# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150812: root_PTN000478645 has function cardiolipin synthase activity (GO:0008808) # cellular_component 20150812: root_PTN000478645 is found in membrane (GO:0016020) 20150812: node_PTN000478646 is found in mitochondrial outer membrane (GO:0005741) 20150812: Bacteria _PTN001291684 is NOT found in mitochondrial outer membrane (GO:0005741) # biological_process 20150812: root_PTN000478645 participates in cardiolipin biosynthetic process (GO:0032049) 20150812: node_PTN000478646 participates in piRNA metabolic process (GO:0034587) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: PLD6_HUMAN cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848) # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).