# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
16 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function

# cellular_component
20140709: root_PTN000404360 is found in axoneme (GO:0005930) 
20140709: root_PTN000404360 is found in ciliary basal body (GO:0036064) 
20140709: Eukaryota_PTN000404361 is found in intraciliary transport particle A (GO:0030991) 
20140709: Eukaryota_PTN000404408 is found in intraciliary transport particle B (GO:0030992) 

# biological_process
20140709: Eukaryota_PTN000404361 participates in cilium assembly (GO:0042384) 
20140709: Eukaryota_PTN000404361 participates in intraciliary retrograde transport (GO:0035721) 
20140709: Eukaryota_PTN000404408 participates in cilium assembly (GO:0042384) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family contains two clades, each of which contains subunits of an Intraflagellar Transport Complex (IFT), either IFT A or IFT B. The MSA indicates some conserved residues across both clades, suggesting that the grouping of the two clades is reasonable, though it is not yet clear exactly what the conserved function between the two clades is (as of July 2014). The IFT complexes are found in all types of cilia, both primary cilia and motile cilia, and are involved in transport of cargo to and from the base and the tip of the cilium (PMID:19253336, PMID:19450523, PMID:23945166).
The IFT140 clade comprises a subunit of the IFT A complex, which is involved in intraciliary retrograde transport within the cilium.
The IFT172 clade comprises a subunit of the IFT B complex, which is involved in intraciliary anterograde transport within the cilium.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).