# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 16 Mar 2016: Updated by: TOUCHUP-v1.14 26 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20131104: Eumetazoa_PTN001074076 has function hormone binding (GO:0042562) 20131122: Eukaryota_PTN000465443 has function receptor activity (GO:0004872) 20131122: Deuterostomia_PTN000465518 has function steroid hormone receptor activity (GO:0003707) 20131104: Deuterostomia_PTN000465518 has function steroid binding (GO:0005496) # cellular_component 20131104: Eumetazoa_PTN001074076 is found in plasma membrane (GO:0005886) 20131104: Deuterostomia_PTN000465518 is found in plasma membrane (GO:0005886) # biological_process 20131104: Fungi_PTN001074096 participates in cellular zinc ion homeostasis (GO:0006882) 20131104: Eumetazoa_PTN001074076 participates in adiponectin-activated signaling pathway (GO:0033211) 20131122: node_PTN000465769 participates in response to hormone (GO:0009725) 20131104: Deuterostomia_PTN000465518 participates in response to steroid hormone (GO:0048545) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES re-annotated mouse adipor1 /adipor2 RGD correct annotation of GO:0044459 plasma membrane part Wrote to David to add new terms and change ontology in consistency, see sourceforge ontology-requests:#10487 Most of the HTP data were not used for paint annotations LN # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).