 
20131010: Euteleostomi_PTN000653899 participates in blood vessel endothelial cell proliferation involved in sprouting angiogenesis (GO:0002043) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
the ankyrin repeat is one of the most common protein-protein interaction motifs in nature. ankyrin repeats are tandemly repeated modules of about 33 amino acids. they occur in a large number of functionally diverse proteins mainly from eukaryotes. the few known examples from prokaryotes and viruses may be the result of horizontal gene transfers (pubmed:8108379). the repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. the ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognized by it.
BP:
Both mouse and zebrafish Ankrd6, blocks canonical Wnt signaling, but promotes JNK-dependent gene transcription. SO both term were propagate to that clay.
Multiple propagations in the Nrarp clay based on PMID:19154719 (some of annotations exclude the sea urchin protein, since I am not sure whether sea urchin has blood vessel).
Since regulation of canonical Wnt receptor signaling pathway annotation exist in both Ankrd6 and Nrarp clays, I propagate GO:0060828 regulation of canonical Wnt receptor signaling pathway to the root.
Since ankyrin repeat has been found in proteins of diverse function, so I will not propagate other process term at the moment.
LN 10/10/2013

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).