# HISTORY 28 Nov 2016: Saved by mfeuerma using Paint 2.28 on 28 Nov 2016 using PANTHER version UPL 11.0 # molecular_function 20161128: node_PTN001140629 has function volume-sensitive anion channel activity (GO:0005225) 20161128: Euteleostomi_PTN000569624 has LOST/MODIFIED function volume-sensitive anion channel activity (GO:0005225) 20161128: Euteleostomi_PTN000569624 has function ubiquitin protein ligase activity (GO:0061630) 20161128: Euteleostomi_PTN000568857 has LOST/MODIFIED function volume-sensitive anion channel activity (GO:0005225) 20161128: Bilateria_PTN001140822 has function protein serine/threonine phosphatase activity (GO:0004722) 20161128: Euteleostomi_PTN000568494 has function receptor binding (GO:0005102) 20161128: Euteleostomi_PTN000568494 has function integrin binding (GO:0005178) 20161128: Euteleostomi_PTN000568718 has function protein serine/threonine phosphatase activity (GO:0004722) 20161128: Eukaryota_PTN001504428 has function protein phosphatase binding (GO:0019903) 20161128: Eukaryota_PTN002351899 has function protein phosphatase regulator activity (GO:0019888) 20161128: Eukaryota_PTN002351899 has function protein phosphatase binding (GO:0019903) # cellular_component 20161128: node_PTN001140629 is found in plasma membrane (GO:0005886) 20161128: node_PTN001140629 is found in cytoplasm (GO:0005737) 20161128: node_PTN001140629 is found in ion channel complex (GO:0034702) 20161128: Euteleostomi_PTN000569624 is NOT found in ion channel complex (GO:0034702) 20161128: Euteleostomi_PTN000568857 is NOT found in ion channel complex (GO:0034702) 20161128: Bilateria_PTN001140822 is found in photoreceptor outer segment membrane (GO:0042622) 20161128: Bilateria_PTN001140822 is found in photoreceptor inner segment (GO:0001917) 20161128: Embryophyta_PTN002352237 is found in plasma membrane (GO:0005886) 20161128: Eukaryota_PTN001901640 is found in plasma membrane (GO:0005886) 20161128: Euteleostomi_PTN000568494 is found in basolateral plasma membrane (GO:0016323) 20161128: Eukaryota_PTN001900148 is found in cytoplasm (GO:0005737) 20161128: Euteleostomi_PTN000722353 is found in neuron projection (GO:0043005) 20161128: root_PTN002351852 is found in plasma membrane (GO:0005886) 20161128: Euteleostomi_PTN000568718 is found in cytoplasm (GO:0005737) 20161128: Euteleostomi_PTN000568718 is found in nuclear membrane (GO:0031965) 20161128: Eukaryota_PTN002352077 is found in cytoplasm (GO:0005737) 20161128: Eukaryota_PTN002352077 is found in basolateral plasma membrane (GO:0016323) 20161128: Eukaryota_PTN001504428 is found in protein phosphatase type 1 complex (GO:0000164) 20161128: Eukaryota_PTN002351899 is NOT found in plasma membrane (GO:0005886) 20161128: Eukaryota_PTN002351899 is found in cytoplasm (GO:0005737) 20161128: Eukaryota_PTN002352017 is NOT found in plasma membrane (GO:0005886) # biological_process 20161128: node_PTN001140629 participates in anion transmembrane transport (GO:0098656) 20161128: Euteleostomi_PTN000569624 does NOT participate in anion transmembrane transport (GO:0098656) 20161128: Euteleostomi_PTN000569624 participates in ubiquitin-dependent endocytosis (GO:0070086) 20161128: Euteleostomi_PTN000569624 participates in positive regulation of xenophagy (GO:1904417) 20161128: Euteleostomi_PTN000569624 participates in positive regulation of autophagosome assembly (GO:2000786) 20161128: Euteleostomi_PTN000568857 does NOT participate in anion transmembrane transport (GO:0098656) 20161128: Bilateria_PTN001140822 participates in protein dephosphorylation (GO:0006470) 20161128: Eukaryota_PTN001901640 participates in signal transduction (GO:0007165) 20161128: Euteleostomi_PTN000568494 participates in epidermal growth factor receptor signaling pathway (GO:0007173) 20161128: Euteleostomi_PTN000722353 participates in positive regulation of neuron projection development (GO:0010976) 20161128: Euteleostomi_PTN000568494 participates in cellular response to tumor necrosis factor (GO:0071356) 20161128: Euteleostomi_PTN000568718 participates in protein dephosphorylation (GO:0006470) 20161128: Euteleostomi_PTN000568718 participates in regulation of MAPK cascade (GO:0043408) 20161128: Euteleostomi_PTN000568718 participates in regulation of p38MAPK cascade (GO:1900744) 20161128: Euteleostomi_PTN000568718 participates in regulation of JNK cascade (GO:0046328) 20161128: Euteleostomi_PTN000568718 participates in regulation of protein kinase B signaling (GO:0051896) 20161128: Euteleostomi_PTN000568718 participates in regulation of protein kinase C signaling (GO:0090036) 20161128: Eukaryota_PTN002353024 participates in signal transduction (GO:0007165) 20161128: Eukaryota_PTN002353024 participates in G-protein coupled receptor signaling pathway (GO:0007186) 20161128: Magnoliophyta_PTN002353049 participates in defense response (GO:0006952) 20161128: root_PTN002351852 participates in signal transduction (GO:0007165) 20161128: Embryophyta_PTN001901267 participates in defense response (GO:0006952) 20161128: Magnoliophyta_PTN001140936 participates in plant-type hypersensitive response (GO:0009626) 20161128: Magnoliophyta_PTN001902120 participates in plant-type hypersensitive response (GO:0009626) 20161128: Eukaryota_PTN002351899 participates in Ras protein signal transduction (GO:0007265) 20161128: Eukaryota_PTN002352077 participates in maintenance of epithelial cell apical/basal polarity (GO:0045199) 20161128: Viridiplantae_PTN002352121 participates in defense response (GO:0006952) 20161128: Fungi_PTN002352219 participates in cell separation after cytokinesis (GO:0000920) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).