# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140729: Bacteria _PTN000424265 has function 2-methylcitrate dehydratase activity (GO:0047547) 20140729: Chordata_PTN001048076 has function aconitate decarboxylase activity (GO:0047613) # cellular_component 20140915: Dikarya_PTN001048090 is found in mitochondrion (GO:0005739) 20140729: Chordata_PTN001048076 is found in mitochondrion (GO:0005739) # biological_process 20140729: Bacteria _PTN000424265 participates in propionate metabolic process, methylcitrate cycle (GO:0019679) 20140729: Chordata_PTN001048076 participates in defense response (GO:0006952) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES There is interesting horizontal gene transfer going on in this family. There is one clade in this family with a very diverged function (aconitate decarboxylase). Since the methylcitrate dehydratase function is conserved between the Ecoli and Yeast genes, this function was propagated just to this node and the aconitate decarboxylase was propagated to the immediate ancestor. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).