# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 17 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20150728: root_PTN000595684 is found in CCR4-NOT core complex (GO:0030015) 20150728: root_PTN000595684 is found in cytoplasmic mRNA processing body (GO:0000932) # biological_process 20150728: root_PTN000595684 participates in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288) 20150728: root_PTN000595684 participates in negative regulation of translation (GO:0017148) 20150728: Tetrapoda_PTN000595691 participates in regulation of stem cell population maintenance (GO:2000036) 20150728: Tetrapoda_PTN000595763 participates in regulation of stem cell population maintenance (GO:2000036) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).